The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform
Gopesh Srivastava - One of the best experts on this subject based on the ideXlab platform.
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malignant Lymphoma of the thyroid a 30 year clinicopathologic experience and an evaluation of the presence of epstein barr virus
American Journal of Clinical Pathology, 1999Co-Authors: K Y Lam, Dora L W Kwong, Joyce Manfong Lee, Gopesh SrivastavaAbstract:Lymphoma of thyroid is uncommon, and Epstein- Barr virus (EBV) is found in many Lymphomas. We studied the clinicopathologic characteristics in Hong Kong Chinese and analyzed the presence of EBV in thyroid Lymphomas by reviewing data collected during 3 decades. We studied EBV gene expression by in situ hybridization and immunohistochemistry. Primary thyroid Lymphomas were found in 23 patients (diffuse large B-cell Lymphoma, 18; marginal zone B-cell Lymphoma, 4; plasmacytoma, 1), and secondary Lymphomas were found in 9 patients (diffuse large Bcell Lymphoma, 3; Burkitt Lymphomas, 2; Burkitt-like Lymphoma, 1; hairy cell leukemia, 1; nasal T-cell and natural killer cell Lymphoma, 1; and intestinal T-cell Lymphoma, 1). Primary thyroid Lymphomas were large (mean, 7 cm), found commonly in older women, and often misdiagnosed as undifferentiated carcinomas. Fine-needle aspiration was not helpful for diagnosis. Fifteen patients had Hashimoto thyroiditis. A history of thyrotoxicosis was found in 3 patients, and coexistence of 3 diseases (papillary microcarcinomas, primary thyroid Lymphoma, and Hashimoto thyroiditis) was found 4 patients. The 5-year survival rate for primary thyroid Lymphoma was 53%. Combined surgery and radiotherapy seemed to be the best treatment. Secondary thyroid Lymphomas often were asymptomatic. EBV messenger RNAs were detected in 1 primary and 1 secondary thyroid Lymphoma. The EBV gene expression in primary thyroid Lymphoma showed a type II latency pattern. Thyroid Lymphomas in Chinese had important clinicopathologic features. EBV may have a role in a subset of cases.
Susan Kennedy - One of the best experts on this subject based on the ideXlab platform.
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Ocular adnexal Lymphoma—comparison of MALT Lymphoma with other histological types
The British journal of ophthalmology, 1999Co-Authors: Mark Cahill, Colma Barnes, Paul Moriarty, Peter Daly, Susan KennedyAbstract:AIMS—To correlate histological features of ocular adnexal Lymphoma using the revised European American Lymphoma classification (REAL), with stage of disease at presentation, treatment modalities, and patient outcome. MALT Lymphoma defines an extranodal marginal zone B cell Lymphoma as outlined in the REAL classification. Comparison groups of patients included those with primary ocular adnexal MALT Lymphoma versus primary ocular adnexal Lymphomas of other types, MALT Lymphoma versus non-MALT Lymphomas (primary and secondary), and primary ocular adnexal Lymphoma (MALT Lymphomas and other types) versus secondary ocular adnexal Lymphomas. METHODS—A retrospective review of the National Ophthalmic Pathology Laboratory records identified 20 cases of ocular adnexal Lymphoma over a 10 year period which were reclassified using appropriate immunohistochemical stains. Patients' medical records were examined for data including stage of the disease at presentation, mode of treatment, and patient outcome. RESULTS—Among the 20 cases identified 14 had primary ocular adnexal Lymphomas. 10 of the primary Lymphomas had histological features of MALT Lymphoma. One case was a primary ocular adnexal T cell Lymphoma, one a follicular centre, follicular B cell Lymphoma, and two were large cell B cell Lymphomas. Six cases had systemic disease, four large B cell, one follicular centre, follicular B cell, and one mantle cell. A significantly higher proportion of patients with MALT Lymphomas had early disease (p = 0.005), initially required local treatment (p = 0.005) and were alive at last follow up (p = 0.001) than those without. Two patients with MALT Lymphoma had recurrence of Lymphoma which responded to further treatment. CONCLUSIONS—Patients with primary ocular adnexal MALT Lymphomas present with localised disease requiring local treatment and have a better outcome compared with patients with other types. As a small percentage of these tumours recur, patients should be followed up indefinitely.
