The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Dante Cicchetti - One of the best experts on this subject based on the ideXlab platform.
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identifying Maltreatment subgroups with patterns of Maltreatment subtype and chronicity a latent class analysis approach
Child Abuse & Neglect, 2019Co-Authors: Jennifer M Warmingham, Dante Cicchetti, Fred A Rogosch, Elizabeth D Handley, Jody Todd ManlyAbstract:Abstract Maltreatment experiences are complex, and it is difficult to characterize the heterogeneity in types of Maltreatment. Subtypes, such as emotional Maltreatment, sexual abuse, physical abuse, and neglect commonly co-occur and may persist across development. Therefore, treating individual Maltreatment subtypes as independently occurring is not representative of the nature of Maltreatment as it occurs in children’s lives. Latent class analysis (LCA) is employed herein to identify subgroups of maltreated children based on commonalities in Maltreatment subtype and chronicity. In a sample of 674 low-income urban children, 51.6% of whom experienced officially documented Maltreatment, our analyses identified four classes of children, with three distinct classes based on Maltreatment subtypes and chronicity, and one group of children who did not experience Maltreatment. The largest class of maltreated children identified was the chronic, multi-subtype Maltreatment class (57% of maltreated children); a second class was characterized by only neglect in a single developmental period (31% of maltreated children), and the smallest class was characterized by a single subtype of Maltreatment (emotional Maltreatment, physical, or sexual abuse) occurring in a single developmental period (12% of maltreated children). Characterization of these groups confirms the overlapping nature of Maltreatment subtypes. There were notable differences between latent classes on child behavioral and socio-emotional outcomes measured by child self-report and camp counselors report during a one-week summer camp. The largest differences were between the non-maltreated class and the chronic Maltreatment class. Children who experienced chronic, multi-subtype Maltreatment showed higher levels of externalizing behavior, emotion dysregulation, depression, and anxiety.
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childhood Maltreatment and its effect on neurocognitive functioning timing and chronicity matter
Development and Psychopathology, 2015Co-Authors: Raquel A Cowell, Dante Cicchetti, Fred A Rogosch, Sheree L TothAbstract:Childhood Maltreatment represents a complex stressor, with the developmental timing, duration, frequency, and type of Maltreatment varying with each child (Barnett, Manly, & Cicchetti, 1993; Cicchetti & Manly, 2001). Multiple brain regions and neural circuits are disrupted by the experience of child Maltreatment (Cicchetti & Toth, in press; DeBellis et al., 2002; McCrory & Viding, 2010; Teicher, Anderson, & Polcari, 2012). These neurobiological compromises indicate the impairment of a number of important cognitive functions, including working memory and inhibitory control. The present study extends prior research by examining the effect of childhood Maltreatment on neurocognitive functioning based on developmental timing of Maltreatment, including onset, chronicity, and recency, in a sample of 3- to 9-year-old nonmaltreated (n = 136) and maltreated children (n = 223). Maltreated children performed more poorly on inhibitory control and working-memory tasks than did nonmaltreated children. Group differences between maltreated children based on the timing of Maltreatment and the chronicity of Maltreatment also were evident. Specifically, children who were maltreated during infancy, and children with a chronic history of Maltreatment, exhibited significantly poorer inhibitory control and working-memory performance than did children without a history of Maltreatment. The results suggest that Maltreatment occurring during infancy, a period of major brain organization, disrupts normative structure and function, and these deficits are further instantiated by the prolonged stress of chronic Maltreatment during the early years of life.
