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Luis Carlos Cucé - One of the best experts on this subject based on the ideXlab platform.
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mycetoma a retrospective study of 41 cases seen in sao paulo brazil from 1978 to 1989
Mycoses, 2009Co-Authors: Luiz G M Castro, Walter Belda, A Salebian, Luis Carlos CucéAbstract:Summary. Clinical and epidemiological aspects of 41 cases of mycetoma seen in Sao Paulo city from January 1978 to December 1989 are presented. Twenty-eight cases (68%) were caused by actinomycetes, while 13 (32%) were caused by true fungi. In only 22 (78%) actinomycetoma cases was it possible to identify the agent. Nocardia brasiliensis, by far the commonest actinomycete isolated, was responsible for 13 cases. Among eumycetomata, Madurella grisea was isolated from 3 cases, Scedosporium apiospermum from 2 cases, and Madurella mycetomatis from 1 case, and in 7 cases the agent was not identified. Distribution by sex and age was similar to that reported in the literature. Feet and legs were the commonest sites affected. The mean age of actinomycetoma patients was 33.2 years, while patients with eumycetoma were an average of 32.8 years. Mean duration of the disease was 6.8 and 9.8 years respectively. Most patients came from rural areas in the north-eastern region of the country and worked as field labourers. Bone involvement was frequent for both actinomycetomata and eumycetomata and was characterized by osteoporosis, periostal reaction and cavitation. The authors' elected treatment consists of combining sulfamethoxazole (800 mg) and trimethoprim (100 mg) with prednisone (10 mg) orally, daily. Zusammenfassung. Es werden die klinischen und epidemiologischen Aspekte von 41 Myzetompatienten vorgestellt, die in Sao Paulo in der Zeit von Januar 1978 bis Dezember 1989 beobachtet wurden. Achtundzwanzig Falle wurden durch Aktinomyzeten verursacht (68%), 13 durch Eumyzeten (32%). Nur bei 22 Aktinomyzetomen (78%) war es moglich, den Erreger zu identifizieren. Nocardia brasiliensis stellte mit 13 Fallen den grosten Anteil. Bei den Eumyzetomen wurde Madurella grisea dreimal, Scedosporium apiospermum zweimal und Madurella mycetomatis einmal isoliert, in sieben Fallen konnte der Erreger nicht identifiziert werden. Die Geschlechts- und Altersverteilung entsprach den Literaturangaben. Die unteren Extremitaten waren die am haufigsten befallenen Bereiche. Das Durchschnittsalter der Aktinomyzetom-Patienten lag bei 33.2 Jahren, das der EumyzetomPatienten bei 32.8 Jahren. Die mittlere Dauer der Krankheit lag bei 6.8 Bzw. 9.8 Jahren. Die meisten Patienten kamen von landlichen Gegenden der Nordostregion des Landes, bei der Mehrzahl handelte es sich um Landarbeiter. Knochenbeteiligung war haufig und war charakterisiert durch Osteoporose, periostale Reaktionen und Kavitatenbildung. Die Autoren behandelten mit Sulfamethoxazol (800 mg) und Trimethoprim (100 mg) kombiniert mit Prednison (10 mg) taglich oral.
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eumicetoma de graos pretos por Madurella grisea registro de dois casos
Revista Do Instituto De Medicina Tropical De Sao Paulo, 1992Co-Authors: Luís Antonio De Paula Machado, Luis Carlos Cucé, Carlos Da Silva Lacaz, Walter Belda, Maria Cecília Da Matta Rivitti, Alberto Salebian, Elisabeth Maria Heinsvaccari, Natalina Takahashi De MeloAbstract:Os Autores registram dois casos de eumicetoma de graos pretos, com localizacao podal, procedentes da Bahia, provocados por Madurella grisea Mackinnon et al., 1949. Sao estudadas a estrutura dos graos, bem como as caracteristicas micromorfologicas do fungo em vida saprofitica. Acreditam os Autores que estas observacoes correspondem ao setimo e oitavo casos registrados na literatura do pais, provocadas por este fungo. Os Autores consideram nomen dubium ou nomina confusa as seguintes especies de Madurella: M. ramiroi, M. oswaldoi, M. bovoi, M. tozeuri, M. mansonii, M. brumpti, M. reynieri, M. americana, M. lackawanna e M. ikedae, o mesmo ocorrendo com a chamada RubroMadurella mycetomi. As unicas especies validas sao Madurella mycetomatis McGinnis, 1980 (=Madurella mycetomi Brumpt, 1905) e Madurella grisea Mackinnon et al., 1949. Nos dois casos registrados o tratamento com itraconazol, por um periodo de 3 meses nao fez regredir as lesoes, havendo ligeira melhora clinica.
