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Mansoor A. Khan - One of the best experts on this subject based on the ideXlab platform.
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Difference in the lubrication efficiency of bovine and vegetable-derived Magnesium Stearate during tabletting.
AAPS PharmSciTech, 2009Co-Authors: Abhay Gupta, Mazen L. Hamad, Vilayat A. Sayeed, Mobin A. Tawakkul, Mansoor A. KhanAbstract:The purpose of this work was to evaluate and compare the functionality of bovine fatty acids-derived (MgSt-B) and vegetable fatty acids-derived (MgSt-V) Magnesium Stearate powders when used for the lubrication of granules prepared by high-shear (HSG) and fluid bed (FBG) wet granulation methods. The work included evaluation of tablet compression and ejection forces during tabletting and dissolution testing of the compressed tablets. Granules prepared by both granulation methods required significantly lower ejection force (p < 0.01) when lubricated with the MgSt-V powder as compared to those lubricated with the MgSt-B powder. Granules prepared by the HSG method and lubricated with the MgSt-V powder also required significantly lower compression force (p < 0.01) to produce tablets of similar weight and hardness as compared to those lubricated with the MgSt-B powder. The dissolution profiles were not affected by these differences and were the same for tablets prepared by same granulation method and lubricated with either Magnesium Stearate powder. The results indicate significant differences (p < 0.01) between lubrication efficiency of the MgSt-B and the MgSt-V powders and emphasize the importance of functionality testing of the MgSt powders to understand the impact of these differences.
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functionality of Magnesium Stearate derived from bovine and vegetable sources dry granulated tablets
Journal of Pharmaceutical Sciences, 2008Co-Authors: Mazen L. Hamad, Abhay Gupta, Rakhi B. Shah, Robbe C. Lyon, Vilayat A. Sayeed, Mansoor A. KhanAbstract:Abstract Magnesium Stearate is a functional excipient used to ensure efficient ejection of tablets. This study compares the functionality of a vegetable and bovine grade of Magnesium Stearate. Tablets were prepared by direct compression and dry granulation of a model formulation. Physical and chemical tests were performed on bulk powders, granule intermediates, and finished tablets to provide a comprehensive comparison of the two grades of Magnesium Stearates. Raw material characterization of the two grades showed no difference in particle size, surface area, true density, and total moisture content. However, significant differences in fatty acid composition, surface tension, and zeta potential were detected. Tablet ejection force for the physical mixture formulations was variable, showing similar ejection force for the two grades of Magnesium Stearate at some concentrations and different ejection forces at other concentrations. The dry granulated formulation containing vegetable‐based Magnesium Stearate showed a lower ejection force than the formulation containing bovine‐based Magnesium Stearate. There was no difference between the dissolution profiles of the tablets containing the two grades of Magnesium Stearate prepared by both methods. The results indicated that Magnesium Stearate interchangeability with respect to lubricant efficiency depends upon the level in which it is used and the manufacturing method. © 2008 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:5328–5340, 2008
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Functionality of Magnesium Stearate derived from bovine and vegetable sources: Dry granulated tablets
Journal of pharmaceutical sciences, 2008Co-Authors: Mazen L. Hamad, Abhay Gupta, Rakhi B. Shah, Robbe C. Lyon, Vilayat A. Sayeed, Mansoor A. KhanAbstract:Magnesium Stearate is a functional excipient used to ensure efficient ejection of tablets. This study compares the functionality of a vegetable and bovine grade of Magnesium Stearate. Tablets were prepared by direct compression and dry granulation of a model formulation. Physical and chemical tests were performed on bulk powders, granule intermediates, and finished tablets to provide a comprehensive comparison of the two grades of Magnesium Stearates. Raw material characterization of the two grades showed no difference in particle size, surface area, true density, and total moisture content. However, significant differences in fatty acid composition, surface tension, and zeta potential were detected. Tablet ejection force for the physical mixture formulations was variable, showing similar ejection force for the two grades of Magnesium Stearate at some concentrations and different ejection forces at other concentrations. The dry granulated formulation containing vegetable-based Magnesium Stearate showed a lower ejection force than the formulation containing bovine-based Magnesium Stearate. There was no difference between the dissolution profiles of the tablets containing the two grades of Magnesium Stearate prepared by both methods. The results indicated that Magnesium Stearate interchangeability with respect to lubricant efficiency depends upon the level in which it is used and the manufacturing method.
Yousef Tamsilian - One of the best experts on this subject based on the ideXlab platform.
