Magnesium Excretion

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Stephan J L Bakker - One of the best experts on this subject based on the ideXlab platform.

  • Higher Dietary Magnesium Intake and Higher Magnesium Status Are Associated with Lower Prevalence of Coronary Heart Disease in Patients with Type 2 Diabetes.
    Nutrients, 2018
    Co-Authors: Christina M. Gant, Gerjan Navis, Stephan J L Bakker, Sabita S. Soedamah-muthu, S. Heleen Binnenmars, Gozewijn D. Laverman
    Abstract:

    In type 2 diabetes mellitus (T2D), the handling of Magnesium is disturbed. Magnesium deficiency may be associated with a higher risk of coronary heart disease (CHD). We investigated the associations between (1) dietary Magnesium intake; (2) 24 h urinary Magnesium Excretion; and (3) plasma Magnesium concentration with prevalent CHD in T2D patients. This cross-sectional analysis was performed on baseline data from the DIAbetes and LifEstyle Cohort Twente-1 (DIALECT-1, n = 450, age 63 ± 9 years, 57% men, and diabetes duration of 11 (7–18) years). Prevalence ratios (95% CI) of CHD by sex-specific quartiles of Magnesium indicators, as well as by Magnesium intake per dietary source, were determined using multivariable Cox proportional hazard models. CHD was present in 100 (22%) subjects. Adjusted CHD prevalence ratios for the highest compared to the lowest quartiles were 0.40 (0.20, 0.79) for Magnesium intake, 0.63 (0.32, 1.26) for 24 h urinary Magnesium Excretion, and 0.62 (0.32, 1.20) for plasma Magnesium concentration. For every 10 mg increase of Magnesium intake from vegetables, the prevalence of CHD was, statistically non-significantly, lower (0.75 (0.52, 1.08)). In this T2D cohort, higher Magnesium intake, higher 24 h urinary Magnesium Excretion, and higher plasma Magnesium concentration are associated with a lower prevalence of CHD.

  • urinary Magnesium Excretion and risk of hypertensionnovelty and significance
    Hypertension, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Jenny E Kootstraros, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Stephan J L Bakker
    Abstract:

    Observational studies on dietary or circulating Magnesium and risk of hypertension have reported weak-to-modest inverse associations, but have lacked measures of actual dietary uptake. Urinary Magnesium Excretion, an indicator of intestinal Magnesium absorption, may provide a better insight in this association. We examined 5511 participants aged 28 to 75 years free of hypertension in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population–based cohort study. Circulating Magnesium was measured in plasma and urinary Magnesium in two 24-hour urine collections, both at baseline. Incident hypertension was defined as blood pressure ≥140 mm Hg systolic or ≥90 mm Hg diastolic, or initiation of antihypertensive medication. During a median follow-up of 7.6 years (interquartile range, 5.0–9.3 years), 1172 participants developed hypertension. The median urinary Magnesium Excretion was 3.8 mmol/24 hour (interquartile range, 2.9–4.8 mmol/24 hour). Urinary Magnesium Excretion was associated with risk of hypertension in an inverse log-linear fashion, and this association remained after adjustment for age, sex, body mass index, smoking status, alcohol intake, parental history of hypertension, and urinary Excretion of sodium, potassium, and calcium. Each 1-unit increment in ln-transformed urinary Magnesium Excretion was associated with a 21% lower risk of hypertension after multivariable adjustment (adjusted hazard ratio, 0.79; 95% confidence interval, 0.71–0.88). No associations were observed between circulating Magnesium and risk of hypertension. In conclusion, in this cohort of men and women, urinary Magnesium Excretion was inversely associated with risk of hypertension across the entire range of habitual dietary intake. # Novelty and Significance {#article-title-42}

  • urinary Magnesium Excretion and risk of hypertension the prevention of renal and vascular end stage disease study
    Hypertension, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Jenny E Kootstraros, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Stephan J L Bakker
    Abstract:

    Observational studies on dietary or circulating Magnesium and risk of hypertension have reported weak-to-modest inverse associations, but have lacked measures of actual dietary uptake. Urinary Magnesium Excretion, an indicator of intestinal Magnesium absorption, may provide a better insight in this association. We examined 5511 participants aged 28 to 75 years free of hypertension in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population–based cohort study. Circulating Magnesium was measured in plasma and urinary Magnesium in two 24-hour urine collections, both at baseline. Incident hypertension was defined as blood pressure ≥140 mm Hg systolic or ≥90 mm Hg diastolic, or initiation of antihypertensive medication. During a median follow-up of 7.6 years (interquartile range, 5.0–9.3 years), 1172 participants developed hypertension. The median urinary Magnesium Excretion was 3.8 mmol/24 hour (interquartile range, 2.9–4.8 mmol/24 hour). Urinary Magnesium Excretion was associated with risk of hypertension in an inverse log-linear fashion, and this association remained after adjustment for age, sex, body mass index, smoking status, alcohol intake, parental history of hypertension, and urinary Excretion of sodium, potassium, and calcium. Each 1-unit increment in ln-transformed urinary Magnesium Excretion was associated with a 21% lower risk of hypertension after multivariable adjustment (adjusted hazard ratio, 0.79; 95% confidence interval, 0.71–0.88). No associations were observed between circulating Magnesium and risk of hypertension. In conclusion, in this cohort of men and women, urinary Magnesium Excretion was inversely associated with risk of hypertension across the entire range of habitual dietary intake.

