The Experts below are selected from a list of 90 Experts worldwide ranked by ideXlab platform

Michael Douek - One of the best experts on this subject based on the ideXlab platform.

  • meta analysis of sentinel lymph node biopsy in breast cancer using the Magnetic Technique
    British Journal of Surgery, 2016
    Co-Authors: Ali Zada, Mirjam C L Peek, Muneer Ahmed, Bauke Anninga, Rose Baker, Moriaki Kusakabe, Masaki Sekino, J M Klaase, Ten B Haken, Michael Douek
    Abstract:

    Background 3 The gold standard for sentinel lymph node biopsy (SLNB), the dual Technique (radiolabelled tracer and 4 blue dye), has several drawbacks. A novel Magnetic Technique without these drawbacks, has been 5 evaluated in a number of clinical trials. It utilizes a Magnetic tracer and a hand-held magnetometer to 6 identify and excise sentinel lymph nodes (SLNs). A systematic review and meta-analysis was performed 7 to assess the performance and utility of Magnetic in comparison to the standard Technique. 8 Method 9 Medline, PubMed, Embase and the Cochrane online literature databases were used to identify all 10 original articles published up to April 2016, evaluating the Magnetic Technique for SLNB. Studies were 11 included if they were prospectively conducted clinical trials comparing Magnetic to standard Technique 12 for SLNB in patients with breast cancer. 13 Results 14 Seven studies were included and Magnetic Technique was non-inferior to standard Technique (z=3.87, 15 p<0.001), at a 2% non-inferiority margin. The mean identification rates for standard and Magnetic 16 Technique were 96.8% (94.2-99.0%) and 97.1% (94.4-98.0%) respectively (p=0.690, RD 0.0, 95% CI [- 17 0.01-0.01]). The total lymph node retrieval (LNR) was significantly higher with Magnetic compared to 18 standard Technique (2,113 (1.9 per patient) versus 2,000 (1.8 per patient); p=0.003, RD 0.05, 95% CI 19 [0.03-0.06]). False-negative rates were 10.9% (5.6-22.3%) for standard Technique and 8.4% (1.6-22.3%) 20 for Magnetic Technique (p=0.551, RD 0.03; 95% CI [0.00-0.06]). The mean discordance rate was 3.9% 21 (1.7-6.9%). 22 Conclusion 23 The Magnetic Technique for SLNB is non-inferior to standard Technique, with a high identification rate 24 but with a significantly higher lymph node retrieval rate.

  • Magnetic sentinel node and occult lesion localization in breast cancer magsnoll trial
    British Journal of Surgery, 2015
    Co-Authors: Muneer Ahmed, Bauke Anninga, Michael Douek, S Goyal, Philippa Young, Q A Pankhurst
    Abstract:

    BACKGROUND: Non‐palpable breast cancers require localization‐guided surgery and axillary staging using sentinel lymph node biopsy (SLNB). This study investigated the novel Technique of Magnetic‐guided lesion localization and concurrent SLNB, which avoids the need for wire‐guided localization and radioisotopes. METHODS: An ultrasound‐guided intratumoral injection of Magnetic tracer (0·5 ml) was performed in a protocol‐driven predefined minimum of ten patients with palpable breast cancer to assess the ability of the Magnetic tracer safely to localize the tumour at the site of injection and concurrently drain to the lymphatics. Once successful lesion localization had been confirmed (peak magnetometer count retained at the centre of the tumour), the Technique was undertaken in a further 20 patients with non‐palpable breast cancers awaiting wide local excision and SLNB. All patients underwent SLNB with both the Magnetic and standard dual (radioisotope and Patent Blue V dye) Techniques. RESULTS: Thirty‐two patients were recruited, of whom 12 (1 with bilateral disease) presented with palpable and 20 with non‐palpable breast cancer. Peak magnetometer counts were retained at the tumour centre in all palpable (13) and non‐palpable (20) breast cancers. Re‐excisions for involved margins were necessary in two patients with non‐palpable breast cancers. The sentinel lymph node identification rates were 28 of 33 procedures for the Magnetic Technique alone, 32 of 33 for the Magnetic Technique combined with blue dye, and 32 of 33 for the standard dual Technique. CONCLUSION: Magnetic lesion localization is feasible, with intratumoral Magnetic tracer injection combined with a periareolar injection of blue dye for subsequent SNLB.