German Ott - One of the best experts on this subject based on the ideXlab platform.
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Grey zone Lymphomas: limitations of the classification of aggressive B-cell Lymphomas
Der Pathologe, 2013Co-Authors: M.m. Ott, Andreas Rosenwald, Heike Horn, German OttAbstract:Grey zone Lymphomas are lymphatic tumors that cannot be assigned to a defined Lymphoma entity due to morphological, clinical or genetic reasons. As a defining criterion they present with features of two overlapping entities or features that are intermediate. Such Lymphomas may represent a grey zone in the differentiation between indolent and aggressive Lymphomas. Often they may show morphological features of one entity but be more related to another entity with respect to the immunophenotype and/or genetic constitution, such as Lymphomas in the grey zone between primary mediastinal large B-cell Lymphoma and primary nodal diffuse large B-cell Lymphoma. The B-cell Lymphoma, unclassified, with features intermediate between diffuse large B-cell Lymphoma and Burkitt Lymphoma has recently been recognized as a provisional category in the updated WHO 2008 classification of malignant Lymphomas. This corresponds to a practical Lymphoma category that obviously contains several entities with a Burkitt-like appearance and aggressive clinical behavior. Genetically, tumors in this category are frequently characterized by an atypical MYC translocation and complex karyotypic alterations. As yet, no adequate therapy concept exists.
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chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression defined burkitt s Lymphoma
Haematologica, 2008Co-Authors: Itziar Salaverria, Andreas Zettl, German Ott, Silvia Bea, Elena Hartmann, Sandeep S Dave, George W Wright, Evert Jan Boerma, Philip M KluinAbstract:Background Burkitt’s Lymphoma is an aggressive B-cell Lymphoma characterized by typical morphological, immunophenotypic and molecular features. Gene expression profiling provided a molecular signature of Burkitt’s Lymphoma, but also demonstrated that a subset of aggressive B-cell Lymphomas not fulfilling the current World Health Organization criteria for the diagnosis of Burkitt’s Lymphoma nonetheless show a molecular signature of Burkitt’s Lymphoma (‘discrepant Burkitt’s Lymphoma’). Given the different treatment of Burkitt’s Lymphoma and diffuse large B-cell Lymphomas we investigated molecular differences within gene expression-defined Burkitt’s Lymphoma. Design and Methods We studied tumors from 51 Burkitt’s Lymphoma patients, comprising 26 with classic Burkitt’s Lymphoma, 17 with atypical Burkitt’s Lymphoma and 8 with ‘discrepant Burkitt’s Lymphoma’, by comparative genomic hybridization and gene expression profiling. Results Classic and atypical Burkitt’s Lymphoma (excluding ‘discrepant Burkitt’s Lymphoma’), in adult and pediatric cases do not differ in underlying genomic imbalances or gene expression suggesting that these subgroups are molecularly homogeneous. ‘Discrepant Burkitt’s Lymphoma’, however, differ dramatically in the absolute number of alterations from classic/atypical Burkitt’s Lymphoma and from diffuse large B-cell Lymphoma. Moreover, this category includes Lymphomas that carry both the t(14;18) and t(8;14) translocations and are clinically characterized by presentation in adult patients and an aggressive course. Conclusions Pediatric and adult Burkitt’s Lymphoma are molecularly homogeneous, whereas ‘discrepant Burkitt’s Lymphoma’ differ in underlying genetic and clinical features from typical/atypical Burkitt’s Lymphoma. ‘Discrepant Burkitt’s Lymphoma’ may therefore form a distinct genetic subgroup of aggressive B-cell Lymphomas, which show poor response to multi-agent chemotherapy.
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Pathology of Lymphoma progression.
