The Experts below are selected from a list of 66 Experts worldwide ranked by ideXlab platform
Michela Codini - One of the best experts on this subject based on the ideXlab platform.
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Solid Dispersion of Resveratrol Supported on Magnesium Dihydroxide (Resv@MDH) Microparticles Improves Oral Bioavailability
Nutrients, 2018Co-Authors: Roberto Spogli, Maria Bastianini, Francesco Ragonese, Rossana G. Iannitti, Lorenzo Monarca, Federica Bastioli, I. Nakashidze, Gabriele Brecchia, Laura Menchetti, Michela CodiniAbstract:Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on Magnesium Dihydroxide (Resv@MDH) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy analysis displays three types of microparticles with similar size: Type 1 that emitted preferably fluorescence at 445 nm with bandwidth of 50 nm, type 2 that emitted preferably fluorescence at 605 nm with bandwidth of 70 nm and type 3 that is non-fluorescent. Micronized pure resveratrol displays only microparticles type 1 whereas type 3 are associated to pure Magnesium Dihydroxide. Dissolution test in simulated gastric environment resveratrol derived from Resv@MDH in comparison to resveratrol alone displayed better solubility. A 3-fold increase of resveratrol bioavailability was observed after oral administration of 50 mg/kg of resveratrol from Resv@MDH in rabbits. We hypothesize that type 2 microparticles represent Magnesium Dihydroxide microparticles with a resveratrol shell and that they are responsible for the improved resveratrol solubility and bioavailability of Resv@MDH.
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solid dispersion of resveratrol supported on Magnesium Dihydroxide resv mdh microparticles improves oral bioavailability
Nutrients, 2018Co-Authors: Roberto Spogli, Maria Bastianini, Francesco Ragonese, Rossana G. Iannitti, Lorenzo Monarca, Federica Bastioli, I. Nakashidze, Gabriele Brecchia, Laura Menchetti, Michela CodiniAbstract:Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on Magnesium Dihydroxide (Resv@MDH) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy analysis displays three types of microparticles with similar size: Type 1 that emitted preferably fluorescence at 445 nm with bandwidth of 50 nm, type 2 that emitted preferably fluorescence at 605 nm with bandwidth of 70 nm and type 3 that is non-fluorescent. Micronized pure resveratrol displays only microparticles type 1 whereas type 3 are associated to pure Magnesium Dihydroxide. Dissolution test in simulated gastric environment resveratrol derived from Resv@MDH in comparison to resveratrol alone displayed better solubility. A 3-fold increase of resveratrol bioavailability was observed after oral administration of 50 mg/kg of resveratrol from Resv@MDH in rabbits. We hypothesize that type 2 microparticles represent Magnesium Dihydroxide microparticles with a resveratrol shell and that they are responsible for the improved resveratrol solubility and bioavailability of Resv@MDH.
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Solid Dispersion of Resveratrol Supported on Magnesium Dihydroxide (RESV@MDH) Microparticles Improves Oral Bioavailability
2018Co-Authors: Roberto Spogli, Maria Bastianini, Francesco Ragonese, Rossana G. Iannitti, Lorenzo Monarca, Federica Bastioli, I. Nakashidze, Gabriele Brecchia, Laura Menchetti, Michela CodiniAbstract:Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on Magnesium Dihydroxide (RESV@MDH) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy and granulometric analysis display three types of microparticles with similar size: type 1 that emitted preferably fluorescence at 463 nm (λecc 358 nm), type 2 that emitted preferably fluorescence at 605 nm (λecc 550 nm) andtype 3 that are non-fluorescent. Micronized pure resveratrol display only microparticles type 1 whereas type 3 are associated to pure Magnesium Dihydroxide. Dissolution test in simulated gastric environment resveratrol derived from RESV@MDH in comparison to resveratrol alone displayed better solubility. According to the biopharmaceutical classification, an increase of 3 fold of resveratrol bioavailabilitywas observed after oral administration of 50 mg/Kg of resveratrol of RESV@MDH in rabbits. We hypothesize that type 2 microparticles represent Magnesium Dihydroxide microparticles with a resveratrol shell and that they are responsible for the improved resveratrol solubility and bioavailability of RESV@MDH.
