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Carine Brouat - One of the best experts on this subject based on the ideXlab platform.

  • Seroprevalence of Toxoplasma gondii in commensal rodents sampled across Senegal, West Africa
    Parasite, 2018
    Co-Authors: Carine Brouat, Christophe Amidi Diagne, Khadija Ismaïl, Abdelkrim Aroussi, Ambroise Dalecky, Mamadou Kane, Youssoupha Niang, Mamoudou Diallo, Aliou Sow, Lokman Galal
    Abstract:

    Risks related to Toxoplasma gondii infection in humans remain poorly known in Senegal. Although rodent surveys could help to assess the circulation of T. gondii, they have seldom been set up in sub-Saharan Africa. The aim of this study was to examine Toxoplasma seroprevalence in rodents from villages and towns across Senegal. Rodents were sampled in 40 localities using a standardised trapping protocol. Detection of T. gondii antibodies was performed on 1205 rodents, using a modified agglutination test (MAT) technique. Seroprevalence data were analysed depending on geography, the local rodent community, and individual characteristics of the rodent hosts. We found 44 seropositive rodents from four different species (Mastomys erythroleucus, Mastomys natalensis, Mus musculus domesticus, Rattus rattus). Toxoplasma seroprevalence was low, averaging 4% in the localities. Higher Toxoplasma seroprevalence (up to 24%) was found in northern Senegal, a region known to be the heart of pastoral herding in the country.

  • Seroprevalence of
    'EDP Sciences', 2018
    Co-Authors: Carine Brouat, Christophe Amidi Diagne, Khadija Ismaïl, Abdelkrim Aroussi, Ambroise Dalecky, Mamadou Kane, Youssoupha Niang, Mamoudou Diallo, Aliou Sow
    Abstract:

    Risks related to Toxoplasma gondii infection in humans remain poorly known in Senegal. Although rodent surveys could help to assess the circulation of T. gondii, they have seldom been set up in sub-Saharan Africa. The aim of this study was to examine Toxoplasma seroprevalence in rodents from villages and towns across Senegal. Rodents were sampled in 40 localities using a standardised trapping protocol. Detection of T. gondii antibodies was performed on 1205 rodents, using a modified agglutination test (MAT) technique. Seroprevalence data were analysed depending on geography, the local rodent community, and individual characteristics of the rodent hosts. We found 44 seropositive rodents from four different species (Mastomys erythroleucus, Mastomys natalensis, Mus musculus domesticus, Rattus rattus). Toxoplasma seroprevalence was low, averaging 4% in the localities. Higher Toxoplasma seroprevalence (up to 24%) was found in northern Senegal, a region known to be the heart of pastoral herding in the country

  • Serological Survey of Zoonotic Viruses in Invasive and Native Commensal Rodents in Senegal, West Africa
    Vector-Borne and Zoonotic Diseases, 2017
    Co-Authors: Christophe Amidi Diagne, Nathalie Charbonnel, Heikki Henttonen, Tarja Sironen, Carine Brouat
    Abstract:

    Increasing studies on rodent-borne diseases still highlight the major role of rodents as reservoirs of numerous zoonoses of which the frequency is likely to increase worldwide as a result of accelerated anthropogenic changes, including biological invasions. Such a situation makes pathogen detection in rodent populations important, especially in the context of developing countries characterized by high infectious disease burden. Here, we used indirect fluorescent antibody tests to describe the circulation of potentially zoonotic viruses in both invasive (Mus musculus domesticus and Rattus rattus) and native (Mastomys erythroleucus and Mastomys natalensis) murine rodent populations in Senegal (West Africa). Of the 672 rodents tested, we reported 22 seropositive tests for Hantavirus, Orthopoxvirus, and Mammarenavirus genera, and no evidence of viral coinfection. This study is the first to report serological detection of Orthopoxvirus in rodents from Senegal, Mammarenavirus in R. rattus from Africa, and Hantavirus in M. m. domesticus and in M. erythroleucus. Further specific identification of the viral agents highlighted here is urgently needed for crucial public health concerns.

  • Whipworm diversity in West African rodents: a molecular approach and the description of Trichuris duplantieri n. sp (Nematoda: Trichuridae)
    Parasitology Research, 2017
    Co-Authors: Alexis Ribas, Christophe Amidi Diagne, Mamoudou Diallo, Caroline Tatard, Srisupaph Poonlaphdecha, Carine Brouat
    Abstract:

    Whipworms were collected from rodents (Muridae) from six West African countries: Burkina-Faso, the Islamic Republic of Mauritania, and the Republics of Benin, Guinea, Mali and Senegal. Molecular sequences (ITS-1, 5.8S and ITS-2 of the ribosomal DNA gene) and morphometric characters were analysed in Trichuris (Nematoda: Trichuridae) specimens found in seven host species: Arvicanthis niloticus, Gerbilliscus gambianus, Gerbillus gerbillus, G. tarabuli, Mastomys erythroleucus, M. huberti and M. natalensis. Phylogenetic analyses revealed three clades, one recognised as Trichuris Mastomysi, previously recorded in M. natalensis from Tanzania, and the other two previously undescribed. A new species named Trichuris duplantieri n. sp., found in Gerbillus spp. from Mauritania, was characterised using molecular and morphometric methods.

