The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
Gu Su-ying - One of the best experts on this subject based on the ideXlab platform.
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The Application of FFDM Galatograghy in Nipple Discharge Disease
Chinese Journal of General Practice, 2011Co-Authors: Gu Su-yingAbstract:Objective To explore the application value of digital galactography in the diagnosis of nipple discharge disease.Methods The galactography and routine mammography image feature of 121 pathologically confirmed patients were analyzed retrospectively,a contrast diagnosis combined with pathology was made.Results The galactography image showing:36 cases were diagnosed as Mammary Duct Ectasia(MDE),43 intraDuctal papilloma,12 cystic hyperplasia of breast,9 Duct Ectasia with inflammation,15 DCIS(Ductal carcinoma in situ),and 6 invasive Ductal carcinoma.Pathology results:36 cases were diagnosed as Mammary Duct Ectasia,45 intraDuctal papilloma,10 Ductal cystic Ectasia,9 Duct Ectasia with inflammation,14 DCIS(Ductal carcinoma in situ).1 of the 121 cases was invasive intraDuctal carcinoma of early stage,6 invasive carcinoma.Compared with pathological diagnosis,correct diagnosis rate of galactography was 96.7%.Conclusion Digital galactography played an important role in the diagnosis of nipple discharge disease and differential diagnosis of the benign and malignant breast Duct tumor,and provide guidance and approach for the surgery.
Wentao Wang - One of the best experts on this subject based on the ideXlab platform.
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dexamethasone combined metronidazole on Mammary Duct Ectasia and its relationship with serum il 10 and il 17
Journal of Obstetrics and Gynaecology Research, 2020Co-Authors: Yuwen Tong, Yuandong Hao, Xiangyu Gao, Yanshen Sun, Wentao WangAbstract:AIM To explore the effect of dexamethasone combined with metronidazole in the treatment of Mammary Duct Ectasia (MDE) and its relationship with changes in serum interleukin-10 (IL-10) and IL-17 expression. METHODS One hundred and twenty patients with MDE were divided into two groups randomly, control and observation groups (each n = 60). Another 50 patients with normal physical examination were recruited in the normal group. The expressions of serum IL-10 and IL-17 in three groups before and after treatment were observed. The prediction value of IL-10 and IL-17 in clinical efficacy was evaluated. RESULTS Among three groups, the expression of IL-10 in the normal group was the highest (P < 0.001), but the expression of IL-17 was the lowest (P < 0.001). After treatment, the expression of IL-17 in observation group was lower (P < 0.001), the expression of IL-10 was higher (P < 0.05) than that in the control group. The areas under the IL-10 and IL-17 curve were 0.874 and 0.806, respectively. CONCLUSIONS Dexamethasone combined with metronidazole can effectively improve the clinical efficacy of MDE patient treatment and serum IL-10 and IL-17 can be used as potential predictors of treatment efficacy.
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Dexamethasone combined metronidazole on Mammary Duct Ectasia and its relationship with serum IL-10 and IL-17.
The journal of obstetrics and gynaecology research, 2020Co-Authors: Yuwen Tong, Yuandong Hao, Xiangyu Gao, Yanshen Sun, Wentao WangAbstract:AIM To explore the effect of dexamethasone combined with metronidazole in the treatment of Mammary Duct Ectasia (MDE) and its relationship with changes in serum interleukin-10 (IL-10) and IL-17 expression. METHODS One hundred and twenty patients with MDE were divided into two groups randomly, control and observation groups (each n = 60). Another 50 patients with normal physical examination were recruited in the normal group. The expressions of serum IL-10 and IL-17 in three groups before and after treatment were observed. The prediction value of IL-10 and IL-17 in clinical efficacy was evaluated. RESULTS Among three groups, the expression of IL-10 in the normal group was the highest (P
N. Florea - One of the best experts on this subject based on the ideXlab platform.
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91 P - PeriDuctal mastitis and Mammary Duct Ectasia - two stages of the same disease?
European Journal of Cancer, 1996Co-Authors: C. Diaconu, D. Socolov, C. Dragomir, G. Costachescu, N. FloreaAbstract:This paper deals with a disease known under several names: obliterative mastitis, plasma cell mastitis, periDuctal mastitis, comedomastitis, Mammary Duct Ectasia, which seem to define different stages of the same illness. Out of 67 cases of benign breast diseases recorded in our hospital during a 3-year interval, 15 cases were diagnosed as periDuctal mastitis or Mammary Duct Ectasia. The dominant pathological findings in younger patients (17–40 years) were periDuctal infiltration with plasma cells, lymphocytes or polymorphic cells, while in older patients (over 52) Duct Ectasia and nipple retraction were prevalent, being frequently associated with periDuctal infiltration. Microbiological examination of the intraoperative samples showed different germs in most cases. Thus antibiotic prophylaxis was justifted in our cases. Our study supports the idea that this disease begins with a silent Ductal infection with periDuctal infiltration, and ends with chronic inflammation and fibrosis with consequent Duct Ectasia. Therefore, periDuctal mastitis, non-puerperal mastitis and Duct Ectasia arc stages of the same pathological process. Due to the clinical similarity with breast cancer, treatment by sectorectomy becomes mandatory.