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Eumicetoma de grãos pretos por Madurella grisea: registro de dois casos Eumycotic mycetoma of black grains caused by Madurella grisea: report of two cases
Universidade de São Paulo, 1992Co-Authors: Luís Antonio De Paula Machado, Luis Carlos Cucé, Carlos Da Silva Lacaz, Walter Belda, Maria Cecília Da Matta Rivitti, Alberto Salebian, Elisabeth Maria Heins-vaccari, Natalina Takahashi De MeloAbstract:Os Autores registram dois casos de eumicetoma de grãos pretos, com localização podal, procedentes da Bahia, provocados por Madurella grisea Mackinnon et al., 1949. São estudadas a estrutura dos grãos, bem como as características micromorfológicas do fungo em vida saprofítica. Acreditam os Autores que estas observações correspondem ao sétimo e oitavo casos registrados na literatura do país, provocadas por este fungo. Os Autores consideram nomen dubium ou nomina confusa as seguintes espécies de Madurella: M. ramiroi, M. oswaldoi, M. bovoi, M. tozeuri, M. mansonii, M. brumpti, M. reynieri, M. americana, M. lackawanna e M. ikedae, o mesmo ocorrendo com a chamada RubroMadurella mycetomi. As únicas espécies válidas são Madurella mycetomatis McGinnis, 1980 (=Madurella mycetomi Brumpt, 1905) e Madurella grisea Mackinnon et al., 1949. Nos dois casos registrados o tratamento com itraconazol, por um período de 3 meses não fez regredir as lesões, havendo ligeira melhora clínica.Two cases of black grains eumycotic mycetoma, occurring on a foot, are reported. Both proceeded from the State of Bahia (Brazil), and in both the etiologic agent was Madurella grisea Mackinnon et al., 1949. The grains structure as well as the micromorphologic characteristics of the fungus in saprophytic life were studied. It is the Author's belief that these observations correspond to the 7th and 8th cases reported in the Brazilian medical literature. The Authors do consider the following Madurella species as nomen dubium or nomina confusa: M. ramiroi, M. oswaldoi, M. bovoi, M. tozeuri, M. mansonii, M. brumpti, M. reynieri, M. americana, M. lackawanna e M. ikedae and the same for RubroMadurella mycetomi. The only valid species must be Madurella mycetomatis McGinnis, 1980 (=Madurella mycetomi Brumpt, 1905) and Madurella grisea Mackinnon et al., 1949. Treatment with itraconazole in both reported cases, for a 3 month duration, did not produce any regression of the lesions, the clinical improvement being meager
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Eumycotic mycetoma of black grains caused by Madurella grisea: report of two cases
Revista do Instituto de Medicina Tropical de São Paulo, 1992Co-Authors: Luís Antonio De Paula Machado, Luis Carlos Cucé, Carlos Da Silva Lacaz, Walter Belda, Maria Cecília Da Matta Rivitti, Alberto Salebian, Elisabeth Maria Heins-vaccari, Natalina Takahashi De MeloAbstract:Two cases of black grains eumycotic mycetoma, occurring on a foot, are reported. Both proceeded from the State of Bahia (Brazil), and in both the etiologic agent was Madurella grisea Mackinnon et al., 1949. The grains structure as well as the micromorphologic characteristics of the fungus in saprophytic life were studied. It is the Author's belief that these observations correspond to the 7th and 8th cases reported in the Brazilian medical literature. The Authors do consider the following Madurella species as nomen dubium or nomina confusa: M. ramiroi, M. oswaldoi, M. bovoi, M. tozeuri, M. mansonii, M. brumpti, M. reynieri, M. americana, M. lackawanna e M. ikedae and the same for RubroMadurella mycetomi. The only valid species must be Madurella mycetomatis McGinnis, 1980 (=Madurella mycetomi Brumpt, 1905) and Madurella grisea Mackinnon et al., 1949. Treatment with itraconazole in both reported cases, for a 3 month duration, did not produce any regression of the lesions, the clinical improvement being meager.
