The Experts below are selected from a list of 5937 Experts worldwide ranked by ideXlab platform
Takuji Tanaka - One of the best experts on this subject based on the ideXlab platform.
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the inhibitory effect of Magnesium Hydroxide on the bile acid induced cell proliferation of colon epithelium in rats with comparison to the action of calcium lactate
Carcinogenesis, 1994Co-Authors: Aijin Wang, Naoki Yoshimi, Takuji TanakaAbstract:The modulating effects of Magnesium Hydroxide and calcium lactate on the cholic acid-induced hyperproliferation of cells in rat colon epithelium were investigated. Rats were divided into six groups (10 rats/group) and fed the following diets for 8 weeks: 0.25% cholic acid alone (group 1), cholic acid plus 0.2% Magnesium Hydroxide (group 2), cholic acid plus 1.18% calcium in the form of calcium lactate (group 3), calcium lactate alone (group 4), Magnesium hydroxyde alone (group 5) and the basal diet alone (group 6). At the end of the experiment, all rats were killed for the immunocytochemical examination of 5-bromo-2'-deoxyuridine (BrdU) incorporation in the cell nuclei of colonic epithelium
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The inhibitory effect of Magnesium Hydroxide on the bile acid-induced cell proliferation of colon epithelium in rats with comparison to the action of calcium lactate
Carcinogenesis, 1994Co-Authors: Aijin Wang, Naoki Yoshimi, Takuji Tanaka, Hideki MoriAbstract:The modulating effects of Magnesium Hydroxide and calcium lactate on the cholic acid-induced hyperproliferation of cells in rat colon epithelium were investigated. Rats were divided into six groups (10 rats/group) and fed the following diets for 8 weeks: 0.25% cholic acid alone (group 1), cholic acid plus 0.2% Magnesium Hydroxide (group 2), cholic acid plus 1.18% calcium in the form of calcium lactate (group 3), calcium lactate alone (group 4), Magnesium Hydroxide alone (group 5) and the basal diet alone (group 6). At the end of the experiment, all rats were killed for the immunocytochemical examination of 5-bromo-2'-deoxyuridine (BrdU) incorporation in the cell nuclei of colonic epithelium. Magnesium Hydroxide reduced the cholic acid-induced BrdU incorporation by 33% at the distal part and 40% at the proximal part. Calcium lactate also reduced the BrdU incorporation by 48% and 51% respectively. Exposure of Magnesium Hydroxide or calcium lactate alone had no influence on BrdU incorporation. The results suggest that Magnesium Hydroxide might exert anti-carcinogenic effects as does calcium by reducing increased cell proliferation of colonic epithelium induced by toxic effects of bile acids, which are regarded as colon tumor promoters or cocarcinogens.
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inhibitory effects of Magnesium Hydroxide on c myc expression and cell proliferation induced by methylazoxymethanol acetate in rat colon
Cancer Letters, 1993Co-Authors: Aijin Wang, Naoki Yoshimi, Takuji Tanaka, Hideki MoriAbstract:Abstract The effects of Magnesium Hydroxide were examined on methylazoxymethanol (MAM) acetate-induced c- myc expression and cell proliferation of colonic mucosal epithelium in rats. Rats were divided into four groups and treated as follows: MAM acetate alone (25 mg/kg i.p.injection, five times, once a week for 5 weeks), MAM acetate and feeding of 0.2% Magnesium Hydroxide in diet, Magnesium Hydroxide alone and non-treatment. At 4, 8 and 16 weeks after the start of experiment, 10 rats in each group were sacrificed. Magnesium Hydroxide inhibited the MAM-induced expression of c- myc proto-oncogene, and also suppressed the increased bromodeoxyuridine (BrdU) and proliferating cell nuclear antigen (PCNA) labelling indexes induced by MAM acetate in colon mucosa in initiation and post-initiation phase. These results suggest that the anti-carcinogenic effect of Magnesium Hydroxide on rat colon carcinogenesis induced by MAM acetate may be related to the inhibition of the carcinogen-induced expression of c- myc protooncogene and cell proliferation.
