The Experts below are selected from a list of 249 Experts worldwide ranked by ideXlab platform
Christian P Speer - One of the best experts on this subject based on the ideXlab platform.
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Systemic fetal inflammation and reduced concentrations of Macrophage Migration inhibitory factor in tracheobronchial aspirate fluid of extremely premature infants.
American journal of obstetrics and gynecology, 2008Co-Authors: Wolfgang Thomas, Silvia Seidenspinner, Natalia Kawczyńska-leda, Boris W Kramer, Maria Chmielnicka-kopaczyk, Alexander Marx, Marta Szymankiewicz, Christian P SpeerAbstract:Macrophage Migration inhibitory factor is a proinflammatory mediator of innate immunity, enhances cell growth, and plays a role in preterm delivery. We speculated that funisitis, reflecting fetal systemic inflammation, would be associated with higher concentrations of Macrophage Migration inhibitory factor in airways of extremely premature infants. We measured Macrophage Migration inhibitory factor by enzyme linked immunosorbent assay in tracheobronchial aspirate fluid of 35 ventilated infants less than 30 weeks' gestational age, throughout the first week of life. Three groups were distinguished histologically: chorioamnionitis, funisitis, and control. Unexpectedly, funisitis was associated with significantly decreased Macrophage Migration inhibitory factor in tracheobronchial aspirate fluid on day 1 (P < .01) and levels remained lower than in the chorioamnionitis group thereafter. For the 35 patients in total, Macrophage Migration inhibitory factor steadily declined. Decreased Macrophage Migration inhibitory factor concentrations in airways of extremely premature infants with systemic fetal inflammation early in life might predispose them to pulmonary infection and interfere with maturation of the lung, contributing to adverse pulmonary outcome.
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Systemic fetal inflammation and reduced concentrations of Macrophage Migration inhibitory factor in tracheobronchial aspirate fluid of extremely premature infants.
American Journal of Obstetrics and Gynecology, 2007Co-Authors: Wolfgang Thomas, Silvia Seidenspinner, Natalia Kawczyńska-leda, Boris W Kramer, Maria Chmielnicka-kopaczyk, Alexander Marx, Marta Szymankiewicz, Christian P SpeerAbstract:Objective Macrophage Migration inhibitory factor is a proinflammatory mediator of innate immunity, enhances cell growth, and plays a role in preterm delivery. We speculated that funisitis, reflecting fetal systemic inflammation, would be associated with higher concentrations of Macrophage Migration inhibitory factor in airways of extremely premature infants. Study Design We measured Macrophage Migration inhibitory factor by enzyme linked immunosorbent assay in tracheobronchial aspirate fluid of 35 ventilated infants less than 30 weeks' gestational age, throughout the first week of life. Three groups were distinguished histologically: chorioamnionitis, funisitis, and control. Results Unexpectedly, funisitis was associated with significantly decreased Macrophage Migration inhibitory factor in tracheobronchial aspirate fluid on day 1 ( P Conclusion Decreased Macrophage Migration inhibitory factor concentrations in airways of extremely premature infants with systemic fetal inflammation early in life might predispose them to pulmonary infection and interfere with maturation of the lung, contributing to adverse pulmonary outcome.
Poul Thorsen - One of the best experts on this subject based on the ideXlab platform.
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Serum Macrophage Migration inhibitory factor in the prediction of preterm delivery.