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genetic moderation of child Maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region 5 httlpr brain derived neurotrophic factor bdnf norepinephrine transporter net and corticotropin releasing ho
Development and Psychopathology, 2014Co-Authors: Dante Cicchetti, Fred A RogoschAbstract:Genetic moderation of the effects of child Maltreatment on depression and internalizing symptoms was investigated in a sample of low-income maltreated and nonmaltreated African American children (N = 1,096). Lifetime child Maltreatment experiences were independently coded from Child Protective Services records and maternal report. Child depression and internalizing problems were assessed in the context of a summer research camp by self-report on the Children's Depression Inventory and adult counselor report on the Teacher Report Form. DNA was obtained from buccal cell or saliva samples and genotyped for polymorphisms of the following genes: serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter, and corticotropin releasing hormone receptor 1. Analyses of covariance with age and gender as covariates were conducted, with Maltreatment status and respective polymorphism as main effects and their Gene × Environment (G × E) interactions. Maltreatment consistently was associated with higher Children's Depression Inventory and Teacher Report Form symptoms. The results for child self-report symptoms indicated a G × E interaction for BDNF and Maltreatment. In addition, BDNF and triallelic 5-HTTLPR interacted with child Maltreatment in a G × G × E interaction. Analyses for counselor report of child anxiety/depression symptoms on the Teacher Report Form indicated moderation of child Maltreatment effects by triallelic 5-HTTLPR. These effects were elaborated based on variation in developmental timing of Maltreatment experiences. Norepinephrine transporter was found to further moderate the G × E interaction of 5-HTTLPR and Maltreatment status, revealing a G × G × E interaction. This G × G × E was extended by consideration of variation in Maltreatment subtype experiences. Finally, G × G × E effects were observed for the co-action of BDNF and the corticotropin releasing hormone receptor 1 haplotype. The findings illustrate the variable influence of specific genotypes in G × E interactions based on variation in Maltreatment experiences and the importance of a multigenic approach for understanding influences on depression and internalizing symptoms among African American children.
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the effects of child Maltreatment on early signs of antisocial behavior genetic moderation by tryptophan hydroxylase serotonin transporter and monoamine oxidase a genes
Development and Psychopathology, 2012Co-Authors: Dante Cicchetti, Fred A Rogosch, Eric L ThibodeauAbstract:Gene-environment interaction effects in predicting antisocial behavior in late childhood were investigated among maltreated and nonmaltreated low-income children (N = 627, M age = 11.27). Variants in three genes were examined: tryptophan hydroxylase 1 (TPH1), serotonin transporter linked polymorphic region (5-HTTLPR), and monoamine oxidase A (MAOA) upstream variable number tandem repeat. In addition to child Maltreatment status, we considered the impact of Maltreatment subtypes, developmental timing of Maltreatment, and chronicity. Indicators of antisocial behavior were obtained from self-, peer, and adult counselor reports. In a series of analyses of covariance, child Maltreatment and its parameters demonstrated strong main effects on early antisocial behavior as assessed by all report forms. Genetic effects operated primarily in the context of gene-environment interactions, moderating the impact of child Maltreatment on outcomes. Across the three genes, among nonmaltreated children no differences in antisocial behavior were found based on genetic variation. In contrast, among maltreated children specific polymorphisms of TPH1, 5-HTTLPR, and MAOA were each related to heightened self-report of antisocial behavior; the interaction of 5-HTTLPR and developmental timing of Maltreatment also indicated more severe antisocial outcomes for children with early onset and recurrent Maltreatment based on genotype. TPH1 and 5-HTTLPR interacted with Maltreatment subtype to predict peer reports of antisocial behavior; genetic variation contributed to larger differences in antisocial behavior among abused children. The TPH1 and 5-HTTLPR polymorphisms also moderated the effects of Maltreatment subtype on adult reports of antisocial behavior; again, the genetic effects were strongest for children who were abused. In addition, TPH1 moderated the effect of developmental timing of Maltreatment and chronicity on adult reports of antisocial behavior. The findings elucidate how genetic variation contributes to identifying which maltreated children are most vulnerable to antisocial development. Language: en
