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P.j. Guillou - One of the best experts on this subject based on the ideXlab platform.
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bladder and Sexual Function following resection for rectal cancer in a randomized clinical trial of laparoscopic versus open technique
British Journal of Surgery, 2005Co-Authors: David G. Jayne, Julia Brown, Hannah Thorpe, J. Walker, P Quirke, P.j. GuillouAbstract:BACKGROUND: Bladder and Sexual dysFunction are recognized complications of mesorectal resection. Their incidence following laparoscopic surgery is unknown. METHODS: Bladder and Sexual Function were assessed in patients who had undergone laparoscopic rectal, open rectal or laparoscopic colonic resection as part of the UK Medical Research Council Conventional versus Laparoscopic-Assisted Surgery In Colorectal Cancer (CLASICC) trial, using the International Prostatic Symptom Score, the International Index of Erectile Function and the FeMale Sexual Function Index. Sexual and bladder Function data from the European Organization for Research and Treatment of Cancer QLQ-CR38 collected in the CLASICC trial were used for comparison. RESULTS: Two hundred and forty-seven (71.2 per cent) of 347 patients completed questionnaires. Bladder Function was similar after laparoscopic and open rectal operations for rectal cancer. Overall Sexual Function and erectile Function tended to be worse in men after laparoscopic rectal surgery than after open rectal surgery (overall Function: difference - 11.18 (95 per cent confidence interval (c.i.) -22.99 to 0.63), P = 0.063; erectile Function: difference -5.84 (95 per cent c.i. -10.94 to -0.74), P = 0.068). Total mesorectal excision (TME) was more commonly performed in the laparoscopic rectal group than in the open rectal group. TME (odds ratio (OR) 6.38, P = 0.054) and conversion to open operation (OR 2.86, P = 0.041) were independent predictors of postoperative Male Sexual dysFunction. No differences were detected in feMale Sexual Function. CONCLUSION: Laparoscopic rectal resection did not adversely affect bladder Function, but there was a trend towards worse Male Sexual Function. This may be explained by the higher rate of TME in the laparoscopic rectal resection group.
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bladder and Sexual Function following resection for rectal cancer in a randomized clinical trial of laparoscopic versus open technique
British Journal of Surgery, 2005Co-Authors: David G. Jayne, Julia Brown, Hannah Thorpe, J. Walker, P Quirke, P.j. GuillouAbstract:BACKGROUND: Bladder and Sexual dysFunction are recognized complications of mesorectal resection. Their incidence following laparoscopic surgery is unknown. METHODS: Bladder and Sexual Function were assessed in patients who had undergone laparoscopic rectal, open rectal or laparoscopic colonic resection as part of the UK Medical Research Council Conventional versus Laparoscopic-Assisted Surgery In Colorectal Cancer (CLASICC) trial, using the International Prostatic Symptom Score, the International Index of Erectile Function and the FeMale Sexual Function Index. Sexual and bladder Function data from the European Organization for Research and Treatment of Cancer QLQ-CR38 collected in the CLASICC trial were used for comparison. RESULTS: Two hundred and forty-seven (71.2 per cent) of 347 patients completed questionnaires. Bladder Function was similar after laparoscopic and open rectal operations for rectal cancer. Overall Sexual Function and erectile Function tended to be worse in men after laparoscopic rectal surgery than after open rectal surgery (overall Function: difference - 11.18 (95 per cent confidence interval (c.i.) -22.99 to 0.63), P = 0.063; erectile Function: difference -5.84 (95 per cent c.i. -10.94 to -0.74), P = 0.068). Total mesorectal excision (TME) was more commonly performed in the laparoscopic rectal group than in the open rectal group. TME (odds ratio (OR) 6.38, P = 0.054) and conversion to open operation (OR 2.86, P = 0.041) were independent predictors of postoperative Male Sexual dysFunction. No differences were detected in feMale Sexual Function. CONCLUSION: Laparoscopic rectal resection did not adversely affect bladder Function, but there was a trend towards worse Male Sexual Function. This may be explained by the higher rate of TME in the laparoscopic rectal resection group.