American journal of obstetrics and gynecology, 2008Co-Authors: Brad D Pearce, Sicily E Garvin, Jakob Grove, Elizabeth A Bonney, Donald J Dudley, Diana E Schendel, Poul ThorsenAbstract:Macrophage Migration inhibitory factor is a soluble mediator that helps govern the interaction between cytokines and stress hormones (eg, cortisol). We determined whether maternal Macrophage Migration inhibitory factor levels predicted subsequent preterm delivery. A nested case-control study measuring serum Macrophage Migration inhibitory factor concentration at 9-23 weeks' gestation in women who ultimately delivered preterm (n = 60) compared with control women who delivered at term (n = 122). We also examined the connection of Macrophage Migration inhibitory factor with self-reported psychosocial variables. Macrophage Migration inhibitory factor was elevated in the preterm delivery cases (P = .0004), and log Macrophage Migration inhibitory factor concentration showed a graded response relationship with likelihood of preterm delivery. High-Macrophage Migration inhibitory factor was also associated with maternal risk-taking behavior, which itself was a risk factor for preterm delivery. Macrophage Migration inhibitory factor remained associated independently with preterm delivery after adjusting regression models for several other preterm delivery risk factors (odds ratio, 3.11, 95% confidence interval, 1.54-6.30). High-serum Macrophage Migration inhibitory concentration in early to midpregnancy is linked with subsequent preterm delivery.
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Serum Macrophage Migration inhibitory factor in the prediction of preterm delivery.
American Journal of Obstetrics and Gynecology, 2008Co-Authors: Brad D Pearce, Sicily E Garvin, Jakob Grove, Elizabeth A Bonney, Donald J Dudley, Diana Schendel, Poul ThorsenAbstract:Objective Macrophage Migration inhibitory factor is a soluble mediator that helps govern the interaction between cytokines and stress hormones (eg, cortisol). We determined whether maternal Macrophage Migration inhibitory factor levels predicted subsequent preterm delivery. Study Design A nested case-control study measuring serum Macrophage Migration inhibitory factor concentration at 9-23 weeks' gestation in women who ultimately delivered preterm (n = 60) compared with control women who delivered at term (n = 122). We also examined the connection of Macrophage Migration inhibitory factor with self-reported psychosocial variables. Results Macrophage Migration inhibitory factor was elevated in the preterm delivery cases ( P = .0004), and log Macrophage Migration inhibitory factor concentration showed a graded response relationship with likelihood of preterm delivery. High-Macrophage Migration inhibitory factor was also associated with maternal risk-taking behavior, which itself was a risk factor for preterm delivery. Macrophage Migration inhibitory factor remained associated independently with preterm delivery after adjusting regression models for several other preterm delivery risk factors (odds ratio, 3.11, 95% confidence interval, 1.54-6.30). Conclusion High-serum Macrophage Migration inhibitory concentration in early to midpregnancy is linked with subsequent preterm delivery.
Wolfgang Thomas - One of the best experts on this subject based on the ideXlab platform.
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Systemic fetal inflammation and reduced concentrations of Macrophage Migration inhibitory factor in tracheobronchial aspirate fluid of extremely premature infants.
American journal of obstetrics and gynecology, 2008Co-Authors: Wolfgang Thomas, Silvia Seidenspinner, Natalia Kawczyńska-leda, Boris W Kramer, Maria Chmielnicka-kopaczyk, Alexander Marx, Marta Szymankiewicz, Christian P SpeerAbstract:Macrophage Migration inhibitory factor is a proinflammatory mediator of innate immunity, enhances cell growth, and plays a role in preterm delivery. We speculated that funisitis, reflecting fetal systemic inflammation, would be associated with higher concentrations of Macrophage Migration inhibitory factor in airways of extremely premature infants. We measured Macrophage Migration inhibitory factor by enzyme linked immunosorbent assay in tracheobronchial aspirate fluid of 35 ventilated infants less than 30 weeks' gestational age, throughout the first week of life. Three groups were distinguished histologically: chorioamnionitis, funisitis, and control. Unexpectedly, funisitis was associated with significantly decreased Macrophage Migration inhibitory factor in tracheobronchial aspirate fluid on day 1 (P < .01) and levels remained lower than in the chorioamnionitis group thereafter. For the 35 patients in total, Macrophage Migration inhibitory factor steadily declined. Decreased Macrophage Migration inhibitory factor concentrations in airways of extremely premature infants with systemic fetal inflammation early in life might predispose them to pulmonary infection and interfere with maturation of the lung, contributing to adverse pulmonary outcome.