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the effects of child Maltreatment on early signs of antisocial behavior genetic moderation by tryptophan hydroxylase serotonin transporter and monoamine oxidase a genes
Development and Psychopathology, 2012Co-Authors: Dante Cicchetti, Fred A Rogosch, Eric L ThibodeauAbstract:Gene-environment interaction effects in predicting antisocial behavior in late childhood were investigated among maltreated and nonmaltreated low-income children (N = 627, M age = 11.27). Variants in three genes were examined: tryptophan hydroxylase 1 (TPH1), serotonin transporter linked polymorphic region (5-HTTLPR), and monoamine oxidase A (MAOA) upstream variable number tandem repeat. In addition to child Maltreatment status, we considered the impact of Maltreatment subtypes, developmental timing of Maltreatment, and chronicity. Indicators of antisocial behavior were obtained from self-, peer, and adult counselor reports. In a series of analyses of covariance, child Maltreatment and its parameters demonstrated strong main effects on early antisocial behavior as assessed by all report forms. Genetic effects operated primarily in the context of gene-environment interactions, moderating the impact of child Maltreatment on outcomes. Across the three genes, among nonmaltreated children no differences in antisocial behavior were found based on genetic variation. In contrast, among maltreated children specific polymorphisms of TPH1, 5-HTTLPR, and MAOA were each related to heightened self-report of antisocial behavior; the interaction of 5-HTTLPR and developmental timing of Maltreatment also indicated more severe antisocial outcomes for children with early onset and recurrent Maltreatment based on genotype. TPH1 and 5-HTTLPR interacted with Maltreatment subtype to predict peer reports of antisocial behavior; genetic variation contributed to larger differences in antisocial behavior among abused children. The TPH1 and 5-HTTLPR polymorphisms also moderated the effects of Maltreatment subtype on adult reports of antisocial behavior; again, the genetic effects were strongest for children who were abused. In addition, TPH1 moderated the effect of developmental timing of Maltreatment and chronicity on adult reports of antisocial behavior. The findings elucidate how genetic variation contributes to identifying which maltreated children are most vulnerable to antisocial development.
Fred A Rogosch - One of the best experts on this subject based on the ideXlab platform.
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identifying Maltreatment subgroups with patterns of Maltreatment subtype and chronicity a latent class analysis approach
Child Abuse & Neglect, 2019Co-Authors: Jennifer M Warmingham, Dante Cicchetti, Fred A Rogosch, Elizabeth D Handley, Jody Todd ManlyAbstract:Abstract Maltreatment experiences are complex, and it is difficult to characterize the heterogeneity in types of Maltreatment. Subtypes, such as emotional Maltreatment, sexual abuse, physical abuse, and neglect commonly co-occur and may persist across development. Therefore, treating individual Maltreatment subtypes as independently occurring is not representative of the nature of Maltreatment as it occurs in children’s lives. Latent class analysis (LCA) is employed herein to identify subgroups of maltreated children based on commonalities in Maltreatment subtype and chronicity. In a sample of 674 low-income urban children, 51.6% of whom experienced officially documented Maltreatment, our analyses identified four classes of children, with three distinct classes based on Maltreatment subtypes and chronicity, and one group of children who did not experience Maltreatment. The largest class of maltreated children identified was the chronic, multi-subtype Maltreatment class (57% of maltreated children); a second class was characterized by only neglect in a single developmental period (31% of maltreated children), and the smallest class was characterized by a single subtype of Maltreatment (emotional Maltreatment, physical, or sexual abuse) occurring in a single developmental period (12% of maltreated children). Characterization of these groups confirms the overlapping nature of Maltreatment subtypes. There were notable differences between latent classes on child behavioral and socio-emotional outcomes measured by child self-report and camp counselors report during a one-week summer camp. The largest differences were between the non-maltreated class and the chronic Maltreatment class. Children who experienced chronic, multi-subtype Maltreatment showed higher levels of externalizing behavior, emotion dysregulation, depression, and anxiety.