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effect of Magnesium Hydroxide on methylazoxymethanol acetate induced epithelial proliferation in the large bowels of rats
Cancer Letters, 1992Co-Authors: Hideki Mori, Naoki Yoshimi, Yukio Morishita, Yoshio Mori, Shigeyuki Sugie, Takuji TanakaAbstract:The effect of Magnesium Hydroxide on the epithelial proliferation of the large bowel was examined using rats given methylazoxymethanol (MAM) acetate. Dietary administration of Magnesium Hydroxide at 250, 500, 1000 or 2000 ppm. for 1, 3 or 5 weeks did not influence the cell cycle of the cryptal cells of the large bowel. However, the exposure to Magnesium Hydroxide under these conditions lowered the bromodeoxyuridine labeling index of the cells of the large bowel of the rats which had been initiated by MAM acetate (25 mg/kg, 3 times). The decrease in labeling index was more apparent in the proximal segment than in the distal segment. Such an inhibitory effect on the DNA synthesis of the epithelial cells by Magnesium Hydroxide may be related to the suppressive action of the trace element on the carcinogen-induced large bowel carcinogenesis.
Hideki Mori - One of the best experts on this subject based on the ideXlab platform.
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The inhibitory effect of Magnesium Hydroxide on the bile acid-induced cell proliferation of colon epithelium in rats with comparison to the action of calcium lactate
Carcinogenesis, 1994Co-Authors: Aijin Wang, Naoki Yoshimi, Takuji Tanaka, Hideki MoriAbstract:The modulating effects of Magnesium Hydroxide and calcium lactate on the cholic acid-induced hyperproliferation of cells in rat colon epithelium were investigated. Rats were divided into six groups (10 rats/group) and fed the following diets for 8 weeks: 0.25% cholic acid alone (group 1), cholic acid plus 0.2% Magnesium Hydroxide (group 2), cholic acid plus 1.18% calcium in the form of calcium lactate (group 3), calcium lactate alone (group 4), Magnesium Hydroxide alone (group 5) and the basal diet alone (group 6). At the end of the experiment, all rats were killed for the immunocytochemical examination of 5-bromo-2'-deoxyuridine (BrdU) incorporation in the cell nuclei of colonic epithelium. Magnesium Hydroxide reduced the cholic acid-induced BrdU incorporation by 33% at the distal part and 40% at the proximal part. Calcium lactate also reduced the BrdU incorporation by 48% and 51% respectively. Exposure of Magnesium Hydroxide or calcium lactate alone had no influence on BrdU incorporation. The results suggest that Magnesium Hydroxide might exert anti-carcinogenic effects as does calcium by reducing increased cell proliferation of colonic epithelium induced by toxic effects of bile acids, which are regarded as colon tumor promoters or cocarcinogens.
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inhibitory effects of Magnesium Hydroxide on c myc expression and cell proliferation induced by methylazoxymethanol acetate in rat colon
Cancer Letters, 1993Co-Authors: Aijin Wang, Naoki Yoshimi, Takuji Tanaka, Hideki MoriAbstract:Abstract The effects of Magnesium Hydroxide were examined on methylazoxymethanol (MAM) acetate-induced c- myc expression and cell proliferation of colonic mucosal epithelium in rats. Rats were divided into four groups and treated as follows: MAM acetate alone (25 mg/kg i.p.injection, five times, once a week for 5 weeks), MAM acetate and feeding of 0.2% Magnesium Hydroxide in diet, Magnesium Hydroxide alone and non-treatment. At 4, 8 and 16 weeks after the start of experiment, 10 rats in each group were sacrificed. Magnesium Hydroxide inhibited the MAM-induced expression of c- myc proto-oncogene, and also suppressed the increased bromodeoxyuridine (BrdU) and proliferating cell nuclear antigen (PCNA) labelling indexes induced by MAM acetate in colon mucosa in initiation and post-initiation phase. These results suggest that the anti-carcinogenic effect of Magnesium Hydroxide on rat colon carcinogenesis induced by MAM acetate may be related to the inhibition of the carcinogen-induced expression of c- myc protooncogene and cell proliferation.
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effect of Magnesium Hydroxide on methylazoxymethanol acetate induced epithelial proliferation in the large bowels of rats
Cancer Letters, 1992Co-Authors: Hideki Mori, Naoki Yoshimi, Yukio Morishita, Yoshio Mori, Shigeyuki Sugie, Takuji TanakaAbstract:The effect of Magnesium Hydroxide on the epithelial proliferation of the large bowel was examined using rats given methylazoxymethanol (MAM) acetate. Dietary administration of Magnesium Hydroxide at 250, 500, 1000 or 2000 ppm. for 1, 3 or 5 weeks did not influence the cell cycle of the cryptal cells of the large bowel. However, the exposure to Magnesium Hydroxide under these conditions lowered the bromodeoxyuridine labeling index of the cells of the large bowel of the rats which had been initiated by MAM acetate (25 mg/kg, 3 times). The decrease in labeling index was more apparent in the proximal segment than in the distal segment. Such an inhibitory effect on the DNA synthesis of the epithelial cells by Magnesium Hydroxide may be related to the suppressive action of the trace element on the carcinogen-induced large bowel carcinogenesis.