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Systemic fetal inflammation and reduced concentrations of Macrophage Migration inhibitory factor in tracheobronchial aspirate fluid of extremely premature infants.
American Journal of Obstetrics and Gynecology, 2007Co-Authors: Wolfgang Thomas, Silvia Seidenspinner, Natalia Kawczyńska-leda, Boris W Kramer, Maria Chmielnicka-kopaczyk, Alexander Marx, Marta Szymankiewicz, Christian P SpeerAbstract:Objective Macrophage Migration inhibitory factor is a proinflammatory mediator of innate immunity, enhances cell growth, and plays a role in preterm delivery. We speculated that funisitis, reflecting fetal systemic inflammation, would be associated with higher concentrations of Macrophage Migration inhibitory factor in airways of extremely premature infants. Study Design We measured Macrophage Migration inhibitory factor by enzyme linked immunosorbent assay in tracheobronchial aspirate fluid of 35 ventilated infants less than 30 weeks' gestational age, throughout the first week of life. Three groups were distinguished histologically: chorioamnionitis, funisitis, and control. Results Unexpectedly, funisitis was associated with significantly decreased Macrophage Migration inhibitory factor in tracheobronchial aspirate fluid on day 1 ( P Conclusion Decreased Macrophage Migration inhibitory factor concentrations in airways of extremely premature infants with systemic fetal inflammation early in life might predispose them to pulmonary infection and interfere with maturation of the lung, contributing to adverse pulmonary outcome.
Brad D Pearce - One of the best experts on this subject based on the ideXlab platform.
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Serum Macrophage Migration inhibitory factor in the prediction of preterm delivery.
American journal of obstetrics and gynecology, 2008Co-Authors: Brad D Pearce, Sicily E Garvin, Jakob Grove, Elizabeth A Bonney, Donald J Dudley, Diana E Schendel, Poul ThorsenAbstract:Macrophage Migration inhibitory factor is a soluble mediator that helps govern the interaction between cytokines and stress hormones (eg, cortisol). We determined whether maternal Macrophage Migration inhibitory factor levels predicted subsequent preterm delivery. A nested case-control study measuring serum Macrophage Migration inhibitory factor concentration at 9-23 weeks' gestation in women who ultimately delivered preterm (n = 60) compared with control women who delivered at term (n = 122). We also examined the connection of Macrophage Migration inhibitory factor with self-reported psychosocial variables. Macrophage Migration inhibitory factor was elevated in the preterm delivery cases (P = .0004), and log Macrophage Migration inhibitory factor concentration showed a graded response relationship with likelihood of preterm delivery. High-Macrophage Migration inhibitory factor was also associated with maternal risk-taking behavior, which itself was a risk factor for preterm delivery. Macrophage Migration inhibitory factor remained associated independently with preterm delivery after adjusting regression models for several other preterm delivery risk factors (odds ratio, 3.11, 95% confidence interval, 1.54-6.30). High-serum Macrophage Migration inhibitory concentration in early to midpregnancy is linked with subsequent preterm delivery.
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Serum Macrophage Migration inhibitory factor in the prediction of preterm delivery.
