The Experts below are selected from a list of 2328 Experts worldwide ranked by ideXlab platform

Hongyu Li - One of the best experts on this subject based on the ideXlab platform.

  • coordination of humoral immune factors dictates compatibility between schistosoma mansoni and biomphalaria glabrata
    eLife, 2020
    Co-Authors: Hongyu Li, Jacob R Hambrook, Emmanuel A Pila, Abdullah A Gharamah, Jing Fang, Xinzhong Wu, Patrick C Hanington
    Abstract:

    : Immune factors in snails of the genus Biomphalaria are critical for combating Schistosoma mansoni, the predominant cause of human intestinal schistosomiasis. Independently, many of these factors play an important role in, but do not fully define, the compatibility between the model snail B. glabrata, and S. mansoni. Here, we demonstrate association between four previously characterized humoral immune molecules; BgFREP3, BgTEP1, BgFREP2 and Biomphalysin. We also identify unique immune determinants in the plasma of S. mansoni-resistant B. glabrata that associate with the incompatible phenotype. These factors coordinate to initiate haemocyte-mediated destruction of S. mansoni sporocysts via production of reactive oxygen species. The inclusion of BgFREP2 in a BgFREP3-initiated complex that also includes BgTEP1 almost completely explains resistance to S. mansoni in this model. Our study unifies many independent lines of investigation to provide a more comprehensive understanding of the snail immune system in the context of infection by this important human parasite.

  • coordination of humoral immune factors dictates compatibility between schistosoma mansoni and biomphalaria glabrata
    bioRxiv, 2019
    Co-Authors: Hongyu Li, Jacob R Hambrook, Emmanuel A Pila, Abdullah A Gharamah, Jing Fang, Xinzhong Wu, Patrick C Hanington
    Abstract:

    Immune factors in snails of the genus Biomphalaria are critical for combating Schistosoma mansoni, the predominant cause of human intestinal schistosomiasis. Independently, many of these factors are known to play an important role in, but not fully define, the compatibility between the model snail B. glabrata, and S. mansoni. Here, we demonstrate association between four, previously characterized humoral immune molecules; BgFREP3, BgTEP1, BgFREP2 and Biomphalysin. We also identify unique immune determinants in the plasma of S. mansoni-resistant B. glabrata that explain the incompatible phenotype. These factors coordinate to initiate haemocyte-mediated deestruction of S. mansoni sporocysts via production of reactive oxygen species. The inclusion of BgFREP2 in a BgFREP3-initiated complex that also includes BgTEP1 almost completely explains resistance to S. mansoni in this model. Our study unifies many independent lines of investigation to provide a more comprehensive understanding of the snail immune system in the context of infection by this important human parasite.

Patrick C Hanington - One of the best experts on this subject based on the ideXlab platform.

  • coordination of humoral immune factors dictates compatibility between schistosoma mansoni and biomphalaria glabrata
    eLife, 2020
    Co-Authors: Hongyu Li, Jacob R Hambrook, Emmanuel A Pila, Abdullah A Gharamah, Jing Fang, Xinzhong Wu, Patrick C Hanington
    Abstract:

    : Immune factors in snails of the genus Biomphalaria are critical for combating Schistosoma mansoni, the predominant cause of human intestinal schistosomiasis. Independently, many of these factors play an important role in, but do not fully define, the compatibility between the model snail B. glabrata, and S. mansoni. Here, we demonstrate association between four previously characterized humoral immune molecules; BgFREP3, BgTEP1, BgFREP2 and Biomphalysin. We also identify unique immune determinants in the plasma of S. mansoni-resistant B. glabrata that associate with the incompatible phenotype. These factors coordinate to initiate haemocyte-mediated destruction of S. mansoni sporocysts via production of reactive oxygen species. The inclusion of BgFREP2 in a BgFREP3-initiated complex that also includes BgTEP1 almost completely explains resistance to S. mansoni in this model. Our study unifies many independent lines of investigation to provide a more comprehensive understanding of the snail immune system in the context of infection by this important human parasite.

