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Mergler Donna - One of the best experts on this subject based on the ideXlab platform.

  • Manganese concentrations in drinking water from villages near banana plantations with aerial Mancozeb spraying in Costa Rica: Results from the Infants' Environmental Health Study (ISA)
    The Authors. Published by Elsevier Ltd., 2016
    Co-Authors: Van Wendel De Joode, Berna, Barbeau Benoit, Bouchard, Maryse F., Mora, Ana María, Skytt Åsa, Córdoba Leonel, Quesada Rosario, Lundh Thomas, Lindh, Christian H., Mergler Donna
    Abstract:

    AbstractElevated manganese (Mn) in drinking water has been reported worldwide. While, naturally occurring Mn in groundwater is generally the major source, anthropogenic contamination by Mn-containing fungicides such as Mancozeb may also occur. The main objective of this study was to examine factors associated with Mn and ethylenethiourea (ETU), a degradation product of Mancozeb, in drinking water samples from villages situated near banana plantations with aerial spraying of Mancozeb. Drinking water samples (n = 126) were obtained from 124 homes of women participating in the Infants' Environmental Health Study (ISA, for its acronym in Spanish), living nearby large-scale banana plantations. Concentrations of Mn, iron (Fe), arsenic (As), lead (Pb), cadmium (Cd) and ethylenethiourea (ETU), a degradation product of Mancozeb, were measured in water samples. Only six percent of samples had detectable ETU concentrations (limit of detection (LOD) = 0.15 μg/L), whereas 94% of the samples had detectable Mn (LOD = 0.05 μg/L). Mn concentrations were higher than 100 and 500 μg/L in 22% and 7% of the samples, respectively. Mn was highest in samples from private and banana farm wells. Distance from a banana plantation was inversely associated with Mn concentrations, with a 61.5% decrease (95% CI: −97.0, −26.0) in Mn concentrations for each km increase in distance. Mn concentrations in water transported with trucks from one village to another were almost 1000 times higher than Mn in water obtained from taps in houses supplied by the same well but not transported, indicating environmental Mn contamination. Elevated Mn in drinking water may be partly explained by aerial spraying of Mancozeb; however, naturally occurring Mn in groundwater, and intensive agriculture may also contribute. Drinking water risk assessment for Mancozeb should consider Mn as a health hazard. The findings of this study evidence the need for health-based World Health Organization (WHO) guidelines on Mn in drinking water

  • Manganese concentrations in drinking water from villages near banana plantations with aerial Mancozeb spraying in Costa Rica: Results from the Infants' Environmental Health Study (ISA)
    'Elsevier BV', 2016
    Co-Authors: Van Wendel De Joode, Berna, Barbeau Benoit, Bouchard, Maryse F., Mora, Ana María, Skytt Åsa, Córdoba Leonel, Quesada Rosario, Lundh Thomas, Lindh, Christian H., Mergler Donna
    Abstract:

    Elevated manganese (Mn) in drinking water has been reported worldwide. While, naturally occurring Mn in groundwater is generally the major source, anthropogenic contamination by Mn-containing fungicides such as Mancozeb may also occur. The main objective of this study was to examine factors associated with Mn and ethylenethiourea (ETU), a degradation product of Mancozeb, in drinking water samples from villages situated near banana plantations with aerial spraying of Mancozeb. Drinking water samples (n = 126) were obtained from 124 homes of women participating in the Infants' Environmental Health Study (ISA, for its acronym in Spanish), living nearby large-scale banana plantations. Concentrations of Mn, iron (Fe), arsenic (As), lead (Pb), cadmium (Cd) and ethylenethiourea (ETU), a degradation product of Mancozeb, were measured in water samples. Only six percent of samples had detectable ETU concentrations (limit of detection (LOD) = 0.15 mu g/L), whereas 94% of the samples had detectable Mn (LOD = 0.05 mu g/L). Mn concentrations were higher than 100 and 500 mu g/L in 22% and 7% of the samples, respectively. Mn was highest in samples from private and banana farm wells. Distance from a banana plantation was inversely associated with Mn concentrations, with a 61.5% decrease (95% CI: 97.0, 26.0) in Mn concentrations for each km increase in distance. Mn concentrations in water transported with trucks from one village to another were almost 1000 times higher than Mn in water obtained from taps in houses supplied by the same well but not transported, indicating environmental Mn contamination. Elevated Mn in drinking water may be partly explained by aerial spraying of Mancozeb; however, naturally occurring Mn in groundwater, and intensive agriculture may also contribute. Drinking water risk assessment for Mancozeb should consider Mn as a health hazard. The findings of this study evidence the need for health-based World Health Organization (WHO) guidelines on Mn in drinking water. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.orgilicensesiby-nc-nd/4.0/)