  • urinary Magnesium Excretion and risk of hypertensionnovelty and significance the prevention of renal and vascular end stage disease study
    Hypertension, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Jenny E Kootstraros, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Stephan J L Bakker
    Abstract:

    Observational studies on dietary or circulating Magnesium and risk of hypertension have reported weak-to-modest inverse associations, but have lacked measures of actual dietary uptake. Urinary Magnesium Excretion, an indicator of intestinal Magnesium absorption, may provide a better insight in this association. We examined 5511 participants aged 28 to 75 years free of hypertension in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population–based cohort study. Circulating Magnesium was measured in plasma and urinary Magnesium in two 24-hour urine collections, both at baseline. Incident hypertension was defined as blood pressure ≥140 mm Hg systolic or ≥90 mm Hg diastolic, or initiation of antihypertensive medication. During a median follow-up of 7.6 years (interquartile range, 5.0–9.3 years), 1172 participants developed hypertension. The median urinary Magnesium Excretion was 3.8 mmol/24 hour (interquartile range, 2.9–4.8 mmol/24 hour). Urinary Magnesium Excretion was associated with risk of hypertension in an inverse log-linear fashion, and this association remained after adjustment for age, sex, body mass index, smoking status, alcohol intake, parental history of hypertension, and urinary Excretion of sodium, potassium, and calcium. Each 1-unit increment in ln-transformed urinary Magnesium Excretion was associated with a 21% lower risk of hypertension after multivariable adjustment (adjusted hazard ratio, 0.79; 95% confidence interval, 0.71–0.88). No associations were observed between circulating Magnesium and risk of hypertension. In conclusion, in this cohort of men and women, urinary Magnesium Excretion was inversely associated with risk of hypertension across the entire range of habitual dietary intake.

  • Urinary and plasma Magnesium and risk of ischemic heart disease
    The American Journal of Clinical Nutrition, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Pim Van Der Harst, Stephan J L Bakker
    Abstract:

    Background: Previous studies on dietary Magnesium and risk of ischemic heart disease (IHD) have yielded inconsistent results, in part because of a lack of direct measures of actual Magnesium uptake. Urinary Excretion of Magnesium, an indicator of dietary Magnesium uptake, might provide more consistent results. Objective: The objective was to investigate whether urinary Magnesium Excretion and plasma Magnesium are associated with HID risk. Design: We examined 7664 adult participants free of known cardiovascular disease in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study a prospective population-based cohort study. Urinary Magnesium Excretion was measured in 2 baseline 24-h urine collections. Results: Mean +/- SD urinary Magnesium Excretion was 4.24 +/- 1.65 mmol/24 h for men and 3.54 +/- 1.40 mmol/24 h for women. During a median follow-up of 10.5 y (IQR: 9.9-10.8 y), 462 fatal and nonfatal IHD events occurred. After multivariable adjustment, urinary Magnesium Excretion had a nonlinear relation with IHD risk (P-curvature = 0.01). The lowest sex-specific quintile (men: Conclusions: Low urinary Magnesium Excretion was independently associated with a higher risk of IHD incidence. An increased dietary intake of Magnesium, particularly in those with the lowest urinary Magnesium, could reduce the risk of IHD.

Michel M Joosten - One of the best experts on this subject based on the ideXlab platform.

  • urinary Magnesium Excretion and risk of hypertensionnovelty and significance
    Hypertension, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Jenny E Kootstraros, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Stephan J L Bakker
    Abstract:

    Observational studies on dietary or circulating Magnesium and risk of hypertension have reported weak-to-modest inverse associations, but have lacked measures of actual dietary uptake. Urinary Magnesium Excretion, an indicator of intestinal Magnesium absorption, may provide a better insight in this association. We examined 5511 participants aged 28 to 75 years free of hypertension in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population–based cohort study. Circulating Magnesium was measured in plasma and urinary Magnesium in two 24-hour urine collections, both at baseline. Incident hypertension was defined as blood pressure ≥140 mm Hg systolic or ≥90 mm Hg diastolic, or initiation of antihypertensive medication. During a median follow-up of 7.6 years (interquartile range, 5.0–9.3 years), 1172 participants developed hypertension. The median urinary Magnesium Excretion was 3.8 mmol/24 hour (interquartile range, 2.9–4.8 mmol/24 hour). Urinary Magnesium Excretion was associated with risk of hypertension in an inverse log-linear fashion, and this association remained after adjustment for age, sex, body mass index, smoking status, alcohol intake, parental history of hypertension, and urinary Excretion of sodium, potassium, and calcium. Each 1-unit increment in ln-transformed urinary Magnesium Excretion was associated with a 21% lower risk of hypertension after multivariable adjustment (adjusted hazard ratio, 0.79; 95% confidence interval, 0.71–0.88). No associations were observed between circulating Magnesium and risk of hypertension. In conclusion, in this cohort of men and women, urinary Magnesium Excretion was inversely associated with risk of hypertension across the entire range of habitual dietary intake. # Novelty and Significance {#article-title-42}

  • urinary Magnesium Excretion and risk of hypertension the prevention of renal and vascular end stage disease study
    Hypertension, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Jenny E Kootstraros, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Stephan J L Bakker
    Abstract:

    Observational studies on dietary or circulating Magnesium and risk of hypertension have reported weak-to-modest inverse associations, but have lacked measures of actual dietary uptake. Urinary Magnesium Excretion, an indicator of intestinal Magnesium absorption, may provide a better insight in this association. We examined 5511 participants aged 28 to 75 years free of hypertension in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population–based cohort study. Circulating Magnesium was measured in plasma and urinary Magnesium in two 24-hour urine collections, both at baseline. Incident hypertension was defined as blood pressure ≥140 mm Hg systolic or ≥90 mm Hg diastolic, or initiation of antihypertensive medication. During a median follow-up of 7.6 years (interquartile range, 5.0–9.3 years), 1172 participants developed hypertension. The median urinary Magnesium Excretion was 3.8 mmol/24 hour (interquartile range, 2.9–4.8 mmol/24 hour). Urinary Magnesium Excretion was associated with risk of hypertension in an inverse log-linear fashion, and this association remained after adjustment for age, sex, body mass index, smoking status, alcohol intake, parental history of hypertension, and urinary Excretion of sodium, potassium, and calcium. Each 1-unit increment in ln-transformed urinary Magnesium Excretion was associated with a 21% lower risk of hypertension after multivariable adjustment (adjusted hazard ratio, 0.79; 95% confidence interval, 0.71–0.88). No associations were observed between circulating Magnesium and risk of hypertension. In conclusion, in this cohort of men and women, urinary Magnesium Excretion was inversely associated with risk of hypertension across the entire range of habitual dietary intake.

  • urinary Magnesium Excretion and risk of hypertensionnovelty and significance the prevention of renal and vascular end stage disease study
    Hypertension, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Jenny E Kootstraros, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Stephan J L Bakker
    Abstract:

    Observational studies on dietary or circulating Magnesium and risk of hypertension have reported weak-to-modest inverse associations, but have lacked measures of actual dietary uptake. Urinary Magnesium Excretion, an indicator of intestinal Magnesium absorption, may provide a better insight in this association. We examined 5511 participants aged 28 to 75 years free of hypertension in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population–based cohort study. Circulating Magnesium was measured in plasma and urinary Magnesium in two 24-hour urine collections, both at baseline. Incident hypertension was defined as blood pressure ≥140 mm Hg systolic or ≥90 mm Hg diastolic, or initiation of antihypertensive medication. During a median follow-up of 7.6 years (interquartile range, 5.0–9.3 years), 1172 participants developed hypertension. The median urinary Magnesium Excretion was 3.8 mmol/24 hour (interquartile range, 2.9–4.8 mmol/24 hour). Urinary Magnesium Excretion was associated with risk of hypertension in an inverse log-linear fashion, and this association remained after adjustment for age, sex, body mass index, smoking status, alcohol intake, parental history of hypertension, and urinary Excretion of sodium, potassium, and calcium. Each 1-unit increment in ln-transformed urinary Magnesium Excretion was associated with a 21% lower risk of hypertension after multivariable adjustment (adjusted hazard ratio, 0.79; 95% confidence interval, 0.71–0.88). No associations were observed between circulating Magnesium and risk of hypertension. In conclusion, in this cohort of men and women, urinary Magnesium Excretion was inversely associated with risk of hypertension across the entire range of habitual dietary intake.

  • Urinary and plasma Magnesium and risk of ischemic heart disease
    The American Journal of Clinical Nutrition, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Pim Van Der Harst, Stephan J L Bakker
    Abstract:

    Background: Previous studies on dietary Magnesium and risk of ischemic heart disease (IHD) have yielded inconsistent results, in part because of a lack of direct measures of actual Magnesium uptake. Urinary Excretion of Magnesium, an indicator of dietary Magnesium uptake, might provide more consistent results. Objective: The objective was to investigate whether urinary Magnesium Excretion and plasma Magnesium are associated with HID risk. Design: We examined 7664 adult participants free of known cardiovascular disease in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study a prospective population-based cohort study. Urinary Magnesium Excretion was measured in 2 baseline 24-h urine collections. Results: Mean +/- SD urinary Magnesium Excretion was 4.24 +/- 1.65 mmol/24 h for men and 3.54 +/- 1.40 mmol/24 h for women. During a median follow-up of 10.5 y (IQR: 9.9-10.8 y), 462 fatal and nonfatal IHD events occurred. After multivariable adjustment, urinary Magnesium Excretion had a nonlinear relation with IHD risk (P-curvature = 0.01). The lowest sex-specific quintile (men: Conclusions: Low urinary Magnesium Excretion was independently associated with a higher risk of IHD incidence. An increased dietary intake of Magnesium, particularly in those with the lowest urinary Magnesium, could reduce the risk of IHD.

