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Hans Luders - One of the best experts on this subject based on the ideXlab platform.

  • in response to commentary on cavernoma related epilepsy review and recommendations for Management Report of the surgical task force of the ilae commission on therapeutic strategies
    Epilepsia, 2014
    Co-Authors: Felix Rosenow, Mario Alonsovanegas, Christoph Baumgartner, Ingmar Blumcke, Mar Carreno, Elke R Gizewski, Hajo M Hamer, Susanne Knake, Philippe Kahane, Hans Luders
    Abstract:

    GRAY MATTERS In response to commentary on cavernoma- related epilepsy: Review and recommendations for Management— Report of the surgical task force of the ILAE commission on therapeutic strategies To the Editors: We thank Dr. Giulioni and colleagues for their interest in our recommendations for the Management of caverno- ma-related epilepsy and their comments regarding inva- sive and noninvasive evaluation of these patients. 1 We agree with Dr. Giulioni that unnecessary invasive evalua- tion should be avoided whenever possible in order to min- imize the risk of complications. Invasive evaluation is not recommended as a general rule in our review, but should be limited to certain specific situations mentioned in our recommendations such as discordant results in noninva- sive video-EEG monitoring (VEM) or epileptogenic cavernomas close to eloquent cortex. 2 In these cases, invasive evaluation including mapping of adjacent cortex can be useful to define the localization and extent of the epileptogenic zone and can provide information that helps to resect as much epileptogenic tissue as possible while avoiding eloquent areas. In addition, invasive VEM might be considered in situations where patients could not be rendered seizure free after resection of the cavernoma. In any case, invasive evaluation should certainly be consid- ered only after noninvasive methods have been exploited. We also agree with Dr. Giulioni and colleagues that for some associated pathologies detection by magnetic reso- nance imaging (MRI) is a challenge, which emphasizes the need for more advanced MRI techniques and stronger field strengths as well as histopathologic evaluation. D ISCLOSURE None of the authors has any conflict of interest to disclose that are rele- vant to this manuscript. We confirm that we have read the Journal’s posi- tion on issues involved in ethical publication and affirm that this Report is consistent with those guidelines. Felix Rosenow* 1 rosenow@med.uni-marburg.de Mario A. Alonso-Vanegas 2 Christoph Baumgartner 3 Ingmar Bl€ umcke 4 Mar Carre~ no 5 Elke R. Gizewski 6 Hajo M. Hamer 7 Susanne Knake 1 Philippe Kahane 8 Hans O. L€ uders 9 Gary W. Mathern 10 Katja Menzler 1 Jonathan Miller 11 Epilepsia, 55(3):465–469, 2014 Taisuke Otsuki 12 Cigdem Ozkara 13 Asla Pitk€ anen 14,15 Steven N. Roper 16 Americo C. Sakamoto 17 Ulrich Sure 18 Matthew C. Walker 19 Bernhard J. Steinhoff 20 for the Surgical Task Force, Commission on Therapeutic Strategies of the ILAE Department of Neurology, Epilepsy Center Hessen, University Hospital and Philipps-University Marburg, Marburg, Germany; ABC Neurological Center & National Institute of Neurology and Neurosurgery, M exico City, Mexico; Second Neurological Department, Karl Landsteiner Institute for Clinical Epilepsy Research and Cognitive Neurology, General Hospital Hietzing with Neurological Center Rosenh€ ugel, Vienna, Austria; Department of Neuropathology, University Hospitals Erlangen, Friedrich-Alexander University Erlangen- Nuremberg, Erlangen, Germany; Clinical Institute of Neurosciences, Epilepsy Unit, Hospital Clinic of Barcelona, Barcelona, Spain; Department of Radiology, University Clinic for Neuroradiology, Medical University Innsbruck, Innsbruck, Austria; Department of Neurology, Epilepsy Center Erlangen, University Hospitals Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany; Department of Neurology and GIN INSERM U836-UJF- CEA, University Hospital of Grenoble, Grenoble, France; Department of Neurosurgery, Epilepsy Center, University Hospitals Case Medical Center/Case Western Reserve University, Cleveland, Ohio, U.S.A.; Departments of Neurosurgery and Psychiatry & BioBehavioral Medicine, David Geffen School of Medicine, Mattel Children’s Hospital, University of California, Los Angeles, California, U.S.A.; Department of Neurosurgery, University Hospitals Case Medical Center/Case Western Reserve University, Cleveland, Ohio, U.S.A.; Epilepsy Center, National Center of Neurology and Psychiatry, Tokyo, Japan; Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland (UEF), Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland; Department of Neurosurgery, University of Florida, Gainesville, Florida, U.S.A.; Department of Neurosciences and Behavioral Science, Ribeir~ ao Preto School of Medicine, University of S~ ao