Feixue Zhang - One of the best experts on this subject based on the ideXlab platform.
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Diagnostic evaluations of ultrasound and magnetic resonance imaging in Mammary Duct Ectasia and breast cancer.
Oncology letters, 2017Co-Authors: Lei Song, Bin Liu, Fengguo Sun, Mingming Guo, Zhengmin Ruan, Feixue ZhangAbstract:The objective of the present study was to evaluate the diagnostic efficiency of ultrasound (US) and magnetic resonance imaging (MRI) in the diagnosis and differential diagnosis of Mammary Duct Ectasia (MDE) and breast cancer. This retrospective study was performed on 35 patients with MDE and 105 patients with breast cancer using US and MRI. Imaging features, semi-quantitative and quantitative parameters were analyzed to determine their diagnostic value for MDE and breast cancer. The average age of patients with breast cancer was increased compared with that of patients with MDE. There were no significant differences in local packages with or without tenderness ratio (P=0.259) and grade of color Doppler flow imaging (P=0.273) between the two groups. However, the morphological changes were significantly increased in breast cancer compared with MDE. In addition, there were significant diagnostic differences in US and MRI between breast cancer and MDE, including resistance index, US elastography, time-signal intensity curve, apparent diffusion coefficient, early-stage enhancement ratio, peak-of-enhancement ratio and Tpeak (P
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diagnostic evaluations of ultrasound and magnetic resonance imaging in Mammary Duct Ectasia and breast cancer
Oncology Letters, 2017Co-Authors: Lei Song, Bin Liu, Fengguo Sun, Mingming Guo, Zhengmin Ruan, Feixue ZhangAbstract:The objective of the present study was to evaluate the diagnostic efficiency of ultrasound (US) and magnetic resonance imaging (MRI) in the diagnosis and differential diagnosis of Mammary Duct Ectasia (MDE) and breast cancer. This retrospective study was performed on 35 patients with MDE and 105 patients with breast cancer using US and MRI. Imaging features, semi-quantitative and quantitative parameters were analyzed to determine their diagnostic value for MDE and breast cancer. The average age of patients with breast cancer was increased compared with that of patients with MDE. There were no significant differences in local packages with or without tenderness ratio (P=0.259) and grade of color Doppler flow imaging (P=0.273) between the two groups. However, the morphological changes were significantly increased in breast cancer compared with MDE. In addition, there were significant diagnostic differences in US and MRI between breast cancer and MDE, including resistance index, US elastography, time-signal intensity curve, apparent diffusion coefficient, early-stage enhancement ratio, peak-of-enhancement ratio and Tpeak (P<0.05). However, there were no observable significant diagnostic differences between US, MRI and US with MRI for MDE and breast cancer (P=0.103, P=0.263 and P=0.403 respectively). Diagnosis of MDE and breast cancer requires full evaluation of multiple parameters and morphological changes of US and MRI to increase the diagnostic efficiency. US, MRI and US with MRI were all of diagnostic value for MDE and breast cancer, while US with MRI had the highest efficacy.
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Ultrasound elastography and magnetic resonance examinations are effective for the accurate diagnosis of Mammary Duct Ectasia
International journal of clinical and experimental medicine, 2015Co-Authors: Feixue Zhang, Mingming Guo, Qing Wang, Fei Zhou, Meng Zhao, Feng Xue, Guangrui ShaoAbstract:Objectives: This study is to investigate the values of multiple quantitative evaluation parameters in the diagnosis of Mammary Duct Ectasia (MDE), using real-time ultrasound elastography (UE) and magnetic resonance imaging (MRI). Methods: This retrospective study was performed on 15 patients (16 lesions) with MDE. Ultrasound examination was performed with the LOGIQ E9 ultrasound instrument, with all lesions being examined by routine ultrasound and UE. MRI examination was performed with a Signa HD × 3.0T TWINSP MR System, including of plain-scan, diffusion-weighted imaging, dynamic contrast-enhanced MRI, and proton magnetic resonance spectroscopy. Imaging features, as well as semi-quantitative and quantitative parameters, were analyzed to determine their diagnostic value for MDE. Results: According to the five-point scale in UE, twelve lesions belonged to 1-3 point scale, and four lesions were in 4-5 point scale, with an average of 2.93 ± 0.77. In dynamic contrast-enhanced MRI, the lesions appeared as obviously enhanced signals. The MRI early-enhancement rate ranged from 0.35 to 1.07 (0.67 ± 0.30 on average); the time peak ranged between 192 and 330 s (248 ± 37 s on average); the peak-enhancement ratio ranged from 2.26 to 3.06, with an average of 2.59 ± 0.33. According to MRI time-signal intensity curves classified into persistently enhancing (type I), plateau (type II) and washout (type III), 12 lesions (75%) belonged to type I, three (18.75%) belonged to type II, and one (6.25%) belonged to type III. Magnetic resonance spectroscopy showed that a total choline peak occurred only in one lesion. The diagnosis accuracy rates for ultrasound alone, MRI alone and the combination of ultrasound and MRI were 75% (12/16), 87.5% (14/16) and 93.75% (15/16), respectively. Conclusions: Both ultrasound and MRI show clinical importance in MDE diagnosis. However, UE, dynamic contrast-enhanced MRI, and magnetic resonance spectroscopy demonstrate significantly better diagnosis and differential diagnosis of MDE.