David G. Jayne - One of the best experts on this subject based on the ideXlab platform.
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bladder and Sexual Function following resection for rectal cancer in a randomized clinical trial of laparoscopic versus open technique
British Journal of Surgery, 2005Co-Authors: David G. Jayne, Julia Brown, Hannah Thorpe, J. Walker, P Quirke, P.j. GuillouAbstract:BACKGROUND: Bladder and Sexual dysFunction are recognized complications of mesorectal resection. Their incidence following laparoscopic surgery is unknown. METHODS: Bladder and Sexual Function were assessed in patients who had undergone laparoscopic rectal, open rectal or laparoscopic colonic resection as part of the UK Medical Research Council Conventional versus Laparoscopic-Assisted Surgery In Colorectal Cancer (CLASICC) trial, using the International Prostatic Symptom Score, the International Index of Erectile Function and the FeMale Sexual Function Index. Sexual and bladder Function data from the European Organization for Research and Treatment of Cancer QLQ-CR38 collected in the CLASICC trial were used for comparison. RESULTS: Two hundred and forty-seven (71.2 per cent) of 347 patients completed questionnaires. Bladder Function was similar after laparoscopic and open rectal operations for rectal cancer. Overall Sexual Function and erectile Function tended to be worse in men after laparoscopic rectal surgery than after open rectal surgery (overall Function: difference - 11.18 (95 per cent confidence interval (c.i.) -22.99 to 0.63), P = 0.063; erectile Function: difference -5.84 (95 per cent c.i. -10.94 to -0.74), P = 0.068). Total mesorectal excision (TME) was more commonly performed in the laparoscopic rectal group than in the open rectal group. TME (odds ratio (OR) 6.38, P = 0.054) and conversion to open operation (OR 2.86, P = 0.041) were independent predictors of postoperative Male Sexual dysFunction. No differences were detected in feMale Sexual Function. CONCLUSION: Laparoscopic rectal resection did not adversely affect bladder Function, but there was a trend towards worse Male Sexual Function. This may be explained by the higher rate of TME in the laparoscopic rectal resection group.
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bladder and Sexual Function following resection for rectal cancer in a randomized clinical trial of laparoscopic versus open technique
British Journal of Surgery, 2005Co-Authors: David G. Jayne, Julia Brown, Hannah Thorpe, J. Walker, P Quirke, P.j. GuillouAbstract:BACKGROUND: Bladder and Sexual dysFunction are recognized complications of mesorectal resection. Their incidence following laparoscopic surgery is unknown. METHODS: Bladder and Sexual Function were assessed in patients who had undergone laparoscopic rectal, open rectal or laparoscopic colonic resection as part of the UK Medical Research Council Conventional versus Laparoscopic-Assisted Surgery In Colorectal Cancer (CLASICC) trial, using the International Prostatic Symptom Score, the International Index of Erectile Function and the FeMale Sexual Function Index. Sexual and bladder Function data from the European Organization for Research and Treatment of Cancer QLQ-CR38 collected in the CLASICC trial were used for comparison. RESULTS: Two hundred and forty-seven (71.2 per cent) of 347 patients completed questionnaires. Bladder Function was similar after laparoscopic and open rectal operations for rectal cancer. Overall Sexual Function and erectile Function tended to be worse in men after laparoscopic rectal surgery than after open rectal surgery (overall Function: difference - 11.18 (95 per cent confidence interval (c.i.) -22.99 to 0.63), P = 0.063; erectile Function: difference -5.84 (95 per cent c.i. -10.94 to -0.74), P = 0.068). Total mesorectal excision (TME) was more commonly performed in the laparoscopic rectal group than in the open rectal group. TME (odds ratio (OR) 6.38, P = 0.054) and conversion to open operation (OR 2.86, P = 0.041) were independent predictors of postoperative Male Sexual dysFunction. No differences were detected in feMale Sexual Function. CONCLUSION: Laparoscopic rectal resection did not adversely affect bladder Function, but there was a trend towards worse Male Sexual Function. This may be explained by the higher rate of TME in the laparoscopic rectal resection group.