  • Manganese concentrations in drinking water from villages near banana plantations with aerial Mancozeb spraying in Costa Rica: Results from the Infants' Environmental Health Study (ISA)
    'Elsevier BV', 2016
    Co-Authors: Van Wendel De Joode, Berna, Barbeau Benoit, Mora, Ana María, Skytt Åsa, Córdoba Leonel, Quesada Rosario, Lundh Thomas, Bouchard Maryse, Lindh Christian, Mergler Donna
    Abstract:

    Elevated manganese (Mn) in drinking water has been reported worldwide. While, naturally occurring Mn in groundwater is generally the major source, anthropogenic contamination by Mn-containing fungicides such as Mancozeb may also occur. The main objective of this study was to examine factors associated with Mn and ethylenethiourea (ETU), a degradation product of Mancozeb, in drinking water samples from villages situated near banana plantations with aerial spraying of Mancozeb. Drinking water samples (n ¼ 126) were obtained from 124 homes of women participating in the Infants' Environmental Health Study (ISA, for its acronym in Spanish), living nearby large-scale banana plantations. Concentrations of Mn, iron (Fe), arsenic (As), lead (Pb), cadmium (Cd) and ethylenethiourea (ETU), a degradation product of Mancozeb, were measured in water samples. Only six percent of samples had detectable ETU concentrations (limit of detection (LOD) ¼ 0.15 mg/L), whereas 94% of the samples had detectable Mn (LOD ¼ 0.05 mg/L). Mn concentrations were higher than 100 and 500 mg/L in 22% and 7% of the samples, respectively. Mn was highest in samples from private and banana farm wells. Distance from a banana plantationwas inversely associated with Mn concentrations, with a 61.5% decrease (95% CI: 97.0, 26.0) in Mn concentrations for each km increase in distance. Mn concentrations in water transported with trucks from one village to another were almost 1000 times higher than Mn in water obtained from taps in houses supplied by the same well but not transported, indicating environmental Mn contamination. Elevated Mn in drinking water may be partly explained by aerial spraying of Mancozeb; however, naturally occurring Mn in groundwater, and intensive agriculture may also contribute. Drinking water risk assessment for Mancozeb should consider Mn as a health hazard. The findings of this study evidence the need for health-based World Health Organization (WHO) guidelines on Mn in drinking water.En todo el mundo se ha informado de la presencia de elevados niveles de manganeso (Mn) en el agua potable. Mientras que, en la naturaleza El Mn en las aguas subterráneas es generalmente la principal fuente, la contaminación antropogénica por el Mn que contiene También pueden aparecer fungicidas como el Mancozeb. El principal objetivo de este estudio fue examinar los factores asociado con el Mn y la etilenotiourea (ETU), un producto de la degradación del Mancozeb, en el agua potable muestras de aldeas situadas cerca de plantaciones de plátanos con fumigación aérea de Mancozeb. El agua potable muestras (n ¼ 126) se obtuvieron de 124 hogares de mujeres que participan en el programa de Estudio de la Salud (ISA), viviendo cerca de plantaciones de bananas a gran escala. Las concentraciones de Mn, hierro (Fe), arsénico (As), plomo (Pb), cadmio (Cd) y etilenotiourea (ETU), una degradación producto del Mancozeb, se midieron en muestras de agua. Sólo el seis por ciento de las muestras tenían ETU detectable (límite de detección (LOD) ¼ 0,15 mg/L), mientras que el 94% de las muestras tenían Mn detectable (LOD ¼ 0.05 mg/L). Las concentraciones de Mn fueron superiores a 100 y 500 mg/L en el 22% y 7% de las muestras, respectivamente. El Mn fue más alto en muestras de pozos privados y de granjas bananeras. La distancia de una banana La plantación se asoció inversamente a las concentraciones de Mn, con una disminución del 61,5% (IC del 95%: 97,0, 26,0) en las concentraciones de Mn por cada km de aumento de la distancia. Las concentraciones de Mn en el agua transportada con los camiones de una aldea a otra eran casi 1000 veces más altos que el Mn en el agua obtenida de los grifos en casas abastecidas por el mismo pozo pero no transportadas, lo que indica una contaminación ambiental de Mn. El Mn elevado en el agua potable puede explicarse en parte por la pulverización aérea de Mancozeb; sin embargo, El Mn natural en las aguas subterráneas y la agricultura intensiva también pueden contribuir. El agua potable La evaluación del riesgo del Mancozeb debe considerar el Mn como un peligro para la salud. Los hallazgos de este estudio evidencian la necesidad de directrices de la Organización Mundial de la Salud (OMS) basadas en la salud sobre el Mn en el agua potable.Universidad Nacional, Costa RicaEcole Polytechnique de Montreal, CanadaUniversity of Montreal, CHUSJ Research Center, CanadaLund University, Lund, SwedenUniversite du Quebec a Montreal, Pavillon des SciencesInstituto Regional de Estudios en Sustancias Tóxicas, Unviersidad Nacional, Costa RicaNSERC-Industrial Chair in Drinking Water, Department of Civil, Mining and Geological Engineering, Ecole Polytechnique de Montreal, CanadaDepartment of Environmental and Occupational Health, University of Montreal, CanadaDivision of Occupational and Environmental Medicine, Lund UniversityCentre de Recherche Interdisciplinaire sur la Biologie, la Santé, la Societe et l' Environnement (CINBIOSE), Universite du Quebec a Montrea