  • urinary Magnesium Excretion and risk of hypertension
    Hypertension, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Jenny E Kootstraros, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Stephan J L Bakker
    Abstract:

    Observational studies on dietary or circulating Magnesium and risk of hypertension have reported weak-to-modest inverse associations, but have lacked measures of actual dietary uptake. Urinary Magnesium Excretion, an indicator of intestinal Magnesium absorption, may provide a better insight in this association. We examined 5511 participants aged 28 to 75 years free of hypertension in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population–based cohort study. Circulating Magnesium was measured in plasma and urinary Magnesium in two 24-hour urine collections, both at baseline. Incident hypertension was defined as blood pressure ≥140 mm Hg systolic or ≥90 mm Hg diastolic, or initiation of antihypertensive medication. During a median follow-up of 7.6 years (interquartile range, 5.0–9.3 years), 1172 participants developed hypertension. The median urinary Magnesium Excretion was 3.8 mmol/24 hour (interquartile range, 2.9–4.8 mmol/24 hour). Urinary Magnesium Excretion was associated with risk of hypertension in an inverse log-linear fashion, and this association remained after adjustment for age, sex, body mass index, smoking status, alcohol intake, parental history of hypertension, and urinary Excretion of sodium, potassium, and calcium. Each 1-unit increment in ln-transformed urinary Magnesium Excretion was associated with a 21% lower risk of hypertension after multivariable adjustment (adjusted hazard ratio, 0.79; 95% confidence interval, 0.71–0.88). No associations were observed between circulating Magnesium and risk of hypertension. In conclusion, in this cohort of men and women, urinary Magnesium Excretion was inversely associated with risk of hypertension across the entire range of habitual dietary intake.

Gerjan Navis - One of the best experts on this subject based on the ideXlab platform.

  • Proton-Pump Inhibitors and Hypomagnesaemia in Kidney Transplant Recipients
    Journal of Clinical Medicine, 2019
    Co-Authors: Rianne M Douwes, António W. Gomes-neto, Joëlle C. Schutten, Else Van Den Berg, Martin H. De Borst, Stefan P. Berger, Daan J. Touw, Hans Blokzijl, Gerjan Navis
    Abstract:

    Proton-pump inhibitors (PPIs) are commonly used after kidney transplantation and there is rarely an incentive to discontinue treatment. In the general population, PPI use has been associated with hypomagnesaemia. We aimed to investigate whether PPI use is associated with plasma Magnesium, 24-h urinary Magnesium Excretion and hypomagnesaemia, in kidney transplant recipients (KTR). Plasma Magnesium and 24-h urinary Magnesium Excretion were measured in 686 stable outpatient KTR with a functioning allograft for ≥1 year from the TransplantLines Food and Nutrition Biobank and Cohort-Study (NCT02811835). PPIs were used by 389 KTR (56.6%). In multivariable linear regression analyses, PPI use was associated with lower plasma Magnesium (β: −0.02, P = 0.02) and lower 24-h urinary Magnesium Excretion (β: −0.82, P 20 mg omeprazole Eq/day) and was independent of adjustment for potential confounders (OR: 2.46; 95% CI 1.32–4.57, P 0.05). These results demonstrate that PPI use is independently associated with lower Magnesium status and hypomagnesaemia in KTR. The concomitant decrease in urinary Magnesium Excretion indicates that this likely is the consequence of reduced intestinal Magnesium absorption. Based on these results, it might be of benefit to monitor Magnesium status periodically in KTR on chronic PPI therapy.

  • Higher Dietary Magnesium Intake and Higher Magnesium Status Are Associated with Lower Prevalence of Coronary Heart Disease in Patients with Type 2 Diabetes.
    Nutrients, 2018
    Co-Authors: Christina M. Gant, Gerjan Navis, Stephan J L Bakker, Sabita S. Soedamah-muthu, S. Heleen Binnenmars, Gozewijn D. Laverman
    Abstract:

    In type 2 diabetes mellitus (T2D), the handling of Magnesium is disturbed. Magnesium deficiency may be associated with a higher risk of coronary heart disease (CHD). We investigated the associations between (1) dietary Magnesium intake; (2) 24 h urinary Magnesium Excretion; and (3) plasma Magnesium concentration with prevalent CHD in T2D patients. This cross-sectional analysis was performed on baseline data from the DIAbetes and LifEstyle Cohort Twente-1 (DIALECT-1, n = 450, age 63 ± 9 years, 57% men, and diabetes duration of 11 (7–18) years). Prevalence ratios (95% CI) of CHD by sex-specific quartiles of Magnesium indicators, as well as by Magnesium intake per dietary source, were determined using multivariable Cox proportional hazard models. CHD was present in 100 (22%) subjects. Adjusted CHD prevalence ratios for the highest compared to the lowest quartiles were 0.40 (0.20, 0.79) for Magnesium intake, 0.63 (0.32, 1.26) for 24 h urinary Magnesium Excretion, and 0.62 (0.32, 1.20) for plasma Magnesium concentration. For every 10 mg increase of Magnesium intake from vegetables, the prevalence of CHD was, statistically non-significantly, lower (0.75 (0.52, 1.08)). In this T2D cohort, higher Magnesium intake, higher 24 h urinary Magnesium Excretion, and higher plasma Magnesium concentration are associated with a lower prevalence of CHD.

