The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
Kelly S. Burns - One of the best experts on this subject based on the ideXlab platform.
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white pine blister rust resistance in limber pine evidence for a Major Gene
Phytopathology, 2014Co-Authors: Anna W. Schoettle, Angelia Kegley, Richard A. Sniezko, Kelly S. BurnsAbstract:Schoettle, A. W., Sniezko, R. A., Kegley, A., and Burns, K. S. 2014. White pine blister rust resistance in limber pine: Evidence for a Major Gene. Phytopathology 104:163-173. Limber pine (Pinus flexilis) is being threatened by the lethal disease white pine blister rust caused by the non-native pathogen Cronartium ribicola. The types and frequencies of Genetic resistance to the rust will likely determine the potential success of restoration or proactive measures. These first extensive inoculation trials using individual tree seed collections from >100 limber pine trees confirm that Genetic segregation of a stem symptom-free trait to blister rust is consistent with inheritance by a single dominant resistance (R) Gene, and the resistance allele appears to be distinct from the R allele in western white pine. Following previous conventions, we are naming the R Gene for limber pine “Cr4.” The frequency of the Cr4 allele across healthy and recently invaded populations in the Southern Rocky Mountains was unexpectedly high (5.0%, ranging from 0 to 13.9%). Cr4 is in equilibrium, suggesting that it is not a product of a recent mutation and may have other adaptive significance within the species, possibly related to other abiotic or biotic stress factors. The identification of Cr4 in native populations of limber pine early in the invasion progress in this region provides useful information for predicting near-term impacts and structuring long-term management strategies.
Gayle E Dupper - One of the best experts on this subject based on the ideXlab platform.
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evidence of cytoplasmic inheritance of virulence in cronartium ribicola to Major Gene resistance in sugar pine
Phytopathology, 1999Co-Authors: Bohun B. Kinloch, Gayle E DupperAbstract:ABSTRACT Tests for Mendelian segregation of virulence and avirulence in Cronartium ribicola, causal agent of white pine blister rust, to a Major Gene (R) for resistance in sugar pine were made using haploid basidiospore progenies from single diploid telia as inoculum on resistant genotypes. The telia were sampled from a small deme in the Siskyou Mountains of northern California, where a few mature sugar pines known to be Rr genotypes had become infected after withstanding the chronic blister rust epidemic for several decades and where intermediate frequencies of virulence in the ambient basidiospore population were subsequently measured. Infection type on inoculated seedlings with R was qualitative: all progenies of 81 single telia tested over 3 different years were either virulent (compatible) or avirulent (inducing hypersensitive necrosis), never a mixture of both reactions. The complete absence of heterozygotes in the telia population is strong evidence that virulence is not controlled by a nuclear gen...
Anna W. Schoettle - One of the best experts on this subject based on the ideXlab platform.
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white pine blister rust resistance in limber pine evidence for a Major Gene
Phytopathology, 2014Co-Authors: Anna W. Schoettle, Angelia Kegley, Richard A. Sniezko, Kelly S. BurnsAbstract:Schoettle, A. W., Sniezko, R. A., Kegley, A., and Burns, K. S. 2014. White pine blister rust resistance in limber pine: Evidence for a Major Gene. Phytopathology 104:163-173. Limber pine (Pinus flexilis) is being threatened by the lethal disease white pine blister rust caused by the non-native pathogen Cronartium ribicola. The types and frequencies of Genetic resistance to the rust will likely determine the potential success of restoration or proactive measures. These first extensive inoculation trials using individual tree seed collections from >100 limber pine trees confirm that Genetic segregation of a stem symptom-free trait to blister rust is consistent with inheritance by a single dominant resistance (R) Gene, and the resistance allele appears to be distinct from the R allele in western white pine. Following previous conventions, we are naming the R Gene for limber pine “Cr4.” The frequency of the Cr4 allele across healthy and recently invaded populations in the Southern Rocky Mountains was unexpectedly high (5.0%, ranging from 0 to 13.9%). Cr4 is in equilibrium, suggesting that it is not a product of a recent mutation and may have other adaptive significance within the species, possibly related to other abiotic or biotic stress factors. The identification of Cr4 in native populations of limber pine early in the invasion progress in this region provides useful information for predicting near-term impacts and structuring long-term management strategies.
Guillermo Antiñolo - One of the best experts on this subject based on the ideXlab platform.