Van Wendel De Joode, Berna - One of the best experts on this subject based on the ideXlab platform.

  • Manganese concentrations in drinking water from villages near banana plantations with aerial Mancozeb spraying in Costa Rica: Results from the Infants' Environmental Health Study (ISA)
    The Authors. Published by Elsevier Ltd., 2016
    Co-Authors: Van Wendel De Joode, Berna, Barbeau Benoit, Bouchard, Maryse F., Mora, Ana María, Skytt Åsa, Córdoba Leonel, Quesada Rosario, Lundh Thomas, Lindh, Christian H., Mergler Donna
    Abstract:

    AbstractElevated manganese (Mn) in drinking water has been reported worldwide. While, naturally occurring Mn in groundwater is generally the major source, anthropogenic contamination by Mn-containing fungicides such as Mancozeb may also occur. The main objective of this study was to examine factors associated with Mn and ethylenethiourea (ETU), a degradation product of Mancozeb, in drinking water samples from villages situated near banana plantations with aerial spraying of Mancozeb. Drinking water samples (n = 126) were obtained from 124 homes of women participating in the Infants' Environmental Health Study (ISA, for its acronym in Spanish), living nearby large-scale banana plantations. Concentrations of Mn, iron (Fe), arsenic (As), lead (Pb), cadmium (Cd) and ethylenethiourea (ETU), a degradation product of Mancozeb, were measured in water samples. Only six percent of samples had detectable ETU concentrations (limit of detection (LOD) = 0.15 μg/L), whereas 94% of the samples had detectable Mn (LOD = 0.05 μg/L). Mn concentrations were higher than 100 and 500 μg/L in 22% and 7% of the samples, respectively. Mn was highest in samples from private and banana farm wells. Distance from a banana plantation was inversely associated with Mn concentrations, with a 61.5% decrease (95% CI: −97.0, −26.0) in Mn concentrations for each km increase in distance. Mn concentrations in water transported with trucks from one village to another were almost 1000 times higher than Mn in water obtained from taps in houses supplied by the same well but not transported, indicating environmental Mn contamination. Elevated Mn in drinking water may be partly explained by aerial spraying of Mancozeb; however, naturally occurring Mn in groundwater, and intensive agriculture may also contribute. Drinking water risk assessment for Mancozeb should consider Mn as a health hazard. The findings of this study evidence the need for health-based World Health Organization (WHO) guidelines on Mn in drinking water