  • urinary Magnesium Excretion and risk of hypertensionnovelty and significance
    Hypertension, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Jenny E Kootstraros, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Stephan J L Bakker
    Abstract:

    Observational studies on dietary or circulating Magnesium and risk of hypertension have reported weak-to-modest inverse associations, but have lacked measures of actual dietary uptake. Urinary Magnesium Excretion, an indicator of intestinal Magnesium absorption, may provide a better insight in this association. We examined 5511 participants aged 28 to 75 years free of hypertension in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population–based cohort study. Circulating Magnesium was measured in plasma and urinary Magnesium in two 24-hour urine collections, both at baseline. Incident hypertension was defined as blood pressure ≥140 mm Hg systolic or ≥90 mm Hg diastolic, or initiation of antihypertensive medication. During a median follow-up of 7.6 years (interquartile range, 5.0–9.3 years), 1172 participants developed hypertension. The median urinary Magnesium Excretion was 3.8 mmol/24 hour (interquartile range, 2.9–4.8 mmol/24 hour). Urinary Magnesium Excretion was associated with risk of hypertension in an inverse log-linear fashion, and this association remained after adjustment for age, sex, body mass index, smoking status, alcohol intake, parental history of hypertension, and urinary Excretion of sodium, potassium, and calcium. Each 1-unit increment in ln-transformed urinary Magnesium Excretion was associated with a 21% lower risk of hypertension after multivariable adjustment (adjusted hazard ratio, 0.79; 95% confidence interval, 0.71–0.88). No associations were observed between circulating Magnesium and risk of hypertension. In conclusion, in this cohort of men and women, urinary Magnesium Excretion was inversely associated with risk of hypertension across the entire range of habitual dietary intake. # Novelty and Significance {#article-title-42}

  • urinary Magnesium Excretion and risk of hypertension the prevention of renal and vascular end stage disease study
    Hypertension, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Jenny E Kootstraros, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Stephan J L Bakker
    Abstract:

    Observational studies on dietary or circulating Magnesium and risk of hypertension have reported weak-to-modest inverse associations, but have lacked measures of actual dietary uptake. Urinary Magnesium Excretion, an indicator of intestinal Magnesium absorption, may provide a better insight in this association. We examined 5511 participants aged 28 to 75 years free of hypertension in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population–based cohort study. Circulating Magnesium was measured in plasma and urinary Magnesium in two 24-hour urine collections, both at baseline. Incident hypertension was defined as blood pressure ≥140 mm Hg systolic or ≥90 mm Hg diastolic, or initiation of antihypertensive medication. During a median follow-up of 7.6 years (interquartile range, 5.0–9.3 years), 1172 participants developed hypertension. The median urinary Magnesium Excretion was 3.8 mmol/24 hour (interquartile range, 2.9–4.8 mmol/24 hour). Urinary Magnesium Excretion was associated with risk of hypertension in an inverse log-linear fashion, and this association remained after adjustment for age, sex, body mass index, smoking status, alcohol intake, parental history of hypertension, and urinary Excretion of sodium, potassium, and calcium. Each 1-unit increment in ln-transformed urinary Magnesium Excretion was associated with a 21% lower risk of hypertension after multivariable adjustment (adjusted hazard ratio, 0.79; 95% confidence interval, 0.71–0.88). No associations were observed between circulating Magnesium and risk of hypertension. In conclusion, in this cohort of men and women, urinary Magnesium Excretion was inversely associated with risk of hypertension across the entire range of habitual dietary intake.

  • urinary Magnesium Excretion and risk of hypertensionnovelty and significance the prevention of renal and vascular end stage disease study
    Hypertension, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Jenny E Kootstraros, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Stephan J L Bakker
    Abstract:

    Observational studies on dietary or circulating Magnesium and risk of hypertension have reported weak-to-modest inverse associations, but have lacked measures of actual dietary uptake. Urinary Magnesium Excretion, an indicator of intestinal Magnesium absorption, may provide a better insight in this association. We examined 5511 participants aged 28 to 75 years free of hypertension in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population–based cohort study. Circulating Magnesium was measured in plasma and urinary Magnesium in two 24-hour urine collections, both at baseline. Incident hypertension was defined as blood pressure ≥140 mm Hg systolic or ≥90 mm Hg diastolic, or initiation of antihypertensive medication. During a median follow-up of 7.6 years (interquartile range, 5.0–9.3 years), 1172 participants developed hypertension. The median urinary Magnesium Excretion was 3.8 mmol/24 hour (interquartile range, 2.9–4.8 mmol/24 hour). Urinary Magnesium Excretion was associated with risk of hypertension in an inverse log-linear fashion, and this association remained after adjustment for age, sex, body mass index, smoking status, alcohol intake, parental history of hypertension, and urinary Excretion of sodium, potassium, and calcium. Each 1-unit increment in ln-transformed urinary Magnesium Excretion was associated with a 21% lower risk of hypertension after multivariable adjustment (adjusted hazard ratio, 0.79; 95% confidence interval, 0.71–0.88). No associations were observed between circulating Magnesium and risk of hypertension. In conclusion, in this cohort of men and women, urinary Magnesium Excretion was inversely associated with risk of hypertension across the entire range of habitual dietary intake.

Kenneth J Mukamal - One of the best experts on this subject based on the ideXlab platform.