Alexandro Bonifaz - One of the best experts on this subject based on the ideXlab platform.
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Nigrograna mackinnonii, Not Trematosphaeria grisea (syn., Madurella grisea), Is the Main Agent of Black Grain Eumycetoma in Latin America.
Journal of clinical microbiology, 2017Co-Authors: Sarah A Ahmed, Gloria M. González, Andrés Tirado-sánchez, Luis Miguel Moreno-lópez, Sybren De Hoog, Alexandro BonifazAbstract:Mycetoma, a chronic and mutilating subcutaneous infection recognized by the WHO as a neglected tropical disease, has been reported in >25 countries in Africa, Asia, and South America. In Latin America, Trematosphaeria grisea is assumed to be the prevalent fungal agent. Recent molecular studies have shown that this is an environmental saprobe in Europe, where it is rarely implicated in human diseases. The aim of the present paper is to establish the identity of Latin American cases ascribed to Trematosphaeria grisea Three cases analyzed were caused by Nigrograna mackinnonii Data on an additional 21 strains in the literature revealed that N. mackinnonii rather than T. grisea is responsible for most cases of black grain eumycetoma in Latin America.
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Actualización de la epidemiología del micetoma en México. Revisión de 3,933 casos
Gaceta medica de Mexico, 2013Co-Authors: Rubén López-martínez, Luis Javier Méndez-tovar, Alexandro Bonifaz, Roberto Arenas, Jorge Mayorga, Oliverio Welsh, Lucio Vera-cabrera, María Del Carmen Padilla-desgarennes, Cudberto Contreras Pérez, Guadalupe Estrada ChávezAbstract:El micetoma es una infeccion subcutanea cronica muy frecuente en regiones tropicales y subtropicales. Objetivo: actualilizar los datos epidemiologicos de los casos de micetoma en Mexico. Metodo: Se realizo una encuesta en los principales centros de diagnostico micologico del pais, solicitando el numero de casos de micetoma, edad, genero, ocupacion, lugar de origen, tipo de micetoma y agentes etiologicos. Resultados: Hasta 2012, se han registrado 3,933 casos en los ultimos 54 anos. El 75.6% corresponde a hombres, 24.4% a mujeres. El 75.72% se presenta en adultos entre 16-50 anos. El grupo laboral predominante son campesinos (58.41%), seguido de amas de casa (21.79%). Los estados con mayores casuisticas son: Jalisco, Morelos, Nuevo Leon, Guerrero, Veracruz y Michoacan. Las regiones corporales mas afectadas on extremidades inferiores (60.29%) y tronco (19.76%). El actinomicetoma tiene una frecuencia de 96.52% y el principal agente etiologico es Nocardia brasiliensis (65.58%). El eumicetoma (3.48%) es causado principalmente por Madurella grisea (28.47%) y M. mycetomatis (26.28%). Conclusiones: El micetoma es una patologia subdiagnosticada y representa un problema de salud en zonas rurales que debe ser atendido con mayor interes por las instituciones de salud.
Natalina Takahashi De Melo - One of the best experts on this subject based on the ideXlab platform.
