The Experts below are selected from a list of 79416 Experts worldwide ranked by ideXlab platform
Herman J Van Eck - One of the best experts on this subject based on the ideXlab platform.
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smooth a statistical method for successful removal of genotyping errors from high density genetic linkage data
Theoretical and Applied Genetics, 2005Co-Authors: Hans Van Os, P Stam, Richard G F Visser, Herman J Van EckAbstract:High-density genetic linkage maps can be used for purposes such as fine-scale targeted gene cloning and anchoring of physical maps. However, their construction is significantly complicated by even relatively small amounts of scoring errors. Currently available Software is not able to solve the ordering ambiguities in marker clusters, which inhibits the application of high-density maps. A statistical method named SMOOTH was developed to remove genotyping errors from genetic linkage data during the Mapping process. The program SMOOTH calculates the difference between the observed and predicted values of data points based on data points of neighbouring loci in a given marker order. Highly improbable data points are removed by the program in an iterative process with a Mapping algorithm that recalculates the map after cleaning. SMOOTH has been tested with simulated data and experimental Mapping data from potato. The simulations prove that this method is able to detect a high amount of scoring errors and demonstrates that the program enables Mapping Software to successfully construct a very accurate high-density map. In potato the application of the program resulted in a reliable placement of nearly 1,000 markers in one linkage group.
Masayuki Zuguchi - One of the best experts on this subject based on the ideXlab platform.
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total entrance skin dose an effective indicator of maximum radiation dose to the skin during percutaneous coronary intervention
American Journal of Roentgenology, 2007Co-Authors: Koichi Chida, Haruo Saito, Masahiro Kohzuki, Shoki Takahashi, Shogo Yamada, Yutaka Kagaya, Yoshihiro Takai, Masayuki ZuguchiAbstract:OBJECTIVE. A number of cases of radiation-associated patient skin injury during percutaneous coronary intervention (PCI) have been reported. To protect against this complication, maximum skin dose to the patient should be monitored in real time. Unfortunately, in most cardiac intervention procedures, real-time monitoring of maximum skin dose is not possible. Angiographic X-ray units, however, display the patient's total entrance skin dose in real time. We therefore investigated the relation between maximum skin dose and total entrance skin dose to determine whether total entrance skin dose can be used to estimate maximum skin dose during PCI.MATERIALS AND METHODS. The dose–area product was measured, and maximum skin dose and total entrance skin dose were calculated with a skin-dose-Mapping Software program. The target vessels of 194 PCI procedures were divided into four groups according to the American Heart Association (AHA) segment system.RESULTS. The maximum skin dose constituted 48%, 52%, 50%, and 52%...
J Farah - One of the best experts on this subject based on the ideXlab platform.
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benchmarking the dacs integrated radiation dose monitor skin dose Mapping Software using xr rv3 gafchromic films
Medical Physics, 2018Co-Authors: Bouchra Habib Geryes, Lama Hadidbeurrier, Mariejosephine Waryn, Antonella Jeanpierre, J FarahAbstract:PURPOSE To perform a benchmark of a new DACS-integrated patient skin dose Mapping solution using on-phantom measurements with Gafchromic® films. MATERIALS AND METHODS To calculate cumulative patient skin dose distribution with 1-cm2 resolution, a Radiation Dose Monitor (RDM, Medsquare), using the Radiation Dose Structured Report (RDSR), tabulated backscatter and mass energy absorption coefficients together with site-specific corrections for table, mattress attenuation, and air kerma calibration factor. Peak skin dose (PSD) and two-dimensional (2D) skin dose distributions calculated with RDM were compared against on-phantom measurements with XR-RV3 Gafchromic® films considering two widely used x-ray equipment. Seventeen different settings which include simple and multiple beam projections with extreme angulations (up to 75°), all available fields-of-view (FOVs 48-11 cm), additional collimation, variable table height and lateral positions, and variable phantom thickness (12, 20, and 30 cm) were involved. RESULTS Due to a careful calibration of films using clinical beam qualities, 22.8% (k = 2) overall measurement uncertainty was achieved. Calculated and measured PSD values agreed with an average difference of 10% ± 7% and 9% ± 7% for 34 test conditions performed on Siemens Artis Zee and GEMS Innova IGS interventional systems, respectively. Finally, RDM's 2D skin dose maps closely matched those registered on XR-RV3 films considering the 1-cm2 resolution. While RDM correctly reproduced beam overlapping due to variable tube projections, FOV, table positions, etc., few challenges were identified related to conversion of rectangular fields to square areas in the RDSR and a stair-step effect visible for large tube projections (>45°). CONCLUSION The accuracy of RDM's DACS-integrated skin dose Mapping Software was acceptable considering measurement uncertainties associated with Gafchromic® films.
William C Strange - One of the best experts on this subject based on the ideXlab platform.
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geography industrial organization and agglomeration
The Review of Economics and Statistics, 2003Co-Authors: Stua S Rosenthal, William C StrangeAbstract:This paper makes two contributions to the empirical literature on agglomeration economies. First, the paper uses a unique and rich database in conjunction with Mapping Software to measure the geographic extent of agglomerative externalities. Previous papers have been forced to assume that agglomeration economies are club goods that operate at a metropolitan scale. Second, the paper tests for the existence of organizational agglomeration economies of the kind studied qualitatively by Saxenian (1994). This is a potentially important source of increasing returns that previous empirical work has not considered. Results indicate that localization economies attenuate rapidly and that industrial organization affects the benefits of agglomeration.
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geography industrial organization and agglomeration
Research Papers in Economics, 1999Co-Authors: Stua S Rosenthal, William C StrangeAbstract:This paper makes two contributions to the empirical literature on agglomeration economies. First, the paper uses a unique and rich database in conjunction with Mapping Software to measure the geographic extent and nature of agglomerative externalities. Previous papers have been forced to assume that agglomeration economies are club goods that operate at a metropolitan scale. Second, the paper tests for the existence of organizational agglomeration economies of the kind studied qualitatively by Saxenian (1994). This is a potentially important source of increasing returns that previous empirical work has not considered. Results indicate that localization economies attenuate rapidly and that industrial organization affects the benefits of agglomeration.
Hans Van Os - One of the best experts on this subject based on the ideXlab platform.
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smooth a statistical method for successful removal of genotyping errors from high density genetic linkage data
Theoretical and Applied Genetics, 2005Co-Authors: Hans Van Os, P Stam, Richard G F Visser, Herman J Van EckAbstract:High-density genetic linkage maps can be used for purposes such as fine-scale targeted gene cloning and anchoring of physical maps. However, their construction is significantly complicated by even relatively small amounts of scoring errors. Currently available Software is not able to solve the ordering ambiguities in marker clusters, which inhibits the application of high-density maps. A statistical method named SMOOTH was developed to remove genotyping errors from genetic linkage data during the Mapping process. The program SMOOTH calculates the difference between the observed and predicted values of data points based on data points of neighbouring loci in a given marker order. Highly improbable data points are removed by the program in an iterative process with a Mapping algorithm that recalculates the map after cleaning. SMOOTH has been tested with simulated data and experimental Mapping data from potato. The simulations prove that this method is able to detect a high amount of scoring errors and demonstrates that the program enables Mapping Software to successfully construct a very accurate high-density map. In potato the application of the program resulted in a reliable placement of nearly 1,000 markers in one linkage group.