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childhood Maltreatment and its effect on neurocognitive functioning timing and chronicity matter
Development and Psychopathology, 2015Co-Authors: Raquel A Cowell, Dante Cicchetti, Fred A Rogosch, Sheree L TothAbstract:Childhood Maltreatment represents a complex stressor, with the developmental timing, duration, frequency, and type of Maltreatment varying with each child (Barnett, Manly, & Cicchetti, 1993; Cicchetti & Manly, 2001). Multiple brain regions and neural circuits are disrupted by the experience of child Maltreatment (Cicchetti & Toth, in press; DeBellis et al., 2002; McCrory & Viding, 2010; Teicher, Anderson, & Polcari, 2012). These neurobiological compromises indicate the impairment of a number of important cognitive functions, including working memory and inhibitory control. The present study extends prior research by examining the effect of childhood Maltreatment on neurocognitive functioning based on developmental timing of Maltreatment, including onset, chronicity, and recency, in a sample of 3- to 9-year-old nonmaltreated (n = 136) and maltreated children (n = 223). Maltreated children performed more poorly on inhibitory control and working-memory tasks than did nonmaltreated children. Group differences between maltreated children based on the timing of Maltreatment and the chronicity of Maltreatment also were evident. Specifically, children who were maltreated during infancy, and children with a chronic history of Maltreatment, exhibited significantly poorer inhibitory control and working-memory performance than did children without a history of Maltreatment. The results suggest that Maltreatment occurring during infancy, a period of major brain organization, disrupts normative structure and function, and these deficits are further instantiated by the prolonged stress of chronic Maltreatment during the early years of life.
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genetic moderation of child Maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region 5 httlpr brain derived neurotrophic factor bdnf norepinephrine transporter net and corticotropin releasing ho
Development and Psychopathology, 2014Co-Authors: Dante Cicchetti, Fred A RogoschAbstract:Genetic moderation of the effects of child Maltreatment on depression and internalizing symptoms was investigated in a sample of low-income maltreated and nonmaltreated African American children (N = 1,096). Lifetime child Maltreatment experiences were independently coded from Child Protective Services records and maternal report. Child depression and internalizing problems were assessed in the context of a summer research camp by self-report on the Children's Depression Inventory and adult counselor report on the Teacher Report Form. DNA was obtained from buccal cell or saliva samples and genotyped for polymorphisms of the following genes: serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter, and corticotropin releasing hormone receptor 1. Analyses of covariance with age and gender as covariates were conducted, with Maltreatment status and respective polymorphism as main effects and their Gene × Environment (G × E) interactions. Maltreatment consistently was associated with higher Children's Depression Inventory and Teacher Report Form symptoms. The results for child self-report symptoms indicated a G × E interaction for BDNF and Maltreatment. In addition, BDNF and triallelic 5-HTTLPR interacted with child Maltreatment in a G × G × E interaction. Analyses for counselor report of child anxiety/depression symptoms on the Teacher Report Form indicated moderation of child Maltreatment effects by triallelic 5-HTTLPR. These effects were elaborated based on variation in developmental timing of Maltreatment experiences. Norepinephrine transporter was found to further moderate the G × E interaction of 5-HTTLPR and Maltreatment status, revealing a G × G × E interaction. This G × G × E was extended by consideration of variation in Maltreatment subtype experiences. Finally, G × G × E effects were observed for the co-action of BDNF and the corticotropin releasing hormone receptor 1 haplotype. The findings illustrate the variable influence of specific genotypes in G × E interactions based on variation in Maltreatment experiences and the importance of a multigenic approach for understanding influences on depression and internalizing symptoms among African American children.
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the effects of child Maltreatment on early signs of antisocial behavior genetic moderation by tryptophan hydroxylase serotonin transporter and monoamine oxidase a genes
