The Experts below are selected from a list of 51513 Experts worldwide ranked by ideXlab platform
Philip T Hicks - One of the best experts on this subject based on the ideXlab platform.
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the mysterious trace amines protean neuromodulators of synaptic transmission in Mammalian Brain
Progress in Neurobiology, 2006Co-Authors: Scott A Burchett, Philip T HicksAbstract:Abstract The trace amines are a structurally related group of amines and their isomers synthesized in Mammalian Brain and peripheral nervous tissues. They are closely associated metabolically with the dopamine, noradrenaline and serotonin neurotransmitter systems in Mammalian Brain. Like dopamine, noradrenaline and serotonin the trace amines have been implicated in a vast array of human disorders of affect and cognition. The trace amines are unique as they are present in trace concentrations, exhibit high rates of metabolism and are distributed heterogeneously in Mammalian Brain. While some are synthesized in their parent amine neurotransmitter systems, there is also evidence to suggest other trace amines may comprise their own independent neurotransmitter systems. A substantial body of evidence suggests that the trace amines may play very significant roles in the coordination of biogenic amine-based synaptic physiology. At high concentrations, they have well-characterized presynaptic “amphetamine-like” effects on catecholamine and indolamine release, reuptake and biosynthesis; at lower concentrations, they possess postsynaptic modulatory effects that potentiate the activity of other neurotransmitters, particularly dopamine and serotonin. The trace amines also possess electrophysiological effects that are in opposition to these neurotransmitters, indicating to some researchers the existence of receptors specific for the trace amines. While binding sites or receptors for a few of the trace amines have been advanced, the absence of cloned receptor protein has impeded significant development of their detailed mechanistic roles in the coordination of catecholamine and indolamine synaptic physiology. The recent discovery and characterization of a family of Mammalian G protein-coupled receptors responsive to trace amines such as β-phenylethylamine, tyramine, and octopamine, including socially ingested psychotropic drugs such as amphetamine, 3,4-methylenedioxymethamphetamine, N,N-dimethyltryptamine, and lysergic acid diethylamide, have revitalized the field of scientific studies investigating trace amine synaptic physiology, and its association with major human disorders of affect and cognition.
Scott A Burchett - One of the best experts on this subject based on the ideXlab platform.
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The mysterious trace amines: protean neuromodulators of synaptic transmission in Mammalian Brain.
Progress in neurobiology, 2006Co-Authors: Scott A Burchett, T Philip HicksAbstract:The trace amines are a structurally related group of amines and their isomers synthesized in Mammalian Brain and peripheral nervous tissues. They are closely associated metabolically with the dopamine, noradrenaline and serotonin neurotransmitter systems in Mammalian Brain. Like dopamine, noradrenaline and serotonin the trace amines have been implicated in a vast array of human disorders of affect and cognition. The trace amines are unique as they are present in trace concentrations, exhibit high rates of metabolism and are distributed heterogeneously in Mammalian Brain. While some are synthesized in their parent amine neurotransmitter systems, there is also evidence to suggest other trace amines may comprise their own independent neurotransmitter systems. A substantial body of evidence suggests that the trace amines may play very significant roles in the coordination of biogenic amine-based synaptic physiology. At high concentrations, they have well-characterized presynaptic "amphetamine-like" effects on catecholamine and indolamine release, reuptake and biosynthesis; at lower concentrations, they possess postsynaptic modulatory effects that potentiate the activity of other neurotransmitters, particularly dopamine and serotonin. The trace amines also possess electrophysiological effects that are in opposition to these neurotransmitters, indicating to some researchers the existence of receptors specific for the trace amines. While binding sites or receptors for a few of the trace amines have been advanced, the absence of cloned receptor protein has impeded significant development of their detailed mechanistic roles in the coordination of catecholamine and indolamine synaptic physiology. The recent discovery and characterization of a family of Mammalian G protein-coupled receptors responsive to trace amines such as beta-phenylethylamine, tyramine, and octopamine, including socially ingested psychotropic drugs such as amphetamine, 3,4-methylenedioxymethamphetamine, N,N-dimethyltryptamine, and lysergic acid diethylamide, have revitalized the field of scientific studies investigating trace amine synaptic physiology, and its association with major human disorders of affect and cognition.