Roberto Spogli - One of the best experts on this subject based on the ideXlab platform.
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resveratrol supported on Magnesium Dihydroxide resv mdh represents an oral formulation of resveratrol with better gastric absorption and bioavailability respect to pure resveratrol
Frontiers in Nutrition, 2020Co-Authors: Rossana G Iannitti, Roberto Spogli, Francesco Ragonese, Lorenzo Monarca, Alessandro Floridi, Andrea Lazzarini, Alice Tantucci, Roberta Russo, Concetta Caglioti, Lucio LeonardiAbstract:Resveratrol attracts great interest because of the plethora of in vitro effects at the micromolar concentration range. Unfortunately, these effects are difficult to establish in vivo, due to the low concentration of resveratrol reached. This discrepancy is due to the molecules low solubility in water that favours the propensity for an intestinal absorption rather than in the gastric compartment. To address these challenges, we developed a Solid Dispersion of Resveratrol Supported by Magnesium Di Hydroxide formulation (Resv@MDH). This formulation displays increased water solubility and better bioavailability relative to pure resveratrol in the rabbit animal model. In our study, we evaluated the pharmacokinetics profile of resveratrol in six healthy human subjects following 180 mg of oral resveratrol administration, derived from Resv@MDH or pure resveratrol. Free resveratrol was evaluated in the whole blood sample by using HPLC - MS/MS. In comparison with pure resveratrol that displays an increase of Cmax at about 90 minutes and 2 M, Resv@MDH displays an earlier peak of resveratrol concentration with an increase of Cmax at about 30 minutes and 6 M). The different kinetics suggest a main gastric route for resveratrol absorption from Resv@MDH, where, because of its improved dissolution rate, there seems to be a higher propensity for an acidic environment, as opposed to with pure resveratrol. This conclusion is also supported by the numerical simulation analysis, which considers the principal steps during the oral route administration. Moreover, there is a twofold increase in the amount of free resveratrol with respect to pure resveratrol confirming a better bioavailability observed in the animal model. The characteristic feature of the pharmacokinetic profile of Resv@MDH implies that the beneficial properties of resveratrol in human health should be capitalized on it.
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Solid Dispersion of Resveratrol Supported on Magnesium Dihydroxide (Resv@MDH) Microparticles Improves Oral Bioavailability
Nutrients, 2018Co-Authors: Roberto Spogli, Maria Bastianini, Francesco Ragonese, Rossana G. Iannitti, Lorenzo Monarca, Federica Bastioli, I. Nakashidze, Gabriele Brecchia, Laura Menchetti, Michela CodiniAbstract:Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on Magnesium Dihydroxide (Resv@MDH) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy analysis displays three types of microparticles with similar size: Type 1 that emitted preferably fluorescence at 445 nm with bandwidth of 50 nm, type 2 that emitted preferably fluorescence at 605 nm with bandwidth of 70 nm and type 3 that is non-fluorescent. Micronized pure resveratrol displays only microparticles type 1 whereas type 3 are associated to pure Magnesium Dihydroxide. Dissolution test in simulated gastric environment resveratrol derived from Resv@MDH in comparison to resveratrol alone displayed better solubility. A 3-fold increase of resveratrol bioavailability was observed after oral administration of 50 mg/kg of resveratrol from Resv@MDH in rabbits. We hypothesize that type 2 microparticles represent Magnesium Dihydroxide microparticles with a resveratrol shell and that they are responsible for the improved resveratrol solubility and bioavailability of Resv@MDH.