  • proton pump inhibitor use is associated with lower urinary Magnesium Excretion
    Nephrology, 2014
    Co-Authors: Jeffrey H William, Kenneth J Mukamal, Rachel Nelson, Najwah S Hayman, John Danziger
    Abstract:

    Aims Although multiple recent studies have confirmed an association between chronic proton-pump inhibitor (PPI) use and hypomagnesaemia, the physiologic explanation for this association remains uncertain. To address this, we investigated the association of PPI use with urinary Magnesium Excretion. Methods We measured 24-hour urine Magnesium Excretion in collections performed for nephrolithiasis evaluation in 278 consecutive ambulatory patients and determined PPI use from contemporaneous medical records. Results There were 50 (18%) PPI users at the time of urine collection. The mean daily urinary Magnesium was 84.6 ± 42.8 mg in PPI users, compared with 101.2 ± 41.1 mg in non-PPI users (P = 0.01). In adjusted analyses, PPI use was associated with 10.54 ± 5.30 mg/day lower daily urinary Magnesium Excretion (P = 0.05). Diuretic use did not significantly modify the effect of PPI on urinary Magnesium. As a control, PPI use was not associated with other urinary indicators of nutritional intake. Conclusions Our findings suggest that PPI use is associated with lower 24-hour urine Magnesium Excretion. Whether this reflects decreased intestinal uptake due to PPI exposure, or residual confounding due to decreased Magnesium intake, requires further study.

  • urinary Magnesium Excretion and risk of hypertensionnovelty and significance
    Hypertension, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Jenny E Kootstraros, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Stephan J L Bakker
    Abstract:

    Observational studies on dietary or circulating Magnesium and risk of hypertension have reported weak-to-modest inverse associations, but have lacked measures of actual dietary uptake. Urinary Magnesium Excretion, an indicator of intestinal Magnesium absorption, may provide a better insight in this association. We examined 5511 participants aged 28 to 75 years free of hypertension in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population–based cohort study. Circulating Magnesium was measured in plasma and urinary Magnesium in two 24-hour urine collections, both at baseline. Incident hypertension was defined as blood pressure ≥140 mm Hg systolic or ≥90 mm Hg diastolic, or initiation of antihypertensive medication. During a median follow-up of 7.6 years (interquartile range, 5.0–9.3 years), 1172 participants developed hypertension. The median urinary Magnesium Excretion was 3.8 mmol/24 hour (interquartile range, 2.9–4.8 mmol/24 hour). Urinary Magnesium Excretion was associated with risk of hypertension in an inverse log-linear fashion, and this association remained after adjustment for age, sex, body mass index, smoking status, alcohol intake, parental history of hypertension, and urinary Excretion of sodium, potassium, and calcium. Each 1-unit increment in ln-transformed urinary Magnesium Excretion was associated with a 21% lower risk of hypertension after multivariable adjustment (adjusted hazard ratio, 0.79; 95% confidence interval, 0.71–0.88). No associations were observed between circulating Magnesium and risk of hypertension. In conclusion, in this cohort of men and women, urinary Magnesium Excretion was inversely associated with risk of hypertension across the entire range of habitual dietary intake. # Novelty and Significance {#article-title-42}

  • urinary Magnesium Excretion and risk of hypertension the prevention of renal and vascular end stage disease study
    Hypertension, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Jenny E Kootstraros, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Stephan J L Bakker
    Abstract:

    Observational studies on dietary or circulating Magnesium and risk of hypertension have reported weak-to-modest inverse associations, but have lacked measures of actual dietary uptake. Urinary Magnesium Excretion, an indicator of intestinal Magnesium absorption, may provide a better insight in this association. We examined 5511 participants aged 28 to 75 years free of hypertension in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population–based cohort study. Circulating Magnesium was measured in plasma and urinary Magnesium in two 24-hour urine collections, both at baseline. Incident hypertension was defined as blood pressure ≥140 mm Hg systolic or ≥90 mm Hg diastolic, or initiation of antihypertensive medication. During a median follow-up of 7.6 years (interquartile range, 5.0–9.3 years), 1172 participants developed hypertension. The median urinary Magnesium Excretion was 3.8 mmol/24 hour (interquartile range, 2.9–4.8 mmol/24 hour). Urinary Magnesium Excretion was associated with risk of hypertension in an inverse log-linear fashion, and this association remained after adjustment for age, sex, body mass index, smoking status, alcohol intake, parental history of hypertension, and urinary Excretion of sodium, potassium, and calcium. Each 1-unit increment in ln-transformed urinary Magnesium Excretion was associated with a 21% lower risk of hypertension after multivariable adjustment (adjusted hazard ratio, 0.79; 95% confidence interval, 0.71–0.88). No associations were observed between circulating Magnesium and risk of hypertension. In conclusion, in this cohort of men and women, urinary Magnesium Excretion was inversely associated with risk of hypertension across the entire range of habitual dietary intake.

  • urinary Magnesium Excretion and risk of hypertensionnovelty and significance the prevention of renal and vascular end stage disease study
    Hypertension, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Jenny E Kootstraros, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Stephan J L Bakker
    Abstract:

    Observational studies on dietary or circulating Magnesium and risk of hypertension have reported weak-to-modest inverse associations, but have lacked measures of actual dietary uptake. Urinary Magnesium Excretion, an indicator of intestinal Magnesium absorption, may provide a better insight in this association. We examined 5511 participants aged 28 to 75 years free of hypertension in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population–based cohort study. Circulating Magnesium was measured in plasma and urinary Magnesium in two 24-hour urine collections, both at baseline. Incident hypertension was defined as blood pressure ≥140 mm Hg systolic or ≥90 mm Hg diastolic, or initiation of antihypertensive medication. During a median follow-up of 7.6 years (interquartile range, 5.0–9.3 years), 1172 participants developed hypertension. The median urinary Magnesium Excretion was 3.8 mmol/24 hour (interquartile range, 2.9–4.8 mmol/24 hour). Urinary Magnesium Excretion was associated with risk of hypertension in an inverse log-linear fashion, and this association remained after adjustment for age, sex, body mass index, smoking status, alcohol intake, parental history of hypertension, and urinary Excretion of sodium, potassium, and calcium. Each 1-unit increment in ln-transformed urinary Magnesium Excretion was associated with a 21% lower risk of hypertension after multivariable adjustment (adjusted hazard ratio, 0.79; 95% confidence interval, 0.71–0.88). No associations were observed between circulating Magnesium and risk of hypertension. In conclusion, in this cohort of men and women, urinary Magnesium Excretion was inversely associated with risk of hypertension across the entire range of habitual dietary intake.