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Magnesium Stearate coated superhydrophobic sponge for oil water separation synthesis properties application
Separation and Purification Technology, 2020Co-Authors: Aliasghar Parsaie, Masoud Riazi, Mohammad Mohammadikhanaposhtani, Yousef TamsilianAbstract:Abstract Separation of an oil/water mixture has become a very attractive subject due to frequent oil spill incidents and industrial oily wastewater treatment. In this study, a robust superhydrophobic/superoleophilic polyurethane sponge comprising Magnesium Stearate coating and phenol-formaldehyde resin was developed by the cost-effective immersion method for the removal of organic materials and oils from the oil/water system. The characterizations of the modified polyurethane by SEM, FESEM, FTIR, Raman and EDX confirmed that it was well coated with phenol-formaldehyde and Magnesium Stearate. The water contact angle measurement results showed a contact angle exceeding 175° and sliding angle less than 3°, which are, compared to other reports up to now, a great unprecedented achievement. Also, no considerable change after abrasing and immersing in the acidic and basic solution was observed. Due to outstanding water contact angle, the organic absorption time is less than 1 s, covering a wide absorption capacity range of 19–38 g/g depending on the viscosity and density of oils and organic solvents. Finally, the modified polyurethane sponge provided an excellent performance capability of the continuous oil/water separation, required for an industrial application.
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Magnesium Stearate-coated superhydrophobic sponge for oil/water separation: Synthesis, properties, application
Separation and Purification Technology, 2020Co-Authors: Aliasghar Parsaie, Mohammad Mohammadi-khanaposhtani, Masoud Riazi, Yousef TamsilianAbstract:Abstract Separation of an oil/water mixture has become a very attractive subject due to frequent oil spill incidents and industrial oily wastewater treatment. In this study, a robust superhydrophobic/superoleophilic polyurethane sponge comprising Magnesium Stearate coating and phenol-formaldehyde resin was developed by the cost-effective immersion method for the removal of organic materials and oils from the oil/water system. The characterizations of the modified polyurethane by SEM, FESEM, FTIR, Raman and EDX confirmed that it was well coated with phenol-formaldehyde and Magnesium Stearate. The water contact angle measurement results showed a contact angle exceeding 175° and sliding angle less than 3°, which are, compared to other reports up to now, a great unprecedented achievement. Also, no considerable change after abrasing and immersing in the acidic and basic solution was observed. Due to outstanding water contact angle, the organic absorption time is less than 1 s, covering a wide absorption capacity range of 19–38 g/g depending on the viscosity and density of oils and organic solvents. Finally, the modified polyurethane sponge provided an excellent performance capability of the continuous oil/water separation, required for an industrial application.
Mazen L. Hamad - One of the best experts on this subject based on the ideXlab platform.
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Difference in the lubrication efficiency of bovine and vegetable-derived Magnesium Stearate during tabletting.
AAPS PharmSciTech, 2009Co-Authors: Abhay Gupta, Mazen L. Hamad, Vilayat A. Sayeed, Mobin A. Tawakkul, Mansoor A. KhanAbstract:The purpose of this work was to evaluate and compare the functionality of bovine fatty acids-derived (MgSt-B) and vegetable fatty acids-derived (MgSt-V) Magnesium Stearate powders when used for the lubrication of granules prepared by high-shear (HSG) and fluid bed (FBG) wet granulation methods. The work included evaluation of tablet compression and ejection forces during tabletting and dissolution testing of the compressed tablets. Granules prepared by both granulation methods required significantly lower ejection force (p < 0.01) when lubricated with the MgSt-V powder as compared to those lubricated with the MgSt-B powder. Granules prepared by the HSG method and lubricated with the MgSt-V powder also required significantly lower compression force (p < 0.01) to produce tablets of similar weight and hardness as compared to those lubricated with the MgSt-B powder. The dissolution profiles were not affected by these differences and were the same for tablets prepared by same granulation method and lubricated with either Magnesium Stearate powder. The results indicate significant differences (p < 0.01) between lubrication efficiency of the MgSt-B and the MgSt-V powders and emphasize the importance of functionality testing of the MgSt powders to understand the impact of these differences.