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Original Article Ultrasound elastography and magnetic resonance examinations are effective for the accurate diagnosis of Mammary Duct Ectasia
2015Co-Authors: Feixue Zhang, Mingming Guo, Qing Wang, Fei Zhou, Meng Zhao, Feng Xue, Guangrui ShaoAbstract:Objectives: This study is to investigate the values of multiple quantitative evaluation parameters in the diagnosis of Mammary Duct Ectasia (MDE), using real-time ultrasound elastography (UE) and magnetic resonance imaging (MRI). Methods: This retrospective study was performed on 15 patients (16 lesions) with MDE. Ultrasound examination was performed with the LOGIQ E9 ultrasound instrument, with all lesions being examined by routine ultrasound and UE. MRI examination was performed with a Signa HD × 3.0T TWINSP MR System, including of plain- scan, diffusion-weighted imaging, dynamic contrast-enhanced MRI, and proton magnetic resonance spectroscopy. Imaging features, as well as semi-quantitative and quantitative parameters, were analyzed to determine their diag- nostic value for MDE. Results: According to the five-point scale in UE, twelve lesions belonged to 1-3 point scale, and four lesions were in 4-5 point scale, with an average of 2.93 ± 0.77. In dynamic contrast-enhanced MRI, the lesions appeared as obviously enhanced signals. The MRI early-enhancement rate ranged from 0.35 to 1.07 (0.67 ± 0.30 on average); the time peak ranged between 192 and 330 s (248 ± 37 s on average); the peak-enhancement ratio ranged from 2.26 to 3.06, with an average of 2.59 ± 0.33. According to MRI time-signal intensity curves classified into persistently enhancing (type I), plateau (type II) and washout (type III), 12 lesions (75%) belonged to type I, three (18.75%) belonged to type II, and one (6.25%) belonged to type III. Magnetic resonance spectroscopy showed that a total choline peak occurred only in one lesion. The diagnosis accuracy rates for ultrasound alone, MRI alone and the combination of ultrasound and MRI were 75% (12/16), 87.5% (14/16) and 93.75% (15/16), respectively. Conclusions: Both ultrasound and MRI show clinical importance in MDE diagnosis. However, UE, dynamic contrast- enhanced MRI, and magnetic resonance spectroscopy demonstrate significantly better diagnosis and differential diagnosis of MDE.
Yuwen Tong - One of the best experts on this subject based on the ideXlab platform.
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dexamethasone combined metronidazole on Mammary Duct Ectasia and its relationship with serum il 10 and il 17
Journal of Obstetrics and Gynaecology Research, 2020Co-Authors: Yuwen Tong, Yuandong Hao, Xiangyu Gao, Yanshen Sun, Wentao WangAbstract:AIM To explore the effect of dexamethasone combined with metronidazole in the treatment of Mammary Duct Ectasia (MDE) and its relationship with changes in serum interleukin-10 (IL-10) and IL-17 expression. METHODS One hundred and twenty patients with MDE were divided into two groups randomly, control and observation groups (each n = 60). Another 50 patients with normal physical examination were recruited in the normal group. The expressions of serum IL-10 and IL-17 in three groups before and after treatment were observed. The prediction value of IL-10 and IL-17 in clinical efficacy was evaluated. RESULTS Among three groups, the expression of IL-10 in the normal group was the highest (P < 0.001), but the expression of IL-17 was the lowest (P < 0.001). After treatment, the expression of IL-17 in observation group was lower (P < 0.001), the expression of IL-10 was higher (P < 0.05) than that in the control group. The areas under the IL-10 and IL-17 curve were 0.874 and 0.806, respectively. CONCLUSIONS Dexamethasone combined with metronidazole can effectively improve the clinical efficacy of MDE patient treatment and serum IL-10 and IL-17 can be used as potential predictors of treatment efficacy.
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Dexamethasone combined metronidazole on Mammary Duct Ectasia and its relationship with serum IL-10 and IL-17.
The journal of obstetrics and gynaecology research, 2020Co-Authors: Yuwen Tong, Yuandong Hao, Xiangyu Gao, Yanshen Sun, Wentao WangAbstract:AIM To explore the effect of dexamethasone combined with metronidazole in the treatment of Mammary Duct Ectasia (MDE) and its relationship with changes in serum interleukin-10 (IL-10) and IL-17 expression. METHODS One hundred and twenty patients with MDE were divided into two groups randomly, control and observation groups (each n = 60). Another 50 patients with normal physical examination were recruited in the normal group. The expressions of serum IL-10 and IL-17 in three groups before and after treatment were observed. The prediction value of IL-10 and IL-17 in clinical efficacy was evaluated. RESULTS Among three groups, the expression of IL-10 in the normal group was the highest (P