  • Urinary and plasma Magnesium and risk of ischemic heart disease
    The American Journal of Clinical Nutrition, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Pim Van Der Harst, Stephan J L Bakker
    Abstract:

    Background: Previous studies on dietary Magnesium and risk of ischemic heart disease (IHD) have yielded inconsistent results, in part because of a lack of direct measures of actual Magnesium uptake. Urinary Excretion of Magnesium, an indicator of dietary Magnesium uptake, might provide more consistent results. Objective: The objective was to investigate whether urinary Magnesium Excretion and plasma Magnesium are associated with HID risk. Design: We examined 7664 adult participants free of known cardiovascular disease in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study a prospective population-based cohort study. Urinary Magnesium Excretion was measured in 2 baseline 24-h urine collections. Results: Mean +/- SD urinary Magnesium Excretion was 4.24 +/- 1.65 mmol/24 h for men and 3.54 +/- 1.40 mmol/24 h for women. During a median follow-up of 10.5 y (IQR: 9.9-10.8 y), 462 fatal and nonfatal IHD events occurred. After multivariable adjustment, urinary Magnesium Excretion had a nonlinear relation with IHD risk (P-curvature = 0.01). The lowest sex-specific quintile (men: Conclusions: Low urinary Magnesium Excretion was independently associated with a higher risk of IHD incidence. An increased dietary intake of Magnesium, particularly in those with the lowest urinary Magnesium, could reduce the risk of IHD.

Ron T Gansevoort - One of the best experts on this subject based on the ideXlab platform.

  • urinary Magnesium Excretion and risk of hypertensionnovelty and significance
    Hypertension, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Jenny E Kootstraros, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Stephan J L Bakker
    Abstract:

    Observational studies on dietary or circulating Magnesium and risk of hypertension have reported weak-to-modest inverse associations, but have lacked measures of actual dietary uptake. Urinary Magnesium Excretion, an indicator of intestinal Magnesium absorption, may provide a better insight in this association. We examined 5511 participants aged 28 to 75 years free of hypertension in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population–based cohort study. Circulating Magnesium was measured in plasma and urinary Magnesium in two 24-hour urine collections, both at baseline. Incident hypertension was defined as blood pressure ≥140 mm Hg systolic or ≥90 mm Hg diastolic, or initiation of antihypertensive medication. During a median follow-up of 7.6 years (interquartile range, 5.0–9.3 years), 1172 participants developed hypertension. The median urinary Magnesium Excretion was 3.8 mmol/24 hour (interquartile range, 2.9–4.8 mmol/24 hour). Urinary Magnesium Excretion was associated with risk of hypertension in an inverse log-linear fashion, and this association remained after adjustment for age, sex, body mass index, smoking status, alcohol intake, parental history of hypertension, and urinary Excretion of sodium, potassium, and calcium. Each 1-unit increment in ln-transformed urinary Magnesium Excretion was associated with a 21% lower risk of hypertension after multivariable adjustment (adjusted hazard ratio, 0.79; 95% confidence interval, 0.71–0.88). No associations were observed between circulating Magnesium and risk of hypertension. In conclusion, in this cohort of men and women, urinary Magnesium Excretion was inversely associated with risk of hypertension across the entire range of habitual dietary intake. # Novelty and Significance {#article-title-42}

  • urinary Magnesium Excretion and risk of hypertension the prevention of renal and vascular end stage disease study
    Hypertension, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Jenny E Kootstraros, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Stephan J L Bakker
    Abstract:

    Observational studies on dietary or circulating Magnesium and risk of hypertension have reported weak-to-modest inverse associations, but have lacked measures of actual dietary uptake. Urinary Magnesium Excretion, an indicator of intestinal Magnesium absorption, may provide a better insight in this association. We examined 5511 participants aged 28 to 75 years free of hypertension in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population–based cohort study. Circulating Magnesium was measured in plasma and urinary Magnesium in two 24-hour urine collections, both at baseline. Incident hypertension was defined as blood pressure ≥140 mm Hg systolic or ≥90 mm Hg diastolic, or initiation of antihypertensive medication. During a median follow-up of 7.6 years (interquartile range, 5.0–9.3 years), 1172 participants developed hypertension. The median urinary Magnesium Excretion was 3.8 mmol/24 hour (interquartile range, 2.9–4.8 mmol/24 hour). Urinary Magnesium Excretion was associated with risk of hypertension in an inverse log-linear fashion, and this association remained after adjustment for age, sex, body mass index, smoking status, alcohol intake, parental history of hypertension, and urinary Excretion of sodium, potassium, and calcium. Each 1-unit increment in ln-transformed urinary Magnesium Excretion was associated with a 21% lower risk of hypertension after multivariable adjustment (adjusted hazard ratio, 0.79; 95% confidence interval, 0.71–0.88). No associations were observed between circulating Magnesium and risk of hypertension. In conclusion, in this cohort of men and women, urinary Magnesium Excretion was inversely associated with risk of hypertension across the entire range of habitual dietary intake.