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solid dispersion of resveratrol supported on Magnesium Dihydroxide resv mdh microparticles improves oral bioavailability
Nutrients, 2018Co-Authors: Roberto Spogli, Maria Bastianini, Francesco Ragonese, Rossana G. Iannitti, Lorenzo Monarca, Federica Bastioli, I. Nakashidze, Gabriele Brecchia, Laura Menchetti, Michela CodiniAbstract:Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on Magnesium Dihydroxide (Resv@MDH) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy analysis displays three types of microparticles with similar size: Type 1 that emitted preferably fluorescence at 445 nm with bandwidth of 50 nm, type 2 that emitted preferably fluorescence at 605 nm with bandwidth of 70 nm and type 3 that is non-fluorescent. Micronized pure resveratrol displays only microparticles type 1 whereas type 3 are associated to pure Magnesium Dihydroxide. Dissolution test in simulated gastric environment resveratrol derived from Resv@MDH in comparison to resveratrol alone displayed better solubility. A 3-fold increase of resveratrol bioavailability was observed after oral administration of 50 mg/kg of resveratrol from Resv@MDH in rabbits. We hypothesize that type 2 microparticles represent Magnesium Dihydroxide microparticles with a resveratrol shell and that they are responsible for the improved resveratrol solubility and bioavailability of Resv@MDH.
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Solid Dispersion of Resveratrol Supported on Magnesium Dihydroxide (RESV@MDH) Microparticles Improves Oral Bioavailability
2018Co-Authors: Roberto Spogli, Maria Bastianini, Francesco Ragonese, Rossana G. Iannitti, Lorenzo Monarca, Federica Bastioli, I. Nakashidze, Gabriele Brecchia, Laura Menchetti, Michela CodiniAbstract:Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on Magnesium Dihydroxide (RESV@MDH) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy and granulometric analysis display three types of microparticles with similar size: type 1 that emitted preferably fluorescence at 463 nm (λecc 358 nm), type 2 that emitted preferably fluorescence at 605 nm (λecc 550 nm) andtype 3 that are non-fluorescent. Micronized pure resveratrol display only microparticles type 1 whereas type 3 are associated to pure Magnesium Dihydroxide. Dissolution test in simulated gastric environment resveratrol derived from RESV@MDH in comparison to resveratrol alone displayed better solubility. According to the biopharmaceutical classification, an increase of 3 fold of resveratrol bioavailabilitywas observed after oral administration of 50 mg/Kg of resveratrol of RESV@MDH in rabbits. We hypothesize that type 2 microparticles represent Magnesium Dihydroxide microparticles with a resveratrol shell and that they are responsible for the improved resveratrol solubility and bioavailability of RESV@MDH.
Carl-eric Wilén - One of the best experts on this subject based on the ideXlab platform.
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Toward halogen-free flame resistant polyethylene extrusion coated paper facings
Progress in Organic Coatings, 2014Co-Authors: Weronika Pawelec, Teija Tirri, Mélanie Aubert, Eva Häggblom, Tommi Lehikoinen, Rune Skåtar, Rudolf Pfaendner, Carl-eric WilénAbstract:Abstract Extrusion coating experiments of flame retarded low density polyethylene (LDPE) onto a standard machine finished Kraft paper have been carried out. A pilot extrusion coating line was used in order to investigate the potential of halogen-free flame retardant system based on azoalkanes such as azocyclohexane (AZO) and 4′,4-bis(cyclohexylazocyclohexyl)methane (BISAZO) for fire resistant coating applications. In comparison, experiments were performed using FlameStab ® NOR116, Magnesium Dihydroxide (MDH) and a brominated additive Luvogard MB81/PE as reference flame retardants. The concentration of azoalkane flame retardants was varied between 0.5 and 1 wt.%. The maximum extrusion temperature was varied between 260 and 290 °C and the coating layer weight from 12.9 to 25.0 g/m 2 . The obtained multilayer facings containing azoalkanes exhibited significantly improved flame retardant properties, especially at the low coating weight of 12.9 g/m 2 . Under all of the used experimental conditions the runnability on the pilot line was flawless for azoalkane formulations. In contrast, our pre-trials using MDH/LDPE (50:50) formulations failed due to poor film quality and visible white aggregates. Moreover, the multilayer facings containing the FlameStab ® NOR116, Luvogard MB81/PE or mixtures thereof, showed inferior flame retardant properties compared to azoalkane based facings.
Francesco Ragonese - One of the best experts on this subject based on the ideXlab platform.