  • sentinel node biopsy using a Magnetic tracer versus standard Technique the sentimag multicentre trial
    Annals of Surgical Oncology, 2014
    Co-Authors: Michael Douek, J M Klaase, Ian Monypenny, Ashutosh Kothari, Katalin Zechmeister, Douglas Brown, Lynda Wyld, P J Drew, Hans Garmo, Olorunsola F Agbaje
    Abstract:

    Background The SentiMAG Multicentre Trial evaluated a new Magnetic Technique for sentinel lymph node biopsy (SLNB) against the standard (radioisotope and blue dye or radioisotope alone). The Magnetic Technique does not use radiation and provides both a color change (brown dye) and a handheld probe for node localization. The primary end point of this trial was defined as the proportion of sentinel nodes detected with each Technique (identification rate). Methods A total of 160 women with breast cancer scheduled for SLNB, who were clinically and radiologically node negative, were recruited from seven centers in the United Kingdom and The Netherlands. SLNB was undertaken after administration of both the Magnetic and standard tracers (radioisotope with or without blue dye). Results A total of 170 SLNB procedures were undertaken on 161 patients, and 1 patient was excluded, leaving 160 patients for further analysis. The identification rate was 95.0 % (152 of 160) with the standard Technique and 94.4 % (151 of 160) with the Magnetic Technique (0.6 % difference; 95 % upper confidence limit 4.4 %; 6.9 % discordance). Of the 22 % (35 of 160) of patients with lymph node involvement, 16 % (25 of 160) had at least 1 macrometastasis, and 6 % (10 of 160) had at least a micrometastasis. Another 2.5 % (4 of 160) had isolated tumor cells. Of 404 lymph nodes removed, 297 (74 %) were true sentinel nodes. The lymph node retrieval rate was 2.5 nodes per patient overall, 1.9 nodes per patient with the standard Technique, and 2.0 nodes per patient with the Magnetic Technique. Conclusions The Magnetic Technique is a feasible Technique for SLNB, with an identification rate that is not inferior to the standard Technique

Muneer Ahmed - One of the best experts on this subject based on the ideXlab platform.

  • meta analysis of sentinel lymph node biopsy in breast cancer using the Magnetic Technique
    British Journal of Surgery, 2016
    Co-Authors: Ali Zada, Mirjam C L Peek, Muneer Ahmed, Bauke Anninga, Rose Baker, Moriaki Kusakabe, Masaki Sekino, J M Klaase, Ten B Haken, Michael Douek
    Abstract:

    Background 3 The gold standard for sentinel lymph node biopsy (SLNB), the dual Technique (radiolabelled tracer and 4 blue dye), has several drawbacks. A novel Magnetic Technique without these drawbacks, has been 5 evaluated in a number of clinical trials. It utilizes a Magnetic tracer and a hand-held magnetometer to 6 identify and excise sentinel lymph nodes (SLNs). A systematic review and meta-analysis was performed 7 to assess the performance and utility of Magnetic in comparison to the standard Technique. 8 Method 9 Medline, PubMed, Embase and the Cochrane online literature databases were used to identify all 10 original articles published up to April 2016, evaluating the Magnetic Technique for SLNB. Studies were 11 included if they were prospectively conducted clinical trials comparing Magnetic to standard Technique 12 for SLNB in patients with breast cancer. 13 Results 14 Seven studies were included and Magnetic Technique was non-inferior to standard Technique (z=3.87, 15 p<0.001), at a 2% non-inferiority margin. The mean identification rates for standard and Magnetic 16 Technique were 96.8% (94.2-99.0%) and 97.1% (94.4-98.0%) respectively (p=0.690, RD 0.0, 95% CI [- 17 0.01-0.01]). The total lymph node retrieval (LNR) was significantly higher with Magnetic compared to 18 standard Technique (2,113 (1.9 per patient) versus 2,000 (1.8 per patient); p=0.003, RD 0.05, 95% CI 19 [0.03-0.06]). False-negative rates were 10.9% (5.6-22.3%) for standard Technique and 8.4% (1.6-22.3%) 20 for Magnetic Technique (p=0.551, RD 0.03; 95% CI [0.00-0.06]). The mean discordance rate was 3.9% 21 (1.7-6.9%). 22 Conclusion 23 The Magnetic Technique for SLNB is non-inferior to standard Technique, with a high identification rate 24 but with a significantly higher lymph node retrieval rate.

