The Experts below are selected from a list of 159 Experts worldwide ranked by ideXlab platform
C F T Snelling - One of the best experts on this subject based on the ideXlab platform.
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comparison of silver sulphadiazine 1 per cent silver sulphadiazine 1 per cent plus chlorhexidine digluconate 0 2 per cent and Mafenide acetate 8 5 per cent for topical antibacterial effect in infected full skin thickness rat burn wounds
Burns, 1991Co-Authors: J H Gray, Frederick J Roberts, Eva Germann, D A Henry, M. Forbes, C F T SnellingAbstract:Abstract Silver sulphadiazine 1 per cent (SS), silver sulphadiazine 1 per cent plus chlorhexidine digluconate 0.2 per cent (SS + CD 0.2 per cent) and Mafenide acetate 8.5 per cent (MA) were compared to assess the antibacterial effect of once daily application on experimental rat 20 per cent full skin thickness burn wounds seeded 24h earlier with 10 8 microorganisms originally isolated from infected wounds of burned patients. Separate series evaluated Staph. aureus, Enterococcus faecalis, Enterobacter cloacae and Ps. aeruginosa . The mean concentration of all four organisms recovered after 1 week from full thickness biopsies of eschar and from separate biopsies of subjacent muscle was less in MA and SS + CD 0.2 per cent treated animals compared with those treated with SS alone. The mean concentration in muscle and eschar following treatment with MA was less for wounds seeded with Staph. aureus and Ps. aeruginosa than with SS + CD 0.2 per cent treatment while the mean concentration in eschar application of SS + CD 0.2 per cent was less than with MA for E. faecalis seeded wounds.
Jorge R Varcelotti - One of the best experts on this subject based on the ideXlab platform.
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serious silver sulphadiazine and Mafenide acetate dermatitis
Burns, 1995Co-Authors: S R Mckenna, Larry M Jones, Roger R Barrette, Harold F Sherman, Barbara A. Latenser, Jorge R VarcelottiAbstract:Infrequently reported, serious allergic reactions to topical antimicrobial agents used in the treatment of burn injuries are a potential source of confusion. To avoid misdirected therapy, an understanding of the manifestations of such reactions is important. Two recent cases of serious allergic reactions, one to silver sulphadiazine, one to Mafenide acetate, are presented and the literature is reviewed.
J H Gray - One of the best experts on this subject based on the ideXlab platform.
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comparison of silver sulphadiazine 1 per cent silver sulphadiazine 1 per cent plus chlorhexidine digluconate 0 2 per cent and Mafenide acetate 8 5 per cent for topical antibacterial effect in infected full skin thickness rat burn wounds
Burns, 1991Co-Authors: J H Gray, Frederick J Roberts, Eva Germann, D A Henry, M. Forbes, C F T SnellingAbstract:Abstract Silver sulphadiazine 1 per cent (SS), silver sulphadiazine 1 per cent plus chlorhexidine digluconate 0.2 per cent (SS + CD 0.2 per cent) and Mafenide acetate 8.5 per cent (MA) were compared to assess the antibacterial effect of once daily application on experimental rat 20 per cent full skin thickness burn wounds seeded 24h earlier with 10 8 microorganisms originally isolated from infected wounds of burned patients. Separate series evaluated Staph. aureus, Enterococcus faecalis, Enterobacter cloacae and Ps. aeruginosa . The mean concentration of all four organisms recovered after 1 week from full thickness biopsies of eschar and from separate biopsies of subjacent muscle was less in MA and SS + CD 0.2 per cent treated animals compared with those treated with SS alone. The mean concentration in muscle and eschar following treatment with MA was less for wounds seeded with Staph. aureus and Ps. aeruginosa than with SS + CD 0.2 per cent treatment while the mean concentration in eschar application of SS + CD 0.2 per cent was less than with MA for E. faecalis seeded wounds.
S R Mckenna - One of the best experts on this subject based on the ideXlab platform.
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serious silver sulphadiazine and Mafenide acetate dermatitis
Burns, 1995Co-Authors: S R Mckenna, Larry M Jones, Roger R Barrette, Harold F Sherman, Barbara A. Latenser, Jorge R VarcelottiAbstract:Infrequently reported, serious allergic reactions to topical antimicrobial agents used in the treatment of burn injuries are a potential source of confusion. To avoid misdirected therapy, an understanding of the manifestations of such reactions is important. Two recent cases of serious allergic reactions, one to silver sulphadiazine, one to Mafenide acetate, are presented and the literature is reviewed.
R.e. Burrell - One of the best experts on this subject based on the ideXlab platform.
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EFFICACY OF TOPICAL SILVER AGAINST FUNGAL BURN WOUND PATHOGENS
American Journal of Infection Control, 1999Co-Authors: J. B. Wright, D. Hansen, R.e. BurrellAbstract:Abstract Background: Fungal infections of burn wounds have become an important cause of burn-associated morbidity and mortality. The nature of fungal infections dictates aggressive treatment to minimize the morbidity associated with these infections. Persons with large total body surface area burns are particularly susceptible to fungal infections and are treated in such a manner as to minimize their risk of infection. Methods: This study examined the in vitro fungicidal efficacy of a variety of different topical agents. By placing fungal inocula in contact with Mafenide acetate, silver nitrate, silver sulfadiazine, and a nanocrystalline silver-coated dressing, we determined the kill kinetics of these topical agents against a spectrum of common burn wound fungal pathogens. Results: The topical antimicrobials that were tested demonstrated varying degrees of efficacy against these pathogens. Conclusion: The nanocrystalline silver-based dressing provided the fastest and broadest-spectrum fungicidal activity and may make it a good candidate for use to minimize the potential of fungal infection, thereby reducing complications that delay wound healing. (AJIC Am J Infect Control 1999;27:344-50)