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resveratrol supported on Magnesium Dihydroxide resv mdh represents an oral formulation of resveratrol with better gastric absorption and bioavailability respect to pure resveratrol
Frontiers in Nutrition, 2020Co-Authors: Rossana G Iannitti, Roberto Spogli, Francesco Ragonese, Lorenzo Monarca, Alessandro Floridi, Andrea Lazzarini, Alice Tantucci, Roberta Russo, Concetta Caglioti, Lucio LeonardiAbstract:Resveratrol attracts great interest because of the plethora of in vitro effects at the micromolar concentration range. Unfortunately, these effects are difficult to establish in vivo, due to the low concentration of resveratrol reached. This discrepancy is due to the molecules low solubility in water that favours the propensity for an intestinal absorption rather than in the gastric compartment. To address these challenges, we developed a Solid Dispersion of Resveratrol Supported by Magnesium Di Hydroxide formulation (Resv@MDH). This formulation displays increased water solubility and better bioavailability relative to pure resveratrol in the rabbit animal model. In our study, we evaluated the pharmacokinetics profile of resveratrol in six healthy human subjects following 180 mg of oral resveratrol administration, derived from Resv@MDH or pure resveratrol. Free resveratrol was evaluated in the whole blood sample by using HPLC - MS/MS. In comparison with pure resveratrol that displays an increase of Cmax at about 90 minutes and 2 M, Resv@MDH displays an earlier peak of resveratrol concentration with an increase of Cmax at about 30 minutes and 6 M). The different kinetics suggest a main gastric route for resveratrol absorption from Resv@MDH, where, because of its improved dissolution rate, there seems to be a higher propensity for an acidic environment, as opposed to with pure resveratrol. This conclusion is also supported by the numerical simulation analysis, which considers the principal steps during the oral route administration. Moreover, there is a twofold increase in the amount of free resveratrol with respect to pure resveratrol confirming a better bioavailability observed in the animal model. The characteristic feature of the pharmacokinetic profile of Resv@MDH implies that the beneficial properties of resveratrol in human health should be capitalized on it.
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Solid Dispersion of Resveratrol Supported on Magnesium Dihydroxide (Resv@MDH) Microparticles Improves Oral Bioavailability
Nutrients, 2018Co-Authors: Roberto Spogli, Maria Bastianini, Francesco Ragonese, Rossana G. Iannitti, Lorenzo Monarca, Federica Bastioli, I. Nakashidze, Gabriele Brecchia, Laura Menchetti, Michela CodiniAbstract:Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on Magnesium Dihydroxide (Resv@MDH) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy analysis displays three types of microparticles with similar size: Type 1 that emitted preferably fluorescence at 445 nm with bandwidth of 50 nm, type 2 that emitted preferably fluorescence at 605 nm with bandwidth of 70 nm and type 3 that is non-fluorescent. Micronized pure resveratrol displays only microparticles type 1 whereas type 3 are associated to pure Magnesium Dihydroxide. Dissolution test in simulated gastric environment resveratrol derived from Resv@MDH in comparison to resveratrol alone displayed better solubility. A 3-fold increase of resveratrol bioavailability was observed after oral administration of 50 mg/kg of resveratrol from Resv@MDH in rabbits. We hypothesize that type 2 microparticles represent Magnesium Dihydroxide microparticles with a resveratrol shell and that they are responsible for the improved resveratrol solubility and bioavailability of Resv@MDH.
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solid dispersion of resveratrol supported on Magnesium Dihydroxide resv mdh microparticles improves oral bioavailability
Nutrients, 2018Co-Authors: Roberto Spogli, Maria Bastianini, Francesco Ragonese, Rossana G. Iannitti, Lorenzo Monarca, Federica Bastioli, I. Nakashidze, Gabriele Brecchia, Laura Menchetti, Michela CodiniAbstract:Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on Magnesium Dihydroxide (Resv@MDH) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy analysis displays three types of microparticles with similar size: Type 1 that emitted preferably fluorescence at 445 nm with bandwidth of 50 nm, type 2 that emitted preferably fluorescence at 605 nm with bandwidth of 70 nm and type 3 that is non-fluorescent. Micronized pure resveratrol displays only microparticles type 1 whereas type 3 are associated to pure Magnesium Dihydroxide. Dissolution test in simulated gastric environment resveratrol derived from Resv@MDH in comparison to resveratrol alone displayed better solubility. A 3-fold increase of resveratrol bioavailability was observed after oral administration of 50 mg/kg of resveratrol from Resv@MDH in rabbits. We hypothesize that type 2 microparticles represent Magnesium Dihydroxide microparticles with a resveratrol shell and that they are responsible for the improved resveratrol solubility and bioavailability of Resv@MDH.