American Journal of Obstetrics and Gynecology, 2008Co-Authors: Brad D Pearce, Sicily E Garvin, Jakob Grove, Elizabeth A Bonney, Donald J Dudley, Diana Schendel, Poul ThorsenAbstract:Objective Macrophage Migration inhibitory factor is a soluble mediator that helps govern the interaction between cytokines and stress hormones (eg, cortisol). We determined whether maternal Macrophage Migration inhibitory factor levels predicted subsequent preterm delivery. Study Design A nested case-control study measuring serum Macrophage Migration inhibitory factor concentration at 9-23 weeks' gestation in women who ultimately delivered preterm (n = 60) compared with control women who delivered at term (n = 122). We also examined the connection of Macrophage Migration inhibitory factor with self-reported psychosocial variables. Results Macrophage Migration inhibitory factor was elevated in the preterm delivery cases ( P = .0004), and log Macrophage Migration inhibitory factor concentration showed a graded response relationship with likelihood of preterm delivery. High-Macrophage Migration inhibitory factor was also associated with maternal risk-taking behavior, which itself was a risk factor for preterm delivery. Macrophage Migration inhibitory factor remained associated independently with preterm delivery after adjusting regression models for several other preterm delivery risk factors (odds ratio, 3.11, 95% confidence interval, 1.54-6.30). Conclusion High-serum Macrophage Migration inhibitory concentration in early to midpregnancy is linked with subsequent preterm delivery.
Marta Szymankiewicz - One of the best experts on this subject based on the ideXlab platform.
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Systemic fetal inflammation and reduced concentrations of Macrophage Migration inhibitory factor in tracheobronchial aspirate fluid of extremely premature infants.
American journal of obstetrics and gynecology, 2008Co-Authors: Wolfgang Thomas, Silvia Seidenspinner, Natalia Kawczyńska-leda, Boris W Kramer, Maria Chmielnicka-kopaczyk, Alexander Marx, Marta Szymankiewicz, Christian P SpeerAbstract:Macrophage Migration inhibitory factor is a proinflammatory mediator of innate immunity, enhances cell growth, and plays a role in preterm delivery. We speculated that funisitis, reflecting fetal systemic inflammation, would be associated with higher concentrations of Macrophage Migration inhibitory factor in airways of extremely premature infants. We measured Macrophage Migration inhibitory factor by enzyme linked immunosorbent assay in tracheobronchial aspirate fluid of 35 ventilated infants less than 30 weeks' gestational age, throughout the first week of life. Three groups were distinguished histologically: chorioamnionitis, funisitis, and control. Unexpectedly, funisitis was associated with significantly decreased Macrophage Migration inhibitory factor in tracheobronchial aspirate fluid on day 1 (P < .01) and levels remained lower than in the chorioamnionitis group thereafter. For the 35 patients in total, Macrophage Migration inhibitory factor steadily declined. Decreased Macrophage Migration inhibitory factor concentrations in airways of extremely premature infants with systemic fetal inflammation early in life might predispose them to pulmonary infection and interfere with maturation of the lung, contributing to adverse pulmonary outcome.
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Systemic fetal inflammation and reduced concentrations of Macrophage Migration inhibitory factor in tracheobronchial aspirate fluid of extremely premature infants.
American Journal of Obstetrics and Gynecology, 2007Co-Authors: Wolfgang Thomas, Silvia Seidenspinner, Natalia Kawczyńska-leda, Boris W Kramer, Maria Chmielnicka-kopaczyk, Alexander Marx, Marta Szymankiewicz, Christian P SpeerAbstract:Objective Macrophage Migration inhibitory factor is a proinflammatory mediator of innate immunity, enhances cell growth, and plays a role in preterm delivery. We speculated that funisitis, reflecting fetal systemic inflammation, would be associated with higher concentrations of Macrophage Migration inhibitory factor in airways of extremely premature infants. Study Design We measured Macrophage Migration inhibitory factor by enzyme linked immunosorbent assay in tracheobronchial aspirate fluid of 35 ventilated infants less than 30 weeks' gestational age, throughout the first week of life. Three groups were distinguished histologically: chorioamnionitis, funisitis, and control. Results Unexpectedly, funisitis was associated with significantly decreased Macrophage Migration inhibitory factor in tracheobronchial aspirate fluid on day 1 ( P Conclusion Decreased Macrophage Migration inhibitory factor concentrations in airways of extremely premature infants with systemic fetal inflammation early in life might predispose them to pulmonary infection and interfere with maturation of the lung, contributing to adverse pulmonary outcome.