  • Magnetic sentinel node and occult lesion localization in breast cancer magsnoll trial
    British Journal of Surgery, 2015
    Co-Authors: Muneer Ahmed, Bauke Anninga, Michael Douek, S Goyal, Philippa Young, Q A Pankhurst
    Abstract:

    BACKGROUND: Non‐palpable breast cancers require localization‐guided surgery and axillary staging using sentinel lymph node biopsy (SLNB). This study investigated the novel Technique of Magnetic‐guided lesion localization and concurrent SLNB, which avoids the need for wire‐guided localization and radioisotopes. METHODS: An ultrasound‐guided intratumoral injection of Magnetic tracer (0·5 ml) was performed in a protocol‐driven predefined minimum of ten patients with palpable breast cancer to assess the ability of the Magnetic tracer safely to localize the tumour at the site of injection and concurrently drain to the lymphatics. Once successful lesion localization had been confirmed (peak magnetometer count retained at the centre of the tumour), the Technique was undertaken in a further 20 patients with non‐palpable breast cancers awaiting wide local excision and SLNB. All patients underwent SLNB with both the Magnetic and standard dual (radioisotope and Patent Blue V dye) Techniques. RESULTS: Thirty‐two patients were recruited, of whom 12 (1 with bilateral disease) presented with palpable and 20 with non‐palpable breast cancer. Peak magnetometer counts were retained at the tumour centre in all palpable (13) and non‐palpable (20) breast cancers. Re‐excisions for involved margins were necessary in two patients with non‐palpable breast cancers. The sentinel lymph node identification rates were 28 of 33 procedures for the Magnetic Technique alone, 32 of 33 for the Magnetic Technique combined with blue dye, and 32 of 33 for the standard dual Technique. CONCLUSION: Magnetic lesion localization is feasible, with intratumoral Magnetic tracer injection combined with a periareolar injection of blue dye for subsequent SNLB.

J M Klaase - One of the best experts on this subject based on the ideXlab platform.

  • meta analysis of sentinel lymph node biopsy in breast cancer using the Magnetic Technique
    British Journal of Surgery, 2016
    Co-Authors: Ali Zada, Mirjam C L Peek, Muneer Ahmed, Bauke Anninga, Rose Baker, Moriaki Kusakabe, Masaki Sekino, J M Klaase, Ten B Haken, Michael Douek
    Abstract:

    Background 3 The gold standard for sentinel lymph node biopsy (SLNB), the dual Technique (radiolabelled tracer and 4 blue dye), has several drawbacks. A novel Magnetic Technique without these drawbacks, has been 5 evaluated in a number of clinical trials. It utilizes a Magnetic tracer and a hand-held magnetometer to 6 identify and excise sentinel lymph nodes (SLNs). A systematic review and meta-analysis was performed 7 to assess the performance and utility of Magnetic in comparison to the standard Technique. 8 Method 9 Medline, PubMed, Embase and the Cochrane online literature databases were used to identify all 10 original articles published up to April 2016, evaluating the Magnetic Technique for SLNB. Studies were 11 included if they were prospectively conducted clinical trials comparing Magnetic to standard Technique 12 for SLNB in patients with breast cancer. 13 Results 14 Seven studies were included and Magnetic Technique was non-inferior to standard Technique (z=3.87, 15 p<0.001), at a 2% non-inferiority margin. The mean identification rates for standard and Magnetic 16 Technique were 96.8% (94.2-99.0%) and 97.1% (94.4-98.0%) respectively (p=0.690, RD 0.0, 95% CI [- 17 0.01-0.01]). The total lymph node retrieval (LNR) was significantly higher with Magnetic compared to 18 standard Technique (2,113 (1.9 per patient) versus 2,000 (1.8 per patient); p=0.003, RD 0.05, 95% CI 19 [0.03-0.06]). False-negative rates were 10.9% (5.6-22.3%) for standard Technique and 8.4% (1.6-22.3%) 20 for Magnetic Technique (p=0.551, RD 0.03; 95% CI [0.00-0.06]). The mean discordance rate was 3.9% 21 (1.7-6.9%). 22 Conclusion 23 The Magnetic Technique for SLNB is non-inferior to standard Technique, with a high identification rate 24 but with a significantly higher lymph node retrieval rate.