Giovanni Corona - One of the best experts on this subject based on the ideXlab platform.
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vitamin d and Male Sexual Function a transversal and longitudinal study
International Journal of Endocrinology, 2018Co-Authors: Giacomo Tirabassi, Giovanni Corona, Maurizio Sudano, Gianmaria Salvio, Melissa Cutini, Giovanna Muscogiuri, Giancarlo BalerciaAbstract:Background. The effects of vitamin D on Sexual Function are very unclear. Therefore, we aimed at evaluating the possible association between vitamin D and Sexual Function and at assessing the influence of vitamin D administration on Sexual Function. Methods. We retrospectively studied 114 men by evaluating clinical, biochemical, and Sexual parameters. A subsample ( ) was also studied longitudinally before and after vitamin D replacement therapy. Results. In the whole sample, after performing logistic regression models, higher levels of 25(OH) vitamin D were significantly associated with high values of total testosterone and of all the International Index of Erectile Function (IIEF) questionnaire parameters. On the other hand, higher levels of total testosterone were positively and significantly associated with high levels of erectile Function and IIEF total score. After vitamin D replacement therapy, total and free testosterone increased and erectile Function improved, whereas other Sexual parameters did not change significantly. At logistic regression analysis, higher levels of vitamin D increase (Δ-) were significantly associated with high values of Δ-erectile Function after adjustment for Δ-testosterone. Conclusions. Vitamin D is important for the wellness of Male Sexual Function, and vitamin D administration improves Sexual Function.
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meta analysis of results of testosterone therapy on Sexual Function based on international index of erectile Function scores
European Urology, 2017Co-Authors: Giovanni Corona, Giulia Rastrelli, Abraham Morgentaler, Alessandra Sforza, Edoardo Mannucci, Mario MaggiAbstract:Abstract Context The interpretation of available clinical evidence related to the effect of testosterone (T) treatment (TTh) on Sexual Function has been inconsistent, in part due to the use of different and self-reported measures to assess outcomes. The International Index of Erectile Function (IIEF) is the most frequently used validated tool to assess Male Sexual Function. Objective To perform a meta-analysis of available data evaluating the effect of TTh on Male Sexual Function using IIEF as the primary outcome. Evidence acquisition An extensive Medline, Embase, and Cochrane search was performed including all placebo-controlled randomized clinical trials enrolling men comparing the effect of TTh on Sexual Function. Evidence synthesis Out of 137 retrieved articles, 14 were included in the study enrolling 2298 participants, with a mean follow-up of 40.1 wk and mean age of 60.2±6.5 yr. Using IIEF-erectile Function domain (IIEF-EFD) as the outcome, we found that TTh significantly improved erectile Function compared with placebo (mean difference=2.31 [1.41;3.22] IIEF-EFD score, p p =0.02). The magnitude of the effect was lower in the presence of metabolic derangements, such as diabetes and obesity. Other aspects of Sexual Function, as evaluated by IIEF subdomains, were also improved with TTh including libido, intercourse satisfaction, orgasm, and overall Sexual satisfaction. Conclusions TTh significantly improves erectile Function and other Sexual parameters as measured by IIEF in hypogonadal men. These results argue that Sexual dysFunction should be considered a hallmark manifestation of T deficiency, since those symptoms can be significantly improved with normalization of serum T. In addition, these results suggest that TTh alone may be considered a reasonable treatment for hypogonadal men with milder degrees of erectile dysFunction, whereas the addition of other treatments, such as phosphodiesterase type 5 inhibitors, may be more appropriate for men with more severe erectile dysFunction. Patient summary We investigated the effect of testosterone treatment on Sexual Function by performing a meta-analysis of all available studies that used the most frequently used assessment tool, the International Index of Erectile Function. We found that testosterone treatment significantly improves erectile dysFunction, as well as other aspects of Sexual Function, in men with testosterone deficiency. This treatment may be all that is required for hypogonadal men with milder erectile dysFunction; however, additional treatments may be necessary in more severe cases.