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eumicetoma de graos pretos por Madurella grisea registro de dois casos
Revista Do Instituto De Medicina Tropical De Sao Paulo, 1992Co-Authors: Luís Antonio De Paula Machado, Luis Carlos Cucé, Carlos Da Silva Lacaz, Walter Belda, Maria Cecília Da Matta Rivitti, Alberto Salebian, Elisabeth Maria Heinsvaccari, Natalina Takahashi De MeloAbstract:Os Autores registram dois casos de eumicetoma de graos pretos, com localizacao podal, procedentes da Bahia, provocados por Madurella grisea Mackinnon et al., 1949. Sao estudadas a estrutura dos graos, bem como as caracteristicas micromorfologicas do fungo em vida saprofitica. Acreditam os Autores que estas observacoes correspondem ao setimo e oitavo casos registrados na literatura do pais, provocadas por este fungo. Os Autores consideram nomen dubium ou nomina confusa as seguintes especies de Madurella: M. ramiroi, M. oswaldoi, M. bovoi, M. tozeuri, M. mansonii, M. brumpti, M. reynieri, M. americana, M. lackawanna e M. ikedae, o mesmo ocorrendo com a chamada RubroMadurella mycetomi. As unicas especies validas sao Madurella mycetomatis McGinnis, 1980 (=Madurella mycetomi Brumpt, 1905) e Madurella grisea Mackinnon et al., 1949. Nos dois casos registrados o tratamento com itraconazol, por um periodo de 3 meses nao fez regredir as lesoes, havendo ligeira melhora clinica.
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Eumycotic mycetoma of black grains caused by Madurella grisea: report of two cases
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo, 1992Co-Authors: Machado, Luís Antonio De Paula, Cucé, Luis Carlos, Lacaz, Carlos Da Silva, Rivitti, Maria Cecília Da Matta, Salebian Alberto, Heins-vaccari, Elisabeth Maria, Belda Jr. Walter, Natalina Takahashi De MeloAbstract:Os Autores registram dois casos de eumicetoma de grãos pretos, com localização podal, procedentes da Bahia, provocados por Madurella grisea Mackinnon et al., 1949. São estudadas a estrutura dos grãos, bem como as características micromorfológicas do fungo em vida saprofítica. Acreditam os Autores que estas observações correspondem ao sétimo e oitavo casos registrados na literatura do país, provocadas por este fungo. Os Autores consideram nomen dubium ou nomina confusa as seguintes espécies de Madurella: M. ramiroi, M. oswaldoi, M. bovoi, M. tozeuri, M. mansonii, M. brumpti, M. reynieri, M. americana, M. lackawanna e M. ikedae, o mesmo ocorrendo com a chamada RubroMadurella mycetomi. As únicas espécies válidas são Madurella mycetomatis McGinnis, 1980 (=Madurella mycetomi Brumpt, 1905) e Madurella grisea Mackinnon et al., 1949. Nos dois casos registrados o tratamento com itraconazol, por um período de 3 meses não fez regredir as lesões, havendo ligeira melhora clínica.Two cases of black grains eumycotic mycetoma, occurring on a foot, are reported. Both proceeded from the State of Bahia (Brazil), and in both the etiologic agent was Madurella grisea Mackinnon et al., 1949. The grains structure as well as the micromorphologic characteristics of the fungus in saprophytic life were studied. It is the Author's belief that these observations correspond to the 7th and 8th cases reported in the Brazilian medical literature. The Authors do consider the following Madurella species as nomen dubium or nomina confusa: M. ramiroi, M. oswaldoi, M. bovoi, M. tozeuri, M. mansonii, M. brumpti, M. reynieri, M. americana, M. lackawanna e M. ikedae and the same for RubroMadurella mycetomi. The only valid species must be Madurella mycetomatis McGinnis, 1980 (=Madurella mycetomi Brumpt, 1905) and Madurella grisea Mackinnon et al., 1949. Treatment with itraconazole in both reported cases, for a 3 month duration, did not produce any regression of the lesions, the clinical improvement being meager
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Eumicetoma de grãos pretos por Madurella grisea: registro de dois casos