Histopathology, 2001Co-Authors: Andreas Zettl, Walther M. Pfeifer, German OttAbstract:Reflecting the stepwise process of oncogenesis, Lymphomas may cumulatively develop a more aggressive phenotype during the course of disease, a process referred to as Lymphoma progression. Although morphological, clinical and biological aspects of Lymphoma progression do not always overlap, changes in Lymphoma morphology frequently indicate alterations in the clinical and biological behaviour of the disease. Indolent and aggressive Lymphomas in disease progression can either be clonally related or represent clonally unrelated neoplasms. We propose to use the term 'Lymphoma progression' in a biological sense denoting only clonal development of and within a Lymphoma entity. The term 'composite Lymphoma' should be used as a merely descriptive morphological designation for different Lymphoma entities in one individual irrespective of clonal relationship. Many types of aggressive B-cell non-Hodgkin's Lymphomas and Hodgkin's Lymphomas are reported to secondarily develop in Lymphoma progression. Genetic changes associated with Lymphoma progression frequently abrogate the differentiating effects of alterations occurring in indolent Lymphomas, leading to increased cell proliferation. Within different Lymphoma entities, high-risk disease variants mimicking Lymphoma progression exist.
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Composite Lymphoma: the interface between Hodgkin's and non-Hodgkin's Lymphoma
Current Diagnostic Pathology, 2000Co-Authors: Thomas Rüdiger, German Ott, Andreas Zettl, H. K. Müller-hermelinkAbstract:Abstract Hodgkin's Lymphoma is a rare neoplasm mainly affecting young people. Within the last decade, nodular lymphocyte-predominant Hodgkin's Lymphoma (NLPHL) has been separated from all other cases of the so-called classical type. Moreover, the derivation of Hodgkin's Lymphoma from germinal centre B-cells has been established, giving rise to a possible clonal relationship between Hodgkin's Lymphoma and the non-Hodgkin's Lymphomas (NHLs). The interface between them therefore has both diagnostic and biological aspects. Diagnostic difficulties arise, due to overlapping definitions, between biologically unrelated entities, e.g. classical Hodgkin's Lymphoma and NLPHL or anaplastic large cell Lymphoma, respectively. On the other hand, there is a biological grey zone regarding composite Lymphomas consisting of Hodgkin's Lymphoma and any NHL. This simultaneous or subsequent occurrence of Hodgkin's Lymphoma and non-Hodgkin's Lymphomas may, or may not, be clonally related. For management purposes Lymphomas, e.g. NLPHL and T cell-rich B-cell Lymphoma, must be distinguished along a continuous spectrum of progression.
Arthur S Grove - One of the best experts on this subject based on the ideXlab platform.
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ocular adnexal Lymphoma a clinicopathologic study with identification of Lymphomas of mucosa associated lymphoid tissue type
Ophthalmology, 1995Co-Authors: William L White, Judith A. Ferry, Nancy L Harris, Arthur S GroveAbstract:Abstract Purpose: Extranodal marginal zone B-cell Lymphoma (low-grade B-cell Lymphoma of mucosa-associated lymphoid tissue [MALT] type) is a distinctive type of Lymphoma that usually arises in association with mucosa or other epithelial structures and has an indolent clinical course. The frequency and clinical features of MALT Lymphomas in the ocular adnexa have not been well studied. Methods: The authors examined the clinicopathologic features of ocular adnexal Lymphoma, identified a subset of cases with MALT characteristics, and determined patient outcome. Results: The 42 patients, 16 men and 26 women age 35-89 years (mean, 64) were followed an average of 4.8 years. Thirty-two patients had ocular adnexal involvement at presentation (primary ocular adnexal Lymphoma) and 10 had a history of Lymphoma that relapsed in the orbit (secondary ocular adnexal Lymphoma). In the primary group, 23 patients had Lymphoma confined to the ocular adnexa, 3 had a single lesion that invaded adjacent structures, and 6 had distant spread at the time of presentation. Twenty-five patients achieved a complete remission. Nine patients, including 6 patients whose disease was localized initially, had progression or relapse of disease in distant sites. At last follow-up, 21 patients were free of disease, 9 were alive with disease and 2 had died of Lymphoma. In the secondary group, at last follow-up, 1 patient had died of other causes, free of Lymphoma, 3 patients were alive with disease and 5 had died of Lymphoma (outcome not known in 1 case). Using the recently described revised European-American Lymphoma classification, we found 16 MALT Lymphomas, 8 diffuse large B cell, 12 follicular center, 3 mantle cell, 1 B-small lymphocytic Lymphoma, and 2 unclassifiable low-grade Lymphomas. The most common type of primary Lymphoma was MALT type (15 of 30 classifiable cases), and the most common secondary Lymphoma was follicular center (6 of 10). No increased frequency of conjunctival or lacrimal gland involvement by MALT Lymphomas was found. All 33 Lymphomas with immunophenotyping were of B lineage. Conclusions: Ocular adnexal Lymphomas are 8-cell tumors that develop in older adults, predominantly among women. Primary orbital Lymphomas have a favorable prognosis; a high proportion of them have MALT characteristics.