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testosterone supplementation and Sexual Function a meta analysis study
The Journal of Sexual Medicine, 2014Co-Authors: Giovanni Corona, Giulia Rastrelli, Alessandra Sforza, Andrea M Isidori, Jaques Buvat, Antonio Aversa, Geoff Hackett, Vincenzo Rochira, Andrea Lenzi, Edoardo MannucciAbstract:Introduction. The role of testosterone supplementation (TS) as a treatment for Male Sexual dysFunction remains questionable. Aim. The aim of this study was to attempt a meta-analysis on the effect of TS on Male Sexual Function and its synergism with the use of phosphodiesterase type 5 inhibitor (PDE5i). Methods. An extensive Medline, Embase, and Cochrane search was performed. Main Outcome Measures. All randomized controlled trials (RCTs) comparing the effect of TS vs. placebo or the effect of TS as add on to PDE5is on Sexual Function were included. Data extraction was performed inde- pendently by two of the authors (A. M. Isidori and G. Corona), and conflicts resolved by the third investigator (M. Maggi). Results. Out of 1,702 retrieved articles, 41 were included in the study. In particular, 29 compared TS vs. placebo, whereas 12 trials evaluated the effect of TS as add on to PDE5is. TS is able to significantly ameliorate erectile Function and to improve other aspects of Male Sexual response in hypogonadal patients. However, the presence of possible publication bias was detected. After applying "trim and fill" method, the positive effect of TS on erectile Function and libido components retained significance only in RCTs partially or completely supported by pharma- ceutical companies (confidence interval (0.04-0.53) and (0.12; 0.52), respectively). In addition, we also report that TS could be associated with an improvement in PDE5i outcome. These results were not confirmed in placebo- controlled studies. The majority of studies, however, included mixed eugonadal/hypogonadal subjects, thus impart- ing uncertainty to the statistical analyses. Conclusions. TS plays positive effects on Male Sexual Function in hypogonadal subjects. The role of TS is uncertain in men who are not clearly hypogonadal. The apparent difference between industry-supported and independent studies could depend on trial design more than on publication bias. New RCTs exploring the effect of TS in selected cases of PDE5i failure that persistently retain low testosterone levels are advisable. Corona G, Isidori AM, Buvat
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androgen receptor gene cag repeat polymorphism independently influences recovery of Male Sexual Function after testosterone replacement therapy in postsurgical hypogonadotropic hypogonadism
The Journal of Sexual Medicine, 2014Co-Authors: Giacomo Tirabassi, Giovanni Corona, Mario Maggi, Nicola Delli Muti, Giancarlo BalerciaAbstract:Abstract Introduction Few and contradictory studies have evaluated the possible influence of androgen receptor ( AR ) gene CAG repeat polymorphism on Male Sexual Function. Aim In this study we evaluated the role of AR gene CAG repeat polymorphism in the recovery of Sexual Function after testosterone replacement therapy (TRT) in men affected by postsurgical hypogonadotropic hypogonadism, a condition which is often associated with hypopituitarism and in which the Sexual benefits of TRT must be distinguished from those of pituitary-Function replacement therapies. Methods Fifteen men affected by postsurgical hypogonadotropic hypogonadism were retrospectively assessed before and after TRT. Main Outcome Measures Main outcome measures included Sexual parameters as assessed by the International Index of Erectile Function questionnaire, levels of pituitary dependent hormones (total testosterone, free T3, free T4, cortisol, insulin-like growth factor-1 [IGF-1], prolactin), and results of genetic analysis ( AR gene CAG repeat number). Results Plasma concentrations of free T3, free T4, cortisol, and prolactin did not vary significantly between the two phases, while testosterone and IGF-1 increased significantly after TRT. A significant improvement in all Sexual parameters studied was found. The number of CAG triplets was negatively and significantly correlated with changes in all the Sexual parameters, while opposite correlations were found between changes in Sexual parameters and changes in testosterone levels; no correlation of change in IGF1 with change in Sexual parameters was reported. On multiple linear regression analysis, after correction for changes in testosterone, nearly all the associations between the number of CAG triplets and changes in Sexual parameters were confirmed. Conclusions Shorter length AR gene CAG repeat number is associated with the recovery of Sexual Function after TRT in postsurgical Male hypogonadotropic hypogonadism, independently of the effects of concomitant pituitary-replacement therapies. Tirabassi G, delli Muti N, Corona G, Maggi M, and Balercia G. Androgen receptor gene CAG repeat polymorphism independently influences recovery of Male Sexual Function after testosterone replacement therapy in postsurgical hypogonadotropic hypogonadism. J Sex Med 2014;11:1302–1308.