  • sentinel node biopsy using a Magnetic tracer versus standard Technique the sentimag multicentre trial
    Annals of Surgical Oncology, 2014
    Co-Authors: Michael Douek, J M Klaase, Ian Monypenny, Ashutosh Kothari, Katalin Zechmeister, Douglas Brown, Lynda Wyld, P J Drew, Hans Garmo, Olorunsola F Agbaje
    Abstract:

    Background The SentiMAG Multicentre Trial evaluated a new Magnetic Technique for sentinel lymph node biopsy (SLNB) against the standard (radioisotope and blue dye or radioisotope alone). The Magnetic Technique does not use radiation and provides both a color change (brown dye) and a handheld probe for node localization. The primary end point of this trial was defined as the proportion of sentinel nodes detected with each Technique (identification rate). Methods A total of 160 women with breast cancer scheduled for SLNB, who were clinically and radiologically node negative, were recruited from seven centers in the United Kingdom and The Netherlands. SLNB was undertaken after administration of both the Magnetic and standard tracers (radioisotope with or without blue dye). Results A total of 170 SLNB procedures were undertaken on 161 patients, and 1 patient was excluded, leaving 160 patients for further analysis. The identification rate was 95.0 % (152 of 160) with the standard Technique and 94.4 % (151 of 160) with the Magnetic Technique (0.6 % difference; 95 % upper confidence limit 4.4 %; 6.9 % discordance). Of the 22 % (35 of 160) of patients with lymph node involvement, 16 % (25 of 160) had at least 1 macrometastasis, and 6 % (10 of 160) had at least a micrometastasis. Another 2.5 % (4 of 160) had isolated tumor cells. Of 404 lymph nodes removed, 297 (74 %) were true sentinel nodes. The lymph node retrieval rate was 2.5 nodes per patient overall, 1.9 nodes per patient with the standard Technique, and 2.0 nodes per patient with the Magnetic Technique. Conclusions The Magnetic Technique is a feasible Technique for SLNB, with an identification rate that is not inferior to the standard Technique

Olorunsola F Agbaje - One of the best experts on this subject based on the ideXlab platform.

  • sentinel node biopsy using a Magnetic tracer versus standard Technique the sentimag multicentre trial
    Annals of Surgical Oncology, 2014
    Co-Authors: Michael Douek, J M Klaase, Ian Monypenny, Ashutosh Kothari, Katalin Zechmeister, Douglas Brown, Lynda Wyld, P J Drew, Hans Garmo, Olorunsola F Agbaje
    Abstract:

    Background The SentiMAG Multicentre Trial evaluated a new Magnetic Technique for sentinel lymph node biopsy (SLNB) against the standard (radioisotope and blue dye or radioisotope alone). The Magnetic Technique does not use radiation and provides both a color change (brown dye) and a handheld probe for node localization. The primary end point of this trial was defined as the proportion of sentinel nodes detected with each Technique (identification rate). Methods A total of 160 women with breast cancer scheduled for SLNB, who were clinically and radiologically node negative, were recruited from seven centers in the United Kingdom and The Netherlands. SLNB was undertaken after administration of both the Magnetic and standard tracers (radioisotope with or without blue dye). Results A total of 170 SLNB procedures were undertaken on 161 patients, and 1 patient was excluded, leaving 160 patients for further analysis. The identification rate was 95.0 % (152 of 160) with the standard Technique and 94.4 % (151 of 160) with the Magnetic Technique (0.6 % difference; 95 % upper confidence limit 4.4 %; 6.9 % discordance). Of the 22 % (35 of 160) of patients with lymph node involvement, 16 % (25 of 160) had at least 1 macrometastasis, and 6 % (10 of 160) had at least a micrometastasis. Another 2.5 % (4 of 160) had isolated tumor cells. Of 404 lymph nodes removed, 297 (74 %) were true sentinel nodes. The lymph node retrieval rate was 2.5 nodes per patient overall, 1.9 nodes per patient with the standard Technique, and 2.0 nodes per patient with the Magnetic Technique. Conclusions The Magnetic Technique is a feasible Technique for SLNB, with an identification rate that is not inferior to the standard Technique

Bauke Anninga - One of the best experts on this subject based on the ideXlab platform.