  • urinary Magnesium Excretion and risk of hypertensionnovelty and significance the prevention of renal and vascular end stage disease study
    Hypertension, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Jenny E Kootstraros, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Stephan J L Bakker
    Abstract:

    Observational studies on dietary or circulating Magnesium and risk of hypertension have reported weak-to-modest inverse associations, but have lacked measures of actual dietary uptake. Urinary Magnesium Excretion, an indicator of intestinal Magnesium absorption, may provide a better insight in this association. We examined 5511 participants aged 28 to 75 years free of hypertension in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population–based cohort study. Circulating Magnesium was measured in plasma and urinary Magnesium in two 24-hour urine collections, both at baseline. Incident hypertension was defined as blood pressure ≥140 mm Hg systolic or ≥90 mm Hg diastolic, or initiation of antihypertensive medication. During a median follow-up of 7.6 years (interquartile range, 5.0–9.3 years), 1172 participants developed hypertension. The median urinary Magnesium Excretion was 3.8 mmol/24 hour (interquartile range, 2.9–4.8 mmol/24 hour). Urinary Magnesium Excretion was associated with risk of hypertension in an inverse log-linear fashion, and this association remained after adjustment for age, sex, body mass index, smoking status, alcohol intake, parental history of hypertension, and urinary Excretion of sodium, potassium, and calcium. Each 1-unit increment in ln-transformed urinary Magnesium Excretion was associated with a 21% lower risk of hypertension after multivariable adjustment (adjusted hazard ratio, 0.79; 95% confidence interval, 0.71–0.88). No associations were observed between circulating Magnesium and risk of hypertension. In conclusion, in this cohort of men and women, urinary Magnesium Excretion was inversely associated with risk of hypertension across the entire range of habitual dietary intake.

  • Urinary and plasma Magnesium and risk of ischemic heart disease
    The American Journal of Clinical Nutrition, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Pim Van Der Harst, Stephan J L Bakker
    Abstract:

    Background: Previous studies on dietary Magnesium and risk of ischemic heart disease (IHD) have yielded inconsistent results, in part because of a lack of direct measures of actual Magnesium uptake. Urinary Excretion of Magnesium, an indicator of dietary Magnesium uptake, might provide more consistent results. Objective: The objective was to investigate whether urinary Magnesium Excretion and plasma Magnesium are associated with HID risk. Design: We examined 7664 adult participants free of known cardiovascular disease in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study a prospective population-based cohort study. Urinary Magnesium Excretion was measured in 2 baseline 24-h urine collections. Results: Mean +/- SD urinary Magnesium Excretion was 4.24 +/- 1.65 mmol/24 h for men and 3.54 +/- 1.40 mmol/24 h for women. During a median follow-up of 10.5 y (IQR: 9.9-10.8 y), 462 fatal and nonfatal IHD events occurred. After multivariable adjustment, urinary Magnesium Excretion had a nonlinear relation with IHD risk (P-curvature = 0.01). The lowest sex-specific quintile (men: Conclusions: Low urinary Magnesium Excretion was independently associated with a higher risk of IHD incidence. An increased dietary intake of Magnesium, particularly in those with the lowest urinary Magnesium, could reduce the risk of IHD.

  • urinary Magnesium Excretion and risk of hypertension
    Hypertension, 2013
    Co-Authors: Michel M Joosten, Ron T Gansevoort, Kenneth J Mukamal, Jenny E Kootstraros, Edith J M Feskens, Johanna M Geleijnse, Gerjan Navis, Stephan J L Bakker
    Abstract:

    Observational studies on dietary or circulating Magnesium and risk of hypertension have reported weak-to-modest inverse associations, but have lacked measures of actual dietary uptake. Urinary Magnesium Excretion, an indicator of intestinal Magnesium absorption, may provide a better insight in this association. We examined 5511 participants aged 28 to 75 years free of hypertension in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population–based cohort study. Circulating Magnesium was measured in plasma and urinary Magnesium in two 24-hour urine collections, both at baseline. Incident hypertension was defined as blood pressure ≥140 mm Hg systolic or ≥90 mm Hg diastolic, or initiation of antihypertensive medication. During a median follow-up of 7.6 years (interquartile range, 5.0–9.3 years), 1172 participants developed hypertension. The median urinary Magnesium Excretion was 3.8 mmol/24 hour (interquartile range, 2.9–4.8 mmol/24 hour). Urinary Magnesium Excretion was associated with risk of hypertension in an inverse log-linear fashion, and this association remained after adjustment for age, sex, body mass index, smoking status, alcohol intake, parental history of hypertension, and urinary Excretion of sodium, potassium, and calcium. Each 1-unit increment in ln-transformed urinary Magnesium Excretion was associated with a 21% lower risk of hypertension after multivariable adjustment (adjusted hazard ratio, 0.79; 95% confidence interval, 0.71–0.88). No associations were observed between circulating Magnesium and risk of hypertension. In conclusion, in this cohort of men and women, urinary Magnesium Excretion was inversely associated with risk of hypertension across the entire range of habitual dietary intake.

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