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Testosterone Supplementation and Sexual Function: A Meta-Analysis Study
'Wiley', 2014Co-Authors: Giovanni Corona, Giulia Rastrelli, Alessandra Sforza, Jaques Buvat, Antonio Aversa, Geoff Hackett, Vincenzo Rochira, Andrea Lenzi, Andrea Isidori, Edoardo MannucciAbstract:Introduction The role of testosterone supplementation (TS) as a treatment for Male Sexual dysFunction remains questionable. Aim The aim of this study was to attempt a meta-analysis on the effect of TS on Male Sexual Function and its synergism with the use of phosphodiesterase type 5 inhibitor (PDE5i). Methods An extensive Medline, Embase, and Cochrane search was performed. Main Outcome Measures All randomized controlled trials (RCTs) comparing the effect of TS vs. placebo or the effect of TS as add on to PDE5is on Sexual Function were included. Data extraction was performed independently by two of the authors (A. M. Isidori and G. Corona), and conflicts resolved by the third investigator (M. Maggi). Results Out of 1,702 retrieved articles, 41 were included in the study. In particular, 29 compared TS vs. placebo, whereas 12 trials evaluated the effect of TS as add on to PDE5is. TS is able to significantly ameliorate erectile Function and to improve other aspects of Male Sexual response in hypogonadal patients. However, the presence of possible publication bias was detected. After applying trim and fill method, the positive effect of TS on erectile Function and libido components retained significance only in RCTs partially or completely supported by pharmaceutical companies (confidence interval [0.04-0.53] and [0.12; 0.52], respectively). In addition, we also report that TS could be associated with an improvement in PDE5i outcome. These results were not confirmed in placebo-controlled studies. The majority of studies, however, included mixed eugonadal/hypogonadal subjects, thus imparting uncertainty to the statistical analyses. Conclusions TS plays positive effects on Male Sexual Function in hypogonadal subjects. The role of TS is uncertain in men who are not clearly hypogonadal. The apparent difference between industry-supported and independent studies could depend on trial design more than on publication bias. New RCTs exploring the effect of TS in selected cases of PDE5i failure that persistently retain low testosterone levels are advisable. Corona G, Isidori AM, Buvat J, Aversa A, Rastrelli G, Hackett G, Rochira V, Sforza A, Lenzi A, Mannucci E., and Maggi M. Testosterone supplementation and Sexual Function: A meta-analysis study. J Sex Med 2014;11:1577-1592