  • New polymorphic microsatellite loci for rodents of the genus Mastomys using PCR multiplexing and cross-species amplification in Myomys and Praomys
    Molecular Ecology Notes, 2007
    Co-Authors: Anne Loiseau, Adam Konecny, Maxime Galan, Josef Bryja, Jean-francois Cosson, Carine Brouat
    Abstract:

    The Praomys complex contains some of the most important agricultural pests of Africa, including Mastomys species. We describe the development of nine supplementary microsatellite markers isolated from Mastomys huberti . We show the potential utility of M. Huberti microsatellites as population markers for two other species of Mastomys , and two other species of the Praomys complex, Myomys daltoni And Praomys cf. rostratus

Ayodeji Olayemi - One of the best experts on this subject based on the ideXlab platform.

  • Widespread arenavirus occurrence and seroprevalence in small mammals, Nigeria
    Parasites & Vectors, 2018
    Co-Authors: Ayodeji Olayemi, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Adetunji Samuel Adesina, Francis Onwe, Kingsley Nnanna Ukwaja, Nnennaya Anthony Ajayi, Toni Rieger, Stephan Günther
    Abstract:

    Background Lassa fever, killing thousands of people annually, is the most reported viral zoonotic disease in Nigeria. Recently, different rodent species carrying diverse lineages of the Lassa virus (LASV) in addition to a novel Mobala-like genetic sequence were detected within the country. Here, screening 906 small mammal specimens from 11 localities for IgG antibodies and incorporating previous PCR detection data involving the same populations, we further describe arenavirus prevalence across Nigeria in relation to host species and geographical location. Methods Small mammals were trapped during the period 2011–2015 according to geographical location (endemic and non-endemic zones for Lassa fever), season (rainy and dry seasons between 2011 and 2012 for certain localities) and habitat (indoors, peridomestic settings and sylvatic vegetation). Identification of animal specimens from genera such as Mastomys and Mus ( Nannomys ) was assisted by DNA sequencing. Small mammals were tested for LASV IgG antibody using an indirect immunofluorescence assay (IFA). Results Small mammals were infected in both the endemic and non-endemic zones for Lassa fever, with a wider range of species IgG-positive ( n = 8) than those which had been previously detected to be PCR-positive ( n = 3). IgG-positive species, according to number of infected individuals, were Mastomys natalensis ( n = 40), Mastomys erythroleucus ( n = 15), Praomys daltoni ( n = 6), Mus baoulei ( n = 5), Rattus rattus ( n = 2) , Crocidura spp. ( n = 2), Mus minutoides ( n = 1) and Praomys misonnei ( n = 1) . Multimammate mice ( Mastomys natalensis and M. erythroleucus ) were the most ubiquitously infected, with animals testing positive by either PCR or IgG in 7 out of the 11 localities sampled. IgG prevalence in M. natalensis ranged from 1% in Abagboro, 17–36 % in Eguare Egoro, Ekpoma and Ngel Nyaki, up to 52 % in Mayo Ranewo. Prevalence according to locality, season and age was not, however, statistically significant for M. natalensis in Eguare Egoro and Ekpoma, localities that were sampled longitudinally. Conclusions Overall, our study demonstrates that arenavirus occurrence is probably more widely distributed geographically and in extent of host taxa than is currently realized. This expanded scope should be taken into consideration in Lassa fever control efforts. Further sampling should also be carried out to isolate and characterize potential arenaviruses present in small mammal populations we found to be seropositive.

  • widespread arenavirus occurrence and seroprevalence in small mammals nigeria
    Parasites & Vectors, 2018
    Co-Authors: Ayodeji Olayemi, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Adetunji Samuel Adesina, Francis Onwe, Kingsley Nnanna Ukwaja, Nnennaya Anthony Ajayi, Toni Rieger, Stephan Günther
    Abstract:

    Lassa fever, killing thousands of people annually, is the most reported viral zoonotic disease in Nigeria. Recently, different rodent species carrying diverse lineages of the Lassa virus (LASV) in addition to a novel Mobala-like genetic sequence were detected within the country. Here, screening 906 small mammal specimens from 11 localities for IgG antibodies and incorporating previous PCR detection data involving the same populations, we further describe arenavirus prevalence across Nigeria in relation to host species and geographical location. Small mammals were trapped during the period 2011–2015 according to geographical location (endemic and non-endemic zones for Lassa fever), season (rainy and dry seasons between 2011 and 2012 for certain localities) and habitat (indoors, peridomestic settings and sylvatic vegetation). Identification of animal specimens from genera such as Mastomys and Mus (Nannomys) was assisted by DNA sequencing. Small mammals were tested for LASV IgG antibody using an indirect immunofluorescence assay (IFA). Small mammals were infected in both the endemic and non-endemic zones for Lassa fever, with a wider range of species IgG-positive (n = 8) than those which had been previously detected to be PCR-positive (n = 3). IgG-positive species, according to number of infected individuals, were Mastomys natalensis (n = 40), Mastomys erythroleucus (n = 15), Praomys daltoni (n = 6), Mus baoulei (n = 5), Rattus rattus (n = 2), Crocidura spp. (n = 2), Mus minutoides (n = 1) and Praomys misonnei (n = 1). Multimammate mice (Mastomys natalensis and M. erythroleucus) were the most ubiquitously infected, with animals testing positive by either PCR or IgG in 7 out of the 11 localities sampled. IgG prevalence in M. natalensis ranged from 1% in Abagboro, 17–36 % in Eguare Egoro, Ekpoma and Ngel Nyaki, up to 52 % in Mayo Ranewo. Prevalence according to locality, season and age was not, however, statistically significant for M. natalensis in Eguare Egoro and Ekpoma, localities that were sampled longitudinally. Overall, our study demonstrates that arenavirus occurrence is probably more widely distributed geographically and in extent of host taxa than is currently realized. This expanded scope should be taken into consideration in Lassa fever control efforts. Further sampling should also be carried out to isolate and characterize potential arenaviruses present in small mammal populations we found to be seropositive.

  • small mammal diversity and dynamics within nigeria with emphasis on reservoirs of the lassa virus
    Systematics and Biodiversity, 2018
    Co-Authors: Ayodeji Olayemi, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Felix Igbahenah, Daniel Ortsega, Stephan Günther, Samuel Fasogbon, Erik Verheyen, Elisabeth Fichetcalvet
    Abstract:

    Nigeria has a rich small mammal community, with several species implicated as carriers of zoonotic microbes such as the Lassa virus (LASV). We sought to elucidate the diversity and distribution of these animals (including known LASV reservoirs) geographically, habitat-wise and seasonally. Our DNA-assisted survey detected at least 19 small mammal species amongst 790 specimens. Diversity indices were similar between ecological zones and also between endemic and non-endemic areas for Lassa fever. Mastomys natalensis, the most renowned LASV host, was present in eight out of nine localities sampled. We also described the spatial occurrence of other known LASV hosts such as M. erythroleucus and Hylomyscus pamfi, including carriers of LASV-like arenaviruses such as Mus (Nannomys) spp. The most numerous rodents (Mastomys natalensis, M. erythroleucus, and Praomys daltoni) were captured mainly inside human dwellings. Reproductive activity occurred throughout the year, but led to population peaks for M. natalensis i...

  • new hosts of the lassa virus
    Scientific Reports, 2016
    Co-Authors: Ayodeji Olayemi, Fode Kourouma, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Toni Rieger, Daniel Cadar, Nfaly Magassouba, Samuel Fasogbon, Sabrina Bockholt
    Abstract:

    Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis, has been assumed to be the sole host of LASV. We found evidence that LASV is also hosted by other rodent species: the African wood mouse Hylomyscus pamfi in Nigeria, and the Guinea multimammate mouse Mastomys erythroleucus in both Nigeria and Guinea. Virus strains from these animals were isolated in the BSL-4 laboratory and fully sequenced. Phylogenetic analyses of viral genes coding for glycoprotein, nucleoprotein, polymerase and matrix protein show that Lassa strains detected in M. erythroleucus belong to lineages III and IV. The strain from H. pamfi clusters close to lineage I (for S gene) and between II &III (for L gene). Discovery of new rodent hosts has implications for LASV evolution and its spread into new areas within West Africa.

  • arenavirus diversity and phylogeography of Mastomys natalensis rodents nigeria
    Emerging Infectious Diseases, 2016
    Co-Authors: Ayodeji Olayemi, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Ayobami Fasogbon, Felix Igbahenah, Daniel Ortsega, Danny A Asogun, Prince Umeh, Innocent Vakkai
    Abstract:

    Mastomys natalensis rodents are natural hosts for Lassa virus (LASV). Detection of LASV in 2 mitochondrial phylogroups of the rodent near the Niger and Benue Rivers in Nigeria underlines the potential for LASV emergence in fresh phylogroups of this rodent. A Mobala-like sequence was also detected in eastern Nigeria.

Akinlabi Oyeyiola - One of the best experts on this subject based on the ideXlab platform.