  • coordination of humoral immune factors dictates compatibility between schistosoma mansoni and biomphalaria glabrata
    bioRxiv, 2019
    Co-Authors: Hongyu Li, Jacob R Hambrook, Emmanuel A Pila, Abdullah A Gharamah, Jing Fang, Xinzhong Wu, Patrick C Hanington
    Abstract:

    Immune factors in snails of the genus Biomphalaria are critical for combating Schistosoma mansoni, the predominant cause of human intestinal schistosomiasis. Independently, many of these factors are known to play an important role in, but not fully define, the compatibility between the model snail B. glabrata, and S. mansoni. Here, we demonstrate association between four, previously characterized humoral immune molecules; BgFREP3, BgTEP1, BgFREP2 and Biomphalysin. We also identify unique immune determinants in the plasma of S. mansoni-resistant B. glabrata that explain the incompatible phenotype. These factors coordinate to initiate haemocyte-mediated deestruction of S. mansoni sporocysts via production of reactive oxygen species. The inclusion of BgFREP2 in a BgFREP3-initiated complex that also includes BgTEP1 almost completely explains resistance to S. mansoni in this model. Our study unifies many independent lines of investigation to provide a more comprehensive understanding of the snail immune system in the context of infection by this important human parasite.

Jing Fang - One of the best experts on this subject based on the ideXlab platform.

  • coordination of humoral immune factors dictates compatibility between schistosoma mansoni and biomphalaria glabrata
    eLife, 2020
    Co-Authors: Hongyu Li, Jacob R Hambrook, Emmanuel A Pila, Abdullah A Gharamah, Jing Fang, Xinzhong Wu, Patrick C Hanington
    Abstract:

    : Immune factors in snails of the genus Biomphalaria are critical for combating Schistosoma mansoni, the predominant cause of human intestinal schistosomiasis. Independently, many of these factors play an important role in, but do not fully define, the compatibility between the model snail B. glabrata, and S. mansoni. Here, we demonstrate association between four previously characterized humoral immune molecules; BgFREP3, BgTEP1, BgFREP2 and Biomphalysin. We also identify unique immune determinants in the plasma of S. mansoni-resistant B. glabrata that associate with the incompatible phenotype. These factors coordinate to initiate haemocyte-mediated destruction of S. mansoni sporocysts via production of reactive oxygen species. The inclusion of BgFREP2 in a BgFREP3-initiated complex that also includes BgTEP1 almost completely explains resistance to S. mansoni in this model. Our study unifies many independent lines of investigation to provide a more comprehensive understanding of the snail immune system in the context of infection by this important human parasite.

  • coordination of humoral immune factors dictates compatibility between schistosoma mansoni and biomphalaria glabrata
    bioRxiv, 2019
    Co-Authors: Hongyu Li, Jacob R Hambrook, Emmanuel A Pila, Abdullah A Gharamah, Jing Fang, Xinzhong Wu, Patrick C Hanington
    Abstract:

    Immune factors in snails of the genus Biomphalaria are critical for combating Schistosoma mansoni, the predominant cause of human intestinal schistosomiasis. Independently, many of these factors are known to play an important role in, but not fully define, the compatibility between the model snail B. glabrata, and S. mansoni. Here, we demonstrate association between four, previously characterized humoral immune molecules; BgFREP3, BgTEP1, BgFREP2 and Biomphalysin. We also identify unique immune determinants in the plasma of S. mansoni-resistant B. glabrata that explain the incompatible phenotype. These factors coordinate to initiate haemocyte-mediated deestruction of S. mansoni sporocysts via production of reactive oxygen species. The inclusion of BgFREP2 in a BgFREP3-initiated complex that also includes BgTEP1 almost completely explains resistance to S. mansoni in this model. Our study unifies many independent lines of investigation to provide a more comprehensive understanding of the snail immune system in the context of infection by this important human parasite.

Xinzhong Wu - One of the best experts on this subject based on the ideXlab platform.

  • coordination of humoral immune factors dictates compatibility between schistosoma mansoni and biomphalaria glabrata
    eLife, 2020
    Co-Authors: Hongyu Li, Jacob R Hambrook, Emmanuel A Pila, Abdullah A Gharamah, Jing Fang, Xinzhong Wu, Patrick C Hanington
    Abstract:

    : Immune factors in snails of the genus Biomphalaria are critical for combating Schistosoma mansoni, the predominant cause of human intestinal schistosomiasis. Independently, many of these factors play an important role in, but do not fully define, the compatibility between the model snail B. glabrata, and S. mansoni. Here, we demonstrate association between four previously characterized humoral immune molecules; BgFREP3, BgTEP1, BgFREP2 and Biomphalysin. We also identify unique immune determinants in the plasma of S. mansoni-resistant B. glabrata that associate with the incompatible phenotype. These factors coordinate to initiate haemocyte-mediated destruction of S. mansoni sporocysts via production of reactive oxygen species. The inclusion of BgFREP2 in a BgFREP3-initiated complex that also includes BgTEP1 almost completely explains resistance to S. mansoni in this model. Our study unifies many independent lines of investigation to provide a more comprehensive understanding of the snail immune system in the context of infection by this important human parasite.