J. Walker - One of the best experts on this subject based on the ideXlab platform.
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bladder and Sexual Function following resection for rectal cancer in a randomized clinical trial of laparoscopic versus open technique
British Journal of Surgery, 2005Co-Authors: David G. Jayne, Julia Brown, Hannah Thorpe, J. Walker, P Quirke, P.j. GuillouAbstract:BACKGROUND: Bladder and Sexual dysFunction are recognized complications of mesorectal resection. Their incidence following laparoscopic surgery is unknown. METHODS: Bladder and Sexual Function were assessed in patients who had undergone laparoscopic rectal, open rectal or laparoscopic colonic resection as part of the UK Medical Research Council Conventional versus Laparoscopic-Assisted Surgery In Colorectal Cancer (CLASICC) trial, using the International Prostatic Symptom Score, the International Index of Erectile Function and the FeMale Sexual Function Index. Sexual and bladder Function data from the European Organization for Research and Treatment of Cancer QLQ-CR38 collected in the CLASICC trial were used for comparison. RESULTS: Two hundred and forty-seven (71.2 per cent) of 347 patients completed questionnaires. Bladder Function was similar after laparoscopic and open rectal operations for rectal cancer. Overall Sexual Function and erectile Function tended to be worse in men after laparoscopic rectal surgery than after open rectal surgery (overall Function: difference - 11.18 (95 per cent confidence interval (c.i.) -22.99 to 0.63), P = 0.063; erectile Function: difference -5.84 (95 per cent c.i. -10.94 to -0.74), P = 0.068). Total mesorectal excision (TME) was more commonly performed in the laparoscopic rectal group than in the open rectal group. TME (odds ratio (OR) 6.38, P = 0.054) and conversion to open operation (OR 2.86, P = 0.041) were independent predictors of postoperative Male Sexual dysFunction. No differences were detected in feMale Sexual Function. CONCLUSION: Laparoscopic rectal resection did not adversely affect bladder Function, but there was a trend towards worse Male Sexual Function. This may be explained by the higher rate of TME in the laparoscopic rectal resection group.
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bladder and Sexual Function following resection for rectal cancer in a randomized clinical trial of laparoscopic versus open technique
British Journal of Surgery, 2005Co-Authors: David G. Jayne, Julia Brown, Hannah Thorpe, J. Walker, P Quirke, P.j. GuillouAbstract:BACKGROUND: Bladder and Sexual dysFunction are recognized complications of mesorectal resection. Their incidence following laparoscopic surgery is unknown. METHODS: Bladder and Sexual Function were assessed in patients who had undergone laparoscopic rectal, open rectal or laparoscopic colonic resection as part of the UK Medical Research Council Conventional versus Laparoscopic-Assisted Surgery In Colorectal Cancer (CLASICC) trial, using the International Prostatic Symptom Score, the International Index of Erectile Function and the FeMale Sexual Function Index. Sexual and bladder Function data from the European Organization for Research and Treatment of Cancer QLQ-CR38 collected in the CLASICC trial were used for comparison. RESULTS: Two hundred and forty-seven (71.2 per cent) of 347 patients completed questionnaires. Bladder Function was similar after laparoscopic and open rectal operations for rectal cancer. Overall Sexual Function and erectile Function tended to be worse in men after laparoscopic rectal surgery than after open rectal surgery (overall Function: difference - 11.18 (95 per cent confidence interval (c.i.) -22.99 to 0.63), P = 0.063; erectile Function: difference -5.84 (95 per cent c.i. -10.94 to -0.74), P = 0.068). Total mesorectal excision (TME) was more commonly performed in the laparoscopic rectal group than in the open rectal group. TME (odds ratio (OR) 6.38, P = 0.054) and conversion to open operation (OR 2.86, P = 0.041) were independent predictors of postoperative Male Sexual dysFunction. No differences were detected in feMale Sexual Function. CONCLUSION: Laparoscopic rectal resection did not adversely affect bladder Function, but there was a trend towards worse Male Sexual Function. This may be explained by the higher rate of TME in the laparoscopic rectal resection group.
Julia Brown - One of the best experts on this subject based on the ideXlab platform.