  • Widespread arenavirus occurrence and seroprevalence in small mammals, Nigeria
    Parasites & Vectors, 2018
    Co-Authors: Ayodeji Olayemi, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Adetunji Samuel Adesina, Francis Onwe, Kingsley Nnanna Ukwaja, Nnennaya Anthony Ajayi, Toni Rieger, Stephan Günther
    Abstract:

    Background Lassa fever, killing thousands of people annually, is the most reported viral zoonotic disease in Nigeria. Recently, different rodent species carrying diverse lineages of the Lassa virus (LASV) in addition to a novel Mobala-like genetic sequence were detected within the country. Here, screening 906 small mammal specimens from 11 localities for IgG antibodies and incorporating previous PCR detection data involving the same populations, we further describe arenavirus prevalence across Nigeria in relation to host species and geographical location. Methods Small mammals were trapped during the period 2011–2015 according to geographical location (endemic and non-endemic zones for Lassa fever), season (rainy and dry seasons between 2011 and 2012 for certain localities) and habitat (indoors, peridomestic settings and sylvatic vegetation). Identification of animal specimens from genera such as Mastomys and Mus ( Nannomys ) was assisted by DNA sequencing. Small mammals were tested for LASV IgG antibody using an indirect immunofluorescence assay (IFA). Results Small mammals were infected in both the endemic and non-endemic zones for Lassa fever, with a wider range of species IgG-positive ( n = 8) than those which had been previously detected to be PCR-positive ( n = 3). IgG-positive species, according to number of infected individuals, were Mastomys natalensis ( n = 40), Mastomys erythroleucus ( n = 15), Praomys daltoni ( n = 6), Mus baoulei ( n = 5), Rattus rattus ( n = 2) , Crocidura spp. ( n = 2), Mus minutoides ( n = 1) and Praomys misonnei ( n = 1) . Multimammate mice ( Mastomys natalensis and M. erythroleucus ) were the most ubiquitously infected, with animals testing positive by either PCR or IgG in 7 out of the 11 localities sampled. IgG prevalence in M. natalensis ranged from 1% in Abagboro, 17–36 % in Eguare Egoro, Ekpoma and Ngel Nyaki, up to 52 % in Mayo Ranewo. Prevalence according to locality, season and age was not, however, statistically significant for M. natalensis in Eguare Egoro and Ekpoma, localities that were sampled longitudinally. Conclusions Overall, our study demonstrates that arenavirus occurrence is probably more widely distributed geographically and in extent of host taxa than is currently realized. This expanded scope should be taken into consideration in Lassa fever control efforts. Further sampling should also be carried out to isolate and characterize potential arenaviruses present in small mammal populations we found to be seropositive.

  • widespread arenavirus occurrence and seroprevalence in small mammals nigeria
    Parasites & Vectors, 2018
    Co-Authors: Ayodeji Olayemi, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Adetunji Samuel Adesina, Francis Onwe, Kingsley Nnanna Ukwaja, Nnennaya Anthony Ajayi, Toni Rieger, Stephan Günther
    Abstract:

    Lassa fever, killing thousands of people annually, is the most reported viral zoonotic disease in Nigeria. Recently, different rodent species carrying diverse lineages of the Lassa virus (LASV) in addition to a novel Mobala-like genetic sequence were detected within the country. Here, screening 906 small mammal specimens from 11 localities for IgG antibodies and incorporating previous PCR detection data involving the same populations, we further describe arenavirus prevalence across Nigeria in relation to host species and geographical location. Small mammals were trapped during the period 2011–2015 according to geographical location (endemic and non-endemic zones for Lassa fever), season (rainy and dry seasons between 2011 and 2012 for certain localities) and habitat (indoors, peridomestic settings and sylvatic vegetation). Identification of animal specimens from genera such as Mastomys and Mus (Nannomys) was assisted by DNA sequencing. Small mammals were tested for LASV IgG antibody using an indirect immunofluorescence assay (IFA). Small mammals were infected in both the endemic and non-endemic zones for Lassa fever, with a wider range of species IgG-positive (n = 8) than those which had been previously detected to be PCR-positive (n = 3). IgG-positive species, according to number of infected individuals, were Mastomys natalensis (n = 40), Mastomys erythroleucus (n = 15), Praomys daltoni (n = 6), Mus baoulei (n = 5), Rattus rattus (n = 2), Crocidura spp. (n = 2), Mus minutoides (n = 1) and Praomys misonnei (n = 1). Multimammate mice (Mastomys natalensis and M. erythroleucus) were the most ubiquitously infected, with animals testing positive by either PCR or IgG in 7 out of the 11 localities sampled. IgG prevalence in M. natalensis ranged from 1% in Abagboro, 17–36 % in Eguare Egoro, Ekpoma and Ngel Nyaki, up to 52 % in Mayo Ranewo. Prevalence according to locality, season and age was not, however, statistically significant for M. natalensis in Eguare Egoro and Ekpoma, localities that were sampled longitudinally. Overall, our study demonstrates that arenavirus occurrence is probably more widely distributed geographically and in extent of host taxa than is currently realized. This expanded scope should be taken into consideration in Lassa fever control efforts. Further sampling should also be carried out to isolate and characterize potential arenaviruses present in small mammal populations we found to be seropositive.