Development and Psychopathology, 2012Co-Authors: Dante Cicchetti, Fred A Rogosch, Eric L ThibodeauAbstract:Gene-environment interaction effects in predicting antisocial behavior in late childhood were investigated among maltreated and nonmaltreated low-income children (N = 627, M age = 11.27). Variants in three genes were examined: tryptophan hydroxylase 1 (TPH1), serotonin transporter linked polymorphic region (5-HTTLPR), and monoamine oxidase A (MAOA) upstream variable number tandem repeat. In addition to child Maltreatment status, we considered the impact of Maltreatment subtypes, developmental timing of Maltreatment, and chronicity. Indicators of antisocial behavior were obtained from self-, peer, and adult counselor reports. In a series of analyses of covariance, child Maltreatment and its parameters demonstrated strong main effects on early antisocial behavior as assessed by all report forms. Genetic effects operated primarily in the context of gene-environment interactions, moderating the impact of child Maltreatment on outcomes. Across the three genes, among nonmaltreated children no differences in antisocial behavior were found based on genetic variation. In contrast, among maltreated children specific polymorphisms of TPH1, 5-HTTLPR, and MAOA were each related to heightened self-report of antisocial behavior; the interaction of 5-HTTLPR and developmental timing of Maltreatment also indicated more severe antisocial outcomes for children with early onset and recurrent Maltreatment based on genotype. TPH1 and 5-HTTLPR interacted with Maltreatment subtype to predict peer reports of antisocial behavior; genetic variation contributed to larger differences in antisocial behavior among abused children. The TPH1 and 5-HTTLPR polymorphisms also moderated the effects of Maltreatment subtype on adult reports of antisocial behavior; again, the genetic effects were strongest for children who were abused. In addition, TPH1 moderated the effect of developmental timing of Maltreatment and chronicity on adult reports of antisocial behavior. The findings elucidate how genetic variation contributes to identifying which maltreated children are most vulnerable to antisocial development. Language: en
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the effects of child Maltreatment on early signs of antisocial behavior genetic moderation by tryptophan hydroxylase serotonin transporter and monoamine oxidase a genes
Development and Psychopathology, 2012Co-Authors: Dante Cicchetti, Fred A Rogosch, Eric L ThibodeauAbstract:Gene-environment interaction effects in predicting antisocial behavior in late childhood were investigated among maltreated and nonmaltreated low-income children (N = 627, M age = 11.27). Variants in three genes were examined: tryptophan hydroxylase 1 (TPH1), serotonin transporter linked polymorphic region (5-HTTLPR), and monoamine oxidase A (MAOA) upstream variable number tandem repeat. In addition to child Maltreatment status, we considered the impact of Maltreatment subtypes, developmental timing of Maltreatment, and chronicity. Indicators of antisocial behavior were obtained from self-, peer, and adult counselor reports. In a series of analyses of covariance, child Maltreatment and its parameters demonstrated strong main effects on early antisocial behavior as assessed by all report forms. Genetic effects operated primarily in the context of gene-environment interactions, moderating the impact of child Maltreatment on outcomes. Across the three genes, among nonmaltreated children no differences in antisocial behavior were found based on genetic variation. In contrast, among maltreated children specific polymorphisms of TPH1, 5-HTTLPR, and MAOA were each related to heightened self-report of antisocial behavior; the interaction of 5-HTTLPR and developmental timing of Maltreatment also indicated more severe antisocial outcomes for children with early onset and recurrent Maltreatment based on genotype. TPH1 and 5-HTTLPR interacted with Maltreatment subtype to predict peer reports of antisocial behavior; genetic variation contributed to larger differences in antisocial behavior among abused children. The TPH1 and 5-HTTLPR polymorphisms also moderated the effects of Maltreatment subtype on adult reports of antisocial behavior; again, the genetic effects were strongest for children who were abused. In addition, TPH1 moderated the effect of developmental timing of Maltreatment and chronicity on adult reports of antisocial behavior. The findings elucidate how genetic variation contributes to identifying which maltreated children are most vulnerable to antisocial development.
Timothy Heeren - One of the best experts on this subject based on the ideXlab platform.