  • meta analysis of sentinel lymph node biopsy in breast cancer using the Magnetic Technique
    British Journal of Surgery, 2016
    Co-Authors: Ali Zada, Mirjam C L Peek, Muneer Ahmed, Bauke Anninga, Rose Baker, Moriaki Kusakabe, Masaki Sekino, J M Klaase, Ten B Haken, Michael Douek
    Abstract:

    Background 3 The gold standard for sentinel lymph node biopsy (SLNB), the dual Technique (radiolabelled tracer and 4 blue dye), has several drawbacks. A novel Magnetic Technique without these drawbacks, has been 5 evaluated in a number of clinical trials. It utilizes a Magnetic tracer and a hand-held magnetometer to 6 identify and excise sentinel lymph nodes (SLNs). A systematic review and meta-analysis was performed 7 to assess the performance and utility of Magnetic in comparison to the standard Technique. 8 Method 9 Medline, PubMed, Embase and the Cochrane online literature databases were used to identify all 10 original articles published up to April 2016, evaluating the Magnetic Technique for SLNB. Studies were 11 included if they were prospectively conducted clinical trials comparing Magnetic to standard Technique 12 for SLNB in patients with breast cancer. 13 Results 14 Seven studies were included and Magnetic Technique was non-inferior to standard Technique (z=3.87, 15 p<0.001), at a 2% non-inferiority margin. The mean identification rates for standard and Magnetic 16 Technique were 96.8% (94.2-99.0%) and 97.1% (94.4-98.0%) respectively (p=0.690, RD 0.0, 95% CI [- 17 0.01-0.01]). The total lymph node retrieval (LNR) was significantly higher with Magnetic compared to 18 standard Technique (2,113 (1.9 per patient) versus 2,000 (1.8 per patient); p=0.003, RD 0.05, 95% CI 19 [0.03-0.06]). False-negative rates were 10.9% (5.6-22.3%) for standard Technique and 8.4% (1.6-22.3%) 20 for Magnetic Technique (p=0.551, RD 0.03; 95% CI [0.00-0.06]). The mean discordance rate was 3.9% 21 (1.7-6.9%). 22 Conclusion 23 The Magnetic Technique for SLNB is non-inferior to standard Technique, with a high identification rate 24 but with a significantly higher lymph node retrieval rate.

  • Magnetic sentinel node and occult lesion localization in breast cancer magsnoll trial
    British Journal of Surgery, 2015
    Co-Authors: Muneer Ahmed, Bauke Anninga, Michael Douek, S Goyal, Philippa Young, Q A Pankhurst
    Abstract:

    BACKGROUND: Non‐palpable breast cancers require localization‐guided surgery and axillary staging using sentinel lymph node biopsy (SLNB). This study investigated the novel Technique of Magnetic‐guided lesion localization and concurrent SLNB, which avoids the need for wire‐guided localization and radioisotopes. METHODS: An ultrasound‐guided intratumoral injection of Magnetic tracer (0·5 ml) was performed in a protocol‐driven predefined minimum of ten patients with palpable breast cancer to assess the ability of the Magnetic tracer safely to localize the tumour at the site of injection and concurrently drain to the lymphatics. Once successful lesion localization had been confirmed (peak magnetometer count retained at the centre of the tumour), the Technique was undertaken in a further 20 patients with non‐palpable breast cancers awaiting wide local excision and SLNB. All patients underwent SLNB with both the Magnetic and standard dual (radioisotope and Patent Blue V dye) Techniques. RESULTS: Thirty‐two patients were recruited, of whom 12 (1 with bilateral disease) presented with palpable and 20 with non‐palpable breast cancer. Peak magnetometer counts were retained at the tumour centre in all palpable (13) and non‐palpable (20) breast cancers. Re‐excisions for involved margins were necessary in two patients with non‐palpable breast cancers. The sentinel lymph node identification rates were 28 of 33 procedures for the Magnetic Technique alone, 32 of 33 for the Magnetic Technique combined with blue dye, and 32 of 33 for the standard dual Technique. CONCLUSION: Magnetic lesion localization is feasible, with intratumoral Magnetic tracer injection combined with a periareolar injection of blue dye for subsequent SNLB.