The Experts below are selected from a list of 1944 Experts worldwide ranked by ideXlab platform
Evan B. Dreyer - One of the best experts on this subject based on the ideXlab platform.
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lateral geniculate nucleus in glaucoma
American Journal of Ophthalmology, 1993Co-Authors: Neena Chaturvedi, Tessa E Hedleywhyte, Evan B. DreyerAbstract:To assess glaucomatous damage to the lateral geniculate nucleus of the thalamus, as well as to its MagnoCellular and parvoCellular layers, we examined the autopsy sections of the lateral geniculate nucleus of individuals with and without glaucoma. Five patients with a documented history of glaucoma and five controls with no ophthalmic or chronic central nervous system disease were included in this study. Neurons were counted in autopsy sections of the lateral geniculate nucleus. Cells were counted in 40 random microscopic fields of the MagnoCellular and parvoCellular layers respectively. The mean MagnoCellular Cell density for the glaucoma group of 2.72 ± 0.13 Cells per square millimeter (mean ± SEM) was significantly less than that for the control group of 3.76 ± 0.13 Cells per square millimeter (P
Neena Chaturvedi - One of the best experts on this subject based on the ideXlab platform.
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lateral geniculate nucleus in glaucoma
American Journal of Ophthalmology, 1993Co-Authors: Neena Chaturvedi, Tessa E Hedleywhyte, Evan B. DreyerAbstract:To assess glaucomatous damage to the lateral geniculate nucleus of the thalamus, as well as to its MagnoCellular and parvoCellular layers, we examined the autopsy sections of the lateral geniculate nucleus of individuals with and without glaucoma. Five patients with a documented history of glaucoma and five controls with no ophthalmic or chronic central nervous system disease were included in this study. Neurons were counted in autopsy sections of the lateral geniculate nucleus. Cells were counted in 40 random microscopic fields of the MagnoCellular and parvoCellular layers respectively. The mean MagnoCellular Cell density for the glaucoma group of 2.72 ± 0.13 Cells per square millimeter (mean ± SEM) was significantly less than that for the control group of 3.76 ± 0.13 Cells per square millimeter (P
Laszlo Zaborszky - One of the best experts on this subject based on the ideXlab platform.
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functional subdivisions of MagnoCellular Cell groups in human basal forebrain test retest resting state study at ultra high field and meta analysis
Cerebral Cortex, 2019Co-Authors: Rui Yuan, Bharat B Biswal, Laszlo ZaborszkyAbstract:The heterogeneous neuronal subgroups of the basal forebrain corticopetal system (BFcs) have been shown to modulate cortical functions through their cholinergic, gamma-aminobutyric acid-ergic, and glutamatergic projections to the entire cortex. Although previous studies suggested that the basalo-cortical projection system influences various cognitive functions, particularly via its cholinergic component, these studies only focused on certain parts of the BFcs or nearby structures, leaving aside a more systematic picture of the functional connectivity of BFcs subcompartments. Moreover, these studies lacked the high-spatial resolution and the probability maps needed to identify specific subcompartments. Recent advances in the ultra-high field 7T functional magnetic resonance imaging (fMRI) provided potentially unprecedented spatial resolution of functional MRI images to study the subdivision of the BFcs. In this study, the BF space containing corticopetal Cells was divided into 3 functionally distinct subdivisions based on functional connection to cortical regions derived from fMRI. The overall functional connection of each BFcs subdivision was examined with a test-retest study. Finally, a meta-analysis was used to study the related functional topics of each BF subdivision. Our results demonstrate distinct functional connectivity patterns of these subdivisions along the rostrocaudal axis of the BF. All three compartments have shown consistent segregation and overlap at specific target regions including the hippocampus, insula, thalamus, and the cingulate gyrus, suggesting functional integration and separation in BFcs.