Instituto de Medicina Tropical, 1992Co-Authors: Machado, Luís Antonio De Paula, Cucé, Luis Carlos, Lacaz, Carlos Da Silva, Rivitti, Maria Cecília Da Matta, Heins-vaccari, Elisabeth Maria, Belda Jr.,walter, Natalina Takahashi De MeloAbstract:Os Autores registram dois casos de eumicetoma de grãos pretos, com localização podal, procedentes da Bahia, provocados por Madurella grisea Mackinnon et al., 1949. São estudadas a estrutura dos grãos, bem como as características micromorfológicas do fungo em vida saprofítica. Acreditam os Autores que estas observações correspondem ao sétimo e oitavo casos registrados na literatura do país, provocadas por este fungo. Os Autores consideram nomen dubium ou nomina confusa as seguintes espécies de Madurella: M. ramiroi, M. oswaldoi, M. bovoi, M. tozeuri, M. mansonii, M. brumpti, M. reynieri, M. americana, M. lackawanna e M. ikedae, o mesmo ocorrendo com a chamada RubroMadurella mycetomi. As únicas espécies válidas são Madurella mycetomatis McGinnis, 1980 (=Madurella mycetomi Brumpt, 1905) e Madurella grisea Mackinnon et al., 1949. Nos dois casos registrados o tratamento com itraconazol, por um período de 3 meses não fez regredir as lesões, havendo ligeira melhora clínica
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Eumicetoma de grãos pretos por Madurella grisea: registro de dois casos Eumycotic mycetoma of black grains caused by Madurella grisea: report of two cases
Universidade de São Paulo, 1992Co-Authors: Luís Antonio De Paula Machado, Luis Carlos Cucé, Carlos Da Silva Lacaz, Walter Belda, Maria Cecília Da Matta Rivitti, Alberto Salebian, Elisabeth Maria Heins-vaccari, Natalina Takahashi De MeloAbstract:Os Autores registram dois casos de eumicetoma de grãos pretos, com localização podal, procedentes da Bahia, provocados por Madurella grisea Mackinnon et al., 1949. São estudadas a estrutura dos grãos, bem como as características micromorfológicas do fungo em vida saprofítica. Acreditam os Autores que estas observações correspondem ao sétimo e oitavo casos registrados na literatura do país, provocadas por este fungo. Os Autores consideram nomen dubium ou nomina confusa as seguintes espécies de Madurella: M. ramiroi, M. oswaldoi, M. bovoi, M. tozeuri, M. mansonii, M. brumpti, M. reynieri, M. americana, M. lackawanna e M. ikedae, o mesmo ocorrendo com a chamada RubroMadurella mycetomi. As únicas espécies válidas são Madurella mycetomatis McGinnis, 1980 (=Madurella mycetomi Brumpt, 1905) e Madurella grisea Mackinnon et al., 1949. Nos dois casos registrados o tratamento com itraconazol, por um período de 3 meses não fez regredir as lesões, havendo ligeira melhora clínica.Two cases of black grains eumycotic mycetoma, occurring on a foot, are reported. Both proceeded from the State of Bahia (Brazil), and in both the etiologic agent was Madurella grisea Mackinnon et al., 1949. The grains structure as well as the micromorphologic characteristics of the fungus in saprophytic life were studied. It is the Author's belief that these observations correspond to the 7th and 8th cases reported in the Brazilian medical literature. The Authors do consider the following Madurella species as nomen dubium or nomina confusa: M. ramiroi, M. oswaldoi, M. bovoi, M. tozeuri, M. mansonii, M. brumpti, M. reynieri, M. americana, M. lackawanna e M. ikedae and the same for RubroMadurella mycetomi. The only valid species must be Madurella mycetomatis McGinnis, 1980 (=Madurella mycetomi Brumpt, 1905) and Madurella grisea Mackinnon et al., 1949. Treatment with itraconazole in both reported cases, for a 3 month duration, did not produce any regression of the lesions, the clinical improvement being meager
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Eumycotic mycetoma of black grains caused by Madurella grisea: report of two cases
Revista do Instituto de Medicina Tropical de São Paulo, 1992Co-Authors: Luís Antonio De Paula Machado, Luis Carlos Cucé, Carlos Da Silva Lacaz, Walter Belda, Maria Cecília Da Matta Rivitti, Alberto Salebian, Elisabeth Maria Heins-vaccari, Natalina Takahashi De MeloAbstract:Two cases of black grains eumycotic mycetoma, occurring on a foot, are reported. Both proceeded from the State of Bahia (Brazil), and in both the etiologic agent was Madurella grisea Mackinnon et al., 1949. The grains structure as well as the micromorphologic characteristics of the fungus in saprophytic life were studied. It is the Author's belief that these observations correspond to the 7th and 8th cases reported in the Brazilian medical literature. The Authors do consider the following Madurella species as nomen dubium or nomina confusa: M. ramiroi, M. oswaldoi, M. bovoi, M. tozeuri, M. mansonii, M. brumpti, M. reynieri, M. americana, M. lackawanna e M. ikedae and the same for RubroMadurella mycetomi. The only valid species must be Madurella mycetomatis McGinnis, 1980 (=Madurella mycetomi Brumpt, 1905) and Madurella grisea Mackinnon et al., 1949. Treatment with itraconazole in both reported cases, for a 3 month duration, did not produce any regression of the lesions, the clinical improvement being meager.