  • Manganese concentrations in drinking water from villages near banana plantations with aerial Mancozeb spraying in Costa Rica: Results from the Infants' Environmental Health Study (ISA)
    'Elsevier BV', 2016
    Co-Authors: Van Wendel De Joode, Berna, Barbeau Benoit, Bouchard, Maryse F., Mora, Ana María, Skytt Åsa, Córdoba Leonel, Quesada Rosario, Lundh Thomas, Lindh, Christian H., Mergler Donna
    Abstract:

    Elevated manganese (Mn) in drinking water has been reported worldwide. While, naturally occurring Mn in groundwater is generally the major source, anthropogenic contamination by Mn-containing fungicides such as Mancozeb may also occur. The main objective of this study was to examine factors associated with Mn and ethylenethiourea (ETU), a degradation product of Mancozeb, in drinking water samples from villages situated near banana plantations with aerial spraying of Mancozeb. Drinking water samples (n = 126) were obtained from 124 homes of women participating in the Infants' Environmental Health Study (ISA, for its acronym in Spanish), living nearby large-scale banana plantations. Concentrations of Mn, iron (Fe), arsenic (As), lead (Pb), cadmium (Cd) and ethylenethiourea (ETU), a degradation product of Mancozeb, were measured in water samples. Only six percent of samples had detectable ETU concentrations (limit of detection (LOD) = 0.15 mu g/L), whereas 94% of the samples had detectable Mn (LOD = 0.05 mu g/L). Mn concentrations were higher than 100 and 500 mu g/L in 22% and 7% of the samples, respectively. Mn was highest in samples from private and banana farm wells. Distance from a banana plantation was inversely associated with Mn concentrations, with a 61.5% decrease (95% CI: 97.0, 26.0) in Mn concentrations for each km increase in distance. Mn concentrations in water transported with trucks from one village to another were almost 1000 times higher than Mn in water obtained from taps in houses supplied by the same well but not transported, indicating environmental Mn contamination. Elevated Mn in drinking water may be partly explained by aerial spraying of Mancozeb; however, naturally occurring Mn in groundwater, and intensive agriculture may also contribute. Drinking water risk assessment for Mancozeb should consider Mn as a health hazard. The findings of this study evidence the need for health-based World Health Organization (WHO) guidelines on Mn in drinking water. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.orgilicensesiby-nc-nd/4.0/)

  • Manganese concentrations in drinking water from villages near banana plantations with aerial Mancozeb spraying in Costa Rica: Results from the Infants' Environmental Health Study (ISA)
    'Elsevier BV', 2016
    Co-Authors: Van Wendel De Joode, Berna, Barbeau Benoit, Mora, Ana María, Skytt Åsa, Córdoba Leonel, Quesada Rosario, Lundh Thomas, Bouchard Maryse, Lindh Christian, Mergler Donna
    Abstract:

    Elevated manganese (Mn) in drinking water has been reported worldwide. While, naturally occurring Mn in groundwater is generally the major source, anthropogenic contamination by Mn-containing fungicides such as Mancozeb may also occur. The main objective of this study was to examine factors associated with Mn and ethylenethiourea (ETU), a degradation product of Mancozeb, in drinking water samples from villages situated near banana plantations with aerial spraying of Mancozeb. Drinking water samples (n ¼ 126) were obtained from 124 homes of women participating in the Infants' Environmental Health Study (ISA, for its acronym in Spanish), living nearby large-scale banana plantations. Concentrations of Mn, iron (Fe), arsenic (As), lead (Pb), cadmium (Cd) and ethylenethiourea (ETU), a degradation product of Mancozeb, were measured in water samples. Only six percent of samples had detectable ETU concentrations (limit of detection (LOD) ¼ 0.15 mg/L), whereas 94% of the samples had detectable Mn (LOD ¼ 0.05 mg/L). Mn concentrations were higher than 100 and 500 mg/L in 22% and 7% of the samples, respectively. Mn was highest in samples from private and banana farm wells. Distance from a banana plantationwas inversely associated with Mn concentrations, with a 61.5% decrease (95% CI: 97.0, 26.0) in Mn concentrations for each km increase in distance. Mn concentrations in water transported with trucks from one village to another were almost 1000 times higher than Mn in water obtained from taps in houses supplied by the same well but not transported, indicating environmental Mn contamination. Elevated Mn in drinking water may be partly explained by aerial spraying of Mancozeb; however, naturally occurring Mn in groundwater, and intensive agriculture may also contribute. Drinking water risk assessment for Mancozeb should consider Mn as a health hazard. The findings of this study evidence the need for health-based World Health Organization (WHO) guidelines on Mn in drinking water.En todo el mundo se ha informado de la presencia de elevados niveles de manganeso (Mn) en el agua potable. Mientras que, en la naturaleza El Mn en las aguas subterráneas es generalmente la principal fuente, la contaminación antropogénica por el Mn que contiene También pueden aparecer fungicidas como el Mancozeb. El principal objetivo de este estudio fue examinar los factores asociado con el Mn y la etilenotiourea (ETU), un producto de la degradación del Mancozeb, en el agua potable muestras de aldeas situadas cerca de plantaciones de plátanos con fumigación aérea de Mancozeb. El agua potable muestras (n ¼ 126) se obtuvieron de 124 hogares de mujeres que participan en el programa de Estudio de la Salud (ISA), viviendo cerca de plantaciones de bananas a gran escala. Las concentraciones de Mn, hierro (Fe), arsénico (As), plomo (Pb), cadmio (Cd) y etilenotiourea (ETU), una degradación producto del Mancozeb, se midieron en muestras de agua. Sólo el seis por ciento de las muestras tenían ETU detectable (límite de detección (LOD) ¼ 0,15 mg/L), mientras que el 94% de las muestras tenían Mn detectable (LOD ¼ 0.05 mg/L). Las concentraciones de Mn fueron superiores a 100 y 500 mg/L en el 22% y 7% de las muestras, respectivamente. El Mn fue más alto en muestras de pozos privados y de granjas bananeras. La distancia de una banana La plantación se asoció inversamente a las concentraciones de Mn, con una disminución del 61,5% (IC del 95%: 97,0, 26,0) en las concentraciones de Mn por cada km de aumento de la distancia. Las concentraciones de Mn en el agua transportada con los camiones de una aldea a otra eran casi 1000 veces más altos que el Mn en el agua obtenida de los grifos en casas abastecidas por el mismo pozo pero no transportadas, lo que indica una contaminación ambiental de Mn. El Mn elevado en el agua potable puede explicarse en parte por la pulverización aérea de Mancozeb; sin embargo, El Mn natural en las aguas subterráneas y la agricultura intensiva también pueden contribuir. El agua potable La evaluación del riesgo del Mancozeb debe considerar el Mn como un peligro para la salud. Los hallazgos de este estudio evidencian la necesidad de directrices de la Organización Mundial de la Salud (OMS) basadas en la salud sobre el Mn en el agua potable.Universidad Nacional, Costa RicaEcole Polytechnique de Montreal, CanadaUniversity of Montreal, CHUSJ Research Center, CanadaLund University, Lund, SwedenUniversite du Quebec a Montreal, Pavillon des SciencesInstituto Regional de Estudios en Sustancias Tóxicas, Unviersidad Nacional, Costa RicaNSERC-Industrial Chair in Drinking Water, Department of Civil, Mining and Geological Engineering, Ecole Polytechnique de Montreal, CanadaDepartment of Environmental and Occupational Health, University of Montreal, CanadaDivision of Occupational and Environmental Medicine, Lund UniversityCentre de Recherche Interdisciplinaire sur la Biologie, la Santé, la Societe et l' Environnement (CINBIOSE), Universite du Quebec a Montrea

Zhaobing Gao - One of the best experts on this subject based on the ideXlab platform.