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the mysterious trace amines protean neuromodulators of synaptic transmission in Mammalian Brain
Progress in Neurobiology, 2006Co-Authors: Scott A Burchett, Philip T HicksAbstract:Abstract The trace amines are a structurally related group of amines and their isomers synthesized in Mammalian Brain and peripheral nervous tissues. They are closely associated metabolically with the dopamine, noradrenaline and serotonin neurotransmitter systems in Mammalian Brain. Like dopamine, noradrenaline and serotonin the trace amines have been implicated in a vast array of human disorders of affect and cognition. The trace amines are unique as they are present in trace concentrations, exhibit high rates of metabolism and are distributed heterogeneously in Mammalian Brain. While some are synthesized in their parent amine neurotransmitter systems, there is also evidence to suggest other trace amines may comprise their own independent neurotransmitter systems. A substantial body of evidence suggests that the trace amines may play very significant roles in the coordination of biogenic amine-based synaptic physiology. At high concentrations, they have well-characterized presynaptic “amphetamine-like” effects on catecholamine and indolamine release, reuptake and biosynthesis; at lower concentrations, they possess postsynaptic modulatory effects that potentiate the activity of other neurotransmitters, particularly dopamine and serotonin. The trace amines also possess electrophysiological effects that are in opposition to these neurotransmitters, indicating to some researchers the existence of receptors specific for the trace amines. While binding sites or receptors for a few of the trace amines have been advanced, the absence of cloned receptor protein has impeded significant development of their detailed mechanistic roles in the coordination of catecholamine and indolamine synaptic physiology. The recent discovery and characterization of a family of Mammalian G protein-coupled receptors responsive to trace amines such as β-phenylethylamine, tyramine, and octopamine, including socially ingested psychotropic drugs such as amphetamine, 3,4-methylenedioxymethamphetamine, N,N-dimethyltryptamine, and lysergic acid diethylamide, have revitalized the field of scientific studies investigating trace amine synaptic physiology, and its association with major human disorders of affect and cognition.
T Philip Hicks - One of the best experts on this subject based on the ideXlab platform.
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The mysterious trace amines: protean neuromodulators of synaptic transmission in Mammalian Brain.
Progress in neurobiology, 2006Co-Authors: Scott A Burchett, T Philip HicksAbstract:The trace amines are a structurally related group of amines and their isomers synthesized in Mammalian Brain and peripheral nervous tissues. They are closely associated metabolically with the dopamine, noradrenaline and serotonin neurotransmitter systems in Mammalian Brain. Like dopamine, noradrenaline and serotonin the trace amines have been implicated in a vast array of human disorders of affect and cognition. The trace amines are unique as they are present in trace concentrations, exhibit high rates of metabolism and are distributed heterogeneously in Mammalian Brain. While some are synthesized in their parent amine neurotransmitter systems, there is also evidence to suggest other trace amines may comprise their own independent neurotransmitter systems. A substantial body of evidence suggests that the trace amines may play very significant roles in the coordination of biogenic amine-based synaptic physiology. At high concentrations, they have well-characterized presynaptic "amphetamine-like" effects on catecholamine and indolamine release, reuptake and biosynthesis; at lower concentrations, they possess postsynaptic modulatory effects that potentiate the activity of other neurotransmitters, particularly dopamine and serotonin. The trace amines also possess electrophysiological effects that are in opposition to these neurotransmitters, indicating to some researchers the existence of receptors specific for the trace amines. While binding sites or receptors for a few of the trace amines have been advanced, the absence of cloned receptor protein has impeded significant development of their detailed mechanistic roles in the coordination of catecholamine and indolamine synaptic physiology. The recent discovery and characterization of a family of Mammalian G protein-coupled receptors responsive to trace amines such as beta-phenylethylamine, tyramine, and octopamine, including socially ingested psychotropic drugs such as amphetamine, 3,4-methylenedioxymethamphetamine, N,N-dimethyltryptamine, and lysergic acid diethylamide, have revitalized the field of scientific studies investigating trace amine synaptic physiology, and its association with major human disorders of affect and cognition.
Gerhard Meissner - One of the best experts on this subject based on the ideXlab platform.
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Expression of a cardiac Ca2+-release channel isoform in Mammalian Brain
Biochemical Journal, 1992Co-Authors: Francis Anthony Lai, Myrna A. R. Dent, C. Wickenden, G. Kumari, M. Misra, H. B. Lee, Madhabananda Sar, Gerhard MeissnerAbstract:Mammalian Brain possesses ryanodine-sensitive Ca2+ channels, which in muscle cells mediate rapid Ca2+ release from intracellular stores during excitation-contraction coupling. Analysis of bovine Brain ryanodine receptor (RyR) channels suggests specific expression of the cardiac-muscle RyR isoform in Mammalian Brain. Localization using cardiac-muscle RyR-specific antibodies and antisense RNA revealed that Brain RyRs were present in dendrites, cell bodies and terminals of rat foreBrain, and highly enriched in the hippocampus. Activity of skeletal-muscle RyR channels is coupled to sarcolemmal voltage sensors, in contrast with cardiac-muscle RyR channels, which are known to be Ca(2+)-induced Ca(2+)-release channels. Thus Ca(2+)-induced Ca2+ release from intracellular stores mediated by Brain RyR channels may be a major Ca(2+)-signalling pathway in specific regions of Mammalian Brain, and hence may play a fundamental role in neuronal Ca2+ homoeostasis.