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child abuse and neglect relations to adolescent binge drinking in the national longitudinal study of adolescent health addhealth study
Addictive Behaviors, 2009Co-Authors: Sunny Hyucksun Shin, Erika M Edwards, Timothy HeerenAbstract:The purpose of this study was to examine the relationship between child Maltreatment and adolescent binge drinking. Given that many victimized children have been maltreated in multiple ways, we examine the effects of co-occurrence of multiple types of Maltreatment on adolescent binge drinking. We used the National Longitudinal Study of Adolescent Health (AddHealth), which included a nationally representative sample of adolescents (n=12,748). Adolescent binge drinking was defined as five or more drinks in a row at least 2-3 times per month in the past year. Among those reporting any Maltreatment, 12.4% reported binge drinking compared to 9.9% among those reporting no Maltreatment. Logistic regression models found that child Maltreatment is a robust risk factor for adolescent binge drinking controlling for parental alcoholism. In particular, all types of or combinations of types of Maltreatment were strongly associated with adolescent binge drinking, controlling for age, gender, race, parental alcoholism and monitoring. Research examining the effect of childhood Maltreatment on later alcohol abuse needs to recognize the clustering effects of multiple types of childhood Maltreatment on alcohol problems. Language: en
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child abuse and neglect relations to adolescent binge drinking in the national longitudinal study of adolescent health addhealth study
Addictive Behaviors, 2009Co-Authors: Sunny Hyucksun Shin, Erika M Edwards, Timothy HeerenAbstract:The purpose of this study was to examine the relationship between child Maltreatment and adolescent binge drinking. Given that many victimized children have been maltreated in multiple ways, we examine the effects of co-occurrence of multiple types of Maltreatment on adolescent binge drinking. We used the National Longitudinal Study of Adolescent Health (AddHealth), which included a nationally representative sample of adolescents (n=12,748). Adolescent binge drinking was defined as five or more drinks in a row at least 2-3 times per month in the past year. Among those reporting any Maltreatment, 12.4% reported binge drinking compared to 9.9% among those reporting no Maltreatment. Logistic regression models found that child Maltreatment is a robust risk factor for adolescent binge drinking controlling for parental alcoholism. In particular, all types of or combinations of types of Maltreatment were strongly associated with adolescent binge drinking, controlling for age, gender, race, parental alcoholism and monitoring. Research examining the effect of childhood Maltreatment on later alcohol abuse needs to recognize the clustering effects of multiple types of childhood Maltreatment on alcohol problems.
Eric L Thibodeau - One of the best experts on this subject based on the ideXlab platform.
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the effects of child Maltreatment on early signs of antisocial behavior genetic moderation by tryptophan hydroxylase serotonin transporter and monoamine oxidase a genes
Development and Psychopathology, 2012Co-Authors: Dante Cicchetti, Fred A Rogosch, Eric L ThibodeauAbstract:Gene-environment interaction effects in predicting antisocial behavior in late childhood were investigated among maltreated and nonmaltreated low-income children (N = 627, M age = 11.27). Variants in three genes were examined: tryptophan hydroxylase 1 (TPH1), serotonin transporter linked polymorphic region (5-HTTLPR), and monoamine oxidase A (MAOA) upstream variable number tandem repeat. In addition to child Maltreatment status, we considered the impact of Maltreatment subtypes, developmental timing of Maltreatment, and chronicity. Indicators of antisocial behavior were obtained from self-, peer, and adult counselor reports. In a series of analyses of covariance, child Maltreatment and its parameters demonstrated strong main effects on early antisocial behavior as assessed by all report forms. Genetic effects operated primarily in the context of gene-environment interactions, moderating the impact of child Maltreatment on outcomes. Across the three genes, among nonmaltreated children no differences in antisocial behavior were found based on genetic variation. In contrast, among maltreated children specific polymorphisms of TPH1, 5-HTTLPR, and MAOA were each related to heightened self-report of antisocial behavior; the interaction of 5-HTTLPR and developmental timing of Maltreatment also indicated more severe antisocial outcomes for children with early onset and recurrent Maltreatment based on genotype. TPH1 and 5-HTTLPR interacted with Maltreatment subtype to predict peer reports of antisocial behavior; genetic variation contributed to larger differences in antisocial behavior among abused children. The TPH1 and 5-HTTLPR polymorphisms also moderated the effects of Maltreatment subtype on adult reports of antisocial behavior; again, the genetic effects were strongest for children who were abused. In addition, TPH1 moderated the effect of developmental timing of Maltreatment and chronicity on adult reports of antisocial behavior. The findings elucidate how genetic variation contributes to identifying which maltreated children are most vulnerable to antisocial development. Language: en