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EYS is a Major Gene for rod-cone dystrophies in France
Human Mutation, 2010Co-Authors: Isabelle Audo, José-alain Sahel, Saddek Mohand-saïd, Marie-elise Lancelot, Aline Antonio, Veselina Moskova-doumanova, Emeline Nandrot, Jordan Atanassov Doumanov, Isabel Barragan, Guillermo AntiñoloAbstract:Autosomal-recessive retinitis pigmentosa (arRP) was recently associated with mutations in a novel Gene EYS, spanning over 2 Mb, making it the largest known Gene expressed in the human eye. The purpose of this study was to establish the prevalence and nature of EYS mutations in a clinically well-characterized cohort of 239 sporadic and arRP French cases. Direct sequencing of EYS was performed in 186 subjects for whom known mutations had previously been excluded by applying microarray technology. We mostly identified novel mutations in EYS in a total of 29 patients: Fifteen of the mutations were predicted to create premature stop codons and two represent exonic deletions. In addition, twenty missense, silent or splice-site mutations were detected. Patients revealed homozygous or compound heterozygous mutations and in some cases, only a single mutation. Most patients showed classical signs of RP with relatively preserved central vision and visual field until late in the course of the disorder. One patient showed predominance of the disease in the inferior part of the retina suggesting potential phenotypic variability. With a prevalence of 12% or more we provide evidence that EYS is a Major Gene for RP in France and probably elsewhere.elsewhere.
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EYS is a Major Gene for rod-cone dystrophies in France.
Human mutation, 2010Co-Authors: Isabelle Audo, José-alain Sahel, Saddek Mohand-saïd, Marie-elise Lancelot, Aline Antonio, Veselina Moskova-doumanova, Emeline Nandrot, Jordan Atanassov Doumanov, Isabel Barragan, Guillermo AntiñoloAbstract:Autosomal-recessive retinitis pigmentosa (arRP) was recently associated with mutations in a novel Gene EYS, spanning over 2 Mb, making it the largest known Gene expressed in the human eye. The purpose of this study was to establish the prevalence and nature of EYS mutations in a clinically well-characterized cohort of 239 sporadic and arRP French cases. Direct sequencing of EYS was performed in 186 subjects for whom known mutations had previously been excluded by applying microarray technology. We mostly identified novel mutations in EYS in a total of 29 patients: Fifteen of the mutations were predicted to create premature stop codons and two represent exonic deletions. In addition, twenty missense, silent or splice-site mutations were detected. Patients revealed homozygous or compound heterozygous mutations and in some cases, only a single mutation. Most patients showed classical signs of RP with relatively preserved central vision and visual field until late in the course of the disorder. One patient showed predominance of the disease in the inferior part of the retina suggesting potential phenotypic variability. With a prevalence of 12% or more we provide evidence that EYS is a Major Gene for RP in France and probably elsewhere. (C) 2010 Wiley-Liss, Inc.
Richard A. Sniezko - One of the best experts on this subject based on the ideXlab platform.
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white pine blister rust resistance in limber pine evidence for a Major Gene
Phytopathology, 2014Co-Authors: Anna W. Schoettle, Angelia Kegley, Richard A. Sniezko, Kelly S. BurnsAbstract:Schoettle, A. W., Sniezko, R. A., Kegley, A., and Burns, K. S. 2014. White pine blister rust resistance in limber pine: Evidence for a Major Gene. Phytopathology 104:163-173. Limber pine (Pinus flexilis) is being threatened by the lethal disease white pine blister rust caused by the non-native pathogen Cronartium ribicola. The types and frequencies of Genetic resistance to the rust will likely determine the potential success of restoration or proactive measures. These first extensive inoculation trials using individual tree seed collections from >100 limber pine trees confirm that Genetic segregation of a stem symptom-free trait to blister rust is consistent with inheritance by a single dominant resistance (R) Gene, and the resistance allele appears to be distinct from the R allele in western white pine. Following previous conventions, we are naming the R Gene for limber pine “Cr4.” The frequency of the Cr4 allele across healthy and recently invaded populations in the Southern Rocky Mountains was unexpectedly high (5.0%, ranging from 0 to 13.9%). Cr4 is in equilibrium, suggesting that it is not a product of a recent mutation and may have other adaptive significance within the species, possibly related to other abiotic or biotic stress factors. The identification of Cr4 in native populations of limber pine early in the invasion progress in this region provides useful information for predicting near-term impacts and structuring long-term management strategies.