Aijin Wang - One of the best experts on this subject based on the ideXlab platform.
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the inhibitory effect of Magnesium Hydroxide on the bile acid induced cell proliferation of colon epithelium in rats with comparison to the action of calcium lactate
Carcinogenesis, 1994Co-Authors: Aijin Wang, Naoki Yoshimi, Takuji TanakaAbstract:The modulating effects of Magnesium Hydroxide and calcium lactate on the cholic acid-induced hyperproliferation of cells in rat colon epithelium were investigated. Rats were divided into six groups (10 rats/group) and fed the following diets for 8 weeks: 0.25% cholic acid alone (group 1), cholic acid plus 0.2% Magnesium Hydroxide (group 2), cholic acid plus 1.18% calcium in the form of calcium lactate (group 3), calcium lactate alone (group 4), Magnesium hydroxyde alone (group 5) and the basal diet alone (group 6). At the end of the experiment, all rats were killed for the immunocytochemical examination of 5-bromo-2'-deoxyuridine (BrdU) incorporation in the cell nuclei of colonic epithelium
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The inhibitory effect of Magnesium Hydroxide on the bile acid-induced cell proliferation of colon epithelium in rats with comparison to the action of calcium lactate
Carcinogenesis, 1994Co-Authors: Aijin Wang, Naoki Yoshimi, Takuji Tanaka, Hideki MoriAbstract:The modulating effects of Magnesium Hydroxide and calcium lactate on the cholic acid-induced hyperproliferation of cells in rat colon epithelium were investigated. Rats were divided into six groups (10 rats/group) and fed the following diets for 8 weeks: 0.25% cholic acid alone (group 1), cholic acid plus 0.2% Magnesium Hydroxide (group 2), cholic acid plus 1.18% calcium in the form of calcium lactate (group 3), calcium lactate alone (group 4), Magnesium Hydroxide alone (group 5) and the basal diet alone (group 6). At the end of the experiment, all rats were killed for the immunocytochemical examination of 5-bromo-2'-deoxyuridine (BrdU) incorporation in the cell nuclei of colonic epithelium. Magnesium Hydroxide reduced the cholic acid-induced BrdU incorporation by 33% at the distal part and 40% at the proximal part. Calcium lactate also reduced the BrdU incorporation by 48% and 51% respectively. Exposure of Magnesium Hydroxide or calcium lactate alone had no influence on BrdU incorporation. The results suggest that Magnesium Hydroxide might exert anti-carcinogenic effects as does calcium by reducing increased cell proliferation of colonic epithelium induced by toxic effects of bile acids, which are regarded as colon tumor promoters or cocarcinogens.
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inhibitory effects of Magnesium Hydroxide on c myc expression and cell proliferation induced by methylazoxymethanol acetate in rat colon
Cancer Letters, 1993Co-Authors: Aijin Wang, Naoki Yoshimi, Takuji Tanaka, Hideki MoriAbstract:Abstract The effects of Magnesium Hydroxide were examined on methylazoxymethanol (MAM) acetate-induced c- myc expression and cell proliferation of colonic mucosal epithelium in rats. Rats were divided into four groups and treated as follows: MAM acetate alone (25 mg/kg i.p.injection, five times, once a week for 5 weeks), MAM acetate and feeding of 0.2% Magnesium Hydroxide in diet, Magnesium Hydroxide alone and non-treatment. At 4, 8 and 16 weeks after the start of experiment, 10 rats in each group were sacrificed. Magnesium Hydroxide inhibited the MAM-induced expression of c- myc proto-oncogene, and also suppressed the increased bromodeoxyuridine (BrdU) and proliferating cell nuclear antigen (PCNA) labelling indexes induced by MAM acetate in colon mucosa in initiation and post-initiation phase. These results suggest that the anti-carcinogenic effect of Magnesium Hydroxide on rat colon carcinogenesis induced by MAM acetate may be related to the inhibition of the carcinogen-induced expression of c- myc protooncogene and cell proliferation.
Naoki Yoshimi - One of the best experts on this subject based on the ideXlab platform.
