The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
T Yamamoto - One of the best experts on this subject based on the ideXlab platform.
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intravascular Lymphomatosis presenting as an ascending cauda equina conus medullaris syndrome remission after biweekly chop therapy
Journal of Neurology Neurosurgery and Psychiatry, 1999Co-Authors: T Nakahara, T Saito, A Muroi, Y Sugiura, M Ogata, Y Sugiyama, T YamamotoAbstract:A 63 year old man developed dysaesthesia in the legs followed by a subacute ascending flaccid paraparesis with sacral sensory and autonomic involvement. Intravascular Lymphomatosis (IVL) was favoured by the presence of low grade fever and raised serum C reactive protein, CSF pleocytosis, raised lymphoma markers (serum LDH, soluble IL-2 receptor), and steroid responsiveness. Only muscle, among several organ biopsies, confirmed IVL. A cytogenetic study of the bone marrow showed chromosome 6 monosomy, as previously reported. The monosomy of chromosome 19, which bears the intercellular cell adhesion molecule-1, newly found in this case, may be related to the unique tumour embolisation of IVL. The CHOP regimen (six courses in 12 weeks) using granulocyte colony stimulating factor (G-CSF) led to gradual resolution of myeloradiculopathy and laboratory supported remission lasting for more than 13 months. The biweekly CHOP with G-CSF support may be a choice of chemotherapy in averting rapidly fatal IVL.
J Sanssabrafen - One of the best experts on this subject based on the ideXlab platform.
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acute pseudobulbar palsy as the initial presentation of intravascular Lymphomatosis
European Journal of Internal Medicine, 2004Co-Authors: Adrià Arboix, Imgard Costa, Carles Besses, J SanssabrafenAbstract:Abstract We describe the case of a 76-year-old male patient who developed acute manifestations of pseudobulbar palsy without a history of stroke or vascular risk factors as the first manifestation of intravascular Lymphomatosis. Neurological symptoms of acute pseudobulbar palsy appeared on the second postoperative day after transurethral prostatectomy for the treatment of prostatic hypertrophy. Intravascular Lymphomatosis was diagnosed from microscopic findings and immunohistochemical staining of the surgical specimen. Chemotherapy was started, but the patient died due to sepsis secondary to bone marrow aplasia. Intravascular Lymphomatosis should be considered a rare potential cause of acute pseudobulbar palsy.
Yoklam Kwong - One of the best experts on this subject based on the ideXlab platform.
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t cell intravascular Lymphomatosis angiotropic large cell lymphoma association with epstein barr viral infection
Histopathology, 1997Co-Authors: W H Shek, John M Nicholls, K M Tse, D Todd, Yoklam KwongAbstract:Aims: Intravascular Lymphomatosis (IVL) is a very rare non-Hodgkin's lymphoma characterized by proliferation of lymphoma cells in the vascular lumina without involvement of adjacent parenchymal tissue. IVL is predominantly of B-cell lineage, but occasional cases of T lineage IVL involving almost exclusively the skin have been described. A case of IVL that occurred initially in the epididymis of a patient with an antecedent nasopharyngeal carcinoma was studied to define the clinicopathological features associated with this unique presentation. Methods and results: This lymphoma was studied by standard histological and immunophenotyping methods. The results showed lymphoma cells confined within the blood vessels, which expressed leucocyte common antigen, and T-cell markers CD3 and UCHL-1. The T-cell origin of the IVL prompted investigations for an assciation with Epstein–Barr virus infection (EBV). In-situ hybridization with digoxigenin-labelled anti-sense RNA probes to EBV encoded RNA (EBER) showed strong signals in the nuclei of virtually all of the lymphoma cells. Conclusions: EBV infection of the malignant cells was demonstrated by in-situ hybridization. This case suggests that T-cell IVL may be another EBV related human neoplasm. This observation will need to be validated by further studies.
W H Shek - One of the best experts on this subject based on the ideXlab platform.