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Solid Dispersion of Resveratrol Supported on Magnesium Dihydroxide (RESV@MDH) Microparticles Improves Oral Bioavailability
2018Co-Authors: Roberto Spogli, Maria Bastianini, Francesco Ragonese, Rossana G. Iannitti, Lorenzo Monarca, Federica Bastioli, I. Nakashidze, Gabriele Brecchia, Laura Menchetti, Michela CodiniAbstract:Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on Magnesium Dihydroxide (RESV@MDH) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy and granulometric analysis display three types of microparticles with similar size: type 1 that emitted preferably fluorescence at 463 nm (λecc 358 nm), type 2 that emitted preferably fluorescence at 605 nm (λecc 550 nm) andtype 3 that are non-fluorescent. Micronized pure resveratrol display only microparticles type 1 whereas type 3 are associated to pure Magnesium Dihydroxide. Dissolution test in simulated gastric environment resveratrol derived from RESV@MDH in comparison to resveratrol alone displayed better solubility. According to the biopharmaceutical classification, an increase of 3 fold of resveratrol bioavailabilitywas observed after oral administration of 50 mg/Kg of resveratrol of RESV@MDH in rabbits. We hypothesize that type 2 microparticles represent Magnesium Dihydroxide microparticles with a resveratrol shell and that they are responsible for the improved resveratrol solubility and bioavailability of RESV@MDH.
Lorenzo Monarca - One of the best experts on this subject based on the ideXlab platform.
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resveratrol supported on Magnesium Dihydroxide resv mdh represents an oral formulation of resveratrol with better gastric absorption and bioavailability respect to pure resveratrol
Frontiers in Nutrition, 2020Co-Authors: Rossana G Iannitti, Roberto Spogli, Francesco Ragonese, Lorenzo Monarca, Alessandro Floridi, Andrea Lazzarini, Alice Tantucci, Roberta Russo, Concetta Caglioti, Lucio LeonardiAbstract:Resveratrol attracts great interest because of the plethora of in vitro effects at the micromolar concentration range. Unfortunately, these effects are difficult to establish in vivo, due to the low concentration of resveratrol reached. This discrepancy is due to the molecules low solubility in water that favours the propensity for an intestinal absorption rather than in the gastric compartment. To address these challenges, we developed a Solid Dispersion of Resveratrol Supported by Magnesium Di Hydroxide formulation (Resv@MDH). This formulation displays increased water solubility and better bioavailability relative to pure resveratrol in the rabbit animal model. In our study, we evaluated the pharmacokinetics profile of resveratrol in six healthy human subjects following 180 mg of oral resveratrol administration, derived from Resv@MDH or pure resveratrol. Free resveratrol was evaluated in the whole blood sample by using HPLC - MS/MS. In comparison with pure resveratrol that displays an increase of Cmax at about 90 minutes and 2 M, Resv@MDH displays an earlier peak of resveratrol concentration with an increase of Cmax at about 30 minutes and 6 M). The different kinetics suggest a main gastric route for resveratrol absorption from Resv@MDH, where, because of its improved dissolution rate, there seems to be a higher propensity for an acidic environment, as opposed to with pure resveratrol. This conclusion is also supported by the numerical simulation analysis, which considers the principal steps during the oral route administration. Moreover, there is a twofold increase in the amount of free resveratrol with respect to pure resveratrol confirming a better bioavailability observed in the animal model. The characteristic feature of the pharmacokinetic profile of Resv@MDH implies that the beneficial properties of resveratrol in human health should be capitalized on it.