  • small mammal diversity and dynamics within nigeria with emphasis on reservoirs of the lassa virus
    Systematics and Biodiversity, 2018
    Co-Authors: Ayodeji Olayemi, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Felix Igbahenah, Daniel Ortsega, Stephan Günther, Samuel Fasogbon, Erik Verheyen, Elisabeth Fichetcalvet
    Abstract:

    Nigeria has a rich small mammal community, with several species implicated as carriers of zoonotic microbes such as the Lassa virus (LASV). We sought to elucidate the diversity and distribution of these animals (including known LASV reservoirs) geographically, habitat-wise and seasonally. Our DNA-assisted survey detected at least 19 small mammal species amongst 790 specimens. Diversity indices were similar between ecological zones and also between endemic and non-endemic areas for Lassa fever. Mastomys natalensis, the most renowned LASV host, was present in eight out of nine localities sampled. We also described the spatial occurrence of other known LASV hosts such as M. erythroleucus and Hylomyscus pamfi, including carriers of LASV-like arenaviruses such as Mus (Nannomys) spp. The most numerous rodents (Mastomys natalensis, M. erythroleucus, and Praomys daltoni) were captured mainly inside human dwellings. Reproductive activity occurred throughout the year, but led to population peaks for M. natalensis i...

  • new hosts of the lassa virus
    Scientific Reports, 2016
    Co-Authors: Ayodeji Olayemi, Fode Kourouma, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Toni Rieger, Daniel Cadar, Nfaly Magassouba, Samuel Fasogbon, Sabrina Bockholt
    Abstract:

    Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis, has been assumed to be the sole host of LASV. We found evidence that LASV is also hosted by other rodent species: the African wood mouse Hylomyscus pamfi in Nigeria, and the Guinea multimammate mouse Mastomys erythroleucus in both Nigeria and Guinea. Virus strains from these animals were isolated in the BSL-4 laboratory and fully sequenced. Phylogenetic analyses of viral genes coding for glycoprotein, nucleoprotein, polymerase and matrix protein show that Lassa strains detected in M. erythroleucus belong to lineages III and IV. The strain from H. pamfi clusters close to lineage I (for S gene) and between II &III (for L gene). Discovery of new rodent hosts has implications for LASV evolution and its spread into new areas within West Africa.

  • arenavirus diversity and phylogeography of Mastomys natalensis rodents nigeria
    Emerging Infectious Diseases, 2016
    Co-Authors: Ayodeji Olayemi, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Ayobami Fasogbon, Felix Igbahenah, Daniel Ortsega, Danny A Asogun, Prince Umeh, Innocent Vakkai
    Abstract:

    Mastomys natalensis rodents are natural hosts for Lassa virus (LASV). Detection of LASV in 2 mitochondrial phylogroups of the rodent near the Niger and Benue Rivers in Nigeria underlines the potential for LASV emergence in fresh phylogroups of this rodent. A Mobala-like sequence was also detected in eastern Nigeria.

Adeoba Obadare - One of the best experts on this subject based on the ideXlab platform.

  • Widespread arenavirus occurrence and seroprevalence in small mammals, Nigeria
    Parasites & Vectors, 2018
    Co-Authors: Ayodeji Olayemi, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Adetunji Samuel Adesina, Francis Onwe, Kingsley Nnanna Ukwaja, Nnennaya Anthony Ajayi, Toni Rieger, Stephan Günther
    Abstract:

    Background Lassa fever, killing thousands of people annually, is the most reported viral zoonotic disease in Nigeria. Recently, different rodent species carrying diverse lineages of the Lassa virus (LASV) in addition to a novel Mobala-like genetic sequence were detected within the country. Here, screening 906 small mammal specimens from 11 localities for IgG antibodies and incorporating previous PCR detection data involving the same populations, we further describe arenavirus prevalence across Nigeria in relation to host species and geographical location. Methods Small mammals were trapped during the period 2011–2015 according to geographical location (endemic and non-endemic zones for Lassa fever), season (rainy and dry seasons between 2011 and 2012 for certain localities) and habitat (indoors, peridomestic settings and sylvatic vegetation). Identification of animal specimens from genera such as Mastomys and Mus ( Nannomys ) was assisted by DNA sequencing. Small mammals were tested for LASV IgG antibody using an indirect immunofluorescence assay (IFA). Results Small mammals were infected in both the endemic and non-endemic zones for Lassa fever, with a wider range of species IgG-positive ( n = 8) than those which had been previously detected to be PCR-positive ( n = 3). IgG-positive species, according to number of infected individuals, were Mastomys natalensis ( n = 40), Mastomys erythroleucus ( n = 15), Praomys daltoni ( n = 6), Mus baoulei ( n = 5), Rattus rattus ( n = 2) , Crocidura spp. ( n = 2), Mus minutoides ( n = 1) and Praomys misonnei ( n = 1) . Multimammate mice ( Mastomys natalensis and M. erythroleucus ) were the most ubiquitously infected, with animals testing positive by either PCR or IgG in 7 out of the 11 localities sampled. IgG prevalence in M. natalensis ranged from 1% in Abagboro, 17–36 % in Eguare Egoro, Ekpoma and Ngel Nyaki, up to 52 % in Mayo Ranewo. Prevalence according to locality, season and age was not, however, statistically significant for M. natalensis in Eguare Egoro and Ekpoma, localities that were sampled longitudinally. Conclusions Overall, our study demonstrates that arenavirus occurrence is probably more widely distributed geographically and in extent of host taxa than is currently realized. This expanded scope should be taken into consideration in Lassa fever control efforts. Further sampling should also be carried out to isolate and characterize potential arenaviruses present in small mammal populations we found to be seropositive.