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the inhibitory effect of Magnesium Hydroxide on the bile acid induced cell proliferation of colon epithelium in rats with comparison to the action of calcium lactate
Carcinogenesis, 1994Co-Authors: Aijin Wang, Naoki Yoshimi, Takuji TanakaAbstract:The modulating effects of Magnesium Hydroxide and calcium lactate on the cholic acid-induced hyperproliferation of cells in rat colon epithelium were investigated. Rats were divided into six groups (10 rats/group) and fed the following diets for 8 weeks: 0.25% cholic acid alone (group 1), cholic acid plus 0.2% Magnesium Hydroxide (group 2), cholic acid plus 1.18% calcium in the form of calcium lactate (group 3), calcium lactate alone (group 4), Magnesium hydroxyde alone (group 5) and the basal diet alone (group 6). At the end of the experiment, all rats were killed for the immunocytochemical examination of 5-bromo-2'-deoxyuridine (BrdU) incorporation in the cell nuclei of colonic epithelium
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The inhibitory effect of Magnesium Hydroxide on the bile acid-induced cell proliferation of colon epithelium in rats with comparison to the action of calcium lactate
Carcinogenesis, 1994Co-Authors: Aijin Wang, Naoki Yoshimi, Takuji Tanaka, Hideki MoriAbstract:The modulating effects of Magnesium Hydroxide and calcium lactate on the cholic acid-induced hyperproliferation of cells in rat colon epithelium were investigated. Rats were divided into six groups (10 rats/group) and fed the following diets for 8 weeks: 0.25% cholic acid alone (group 1), cholic acid plus 0.2% Magnesium Hydroxide (group 2), cholic acid plus 1.18% calcium in the form of calcium lactate (group 3), calcium lactate alone (group 4), Magnesium Hydroxide alone (group 5) and the basal diet alone (group 6). At the end of the experiment, all rats were killed for the immunocytochemical examination of 5-bromo-2'-deoxyuridine (BrdU) incorporation in the cell nuclei of colonic epithelium. Magnesium Hydroxide reduced the cholic acid-induced BrdU incorporation by 33% at the distal part and 40% at the proximal part. Calcium lactate also reduced the BrdU incorporation by 48% and 51% respectively. Exposure of Magnesium Hydroxide or calcium lactate alone had no influence on BrdU incorporation. The results suggest that Magnesium Hydroxide might exert anti-carcinogenic effects as does calcium by reducing increased cell proliferation of colonic epithelium induced by toxic effects of bile acids, which are regarded as colon tumor promoters or cocarcinogens.
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inhibitory effects of Magnesium Hydroxide on c myc expression and cell proliferation induced by methylazoxymethanol acetate in rat colon
Cancer Letters, 1993Co-Authors: Aijin Wang, Naoki Yoshimi, Takuji Tanaka, Hideki MoriAbstract:Abstract The effects of Magnesium Hydroxide were examined on methylazoxymethanol (MAM) acetate-induced c- myc expression and cell proliferation of colonic mucosal epithelium in rats. Rats were divided into four groups and treated as follows: MAM acetate alone (25 mg/kg i.p.injection, five times, once a week for 5 weeks), MAM acetate and feeding of 0.2% Magnesium Hydroxide in diet, Magnesium Hydroxide alone and non-treatment. At 4, 8 and 16 weeks after the start of experiment, 10 rats in each group were sacrificed. Magnesium Hydroxide inhibited the MAM-induced expression of c- myc proto-oncogene, and also suppressed the increased bromodeoxyuridine (BrdU) and proliferating cell nuclear antigen (PCNA) labelling indexes induced by MAM acetate in colon mucosa in initiation and post-initiation phase. These results suggest that the anti-carcinogenic effect of Magnesium Hydroxide on rat colon carcinogenesis induced by MAM acetate may be related to the inhibition of the carcinogen-induced expression of c- myc protooncogene and cell proliferation.
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effect of Magnesium Hydroxide on methylazoxymethanol acetate induced epithelial proliferation in the large bowels of rats
Cancer Letters, 1992Co-Authors: Hideki Mori, Naoki Yoshimi, Yukio Morishita, Yoshio Mori, Shigeyuki Sugie, Takuji TanakaAbstract:The effect of Magnesium Hydroxide on the epithelial proliferation of the large bowel was examined using rats given methylazoxymethanol (MAM) acetate. Dietary administration of Magnesium Hydroxide at 250, 500, 1000 or 2000 ppm. for 1, 3 or 5 weeks did not influence the cell cycle of the cryptal cells of the large bowel. However, the exposure to Magnesium Hydroxide under these conditions lowered the bromodeoxyuridine labeling index of the cells of the large bowel of the rats which had been initiated by MAM acetate (25 mg/kg, 3 times). The decrease in labeling index was more apparent in the proximal segment than in the distal segment. Such an inhibitory effect on the DNA synthesis of the epithelial cells by Magnesium Hydroxide may be related to the suppressive action of the trace element on the carcinogen-induced large bowel carcinogenesis.