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bladder and Sexual Function following resection for rectal cancer in a randomized clinical trial of laparoscopic versus open technique
British Journal of Surgery, 2005Co-Authors: David G. Jayne, Julia Brown, Hannah Thorpe, J. Walker, P Quirke, P.j. GuillouAbstract:BACKGROUND: Bladder and Sexual dysFunction are recognized complications of mesorectal resection. Their incidence following laparoscopic surgery is unknown. METHODS: Bladder and Sexual Function were assessed in patients who had undergone laparoscopic rectal, open rectal or laparoscopic colonic resection as part of the UK Medical Research Council Conventional versus Laparoscopic-Assisted Surgery In Colorectal Cancer (CLASICC) trial, using the International Prostatic Symptom Score, the International Index of Erectile Function and the FeMale Sexual Function Index. Sexual and bladder Function data from the European Organization for Research and Treatment of Cancer QLQ-CR38 collected in the CLASICC trial were used for comparison. RESULTS: Two hundred and forty-seven (71.2 per cent) of 347 patients completed questionnaires. Bladder Function was similar after laparoscopic and open rectal operations for rectal cancer. Overall Sexual Function and erectile Function tended to be worse in men after laparoscopic rectal surgery than after open rectal surgery (overall Function: difference - 11.18 (95 per cent confidence interval (c.i.) -22.99 to 0.63), P = 0.063; erectile Function: difference -5.84 (95 per cent c.i. -10.94 to -0.74), P = 0.068). Total mesorectal excision (TME) was more commonly performed in the laparoscopic rectal group than in the open rectal group. TME (odds ratio (OR) 6.38, P = 0.054) and conversion to open operation (OR 2.86, P = 0.041) were independent predictors of postoperative Male Sexual dysFunction. No differences were detected in feMale Sexual Function. CONCLUSION: Laparoscopic rectal resection did not adversely affect bladder Function, but there was a trend towards worse Male Sexual Function. This may be explained by the higher rate of TME in the laparoscopic rectal resection group.
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bladder and Sexual Function following resection for rectal cancer in a randomized clinical trial of laparoscopic versus open technique
British Journal of Surgery, 2005Co-Authors: David G. Jayne, Julia Brown, Hannah Thorpe, J. Walker, P Quirke, P.j. GuillouAbstract:BACKGROUND: Bladder and Sexual dysFunction are recognized complications of mesorectal resection. Their incidence following laparoscopic surgery is unknown. METHODS: Bladder and Sexual Function were assessed in patients who had undergone laparoscopic rectal, open rectal or laparoscopic colonic resection as part of the UK Medical Research Council Conventional versus Laparoscopic-Assisted Surgery In Colorectal Cancer (CLASICC) trial, using the International Prostatic Symptom Score, the International Index of Erectile Function and the FeMale Sexual Function Index. Sexual and bladder Function data from the European Organization for Research and Treatment of Cancer QLQ-CR38 collected in the CLASICC trial were used for comparison. RESULTS: Two hundred and forty-seven (71.2 per cent) of 347 patients completed questionnaires. Bladder Function was similar after laparoscopic and open rectal operations for rectal cancer. Overall Sexual Function and erectile Function tended to be worse in men after laparoscopic rectal surgery than after open rectal surgery (overall Function: difference - 11.18 (95 per cent confidence interval (c.i.) -22.99 to 0.63), P = 0.063; erectile Function: difference -5.84 (95 per cent c.i. -10.94 to -0.74), P = 0.068). Total mesorectal excision (TME) was more commonly performed in the laparoscopic rectal group than in the open rectal group. TME (odds ratio (OR) 6.38, P = 0.054) and conversion to open operation (OR 2.86, P = 0.041) were independent predictors of postoperative Male Sexual dysFunction. No differences were detected in feMale Sexual Function. CONCLUSION: Laparoscopic rectal resection did not adversely affect bladder Function, but there was a trend towards worse Male Sexual Function. This may be explained by the higher rate of TME in the laparoscopic rectal resection group.