  • cavernoma related epilepsy review and recommendations for Management Report of the surgical task force of the ilae commission on therapeutic strategies
    Epilepsia, 2013
    Co-Authors: Felix Rosenow, Mario Alonsovanegas, Christoph Baumgartner, Ingmar Blumcke, Elke R Gizewski, Hajo M Hamer, Susanne Knake, Philippe Kahane, Maria Carreno, Hans Luders
    Abstract:

    Cerebral cavernous malformations (CCMs) are well-defined, mostly singular lesions present in 0.4-0.9% of the population. Epileptic seizures are the most frequent symptom in patients with CCMs and have a great impact on social function and quality of life. However, patients with CCM-related epilepsy (CRE) who undergo surgical resection achieve postoperative seizure freedom in only about 75% of cases. This is frequently because insufficient efforts are made to adequately define and resect the epileptogenic zone. The Surgical Task Force of the Commission on Therapeutics of the International League Against Epilepsy (ILAE) and invited experts reviewed the pertinent literature on CRE. Definitions of definitive and probable CRE are suggested, and recommendations regarding the diagnostic evaluation and etiology-specific Management of patients with CRE are made. Prospective trials are needed to determine when and how surgery should be done and to define the relations of the hemosiderin rim to the epileptogenic zone.

Daniel I Bromage - One of the best experts on this subject based on the ideXlab platform.

  • the impact of covid 19 on heart failure hospitalization and Management Report from a heart failure unit in london during the peak of the pandemic
    European Journal of Heart Failure, 2020
    Co-Authors: Daniel I Bromage, Antonio Cannata, Irfan A Rind, Caterina Gregorio, Susan Piper, Ajay M Shah, Theresa Mcdonagh
    Abstract:

    Aims To examine the impact of COVID-19 on acute heart failure (AHF) hospitalization rates, clinical characteristics and Management of patients admitted to a tertiary Heart Failure Unit in London during the peak of the pandemic. Methods and results Data from King's College Hospital, London, Reported to the National Heart Failure Audit for England and Wales, between 2 March-19 April 2020 were compared both to a pre-COVID cohort and the corresponding time periods in 2017 to 2019 with respect to absolute hospitalization rates. Furthermore, we performed detailed comparison of patients hospitalized during the COVID-19 pandemic and patients presenting in the same period in 2019 with respect to clinical characteristics and Management during the index admission. A significantly lower admission rate for AHF was observed during the study period compared to all other included time periods. Patients admitted during the COVID-19 pandemic had higher rates of New York Heart Association III or IV symptoms (96% vs. 77%, P = 0.03) and severe peripheral oedema (39% vs. 14%, P = 0.01). We did not observe any differences in inpatient Management, including place of care and pharmacological Management of heart failure with reduced ejection fraction. Conclusion Incident AHF hospitalization significantly declined in our centre during the COVID-19 pandemic, but hospitalized patients had more severe symptoms at admission. Further studies are needed to investigate whether the incidence of AHF declined or patients did not present to hospital while the national lockdown and social distancing restrictions were in place. From a public health perspective, it is imperative to ascertain whether this will be associated with worse long-term outcomes.

Felix Rosenow - One of the best experts on this subject based on the ideXlab platform.

  • in response to commentary on cavernoma related epilepsy review and recommendations for Management Report of the surgical task force of the ilae commission on therapeutic strategies
    Epilepsia, 2014
    Co-Authors: Felix Rosenow, Mario Alonsovanegas, Christoph Baumgartner, Ingmar Blumcke, Mar Carreno, Elke R Gizewski, Hajo M Hamer, Susanne Knake, Philippe Kahane, Hans Luders
    Abstract:

    GRAY MATTERS In response to commentary on cavernoma- related epilepsy: Review and recommendations for Management— Report of the surgical task force of the ILAE commission on therapeutic strategies To the Editors: We thank Dr. Giulioni and colleagues for their interest in our recommendations for the Management of caverno- ma-related epilepsy and their comments regarding inva- sive and noninvasive evaluation of these patients. 1 We agree with Dr. Giulioni that unnecessary invasive evalua- tion should be avoided whenever possible in order to min- imize the risk of complications. Invasive evaluation is not recommended as a general rule in our review, but should be limited to certain specific situations mentioned in our recommendations such as discordant results in noninva- sive video-EEG monitoring (VEM) or epileptogenic cavernomas close to eloquent cortex. 2 In these cases, invasive evaluation including mapping of adjacent cortex can be useful to define the localization and extent of the epileptogenic zone and can provide information that helps to resect as much epileptogenic tissue as possible while avoiding eloquent areas. In addition, invasive VEM might be considered in situations where patients could not be rendered seizure free after resection of the cavernoma. In any case, invasive evaluation should certainly be consid- ered only after noninvasive methods have been exploited. We also agree with Dr. Giulioni and colleagues that for some associated pathologies detection by magnetic reso- nance imaging (MRI) is a challenge, which emphasizes the need for more advanced MRI techniques and stronger field strengths as well as histopathologic evaluation. D ISCLOSURE None of the authors has any conflict of interest to disclose that are rele- vant to this manuscript. We confirm that we have read the Journal’s posi- tion on issues involved in ethical publication and affirm that this Report is consistent with those guidelines. Felix Rosenow* 1 rosenow@med.uni-marburg.de Mario A. Alonso-Vanegas 2 Christoph Baumgartner 3 Ingmar Bl€ umcke 4 Mar Carre~ no 5 Elke R. Gizewski 6 Hajo M. Hamer 7 Susanne Knake 1 Philippe Kahane 8 Hans O. L€ uders 9 Gary W. Mathern 10 Katja Menzler 1 Jonathan Miller 11 Epilepsia, 55(3):465–469, 2014 Taisuke Otsuki 12 Cigdem Ozkara 13 Asla Pitk€ anen 14,15 Steven N. Roper 16 Americo C. Sakamoto 17 Ulrich Sure 18 Matthew C. Walker 19 Bernhard J. Steinhoff 20 for the Surgical Task Force, Commission on Therapeutic Strategies of the ILAE Department of Neurology, Epilepsy Center Hessen, University Hospital and Philipps-University Marburg, Marburg, Germany; ABC Neurological Center & National Institute of Neurology and Neurosurgery, M exico City, Mexico; Second Neurological Department, Karl Landsteiner Institute for Clinical Epilepsy Research and Cognitive Neurology, General Hospital Hietzing with Neurological Center Rosenh€ ugel, Vienna, Austria; Department of Neuropathology, University Hospitals Erlangen, Friedrich-Alexander University Erlangen- Nuremberg, Erlangen, Germany; Clinical Institute of Neurosciences, Epilepsy Unit, Hospital Clinic of Barcelona, Barcelona, Spain; Department of Radiology, University Clinic for Neuroradiology, Medical University Innsbruck, Innsbruck, Austria; Department of Neurology, Epilepsy Center Erlangen, University Hospitals Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany; Department of Neurology and GIN INSERM U836-UJF- CEA, University Hospital of Grenoble, Grenoble, France; Department of Neurosurgery, Epilepsy Center, University Hospitals Case Medical Center/Case Western Reserve University, Cleveland, Ohio, U.S.A.; Departments of Neurosurgery and Psychiatry & BioBehavioral Medicine, David Geffen School of Medicine, Mattel Children’s Hospital, University of California, Los Angeles, California, U.S.A.; Department of Neurosurgery, University Hospitals Case Medical Center/Case Western Reserve University, Cleveland, Ohio, U.S.A.; Epilepsy Center, National Center of Neurology and Psychiatry, Tokyo, Japan; Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland (UEF), Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland; Department of Neurosurgery, University of Florida, Gainesville, Florida, U.S.A.; Department of Neurosciences and Behavioral Science, Ribeir~ ao Preto School of Medicine, University of S~ ao

  • cavernoma related epilepsy review and recommendations for Management Report of the surgical task force of the ilae commission on therapeutic strategies
    Epilepsia, 2013
    Co-Authors: Felix Rosenow, Mario Alonsovanegas, Christoph Baumgartner, Ingmar Blumcke, Elke R Gizewski, Hajo M Hamer, Susanne Knake, Philippe Kahane, Maria Carreno, Hans Luders
    Abstract:

    Cerebral cavernous malformations (CCMs) are well-defined, mostly singular lesions present in 0.4-0.9% of the population. Epileptic seizures are the most frequent symptom in patients with CCMs and have a great impact on social function and quality of life. However, patients with CCM-related epilepsy (CRE) who undergo surgical resection achieve postoperative seizure freedom in only about 75% of cases. This is frequently because insufficient efforts are made to adequately define and resect the epileptogenic zone. The Surgical Task Force of the Commission on Therapeutics of the International League Against Epilepsy (ILAE) and invited experts reviewed the pertinent literature on CRE. Definitions of definitive and probable CRE are suggested, and recommendations regarding the diagnostic evaluation and etiology-specific Management of patients with CRE are made. Prospective trials are needed to determine when and how surgery should be done and to define the relations of the hemosiderin rim to the epileptogenic zone.