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Solid Dispersion of Resveratrol Supported on Magnesium Dihydroxide (Resv@MDH) Microparticles Improves Oral Bioavailability
Nutrients, 2018Co-Authors: Roberto Spogli, Maria Bastianini, Francesco Ragonese, Rossana G. Iannitti, Lorenzo Monarca, Federica Bastioli, I. Nakashidze, Gabriele Brecchia, Laura Menchetti, Michela CodiniAbstract:Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on Magnesium Dihydroxide (Resv@MDH) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy analysis displays three types of microparticles with similar size: Type 1 that emitted preferably fluorescence at 445 nm with bandwidth of 50 nm, type 2 that emitted preferably fluorescence at 605 nm with bandwidth of 70 nm and type 3 that is non-fluorescent. Micronized pure resveratrol displays only microparticles type 1 whereas type 3 are associated to pure Magnesium Dihydroxide. Dissolution test in simulated gastric environment resveratrol derived from Resv@MDH in comparison to resveratrol alone displayed better solubility. A 3-fold increase of resveratrol bioavailability was observed after oral administration of 50 mg/kg of resveratrol from Resv@MDH in rabbits. We hypothesize that type 2 microparticles represent Magnesium Dihydroxide microparticles with a resveratrol shell and that they are responsible for the improved resveratrol solubility and bioavailability of Resv@MDH.
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solid dispersion of resveratrol supported on Magnesium Dihydroxide resv mdh microparticles improves oral bioavailability
Nutrients, 2018Co-Authors: Roberto Spogli, Maria Bastianini, Francesco Ragonese, Rossana G. Iannitti, Lorenzo Monarca, Federica Bastioli, I. Nakashidze, Gabriele Brecchia, Laura Menchetti, Michela CodiniAbstract:Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on Magnesium Dihydroxide (Resv@MDH) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy analysis displays three types of microparticles with similar size: Type 1 that emitted preferably fluorescence at 445 nm with bandwidth of 50 nm, type 2 that emitted preferably fluorescence at 605 nm with bandwidth of 70 nm and type 3 that is non-fluorescent. Micronized pure resveratrol displays only microparticles type 1 whereas type 3 are associated to pure Magnesium Dihydroxide. Dissolution test in simulated gastric environment resveratrol derived from Resv@MDH in comparison to resveratrol alone displayed better solubility. A 3-fold increase of resveratrol bioavailability was observed after oral administration of 50 mg/kg of resveratrol from Resv@MDH in rabbits. We hypothesize that type 2 microparticles represent Magnesium Dihydroxide microparticles with a resveratrol shell and that they are responsible for the improved resveratrol solubility and bioavailability of Resv@MDH.
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Solid Dispersion of Resveratrol Supported on Magnesium Dihydroxide (RESV@MDH) Microparticles Improves Oral Bioavailability
2018Co-Authors: Roberto Spogli, Maria Bastianini, Francesco Ragonese, Rossana G. Iannitti, Lorenzo Monarca, Federica Bastioli, I. Nakashidze, Gabriele Brecchia, Laura Menchetti, Michela CodiniAbstract:Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on Magnesium Dihydroxide (RESV@MDH) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy and granulometric analysis display three types of microparticles with similar size: type 1 that emitted preferably fluorescence at 463 nm (λecc 358 nm), type 2 that emitted preferably fluorescence at 605 nm (λecc 550 nm) andtype 3 that are non-fluorescent. Micronized pure resveratrol display only microparticles type 1 whereas type 3 are associated to pure Magnesium Dihydroxide. Dissolution test in simulated gastric environment resveratrol derived from RESV@MDH in comparison to resveratrol alone displayed better solubility. According to the biopharmaceutical classification, an increase of 3 fold of resveratrol bioavailabilitywas observed after oral administration of 50 mg/Kg of resveratrol of RESV@MDH in rabbits. We hypothesize that type 2 microparticles represent Magnesium Dihydroxide microparticles with a resveratrol shell and that they are responsible for the improved resveratrol solubility and bioavailability of RESV@MDH.