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t cell intravascular Lymphomatosis angiotropic large cell lymphoma association with epstein barr viral infection
Histopathology, 1997Co-Authors: W H Shek, John M Nicholls, K M Tse, D Todd, Yoklam KwongAbstract:Aims: Intravascular Lymphomatosis (IVL) is a very rare non-Hodgkin's lymphoma characterized by proliferation of lymphoma cells in the vascular lumina without involvement of adjacent parenchymal tissue. IVL is predominantly of B-cell lineage, but occasional cases of T lineage IVL involving almost exclusively the skin have been described. A case of IVL that occurred initially in the epididymis of a patient with an antecedent nasopharyngeal carcinoma was studied to define the clinicopathological features associated with this unique presentation. Methods and results: This lymphoma was studied by standard histological and immunophenotyping methods. The results showed lymphoma cells confined within the blood vessels, which expressed leucocyte common antigen, and T-cell markers CD3 and UCHL-1. The T-cell origin of the IVL prompted investigations for an assciation with Epstein–Barr virus infection (EBV). In-situ hybridization with digoxigenin-labelled anti-sense RNA probes to EBV encoded RNA (EBER) showed strong signals in the nuclei of virtually all of the lymphoma cells. Conclusions: EBV infection of the malignant cells was demonstrated by in-situ hybridization. This case suggests that T-cell IVL may be another EBV related human neoplasm. This observation will need to be validated by further studies.
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T-cell intravascular Lymphomatosis (angiotropic large cell lymphoma): Association with Epstein-Barr viral infection
United Kingdom, 1997Co-Authors: K M Tse, Yl Kwong, Todd D, Nicholls J, W H ShekAbstract:Aims: Intravascular Lymphomatosis (IVL) is a very rare non-Hodgkin's lymphoma characterized by proliferation of lymphoma cells in the vascular lumina without involvement of adjacent parenchymal tissue. IVL is predominantly of B-cell lineage, but occasional cases of T lineage IVL involving almost exclusively the skin have been described. A case of IVL that occurred initially in the epididymis of a patient with an antecedent nasopharyngeal carcinoma was studied to define the clinicopathological features associated with this unique presentation. Methods and results: This lymphoma was studied by standard histological and immunophenotyping methods. The results showed lymphoma cells confined within the blood vessels, which expressed leucocyte common antigen, and T-cell markers CD3 and UCHL-1. The T- cell origin of the IVL prompted investigations for an association with Epstein-Barr virus infection (EBV). Insitu hybridization with digoxigenin- labelled anti-sense RNA probes to EBV encoded RNA (EBER) showed strong signals in the nuclei of virtually all of the lymphoma cells. Conclusions: EBV infection of the malignant cells was demonstrated by in-situ hybridization. This case suggests that T-cell IVL may be another EBV related human neoplasm. This observation will need to be validated by further studies.link_to_subscribed_fulltex
T Nakahara - One of the best experts on this subject based on the ideXlab platform.
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intravascular Lymphomatosis presenting as an ascending cauda equina conus medullaris syndrome remission after biweekly chop therapy
Journal of Neurology Neurosurgery and Psychiatry, 1999Co-Authors: T Nakahara, T Saito, A Muroi, Y Sugiura, M Ogata, Y Sugiyama, T YamamotoAbstract:A 63 year old man developed dysaesthesia in the legs followed by a subacute ascending flaccid paraparesis with sacral sensory and autonomic involvement. Intravascular Lymphomatosis (IVL) was favoured by the presence of low grade fever and raised serum C reactive protein, CSF pleocytosis, raised lymphoma markers (serum LDH, soluble IL-2 receptor), and steroid responsiveness. Only muscle, among several organ biopsies, confirmed IVL. A cytogenetic study of the bone marrow showed chromosome 6 monosomy, as previously reported. The monosomy of chromosome 19, which bears the intercellular cell adhesion molecule-1, newly found in this case, may be related to the unique tumour embolisation of IVL. The CHOP regimen (six courses in 12 weeks) using granulocyte colony stimulating factor (G-CSF) led to gradual resolution of myeloradiculopathy and laboratory supported remission lasting for more than 13 months. The biweekly CHOP with G-CSF support may be a choice of chemotherapy in averting rapidly fatal IVL.