Theresa Mcdonagh - One of the best experts on this subject based on the ideXlab platform.

  • the impact of covid 19 on heart failure hospitalization and Management Report from a heart failure unit in london during the peak of the pandemic
    European Journal of Heart Failure, 2020
    Co-Authors: Daniel I Bromage, Antonio Cannata, Irfan A Rind, Caterina Gregorio, Susan Piper, Ajay M Shah, Theresa Mcdonagh
    Abstract:

    Aims To examine the impact of COVID-19 on acute heart failure (AHF) hospitalization rates, clinical characteristics and Management of patients admitted to a tertiary Heart Failure Unit in London during the peak of the pandemic. Methods and results Data from King's College Hospital, London, Reported to the National Heart Failure Audit for England and Wales, between 2 March-19 April 2020 were compared both to a pre-COVID cohort and the corresponding time periods in 2017 to 2019 with respect to absolute hospitalization rates. Furthermore, we performed detailed comparison of patients hospitalized during the COVID-19 pandemic and patients presenting in the same period in 2019 with respect to clinical characteristics and Management during the index admission. A significantly lower admission rate for AHF was observed during the study period compared to all other included time periods. Patients admitted during the COVID-19 pandemic had higher rates of New York Heart Association III or IV symptoms (96% vs. 77%, P = 0.03) and severe peripheral oedema (39% vs. 14%, P = 0.01). We did not observe any differences in inpatient Management, including place of care and pharmacological Management of heart failure with reduced ejection fraction. Conclusion Incident AHF hospitalization significantly declined in our centre during the COVID-19 pandemic, but hospitalized patients had more severe symptoms at admission. Further studies are needed to investigate whether the incidence of AHF declined or patients did not present to hospital while the national lockdown and social distancing restrictions were in place. From a public health perspective, it is imperative to ascertain whether this will be associated with worse long-term outcomes.

Jaiswal, Durgesh Kumar - One of the best experts on this subject based on the ideXlab platform.

  • The Future Digital Work Force: Robotic Process Automation (RPA)
    2019
    Co-Authors: Madakam Somayya, Holmukhe, Rajesh M., Jaiswal, Durgesh Kumar
    Abstract:

    Abstract The Robotic Process Automation (RPA) is a new wave of the future technologies. Robotic Process Automation is one of the most advanced technologies in the area of computers science, electronic and communications, mechanical engineering and information technology. It is a combination of both hardware and software, networking and automation for doing things very simple. In this light, the research manuscript investigated the secondary data - which is available in google, academic and research databases. The investigation went for totally 6 months, i.e., 1-1-2018 to 30-6-2018. A very few empirical articles, white papers, blogs and were found RPA and came across to compose this research manuscript. This study is exploratory in nature because of the contemporary phenomenon. The keywords used in searching of the database were Robotic Process Automation, RPA, Robots, Artificial Intelligence, Blue Prism. The study finally discovered that Robots and Robotic Process Automation technologies are becoming compulsory as a part to do business operations in the organizations across the globe. Robotic Process Automation can bring immediate value to the core business processes including employee payroll, employee status changes, new hire recruitment and on boarding, accounts receivable and payable, invoice processing, inventory Management, Report creation, software installations, data migration, and vendor on boarding etc. to name a few applications. Besides, the Robotic Process Automation has abundant applications including healthcare and pharmaceuticals, financial services, outsourcing, retail, telecom, energy and utilities, real estate and FMCG and many more sectors. To put in the right place of RPA in business operations, their many allied technologies are working at the background level, artificial intelligence, machine learning, deep learning, data analytics, HR analytics, virtual reality (second life), home automation, blockchain technologies, 4D printing etc. Moreover, it covers the content of different start-ups companies and existing companies - their RPA applications used across the world. This manuscript will be a good guideline for the academicians, researchers, students, and practitioners to get an overall idea