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Orazio Taglialatela-scafati - One of the best experts on this subject based on the ideXlab platform.

  • Chapter 17:The Contribution of Marine Chemistry in the Field of Antimalarial Research
    Drug Discovery, 2012
    Co-Authors: Ernesto Fattorusso, Orazio Taglialatela-scafati
    Abstract:

    Malaria is an infectious disease caused by several protozoans belonging to the genus Plasmodium, with P. falciparum being the most widespread aetiological agent and the one responsible of the most severe cases. The protozoan comes in contact with humans through the vector contribution of female Anop...

  • Marine DRUGS
    Marine Antimalarials, 2009
    Co-Authors: Ernesto Fattorusso, Orazio Taglialatela-scafati
    Abstract:

    Malaria is an infectious disease causing at least 1 million deaths per year, and, unfortunately, the chemical entities available to treat malaria are still too limited. In this review we highlight the contribution of Marine Chemistry in the field of antimalarial research by reporting the most important results obtained until the beginning of 2009, with particular emphasis on recent discoveries. About 60 secondary metabolites produced by Marine organisms have been grouped into three structural types and discussed in terms of their reported antimalarial activities. The major groups of metabolites include isonitrile derivatives, alkaloids and endoperoxide derivatives. The following discussion evidences that antimalarial Marine molecules can efficiently integrate the panel of lead compounds isolated from terrestrial sources with new chemical backbones and, sometimes, with unique functional groups.

Ernesto Fattorusso - One of the best experts on this subject based on the ideXlab platform.

  • Chapter 17:The Contribution of Marine Chemistry in the Field of Antimalarial Research
    Drug Discovery, 2012
    Co-Authors: Ernesto Fattorusso, Orazio Taglialatela-scafati
    Abstract:

    Malaria is an infectious disease caused by several protozoans belonging to the genus Plasmodium, with P. falciparum being the most widespread aetiological agent and the one responsible of the most severe cases. The protozoan comes in contact with humans through the vector contribution of female Anop...

  • Marine DRUGS
    Marine Antimalarials, 2009
    Co-Authors: Ernesto Fattorusso, Orazio Taglialatela-scafati
    Abstract:

    Malaria is an infectious disease causing at least 1 million deaths per year, and, unfortunately, the chemical entities available to treat malaria are still too limited. In this review we highlight the contribution of Marine Chemistry in the field of antimalarial research by reporting the most important results obtained until the beginning of 2009, with particular emphasis on recent discoveries. About 60 secondary metabolites produced by Marine organisms have been grouped into three structural types and discussed in terms of their reported antimalarial activities. The major groups of metabolites include isonitrile derivatives, alkaloids and endoperoxide derivatives. The following discussion evidences that antimalarial Marine molecules can efficiently integrate the panel of lead compounds isolated from terrestrial sources with new chemical backbones and, sometimes, with unique functional groups.

Joel D Blum - One of the best experts on this subject based on the ideXlab platform.

Eda Maria Hood - One of the best experts on this subject based on the ideXlab platform.

Han Geurdes - One of the best experts on this subject based on the ideXlab platform.