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functionality of Magnesium Stearate derived from bovine and vegetable sources dry granulated tablets
Journal of Pharmaceutical Sciences, 2008Co-Authors: Mazen L. Hamad, Abhay Gupta, Rakhi B. Shah, Robbe C. Lyon, Vilayat A. Sayeed, Mansoor A. KhanAbstract:Abstract Magnesium Stearate is a functional excipient used to ensure efficient ejection of tablets. This study compares the functionality of a vegetable and bovine grade of Magnesium Stearate. Tablets were prepared by direct compression and dry granulation of a model formulation. Physical and chemical tests were performed on bulk powders, granule intermediates, and finished tablets to provide a comprehensive comparison of the two grades of Magnesium Stearates. Raw material characterization of the two grades showed no difference in particle size, surface area, true density, and total moisture content. However, significant differences in fatty acid composition, surface tension, and zeta potential were detected. Tablet ejection force for the physical mixture formulations was variable, showing similar ejection force for the two grades of Magnesium Stearate at some concentrations and different ejection forces at other concentrations. The dry granulated formulation containing vegetable‐based Magnesium Stearate showed a lower ejection force than the formulation containing bovine‐based Magnesium Stearate. There was no difference between the dissolution profiles of the tablets containing the two grades of Magnesium Stearate prepared by both methods. The results indicated that Magnesium Stearate interchangeability with respect to lubricant efficiency depends upon the level in which it is used and the manufacturing method. © 2008 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:5328–5340, 2008
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Functionality of Magnesium Stearate derived from bovine and vegetable sources: Dry granulated tablets
Journal of pharmaceutical sciences, 2008Co-Authors: Mazen L. Hamad, Abhay Gupta, Rakhi B. Shah, Robbe C. Lyon, Vilayat A. Sayeed, Mansoor A. KhanAbstract:Magnesium Stearate is a functional excipient used to ensure efficient ejection of tablets. This study compares the functionality of a vegetable and bovine grade of Magnesium Stearate. Tablets were prepared by direct compression and dry granulation of a model formulation. Physical and chemical tests were performed on bulk powders, granule intermediates, and finished tablets to provide a comprehensive comparison of the two grades of Magnesium Stearates. Raw material characterization of the two grades showed no difference in particle size, surface area, true density, and total moisture content. However, significant differences in fatty acid composition, surface tension, and zeta potential were detected. Tablet ejection force for the physical mixture formulations was variable, showing similar ejection force for the two grades of Magnesium Stearate at some concentrations and different ejection forces at other concentrations. The dry granulated formulation containing vegetable-based Magnesium Stearate showed a lower ejection force than the formulation containing bovine-based Magnesium Stearate. There was no difference between the dissolution profiles of the tablets containing the two grades of Magnesium Stearate prepared by both methods. The results indicated that Magnesium Stearate interchangeability with respect to lubricant efficiency depends upon the level in which it is used and the manufacturing method.
Aliasghar Parsaie - One of the best experts on this subject based on the ideXlab platform.
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Magnesium Stearate coated superhydrophobic sponge for oil water separation synthesis properties application
Separation and Purification Technology, 2020Co-Authors: Aliasghar Parsaie, Masoud Riazi, Mohammad Mohammadikhanaposhtani, Yousef TamsilianAbstract:Abstract Separation of an oil/water mixture has become a very attractive subject due to frequent oil spill incidents and industrial oily wastewater treatment. In this study, a robust superhydrophobic/superoleophilic polyurethane sponge comprising Magnesium Stearate coating and phenol-formaldehyde resin was developed by the cost-effective immersion method for the removal of organic materials and oils from the oil/water system. The characterizations of the modified polyurethane by SEM, FESEM, FTIR, Raman and EDX confirmed that it was well coated with phenol-formaldehyde and Magnesium Stearate. The water contact angle measurement results showed a contact angle exceeding 175° and sliding angle less than 3°, which are, compared to other reports up to now, a great unprecedented achievement. Also, no considerable change after abrasing and immersing in the acidic and basic solution was observed. Due to outstanding water contact angle, the organic absorption time is less than 1 s, covering a wide absorption capacity range of 19–38 g/g depending on the viscosity and density of oils and organic solvents. Finally, the modified polyurethane sponge provided an excellent performance capability of the continuous oil/water separation, required for an industrial application.
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Magnesium Stearate-coated superhydrophobic sponge for oil/water separation: Synthesis, properties, application
Separation and Purification Technology, 2020Co-Authors: Aliasghar Parsaie, Mohammad Mohammadi-khanaposhtani, Masoud Riazi, Yousef TamsilianAbstract:Abstract Separation of an oil/water mixture has become a very attractive subject due to frequent oil spill incidents and industrial oily wastewater treatment. In this study, a robust superhydrophobic/superoleophilic polyurethane sponge comprising Magnesium Stearate coating and phenol-formaldehyde resin was developed by the cost-effective immersion method for the removal of organic materials and oils from the oil/water system. The characterizations of the modified polyurethane by SEM, FESEM, FTIR, Raman and EDX confirmed that it was well coated with phenol-formaldehyde and Magnesium Stearate. The water contact angle measurement results showed a contact angle exceeding 175° and sliding angle less than 3°, which are, compared to other reports up to now, a great unprecedented achievement. Also, no considerable change after abrasing and immersing in the acidic and basic solution was observed. Due to outstanding water contact angle, the organic absorption time is less than 1 s, covering a wide absorption capacity range of 19–38 g/g depending on the viscosity and density of oils and organic solvents. Finally, the modified polyurethane sponge provided an excellent performance capability of the continuous oil/water separation, required for an industrial application.