  • coordination of humoral immune factors dictates compatibility between schistosoma mansoni and biomphalaria glabrata
    bioRxiv, 2019
    Co-Authors: Hongyu Li, Jacob R Hambrook, Emmanuel A Pila, Abdullah A Gharamah, Jing Fang, Xinzhong Wu, Patrick C Hanington
    Abstract:

    Immune factors in snails of the genus Biomphalaria are critical for combating Schistosoma mansoni, the predominant cause of human intestinal schistosomiasis. Independently, many of these factors are known to play an important role in, but not fully define, the compatibility between the model snail B. glabrata, and S. mansoni. Here, we demonstrate association between four, previously characterized humoral immune molecules; BgFREP3, BgTEP1, BgFREP2 and Biomphalysin. We also identify unique immune determinants in the plasma of S. mansoni-resistant B. glabrata that explain the incompatible phenotype. These factors coordinate to initiate haemocyte-mediated deestruction of S. mansoni sporocysts via production of reactive oxygen species. The inclusion of BgFREP2 in a BgFREP3-initiated complex that also includes BgTEP1 almost completely explains resistance to S. mansoni in this model. Our study unifies many independent lines of investigation to provide a more comprehensive understanding of the snail immune system in the context of infection by this important human parasite.

Jurg Utzinger - One of the best experts on this subject based on the ideXlab platform.

  • accuracy of urine circulating cathodic antigen test for the diagnosis of schistosoma mansoni in preschool aged children before and after treatment
    PLOS Neglected Tropical Diseases, 2013
    Co-Authors: Jean T Coulibaly, Eliezer K Ngoran, Jurg Utzinger, Yves K Ngbesso, Stefanie Knopp, Nicaise A Nguessan, Kigbafori D Silue
    Abstract:

    The Kato-Katz technique is widely used for the diagnosis of Schistosoma mansoni, but shows low sensitivity in light-intensity infections. We assessed the accuracy of a commercially available point-of-care circulating cathodic antigen (POC-CCA) cassette test for the diagnosis of S. mansoni in preschool-aged children before and after praziquantel administration.; A 3-week longitudinal survey with a treatment intervention was conducted in Azaguie, south Cote d'Ivoire. Overall, 242 preschoolers (age range: 2 months to 5.5 years) submitted two stool and two urine samples before praziquantel administration, and 86 individuals were followed-up posttreatment. Stool samples were examined with duplicate Kato-Katz thick smears for S. mansoni. Urine samples were subjected to POC-CCA cassette test for S. mansoni, and a filtration method for S. haematobium diagnosis.; Before treatment, the prevalence of S. mansoni, as determined by quadruplicate Kato-Katz, single CCA considering 'trace' as negative (t-), and single CCA with 'trace' as positive (t+), was 23.1%, 34.3% and 64.5%, respectively. Using the combined results (i.e., four Kato-Katz and duplicate CCA(t-)) as diagnostic 'gold' standard, the sensitivity of a single Kato-Katz, a single CCA(t-) or CCA(t+) was 28.3%, 69.7% and 89.1%, respectively. Three weeks posttreatment, the sensitivity of a single Kato-Katz, single CCA(t-) and CCA(t+) was 4.0%, 80.0% and 84.0%, respectively. The intensity of the POC-CCA test band reaction was correlated with S. mansoni egg burden (odds ratio = 1.2, p = 0.04). CONCLUSIONSSIGNIFICANCE: A single POC-CCA cassette test appears to be more sensitive than multiple Kato-Katz thick smears for the diagnosis of S. mansoni in preschool-aged children before and after praziquantel administration. The POC-CCA cassette test can be recommended for the rapid identification of S. mansoni infections before treatment. Additional studies are warranted to determine the usefulness of POC-CCA for assessing drug efficacy and monitoring the impact of control interventions.