Judith A. Ferry - One of the best experts on this subject based on the ideXlab platform.
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Angioimmunoblastic T-cell Lymphoma.
Advances in anatomic pathology, 2002Co-Authors: Judith A. FerryAbstract:Angioimmunoblastic T-cell Lymphoma (AIL-TCL) is a rare subtype of Lymphoma, making up only 1% to 2% of nonHodgkin's Lymphomas; however, it accounts for a major subset of peripheral T-cell Lymphomas. Angioimmunoblastic T-cell Lymphoma has clinical and pathologic features that set it apart from other B- and T-cell Lymphomas. More recent studies have delineated the immunophenotypic and genetic features of this unusual Lymphoma, and have tentatively identified the cell of origin of this neoplasm.
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ocular adnexal Lymphoma a clinicopathologic study with identification of Lymphomas of mucosa associated lymphoid tissue type
Ophthalmology, 1995Co-Authors: William L White, Judith A. Ferry, Nancy L Harris, Arthur S GroveAbstract:Abstract Purpose: Extranodal marginal zone B-cell Lymphoma (low-grade B-cell Lymphoma of mucosa-associated lymphoid tissue [MALT] type) is a distinctive type of Lymphoma that usually arises in association with mucosa or other epithelial structures and has an indolent clinical course. The frequency and clinical features of MALT Lymphomas in the ocular adnexa have not been well studied. Methods: The authors examined the clinicopathologic features of ocular adnexal Lymphoma, identified a subset of cases with MALT characteristics, and determined patient outcome. Results: The 42 patients, 16 men and 26 women age 35-89 years (mean, 64) were followed an average of 4.8 years. Thirty-two patients had ocular adnexal involvement at presentation (primary ocular adnexal Lymphoma) and 10 had a history of Lymphoma that relapsed in the orbit (secondary ocular adnexal Lymphoma). In the primary group, 23 patients had Lymphoma confined to the ocular adnexa, 3 had a single lesion that invaded adjacent structures, and 6 had distant spread at the time of presentation. Twenty-five patients achieved a complete remission. Nine patients, including 6 patients whose disease was localized initially, had progression or relapse of disease in distant sites. At last follow-up, 21 patients were free of disease, 9 were alive with disease and 2 had died of Lymphoma. In the secondary group, at last follow-up, 1 patient had died of other causes, free of Lymphoma, 3 patients were alive with disease and 5 had died of Lymphoma (outcome not known in 1 case). Using the recently described revised European-American Lymphoma classification, we found 16 MALT Lymphomas, 8 diffuse large B cell, 12 follicular center, 3 mantle cell, 1 B-small lymphocytic Lymphoma, and 2 unclassifiable low-grade Lymphomas. The most common type of primary Lymphoma was MALT type (15 of 30 classifiable cases), and the most common secondary Lymphoma was follicular center (6 of 10). No increased frequency of conjunctival or lacrimal gland involvement by MALT Lymphomas was found. All 33 Lymphomas with immunophenotyping were of B lineage. Conclusions: Ocular adnexal Lymphomas are 8-cell tumors that develop in older adults, predominantly among women. Primary orbital Lymphomas have a favorable prognosis; a high proportion of them have MALT characteristics.