  • widespread arenavirus occurrence and seroprevalence in small mammals nigeria
    Parasites & Vectors, 2018
    Co-Authors: Ayodeji Olayemi, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Adetunji Samuel Adesina, Francis Onwe, Kingsley Nnanna Ukwaja, Nnennaya Anthony Ajayi, Toni Rieger, Stephan Günther
    Abstract:

    Lassa fever, killing thousands of people annually, is the most reported viral zoonotic disease in Nigeria. Recently, different rodent species carrying diverse lineages of the Lassa virus (LASV) in addition to a novel Mobala-like genetic sequence were detected within the country. Here, screening 906 small mammal specimens from 11 localities for IgG antibodies and incorporating previous PCR detection data involving the same populations, we further describe arenavirus prevalence across Nigeria in relation to host species and geographical location. Small mammals were trapped during the period 2011–2015 according to geographical location (endemic and non-endemic zones for Lassa fever), season (rainy and dry seasons between 2011 and 2012 for certain localities) and habitat (indoors, peridomestic settings and sylvatic vegetation). Identification of animal specimens from genera such as Mastomys and Mus (Nannomys) was assisted by DNA sequencing. Small mammals were tested for LASV IgG antibody using an indirect immunofluorescence assay (IFA). Small mammals were infected in both the endemic and non-endemic zones for Lassa fever, with a wider range of species IgG-positive (n = 8) than those which had been previously detected to be PCR-positive (n = 3). IgG-positive species, according to number of infected individuals, were Mastomys natalensis (n = 40), Mastomys erythroleucus (n = 15), Praomys daltoni (n = 6), Mus baoulei (n = 5), Rattus rattus (n = 2), Crocidura spp. (n = 2), Mus minutoides (n = 1) and Praomys misonnei (n = 1). Multimammate mice (Mastomys natalensis and M. erythroleucus) were the most ubiquitously infected, with animals testing positive by either PCR or IgG in 7 out of the 11 localities sampled. IgG prevalence in M. natalensis ranged from 1% in Abagboro, 17–36 % in Eguare Egoro, Ekpoma and Ngel Nyaki, up to 52 % in Mayo Ranewo. Prevalence according to locality, season and age was not, however, statistically significant for M. natalensis in Eguare Egoro and Ekpoma, localities that were sampled longitudinally. Overall, our study demonstrates that arenavirus occurrence is probably more widely distributed geographically and in extent of host taxa than is currently realized. This expanded scope should be taken into consideration in Lassa fever control efforts. Further sampling should also be carried out to isolate and characterize potential arenaviruses present in small mammal populations we found to be seropositive.

  • small mammal diversity and dynamics within nigeria with emphasis on reservoirs of the lassa virus
    Systematics and Biodiversity, 2018
    Co-Authors: Ayodeji Olayemi, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Felix Igbahenah, Daniel Ortsega, Stephan Günther, Samuel Fasogbon, Erik Verheyen, Elisabeth Fichetcalvet
    Abstract:

    Nigeria has a rich small mammal community, with several species implicated as carriers of zoonotic microbes such as the Lassa virus (LASV). We sought to elucidate the diversity and distribution of these animals (including known LASV reservoirs) geographically, habitat-wise and seasonally. Our DNA-assisted survey detected at least 19 small mammal species amongst 790 specimens. Diversity indices were similar between ecological zones and also between endemic and non-endemic areas for Lassa fever. Mastomys natalensis, the most renowned LASV host, was present in eight out of nine localities sampled. We also described the spatial occurrence of other known LASV hosts such as M. erythroleucus and Hylomyscus pamfi, including carriers of LASV-like arenaviruses such as Mus (Nannomys) spp. The most numerous rodents (Mastomys natalensis, M. erythroleucus, and Praomys daltoni) were captured mainly inside human dwellings. Reproductive activity occurred throughout the year, but led to population peaks for M. natalensis i...