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Expression of a cardiac Ca(2+)-release channel isoform in Mammalian Brain.
The Biochemical journal, 1992Co-Authors: Francis Anthony Lai, C. Wickenden, G. Kumari, M. Misra, H. B. Lee, Madhabananda Sar, M Dent, Gerhard MeissnerAbstract:Mammalian Brain possesses ryanodine-sensitive Ca2+ channels, which in muscle cells mediate rapid Ca2+ release from intracellular stores during excitation-contraction coupling. Analysis of bovine Brain ryanodine receptor (RyR) channels suggests specific expression of the cardiac-muscle RyR isoform in Mammalian Brain. Localization using cardiac-muscle RyR-specific antibodies and antisense RNA revealed that Brain RyRs were present in dendrites, cell bodies and terminals of rat foreBrain, and highly enriched in the hippocampus. Activity of skeletal-muscle RyR channels is coupled to sarcolemmal voltage sensors, in contrast with cardiac-muscle RyR channels, which are known to be Ca(2+)-induced Ca(2+)-release channels. Thus Ca(2+)-induced Ca2+ release from intracellular stores mediated by Brain RyR channels may be a major Ca(2+)-signalling pathway in specific regions of Mammalian Brain, and hence may play a fundamental role in neuronal Ca2+ homoeostasis.
Hongjun Song - One of the best experts on this subject based on the ideXlab platform.
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Epitranscriptomes in the Adult Mammalian Brain: Dynamic Changes Regulate Behavior.
Neuron, 2018Co-Authors: Ki Jun Yoon, Guo Li Ming, Hongjun SongAbstract:Epitranscriptomic modification of mRNA affects its metabolism and has recently been shown to regulate Brain development. Two studies in this issue of Neuron, Koranda et al. (2018) and Engel et al. (2018), uncover dynamic and critical roles of m6A/m RNA modifications in the adult Mammalian Brain in regulating physiological and stress-induced behaviors.
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Diversity of Neural Precursors in the Adult Mammalian Brain
Cold Spring Harbor perspectives in biology, 2016Co-Authors: Michael A. Bonaguidi, Guo Li Ming, Ryan P. Stadel, Daniel A. Berg, Jiaqi Sun, Hongjun SongAbstract:Aided by advances in technology, recent studies of neural precursor identity and regulation have revealed various cell types as contributors to ongoing cell genesis in the adult Mammalian Brain. Here, we use stem-cell biology as a framework to highlight the diversity of adult neural precursor populations and emphasize their hierarchy, organization, and plasticity under physiological and pathological conditions.
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DNA modifications in the Mammalian Brain.
Philosophical transactions of the Royal Society of London. Series B Biological sciences, 2014Co-Authors: Jaehoon Shin, Guo Li Ming, Hongjun SongAbstract:DNA methylation is a crucial epigenetic mark in Mammalian development, genomic imprinting, X-inactivation, chromosomal stability and suppressing parasitic DNA elements. DNA methylation in neurons has also been suggested to play important roles for Mammalian neuronal functions, and learning and memory. In this review, we first summarize recent discoveries and fundamental principles of DNA modifications in the general epigenetics field. We then describe the profiles of different DNA modifications in the Mammalian Brain genome. Finally, we discuss roles of DNA modifications in Mammalian Brain development and function.
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Epigenetic regulation of neurogenesis in the adult Mammalian Brain
The European journal of neuroscience, 2011Co-Authors: Jiaqi Sun, Guo Li Ming, Jiawei Sun, Hongjun SongAbstract:Epigenetic regulation represents a fundamental mechanism to maintain cell-type-specific gene expression during development and serves as an essential mediator to interface the extrinsic environment and the intrinsic genetic programme. Adult neurogenesis occurs in discrete regions of the adult Mammalian Brain and is known to be tightly regulated by various physiological, pathological and pharmacological stimuli. Emerging evidence suggests that various epigenetic mechanisms play important roles in fine-tuning and coordinating gene expression during adult neurogenesis. Here we review recent progress in our understanding of various epigenetic mechanisms, including DNA methylation, histone modifications and non-coding RNAs, as well as cross-talk among these mechanisms, in regulating different aspects of adult Mammalian neurogenesis.