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stereotaxic probabilistic maps of the MagnoCellular Cell groups in human basal forebrain
NeuroImage, 2008Co-Authors: Laszlo Zaborszky, Lars Hoemke, Hartmut Mohlberg, Axel Schleicher, Katrin Amunts, Karl ZillesAbstract:Abstract The basal forebrain contains several interdigitating anatomical structures, including the diagonal band of Broca, the basal nucleus of Meynert, the ventral striatum, and also Cell groups underneath the globus pallidus that bridge the centromedial amygdala to the bed nucleus of the stria terminalis. Among the Cell populations, the MagnoCellular, cholinergic corticopetal projection neurons have received particular attention due to their loss in Alzheimer's disease. In MRI images, the precise delineation of these structures is difficult due to limited spatial resolution and contrast. Here, using microscopic delineations in ten human postmortem brains, we present stereotaxic probabilistic maps of the basal forebrain areas containing the MagnoCellular Cell groups. Cytoarchitectonic mapping was performed in silver stained histological serial sections. The positions and the extent of the MagnoCellular Cell groups within the septum (Ch1–2), the horizontal limb of the diagonal band (Ch3), and in the sublenticular part of the basal forebrain (Ch4) were traced in high-resolution digitized histological sections, 3D reconstructed, and warped to the reference space of the MNI single subject brain. The superposition of the cytoarchitectonic maps in the MNI brain shows the intersubject variability of the various Ch compartments and their stereotaxic position relative to other brain structures. Both the right and left Ch4 regions showed significantly smaller volumes when age was considered as a covariate. Probabilistic maps of compartments of the basal forebrain MagnoCellular system are now available as an open source reference for correlation with fMRI, PET, and structural MRI data of the living human brain.
Karl Zilles - One of the best experts on this subject based on the ideXlab platform.
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stereotaxic probabilistic maps of the MagnoCellular Cell groups in human basal forebrain
NeuroImage, 2008Co-Authors: Laszlo Zaborszky, Lars Hoemke, Hartmut Mohlberg, Axel Schleicher, Katrin Amunts, Karl ZillesAbstract:Abstract The basal forebrain contains several interdigitating anatomical structures, including the diagonal band of Broca, the basal nucleus of Meynert, the ventral striatum, and also Cell groups underneath the globus pallidus that bridge the centromedial amygdala to the bed nucleus of the stria terminalis. Among the Cell populations, the MagnoCellular, cholinergic corticopetal projection neurons have received particular attention due to their loss in Alzheimer's disease. In MRI images, the precise delineation of these structures is difficult due to limited spatial resolution and contrast. Here, using microscopic delineations in ten human postmortem brains, we present stereotaxic probabilistic maps of the basal forebrain areas containing the MagnoCellular Cell groups. Cytoarchitectonic mapping was performed in silver stained histological serial sections. The positions and the extent of the MagnoCellular Cell groups within the septum (Ch1–2), the horizontal limb of the diagonal band (Ch3), and in the sublenticular part of the basal forebrain (Ch4) were traced in high-resolution digitized histological sections, 3D reconstructed, and warped to the reference space of the MNI single subject brain. The superposition of the cytoarchitectonic maps in the MNI brain shows the intersubject variability of the various Ch compartments and their stereotaxic position relative to other brain structures. Both the right and left Ch4 regions showed significantly smaller volumes when age was considered as a covariate. Probabilistic maps of compartments of the basal forebrain MagnoCellular system are now available as an open source reference for correlation with fMRI, PET, and structural MRI data of the living human brain.
Katrin Amunts - One of the best experts on this subject based on the ideXlab platform.
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stereotaxic probabilistic maps of the MagnoCellular Cell groups in human basal forebrain
NeuroImage, 2008Co-Authors: Laszlo Zaborszky, Lars Hoemke, Hartmut Mohlberg, Axel Schleicher, Katrin Amunts, Karl ZillesAbstract:Abstract The basal forebrain contains several interdigitating anatomical structures, including the diagonal band of Broca, the basal nucleus of Meynert, the ventral striatum, and also Cell groups underneath the globus pallidus that bridge the centromedial amygdala to the bed nucleus of the stria terminalis. Among the Cell populations, the MagnoCellular, cholinergic corticopetal projection neurons have received particular attention due to their loss in Alzheimer's disease. In MRI images, the precise delineation of these structures is difficult due to limited spatial resolution and contrast. Here, using microscopic delineations in ten human postmortem brains, we present stereotaxic probabilistic maps of the basal forebrain areas containing the MagnoCellular Cell groups. Cytoarchitectonic mapping was performed in silver stained histological serial sections. The positions and the extent of the MagnoCellular Cell groups within the septum (Ch1–2), the horizontal limb of the diagonal band (Ch3), and in the sublenticular part of the basal forebrain (Ch4) were traced in high-resolution digitized histological sections, 3D reconstructed, and warped to the reference space of the MNI single subject brain. The superposition of the cytoarchitectonic maps in the MNI brain shows the intersubject variability of the various Ch compartments and their stereotaxic position relative to other brain structures. Both the right and left Ch4 regions showed significantly smaller volumes when age was considered as a covariate. Probabilistic maps of compartments of the basal forebrain MagnoCellular system are now available as an open source reference for correlation with fMRI, PET, and structural MRI data of the living human brain.