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the effects of child Maltreatment on early signs of antisocial behavior genetic moderation by tryptophan hydroxylase serotonin transporter and monoamine oxidase a genes
Development and Psychopathology, 2012Co-Authors: Dante Cicchetti, Fred A Rogosch, Eric L ThibodeauAbstract:Gene-environment interaction effects in predicting antisocial behavior in late childhood were investigated among maltreated and nonmaltreated low-income children (N = 627, M age = 11.27). Variants in three genes were examined: tryptophan hydroxylase 1 (TPH1), serotonin transporter linked polymorphic region (5-HTTLPR), and monoamine oxidase A (MAOA) upstream variable number tandem repeat. In addition to child Maltreatment status, we considered the impact of Maltreatment subtypes, developmental timing of Maltreatment, and chronicity. Indicators of antisocial behavior were obtained from self-, peer, and adult counselor reports. In a series of analyses of covariance, child Maltreatment and its parameters demonstrated strong main effects on early antisocial behavior as assessed by all report forms. Genetic effects operated primarily in the context of gene-environment interactions, moderating the impact of child Maltreatment on outcomes. Across the three genes, among nonmaltreated children no differences in antisocial behavior were found based on genetic variation. In contrast, among maltreated children specific polymorphisms of TPH1, 5-HTTLPR, and MAOA were each related to heightened self-report of antisocial behavior; the interaction of 5-HTTLPR and developmental timing of Maltreatment also indicated more severe antisocial outcomes for children with early onset and recurrent Maltreatment based on genotype. TPH1 and 5-HTTLPR interacted with Maltreatment subtype to predict peer reports of antisocial behavior; genetic variation contributed to larger differences in antisocial behavior among abused children. The TPH1 and 5-HTTLPR polymorphisms also moderated the effects of Maltreatment subtype on adult reports of antisocial behavior; again, the genetic effects were strongest for children who were abused. In addition, TPH1 moderated the effect of developmental timing of Maltreatment and chronicity on adult reports of antisocial behavior. The findings elucidate how genetic variation contributes to identifying which maltreated children are most vulnerable to antisocial development.
Sunny Hyucksun Shin - One of the best experts on this subject based on the ideXlab platform.
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child abuse and neglect relations to adolescent binge drinking in the national longitudinal study of adolescent health addhealth study
Addictive Behaviors, 2009Co-Authors: Sunny Hyucksun Shin, Erika M Edwards, Timothy HeerenAbstract:The purpose of this study was to examine the relationship between child Maltreatment and adolescent binge drinking. Given that many victimized children have been maltreated in multiple ways, we examine the effects of co-occurrence of multiple types of Maltreatment on adolescent binge drinking. We used the National Longitudinal Study of Adolescent Health (AddHealth), which included a nationally representative sample of adolescents (n=12,748). Adolescent binge drinking was defined as five or more drinks in a row at least 2-3 times per month in the past year. Among those reporting any Maltreatment, 12.4% reported binge drinking compared to 9.9% among those reporting no Maltreatment. Logistic regression models found that child Maltreatment is a robust risk factor for adolescent binge drinking controlling for parental alcoholism. In particular, all types of or combinations of types of Maltreatment were strongly associated with adolescent binge drinking, controlling for age, gender, race, parental alcoholism and monitoring. Research examining the effect of childhood Maltreatment on later alcohol abuse needs to recognize the clustering effects of multiple types of childhood Maltreatment on alcohol problems. Language: en
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child abuse and neglect relations to adolescent binge drinking in the national longitudinal study of adolescent health addhealth study
Addictive Behaviors, 2009Co-Authors: Sunny Hyucksun Shin, Erika M Edwards, Timothy HeerenAbstract:The purpose of this study was to examine the relationship between child Maltreatment and adolescent binge drinking. Given that many victimized children have been maltreated in multiple ways, we examine the effects of co-occurrence of multiple types of Maltreatment on adolescent binge drinking. We used the National Longitudinal Study of Adolescent Health (AddHealth), which included a nationally representative sample of adolescents (n=12,748). Adolescent binge drinking was defined as five or more drinks in a row at least 2-3 times per month in the past year. Among those reporting any Maltreatment, 12.4% reported binge drinking compared to 9.9% among those reporting no Maltreatment. Logistic regression models found that child Maltreatment is a robust risk factor for adolescent binge drinking controlling for parental alcoholism. In particular, all types of or combinations of types of Maltreatment were strongly associated with adolescent binge drinking, controlling for age, gender, race, parental alcoholism and monitoring. Research examining the effect of childhood Maltreatment on later alcohol abuse needs to recognize the clustering effects of multiple types of childhood Maltreatment on alcohol problems.