Walter Belda - One of the best experts on this subject based on the ideXlab platform.
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mycetoma a retrospective study of 41 cases seen in sao paulo brazil from 1978 to 1989
Mycoses, 2009Co-Authors: Luiz G M Castro, Walter Belda, A Salebian, Luis Carlos CucéAbstract:Summary. Clinical and epidemiological aspects of 41 cases of mycetoma seen in Sao Paulo city from January 1978 to December 1989 are presented. Twenty-eight cases (68%) were caused by actinomycetes, while 13 (32%) were caused by true fungi. In only 22 (78%) actinomycetoma cases was it possible to identify the agent. Nocardia brasiliensis, by far the commonest actinomycete isolated, was responsible for 13 cases. Among eumycetomata, Madurella grisea was isolated from 3 cases, Scedosporium apiospermum from 2 cases, and Madurella mycetomatis from 1 case, and in 7 cases the agent was not identified. Distribution by sex and age was similar to that reported in the literature. Feet and legs were the commonest sites affected. The mean age of actinomycetoma patients was 33.2 years, while patients with eumycetoma were an average of 32.8 years. Mean duration of the disease was 6.8 and 9.8 years respectively. Most patients came from rural areas in the north-eastern region of the country and worked as field labourers. Bone involvement was frequent for both actinomycetomata and eumycetomata and was characterized by osteoporosis, periostal reaction and cavitation. The authors' elected treatment consists of combining sulfamethoxazole (800 mg) and trimethoprim (100 mg) with prednisone (10 mg) orally, daily. Zusammenfassung. Es werden die klinischen und epidemiologischen Aspekte von 41 Myzetompatienten vorgestellt, die in Sao Paulo in der Zeit von Januar 1978 bis Dezember 1989 beobachtet wurden. Achtundzwanzig Falle wurden durch Aktinomyzeten verursacht (68%), 13 durch Eumyzeten (32%). Nur bei 22 Aktinomyzetomen (78%) war es moglich, den Erreger zu identifizieren. Nocardia brasiliensis stellte mit 13 Fallen den grosten Anteil. Bei den Eumyzetomen wurde Madurella grisea dreimal, Scedosporium apiospermum zweimal und Madurella mycetomatis einmal isoliert, in sieben Fallen konnte der Erreger nicht identifiziert werden. Die Geschlechts- und Altersverteilung entsprach den Literaturangaben. Die unteren Extremitaten waren die am haufigsten befallenen Bereiche. Das Durchschnittsalter der Aktinomyzetom-Patienten lag bei 33.2 Jahren, das der EumyzetomPatienten bei 32.8 Jahren. Die mittlere Dauer der Krankheit lag bei 6.8 Bzw. 9.8 Jahren. Die meisten Patienten kamen von landlichen Gegenden der Nordostregion des Landes, bei der Mehrzahl handelte es sich um Landarbeiter. Knochenbeteiligung war haufig und war charakterisiert durch Osteoporose, periostale Reaktionen und Kavitatenbildung. Die Autoren behandelten mit Sulfamethoxazol (800 mg) und Trimethoprim (100 mg) kombiniert mit Prednison (10 mg) taglich oral.