  • the ethylene bis dithiocarbamate fungicide Mancozeb activates voltage gated kcnq2 potassium channel
    Toxicology Letters, 2013
    Co-Authors: Jin Zhu, Qingya Kong, Baifeng Jiang, Xia Wan, Jinfeng Yue, Hualiang Jiang, Zhaobing Gao
    Abstract:

    Abstract Mancozeb (manganese/zinc ethylene bis-dithiocarbamate) is an organometallic fungicide that has been associated with human neurotoxicity and neurodegeneration. In a high-throughput screen for modulators of KCNQ2 channel, a fundamental player modulating neuronal excitability, Mancozeb, was found to significantly potentiate KCNQ2 activity. Mancozeb was validated electrophysiologically as a KCNQ2 activator with an EC 50 value of 0.92 ± 0.23 μM. Further examination showed that manganese but not zinc ethylene bis-dithiocarbamate is the active component for the positive modulation effects. In addition, the compounds are effective when the metal ions are substituted by iron but lack potentiation activity when the metal ions are substituted by sodium, signifying the importance of the metal ion. However, the iron (Fe 3+ ) alone, organic ligands alone or the mixture of iron with the organic ligand did not show any potentiation effect, suggesting as the active ingredient is a specific complex rather than two separate additive or synergistic components. Our study suggests that potentiation on KCNQ2 potassium channels might be the possible mechanism of Mancozeb toxicity in the nervous system.

Cesare Maltoni - One of the best experts on this subject based on the ideXlab platform.

  • results of long term experimental studies on the carcinogenicity of ethylene bis dithiocarbamate Mancozeb in rats
    Annals of the New York Academy of Sciences, 2006
    Co-Authors: Fiorella Belpoggi, Morando Soffritti, Marina Guarino, Luca Lambertini, Daniela Cevolani, Cesare Maltoni
    Abstract:

    Mancozeb, an ethylene-bis-dithiocarbamate (EBDC), has been one of the most commonly used fungicides in commercial use for several decades. Nevertheless, up to now, no adequate published experimental studies on the carcinogenicity of Mancozeb have been published. Because of the importance of the compound and of the number of people potentially exposed (workers engaged in the production and use of the fungicide, people living in agricultural areas where the compound is sprayed, and people consuming polluted products), a long-term experimental study of Mancozeb was begun at the Cancer Research Center of the Ramazzini Foundation. Groups of 150 male and female Sprague-Dawley rats, 8 weeks old at the start of the treatment, were administered Mancozeb at the concentration of 1000, 500, 100, 10, and 0 ppm in feed supplied ad libitum for 104 weeks. At the end of the treatment, animals were kept under controlled conditions until spontaneous death. Mancozeb caused an increase in (1) total malignant tumors, (2) malignant mammary tumors, (3) Zymbal gland and ear duct carcinomas, (4) hepatocarcinomas, (5) malignant tumors of the pancreas, (6) malignant tumors of the thyroid gland, (7) osteosarcomas of the bones of the head, and (8) hemolymphoreticular neoplasias. On the basis of these data, Mancozeb must be considered a multipotent carcinogenic agent.

Xia Wan - One of the best experts on this subject based on the ideXlab platform.

  • the ethylene bis dithiocarbamate fungicide Mancozeb activates voltage gated kcnq2 potassium channel
    Toxicology Letters, 2013
    Co-Authors: Jin Zhu, Qingya Kong, Baifeng Jiang, Xia Wan, Jinfeng Yue, Hualiang Jiang, Zhaobing Gao
    Abstract:

    Abstract Mancozeb (manganese/zinc ethylene bis-dithiocarbamate) is an organometallic fungicide that has been associated with human neurotoxicity and neurodegeneration. In a high-throughput screen for modulators of KCNQ2 channel, a fundamental player modulating neuronal excitability, Mancozeb, was found to significantly potentiate KCNQ2 activity. Mancozeb was validated electrophysiologically as a KCNQ2 activator with an EC 50 value of 0.92 ± 0.23 μM. Further examination showed that manganese but not zinc ethylene bis-dithiocarbamate is the active component for the positive modulation effects. In addition, the compounds are effective when the metal ions are substituted by iron but lack potentiation activity when the metal ions are substituted by sodium, signifying the importance of the metal ion. However, the iron (Fe 3+ ) alone, organic ligands alone or the mixture of iron with the organic ligand did not show any potentiation effect, suggesting as the active ingredient is a specific complex rather than two separate additive or synergistic components. Our study suggests that potentiation on KCNQ2 potassium channels might be the possible mechanism of Mancozeb toxicity in the nervous system.