The Experts below are selected from a list of 33 Experts worldwide ranked by ideXlab platform
Liu Bao-rui - One of the best experts on this subject based on the ideXlab platform.
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Appropriate dosage of interleukin-2 for tumor infiltrating lymphocyte cultured in self-supernatant of Malignant Pleura fluid
Journal of Medical Postgraduates, 2007Co-Authors: Liu Bao-ruiAbstract:Objective:To select an appropriate dosage of IL-2 for tumor infiltrating lymphocyte(TIL).Methods:Isolated by the attachment method we established,TIL was cultivated in self-supernatant of Malignant Pleura,with three different concentrations of IL-2,such as 6000u per ml,6000u per ml for the first administration followed by 1000u per ml,or 1000u per ml.The expansion,killing activity and phenotype changes of TIL cultured in different cultures were assessed.Results:As cultured in self-supernatant of Malignant Pleura fluid,the concentrations of IL-2,such as 6000u per ml or 6000u per ml for the first administration followed by 1000u per ml seemed benefit for TIL proliferation.Conclusion:6000u per ml of IL-2 for the first administration was very important.It could help TIL to activate and proliferate early.The study described here offers the possibility for TIL cultured in vitro self-supernatant of Malignant Pleura fluid in vitro for a short time,and then reinfuse to thorax for further expanding and controlling the Malignant Pleura Effusion in the presence of IL-2,and thereby minimizing the risks of contamination.
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The use of autologous supernatant of Malignant Pleura Effusion in culturing human tumor infiltrating lymphocytes in vitro
Journal of Medical Postgraduates, 2005Co-Authors: Liu Bao-ruiAbstract:Objective:To study the effect of autologous supernatant of Malignant Pleura Effusion and RPMI1640 with 10% AB+ serum on the culture of tumor infiltrating lymphocytes (TIL) in vitro. Methods:Isolated by the attachment method we established, TIL was cultured in either autologous supernatant of Malignant Pleura fluid or RPMI1640 with 10% AB+ serum, and various types of cytokines such as (IL-2,) PHA and antibody against CD3 (OKT3) were added into both cultures. The proliferation as well as the killing activity and the phenotype changes of TIL cultured in the two kinds of cultures were compared. Results:There was no difference in the proliferation or the killing activity in vitro as well as the phenotype changes of TIL between the two kinds of cultures. Conclusion: Autologous supernatant of Malignant Pleura fluid could be used as TIL culture medium. The method described here made it possible for TIL to be cultured in vitro for a short time, and then reinfused back to thorax for further expanding and controlling the Malignant Pleura Effusion in the presence of IL-2, and it alsominimized the risks of contamination.
Gary A. Ulaner - One of the best experts on this subject based on the ideXlab platform.
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Patient Repositioning Reveals a Malignant Pleura Effusion Initially Mistaken as a Bone Metastasis on 18FDG PET/CT.
Clinical nuclear medicine, 2019Co-Authors: Julian Kirchner, Christopher C. Riedl, Gary A. UlanerAbstract:A 70-year-old woman with breast cancer underwent F-FDG PET/CT for restaging. An FDG-avid focus corresponding to a rib on CT images was identified and interpreted as suggestive of an osseous metastasis. A PET/CT-guided biopsy was planned with the patient in prone position. Prone images demonstrated the FDG focus "moved" to the anterior chest and corresponding to Pleural fluid. The diagnosis was altered from osseous metastases to Pleural malignancy, and the bone biopsy was not performed. This case not only emphasizes the sensitivity of PET in the detection of malignancy, but also highlights the difficulty localizing small, mobile, FDG-avid foci.
Julian Kirchner - One of the best experts on this subject based on the ideXlab platform.
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Patient Repositioning Reveals a Malignant Pleura Effusion Initially Mistaken as a Bone Metastasis on 18FDG PET/CT.
Clinical nuclear medicine, 2019Co-Authors: Julian Kirchner, Christopher C. Riedl, Gary A. UlanerAbstract:A 70-year-old woman with breast cancer underwent F-FDG PET/CT for restaging. An FDG-avid focus corresponding to a rib on CT images was identified and interpreted as suggestive of an osseous metastasis. A PET/CT-guided biopsy was planned with the patient in prone position. Prone images demonstrated the FDG focus "moved" to the anterior chest and corresponding to Pleural fluid. The diagnosis was altered from osseous metastases to Pleural malignancy, and the bone biopsy was not performed. This case not only emphasizes the sensitivity of PET in the detection of malignancy, but also highlights the difficulty localizing small, mobile, FDG-avid foci.
Xing Li-bao - One of the best experts on this subject based on the ideXlab platform.
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The diagnostic value of detecting of CEA,CYFRA21-1,NSE,in the Malignant Pleural Effusion
Journal of Modern Oncology, 2008Co-Authors: Xing Li-baoAbstract:Objective:To explore the diagnostic value of combined detection of CEA,CYFRA21-1,NSE in theMalignant Pleura Effusion.Methods:The Levels of CEA,CYFRA21-1,NSE in the Pleural Effusion of 176 patientswere assayed by radioimmunity method.Results:CEA,CYFRA21-1,NSE levels were notably elevated in 62 malig-nant Pleura Effusion compared with 70 benign Pleura Effusion (P( 0.01). The levels of CEA,NSE,CYFRA21-1were notably elevated in adenocarcinoma,squamous cell carcinoma and small cell lung cancer respectively.Of thecombination of two index in NSCLC,the accuracy of the combined detection of CEA,CYFRA21-1 were higher thanothers;In SCLC the accuracy of the combined detection of NSE,CYFRA21-1 were higher than others;The sensitivityof the combined detection of CEA,CYFRA21-1,NSE were higher than those of single and double index.Conclu-sion:The combined detection of CEA,CYFRA21 -1,NSE were of clinical importance in the diagnosis of MalignantPleura Effusion diagnosis. In lung cancer with the Malignant Pleura Effusion diagnosis, the level of CEA NSE CY-FRA21-1 were more sensitive in adenocarcinoma,squamous cell carcinoma and small cell lung cancer.
Christopher C. Riedl - One of the best experts on this subject based on the ideXlab platform.
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Patient Repositioning Reveals a Malignant Pleura Effusion Initially Mistaken as a Bone Metastasis on 18FDG PET/CT.
Clinical nuclear medicine, 2019Co-Authors: Julian Kirchner, Christopher C. Riedl, Gary A. UlanerAbstract:A 70-year-old woman with breast cancer underwent F-FDG PET/CT for restaging. An FDG-avid focus corresponding to a rib on CT images was identified and interpreted as suggestive of an osseous metastasis. A PET/CT-guided biopsy was planned with the patient in prone position. Prone images demonstrated the FDG focus "moved" to the anterior chest and corresponding to Pleural fluid. The diagnosis was altered from osseous metastases to Pleural malignancy, and the bone biopsy was not performed. This case not only emphasizes the sensitivity of PET in the detection of malignancy, but also highlights the difficulty localizing small, mobile, FDG-avid foci.