  • new hosts of the lassa virus
    Scientific Reports, 2016
    Co-Authors: Ayodeji Olayemi, Fode Kourouma, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Toni Rieger, Daniel Cadar, Nfaly Magassouba, Samuel Fasogbon, Sabrina Bockholt
    Abstract:

    Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis, has been assumed to be the sole host of LASV. We found evidence that LASV is also hosted by other rodent species: the African wood mouse Hylomyscus pamfi in Nigeria, and the Guinea multimammate mouse Mastomys erythroleucus in both Nigeria and Guinea. Virus strains from these animals were isolated in the BSL-4 laboratory and fully sequenced. Phylogenetic analyses of viral genes coding for glycoprotein, nucleoprotein, polymerase and matrix protein show that Lassa strains detected in M. erythroleucus belong to lineages III and IV. The strain from H. pamfi clusters close to lineage I (for S gene) and between II &III (for L gene). Discovery of new rodent hosts has implications for LASV evolution and its spread into new areas within West Africa.

  • arenavirus diversity and phylogeography of Mastomys natalensis rodents nigeria
    Emerging Infectious Diseases, 2016
    Co-Authors: Ayodeji Olayemi, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Ayobami Fasogbon, Felix Igbahenah, Daniel Ortsega, Danny A Asogun, Prince Umeh, Innocent Vakkai
    Abstract:

    Mastomys natalensis rodents are natural hosts for Lassa virus (LASV). Detection of LASV in 2 mitochondrial phylogroups of the rodent near the Niger and Benue Rivers in Nigeria underlines the potential for LASV emergence in fresh phylogroups of this rodent. A Mobala-like sequence was also detected in eastern Nigeria.

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  • Widespread arenavirus occurrence and seroprevalence in small mammals, Nigeria
    Parasites & Vectors, 2018
    Co-Authors: Ayodeji Olayemi, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Adetunji Samuel Adesina, Francis Onwe, Kingsley Nnanna Ukwaja, Nnennaya Anthony Ajayi, Toni Rieger, Stephan Günther
    Abstract:

    Background Lassa fever, killing thousands of people annually, is the most reported viral zoonotic disease in Nigeria. Recently, different rodent species carrying diverse lineages of the Lassa virus (LASV) in addition to a novel Mobala-like genetic sequence were detected within the country. Here, screening 906 small mammal specimens from 11 localities for IgG antibodies and incorporating previous PCR detection data involving the same populations, we further describe arenavirus prevalence across Nigeria in relation to host species and geographical location. Methods Small mammals were trapped during the period 2011–2015 according to geographical location (endemic and non-endemic zones for Lassa fever), season (rainy and dry seasons between 2011 and 2012 for certain localities) and habitat (indoors, peridomestic settings and sylvatic vegetation). Identification of animal specimens from genera such as Mastomys and Mus ( Nannomys ) was assisted by DNA sequencing. Small mammals were tested for LASV IgG antibody using an indirect immunofluorescence assay (IFA). Results Small mammals were infected in both the endemic and non-endemic zones for Lassa fever, with a wider range of species IgG-positive ( n = 8) than those which had been previously detected to be PCR-positive ( n = 3). IgG-positive species, according to number of infected individuals, were Mastomys natalensis ( n = 40), Mastomys erythroleucus ( n = 15), Praomys daltoni ( n = 6), Mus baoulei ( n = 5), Rattus rattus ( n = 2) , Crocidura spp. ( n = 2), Mus minutoides ( n = 1) and Praomys misonnei ( n = 1) . Multimammate mice ( Mastomys natalensis and M. erythroleucus ) were the most ubiquitously infected, with animals testing positive by either PCR or IgG in 7 out of the 11 localities sampled. IgG prevalence in M. natalensis ranged from 1% in Abagboro, 17–36 % in Eguare Egoro, Ekpoma and Ngel Nyaki, up to 52 % in Mayo Ranewo. Prevalence according to locality, season and age was not, however, statistically significant for M. natalensis in Eguare Egoro and Ekpoma, localities that were sampled longitudinally. Conclusions Overall, our study demonstrates that arenavirus occurrence is probably more widely distributed geographically and in extent of host taxa than is currently realized. This expanded scope should be taken into consideration in Lassa fever control efforts. Further sampling should also be carried out to isolate and characterize potential arenaviruses present in small mammal populations we found to be seropositive.