Vilayat A. Sayeed - One of the best experts on this subject based on the ideXlab platform.
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Difference in the lubrication efficiency of bovine and vegetable-derived Magnesium Stearate during tabletting.
AAPS PharmSciTech, 2009Co-Authors: Abhay Gupta, Mazen L. Hamad, Vilayat A. Sayeed, Mobin A. Tawakkul, Mansoor A. KhanAbstract:The purpose of this work was to evaluate and compare the functionality of bovine fatty acids-derived (MgSt-B) and vegetable fatty acids-derived (MgSt-V) Magnesium Stearate powders when used for the lubrication of granules prepared by high-shear (HSG) and fluid bed (FBG) wet granulation methods. The work included evaluation of tablet compression and ejection forces during tabletting and dissolution testing of the compressed tablets. Granules prepared by both granulation methods required significantly lower ejection force (p < 0.01) when lubricated with the MgSt-V powder as compared to those lubricated with the MgSt-B powder. Granules prepared by the HSG method and lubricated with the MgSt-V powder also required significantly lower compression force (p < 0.01) to produce tablets of similar weight and hardness as compared to those lubricated with the MgSt-B powder. The dissolution profiles were not affected by these differences and were the same for tablets prepared by same granulation method and lubricated with either Magnesium Stearate powder. The results indicate significant differences (p < 0.01) between lubrication efficiency of the MgSt-B and the MgSt-V powders and emphasize the importance of functionality testing of the MgSt powders to understand the impact of these differences.
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functionality of Magnesium Stearate derived from bovine and vegetable sources dry granulated tablets
Journal of Pharmaceutical Sciences, 2008Co-Authors: Mazen L. Hamad, Abhay Gupta, Rakhi B. Shah, Robbe C. Lyon, Vilayat A. Sayeed, Mansoor A. KhanAbstract:Abstract Magnesium Stearate is a functional excipient used to ensure efficient ejection of tablets. This study compares the functionality of a vegetable and bovine grade of Magnesium Stearate. Tablets were prepared by direct compression and dry granulation of a model formulation. Physical and chemical tests were performed on bulk powders, granule intermediates, and finished tablets to provide a comprehensive comparison of the two grades of Magnesium Stearates. Raw material characterization of the two grades showed no difference in particle size, surface area, true density, and total moisture content. However, significant differences in fatty acid composition, surface tension, and zeta potential were detected. Tablet ejection force for the physical mixture formulations was variable, showing similar ejection force for the two grades of Magnesium Stearate at some concentrations and different ejection forces at other concentrations. The dry granulated formulation containing vegetable‐based Magnesium Stearate showed a lower ejection force than the formulation containing bovine‐based Magnesium Stearate. There was no difference between the dissolution profiles of the tablets containing the two grades of Magnesium Stearate prepared by both methods. The results indicated that Magnesium Stearate interchangeability with respect to lubricant efficiency depends upon the level in which it is used and the manufacturing method. © 2008 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:5328–5340, 2008
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Functionality of Magnesium Stearate derived from bovine and vegetable sources: Dry granulated tablets
Journal of pharmaceutical sciences, 2008Co-Authors: Mazen L. Hamad, Abhay Gupta, Rakhi B. Shah, Robbe C. Lyon, Vilayat A. Sayeed, Mansoor A. KhanAbstract:Magnesium Stearate is a functional excipient used to ensure efficient ejection of tablets. This study compares the functionality of a vegetable and bovine grade of Magnesium Stearate. Tablets were prepared by direct compression and dry granulation of a model formulation. Physical and chemical tests were performed on bulk powders, granule intermediates, and finished tablets to provide a comprehensive comparison of the two grades of Magnesium Stearates. Raw material characterization of the two grades showed no difference in particle size, surface area, true density, and total moisture content. However, significant differences in fatty acid composition, surface tension, and zeta potential were detected. Tablet ejection force for the physical mixture formulations was variable, showing similar ejection force for the two grades of Magnesium Stearate at some concentrations and different ejection forces at other concentrations. The dry granulated formulation containing vegetable-based Magnesium Stearate showed a lower ejection force than the formulation containing bovine-based Magnesium Stearate. There was no difference between the dissolution profiles of the tablets containing the two grades of Magnesium Stearate prepared by both methods. The results indicated that Magnesium Stearate interchangeability with respect to lubricant efficiency depends upon the level in which it is used and the manufacturing method.