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eumicetoma de graos pretos por Madurella grisea registro de dois casos
Revista Do Instituto De Medicina Tropical De Sao Paulo, 1992Co-Authors: Luís Antonio De Paula Machado, Luis Carlos Cucé, Carlos Da Silva Lacaz, Walter Belda, Maria Cecília Da Matta Rivitti, Alberto Salebian, Elisabeth Maria Heinsvaccari, Natalina Takahashi De MeloAbstract:Os Autores registram dois casos de eumicetoma de graos pretos, com localizacao podal, procedentes da Bahia, provocados por Madurella grisea Mackinnon et al., 1949. Sao estudadas a estrutura dos graos, bem como as caracteristicas micromorfologicas do fungo em vida saprofitica. Acreditam os Autores que estas observacoes correspondem ao setimo e oitavo casos registrados na literatura do pais, provocadas por este fungo. Os Autores consideram nomen dubium ou nomina confusa as seguintes especies de Madurella: M. ramiroi, M. oswaldoi, M. bovoi, M. tozeuri, M. mansonii, M. brumpti, M. reynieri, M. americana, M. lackawanna e M. ikedae, o mesmo ocorrendo com a chamada RubroMadurella mycetomi. As unicas especies validas sao Madurella mycetomatis McGinnis, 1980 (=Madurella mycetomi Brumpt, 1905) e Madurella grisea Mackinnon et al., 1949. Nos dois casos registrados o tratamento com itraconazol, por um periodo de 3 meses nao fez regredir as lesoes, havendo ligeira melhora clinica.
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Eumicetoma de grãos pretos por Madurella grisea: registro de dois casos Eumycotic mycetoma of black grains caused by Madurella grisea: report of two cases
Universidade de São Paulo, 1992Co-Authors: Luís Antonio De Paula Machado, Luis Carlos Cucé, Carlos Da Silva Lacaz, Walter Belda, Maria Cecília Da Matta Rivitti, Alberto Salebian, Elisabeth Maria Heins-vaccari, Natalina Takahashi De MeloAbstract:Os Autores registram dois casos de eumicetoma de grãos pretos, com localização podal, procedentes da Bahia, provocados por Madurella grisea Mackinnon et al., 1949. São estudadas a estrutura dos grãos, bem como as características micromorfológicas do fungo em vida saprofítica. Acreditam os Autores que estas observações correspondem ao sétimo e oitavo casos registrados na literatura do país, provocadas por este fungo. Os Autores consideram nomen dubium ou nomina confusa as seguintes espécies de Madurella: M. ramiroi, M. oswaldoi, M. bovoi, M. tozeuri, M. mansonii, M. brumpti, M. reynieri, M. americana, M. lackawanna e M. ikedae, o mesmo ocorrendo com a chamada RubroMadurella mycetomi. As únicas espécies válidas são Madurella mycetomatis McGinnis, 1980 (=Madurella mycetomi Brumpt, 1905) e Madurella grisea Mackinnon et al., 1949. Nos dois casos registrados o tratamento com itraconazol, por um período de 3 meses não fez regredir as lesões, havendo ligeira melhora clínica.Two cases of black grains eumycotic mycetoma, occurring on a foot, are reported. Both proceeded from the State of Bahia (Brazil), and in both the etiologic agent was Madurella grisea Mackinnon et al., 1949. The grains structure as well as the micromorphologic characteristics of the fungus in saprophytic life were studied. It is the Author's belief that these observations correspond to the 7th and 8th cases reported in the Brazilian medical literature. The Authors do consider the following Madurella species as nomen dubium or nomina confusa: M. ramiroi, M. oswaldoi, M. bovoi, M. tozeuri, M. mansonii, M. brumpti, M. reynieri, M. americana, M. lackawanna e M. ikedae and the same for RubroMadurella mycetomi. The only valid species must be Madurella mycetomatis McGinnis, 1980 (=Madurella mycetomi Brumpt, 1905) and Madurella grisea Mackinnon et al., 1949. Treatment with itraconazole in both reported cases, for a 3 month duration, did not produce any regression of the lesions, the clinical improvement being meager
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Eumycotic mycetoma of black grains caused by Madurella grisea: report of two cases
Revista do Instituto de Medicina Tropical de São Paulo, 1992Co-Authors: Luís Antonio De Paula Machado, Luis Carlos Cucé, Carlos Da Silva Lacaz, Walter Belda, Maria Cecília Da Matta Rivitti, Alberto Salebian, Elisabeth Maria Heins-vaccari, Natalina Takahashi De MeloAbstract:Two cases of black grains eumycotic mycetoma, occurring on a foot, are reported. Both proceeded from the State of Bahia (Brazil), and in both the etiologic agent was Madurella grisea Mackinnon et al., 1949. The grains structure as well as the micromorphologic characteristics of the fungus in saprophytic life were studied. It is the Author's belief that these observations correspond to the 7th and 8th cases reported in the Brazilian medical literature. The Authors do consider the following Madurella species as nomen dubium or nomina confusa: M. ramiroi, M. oswaldoi, M. bovoi, M. tozeuri, M. mansonii, M. brumpti, M. reynieri, M. americana, M. lackawanna e M. ikedae and the same for RubroMadurella mycetomi. The only valid species must be Madurella mycetomatis McGinnis, 1980 (=Madurella mycetomi Brumpt, 1905) and Madurella grisea Mackinnon et al., 1949. Treatment with itraconazole in both reported cases, for a 3 month duration, did not produce any regression of the lesions, the clinical improvement being meager.