  • widespread arenavirus occurrence and seroprevalence in small mammals nigeria
    Parasites & Vectors, 2018
    Co-Authors: Ayodeji Olayemi, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Adetunji Samuel Adesina, Francis Onwe, Kingsley Nnanna Ukwaja, Nnennaya Anthony Ajayi, Toni Rieger, Stephan Günther
    Abstract:

    Lassa fever, killing thousands of people annually, is the most reported viral zoonotic disease in Nigeria. Recently, different rodent species carrying diverse lineages of the Lassa virus (LASV) in addition to a novel Mobala-like genetic sequence were detected within the country. Here, screening 906 small mammal specimens from 11 localities for IgG antibodies and incorporating previous PCR detection data involving the same populations, we further describe arenavirus prevalence across Nigeria in relation to host species and geographical location. Small mammals were trapped during the period 2011–2015 according to geographical location (endemic and non-endemic zones for Lassa fever), season (rainy and dry seasons between 2011 and 2012 for certain localities) and habitat (indoors, peridomestic settings and sylvatic vegetation). Identification of animal specimens from genera such as Mastomys and Mus (Nannomys) was assisted by DNA sequencing. Small mammals were tested for LASV IgG antibody using an indirect immunofluorescence assay (IFA). Small mammals were infected in both the endemic and non-endemic zones for Lassa fever, with a wider range of species IgG-positive (n = 8) than those which had been previously detected to be PCR-positive (n = 3). IgG-positive species, according to number of infected individuals, were Mastomys natalensis (n = 40), Mastomys erythroleucus (n = 15), Praomys daltoni (n = 6), Mus baoulei (n = 5), Rattus rattus (n = 2), Crocidura spp. (n = 2), Mus minutoides (n = 1) and Praomys misonnei (n = 1). Multimammate mice (Mastomys natalensis and M. erythroleucus) were the most ubiquitously infected, with animals testing positive by either PCR or IgG in 7 out of the 11 localities sampled. IgG prevalence in M. natalensis ranged from 1% in Abagboro, 17–36 % in Eguare Egoro, Ekpoma and Ngel Nyaki, up to 52 % in Mayo Ranewo. Prevalence according to locality, season and age was not, however, statistically significant for M. natalensis in Eguare Egoro and Ekpoma, localities that were sampled longitudinally. Overall, our study demonstrates that arenavirus occurrence is probably more widely distributed geographically and in extent of host taxa than is currently realized. This expanded scope should be taken into consideration in Lassa fever control efforts. Further sampling should also be carried out to isolate and characterize potential arenaviruses present in small mammal populations we found to be seropositive.

  • small mammal diversity and dynamics within nigeria with emphasis on reservoirs of the lassa virus
    Systematics and Biodiversity, 2018
    Co-Authors: Ayodeji Olayemi, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Felix Igbahenah, Daniel Ortsega, Stephan Günther, Samuel Fasogbon, Erik Verheyen, Elisabeth Fichetcalvet
    Abstract:

    Nigeria has a rich small mammal community, with several species implicated as carriers of zoonotic microbes such as the Lassa virus (LASV). We sought to elucidate the diversity and distribution of these animals (including known LASV reservoirs) geographically, habitat-wise and seasonally. Our DNA-assisted survey detected at least 19 small mammal species amongst 790 specimens. Diversity indices were similar between ecological zones and also between endemic and non-endemic areas for Lassa fever. Mastomys natalensis, the most renowned LASV host, was present in eight out of nine localities sampled. We also described the spatial occurrence of other known LASV hosts such as M. erythroleucus and Hylomyscus pamfi, including carriers of LASV-like arenaviruses such as Mus (Nannomys) spp. The most numerous rodents (Mastomys natalensis, M. erythroleucus, and Praomys daltoni) were captured mainly inside human dwellings. Reproductive activity occurred throughout the year, but led to population peaks for M. natalensis i...

  • new hosts of the lassa virus
    Scientific Reports, 2016
    Co-Authors: Ayodeji Olayemi, Fode Kourouma, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Toni Rieger, Daniel Cadar, Nfaly Magassouba, Samuel Fasogbon, Sabrina Bockholt
    Abstract:

    Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis, has been assumed to be the sole host of LASV. We found evidence that LASV is also hosted by other rodent species: the African wood mouse Hylomyscus pamfi in Nigeria, and the Guinea multimammate mouse Mastomys erythroleucus in both Nigeria and Guinea. Virus strains from these animals were isolated in the BSL-4 laboratory and fully sequenced. Phylogenetic analyses of viral genes coding for glycoprotein, nucleoprotein, polymerase and matrix protein show that Lassa strains detected in M. erythroleucus belong to lineages III and IV. The strain from H. pamfi clusters close to lineage I (for S gene) and between II &III (for L gene). Discovery of new rodent hosts has implications for LASV evolution and its spread into new areas within West Africa.

  • arenavirus diversity and phylogeography of Mastomys natalensis rodents nigeria
    Emerging Infectious Diseases, 2016
    Co-Authors: Ayodeji Olayemi, Adeoba Obadare, Akinlabi Oyeyiola, Joseph Igbokwe, Ayobami Fasogbon, Felix Igbahenah, Daniel Ortsega, Danny A Asogun, Prince Umeh, Innocent Vakkai
    Abstract:

    Mastomys natalensis rodents are natural hosts for Lassa virus (LASV). Detection of LASV in 2 mitochondrial phylogroups of the rodent near the Niger and Benue Rivers in Nigeria underlines the potential for LASV emergence in fresh phylogroups of this rodent. A Mobala-like sequence was also detected in eastern Nigeria.

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