Stanley L Hem - One of the best experts on this subject based on the ideXlab platform.
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effect of heterocoagulation on the rheology of suspensions containing aluminum hydroxycarbonate and Magnesium Hydroxide
Journal of Colloid and Interface Science, 1994Co-Authors: William J Mclaughlin, Joe L. White, Stanley L HemAbstract:Abstract Heterocoagulation in suspensions containing both aluminum hydroxycarbonate and Magnesium Hydroxide leads to the development of an aluminum hydroxycarbonate coating on the Magnesium Hydroxide particles. For this reason, mixed suspensions exhibit isoelectric points similar to those or aluminum hydroxycarbonate, but markedly different from Magnesium Hydroxide. The finding is significant in relation to physical properties of the systems as mixed suspensions demonstrated theological behavior which responded to changes in media pH in a manner analogous to aluminum hydroxycarbonate suspensions. Thus, a maximum yield value of the mixed suspension was observed at a pH corresponding to the isoelectric point of the aluminum hydroxycarbonate coating.
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influence of heterocoagulation on the formation of hydrotalcite in mixed suspensions of Magnesium Hydroxide and aluminum hydroxycarbonate
Joint International Conference on Information Sciences, 1994Co-Authors: William J Mclaughlin, Joe L. White, Stanley L HemAbstract:Abstract The formation of hydrotalcite in mixed suspensions of Magnesium Hydroxide and aluminum hydroxycarbonate was found to be influenced by factors affecting heterocoagulation of the separate particles. A model of the system employing large particles of Magnesium Hydroxide exposed to an aluminum hydroxycarbonate suspension demonstrated rapid hydrotalcite formation when pH conditions were adjusted to prohibit heterocoagulation. Scanning electron micrographs of the particles indicated that nucleation and growth of the mixed crystal was occurring directly on the Magnesium Hydroxide surface. The appearance of hydrotalcite was delayed in mixed suspensions wherein heterocoagulation resulted in an occlusive coating of aluminum hydroxycarbonate on the Magnesium Hydroxide. Formation of hydrotalcite occurred sooner in systems having higher initial pH values presumably due to earlier exposure of Magnesium Hydroxide surfaces resulting from more rapid aging of the aluminum hydroxycarbonate coating. Mixed suspensions of Magnesium Hydroxide and other aluminum-containing Hydroxides, wherein an occlusive coating did not form on the Magnesium Hydroxide particles, demonstrated rapid hydrotalcite formation.
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the surface chemistry of agglomerates formed in suspensions containing aluminum hydroxycarbonate and Magnesium Hydroxide
Journal of Colloid and Interface Science, 1993Co-Authors: William J Mclaughlin, Joe L. White, Stanley L HemAbstract:Abstract A dissolution and reprecipitation process contributes significantly to the formation of an aluminum hydroxycarbonate coating on Magnesium Hydroxide particles in aqueous suspensions containing the two types of particles. Shortly after the two suspensions are mixed, heterogeneous particles form consisting of Magnesium Hydroxide crystallites coated with aluminum hydroxycarbonate. The alkaline nature of the Magnesium Hydroxide surface enhances dissolution of the aluminum hydroxycarbonate particles and promotes desorption of carbonate anion from potential-determining sites on these particles. Loss of carbonate anion results in an increased isoelectric point of the aluminum hydroxycarbonate phase of the mixtures and thus of the heterogeneous particles as well. For this reason the isoelectric points of mixtures are increased compared to those of aluminum hydroxycarbonate suspensions. Both the particle size of Magnesium Hydroxide and media pH influence the magnitude of this increase.
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heterocoagulation in Magnesium Hydroxide and aluminum hydroxycarbonate suspensions
Joint International Conference on Information Sciences, 1993Co-Authors: William J Mclaughlin, Joe L. White, Stanley L HemAbstract:Abstract Magnesium Hydroxide and aluminum hydroxycarbonate interact in mixed suspensions resulting in the formation of agglomerates containing both types of particles. Direct visual evidence of the phenomenon was gained from scanning electron microscopy studies carried out on a model of the system employing a highly crystalline Magnesium Hydroxide of large particle size and from transmission electron microscopy of mixed colloidal suspensions. Doppler electrophoretic light scattering measurements on mixed colloid systems supported the findings as two distinct electrokinetic populations of particles were initially present which corresponded to the zeta potentials of Magnesium Hydroxide and aluminum hydroxycarbonate. The two populations were observed to transform over time into a single population having an intermediate zeta potential. Solubilization of both types of particles apparently takes place, leading to changes in bulk pH and ionic strength of the mixtures.