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Nigrograna mackinnonii, Not Trematosphaeria grisea (syn., Madurella grisea), Is the Main Agent of Black Grain Eumycetoma in Latin America.
Journal of clinical microbiology, 2017Co-Authors: Sarah A Ahmed, Gloria M. González, Andrés Tirado-sánchez, Luis Miguel Moreno-lópez, Sybren De Hoog, Alexandro BonifazAbstract:Mycetoma, a chronic and mutilating subcutaneous infection recognized by the WHO as a neglected tropical disease, has been reported in >25 countries in Africa, Asia, and South America. In Latin America, Trematosphaeria grisea is assumed to be the prevalent fungal agent. Recent molecular studies have shown that this is an environmental saprobe in Europe, where it is rarely implicated in human diseases. The aim of the present paper is to establish the identity of Latin American cases ascribed to Trematosphaeria grisea Three cases analyzed were caused by Nigrograna mackinnonii Data on an additional 21 strains in the literature revealed that N. mackinnonii rather than T. grisea is responsible for most cases of black grain eumycetoma in Latin America.
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Revision of agents of black-grain eumycetoma in the order Pleosporales
Persoonia - Molecular Phylogeny and Evolution of Fungi, 2014Co-Authors: Sarah A Ahmed, Ahmed Hassan Fahal, David A Stevens, W. W. J. Van De Sande, A.d. Van Diepeningen, Steph B. J. Menken, G.s. De HoogAbstract:Eumycetoma is a chronic fungal infection characterised by large subcutaneous masses and the pres- ence of sinuses discharging coloured grains. The causative agents of black-grain eumycetoma mostly belong to the orders Sordariales and Pleosporales. The aim of the present study was to clarify the phylogeny and taxonomy of pleosporalean agents, viz. Madurella grisea, Medicopsis romeroi (syn.: Pyrenochaeta romeroi), Nigrograna mackin nonii (syn. Pyrenochaeta mackinnonii), Leptosphaeria senegalensis, L. tompkinsii, and Pseudochaetosphaeronema larense. A phylogenetic analysis based on five loci was performed: the Internal Transcribed Spacer (ITS), large (LSU) and small (SSU) subunit ribosomal RNA, the second largest RNA polymerase subunit (RPB2), and transla- tion elongation factor 1-alpha (TEF1) gene. In addition, the morphological and physiological characteristics were determined. Three species were well-resolved at the family and genus level. Madurella grisea, L. senegalensis, and L. tompkinsii were found to belong to the family Trematospheriaceae and are reclassified as Trematosphaeria grisea comb. nov., Falciformispora senegalensis comb. nov., and F. tompkinsii comb. nov. Medicopsis romeroi and Pseu dochaetosphaeronema larense were phylogenetically distant and both names are accepted. The genus Nigrograna is reduced to synonymy of Biatriospora and therefore N. mackinnonii is reclassified as B. mackinnonii comb. nov. Mycetoma agents in Pleosporales were phylogenetically quite diverse despite their morphological similarity in the formation of pycnidia, except for the ascosporulating genus Falciformispora (formerly in Leptosphaeria). Most of the species diagnosed from human mycetoma were found to be related to waterborne or marine fungi, suggesting an association of the virulence factors with oligotrophism or halotolerance.
