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Yun-chul Hong - One of the best experts on this subject based on the ideXlab platform.

  • Maternal Exposure to environmental tobacco smoke, GSTM1/T1 polymorphisms and oxidative stress.
    Reproductive Toxicology, 2008
    Co-Authors: Eun Young Park, Yun-chul Hong, Kwan-hee Lee, Young Ju Kim
    Abstract:

    Abstract Environmental tobacco smoking (ETS) is known to be associated with adverse pregnancy outcomes. The purpose of this study was to investigate the relationship between Maternal Exposure to ETS and oxidative stress for neonates, as well as the effect of Maternal genetic polymorphisms, glutathione- S -transferase M1 (GSTM1) and GSTT1, on this relationship. We used the radioimmunoassay to measure the urinary concentration of cotinine in 266 pregnant women who denied smoking cigarettes during pregnancy and in their singleton babies. In addition, the urinary concentration of malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OH-dG) were assessed using high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. We also extracted DNA from whole blood obtained from the mothers and then conducted polymerase chain reaction on the samples to determine the GSTM1 and GSTT1 genotypes. The Maternal cotinine concentration was found to be significantly associated with the fetal cotinine concentration, particularly for mothers whose urine cotinine concentrations were above 120 μg/g cr ( p p p p These results suggest that the Maternal Exposure to ETS affects the fetal urine cotinine concentration and induces production of Maternal oxidative stress. In addition, Maternal genetic polymorphisms of GSTM1 and GSTT1 may modify the oxidative stress by Maternal Exposure to ETS.

  • Maternal Exposure to environmental tobacco smoke, GSTM1/T1 polymorphisms and oxidative stress.
    Reproductive toxicology (Elmsford N.Y.), 2008
    Co-Authors: Eun Young Park, Yun-chul Hong, Kwan-hee Lee, Young Ju Kim
    Abstract:

    Environmental tobacco smoking (ETS) is known to be associated with adverse pregnancy outcomes. The purpose of this study was to investigate the relationship between Maternal Exposure to ETS and oxidative stress for neonates, as well as the effect of Maternal genetic polymorphisms, glutathione-S-transferase M1 (GSTM1) and GSTT1, on this relationship. We used the radioimmunoassay to measure the urinary concentration of cotinine in 266 pregnant women who denied smoking cigarettes during pregnancy and in their singleton babies. In addition, the urinary concentration of malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OH-dG) were assessed using high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. We also extracted DNA from whole blood obtained from the mothers and then conducted polymerase chain reaction on the samples to determine the GSTM1 and GSTT1 genotypes. The Maternal cotinine concentration was found to be significantly associated with the fetal cotinine concentration, particularly for mothers whose urine cotinine concentrations were above 120 microg/gcr (p

  • Effects of the GSTM1 and GSTT1 polymorphisms on the relationship between Maternal Exposure to environmental tobacco smoke and neonatal birth weight.
    Journal of occupational and environmental medicine, 2003
    Co-Authors: Yun-chul Hong, Kwan-hee Lee, Byong Kwan Son, Hye Sung Moon
    Abstract:

    The purpose of the investigation was to determine whether genetic polymorphisms in enzymes that metabolize exogenous chemicals modulate the effects of environmental tobacco smoke (ETS) Exposure on birth weight. A survey was conducted from 2000 to 2001 among 266 pregnant women who were hospitalized for delivery and on their singleton live births. We determined Maternal GSTM1 and GSTT1 polymorphisms by polymerase chain reaction and measured the urinary cotinine of pregnant women at delivery by radioimmunoassay. Birth weight was found to decrease significantly with increasing concentrations of Maternal urinary cotinine (P < 0.05). The interactive effect of Exposure to ETS and the presence of the GSTT1 polymorphism was found to be significant by multivariate analysis (P < 0.01), whereas the interactive effect of Exposure to ETS and the presence of GSTM1 polymorphism did not reach statistical significance (P = 0.21). A combination of the GSTM1-null and the GSTT1 null-genotypes was found to exacerbate the effect of Maternal Exposure to ETS on birth weight more than the presence of either genotype alone. Our data indicate that Maternal Exposure to ETS negatively affects neonatal birth weight, and the adverse effect of Maternal Exposure to ETS on neonatal birth weight could be modified by the Maternal metabolic genotypes, GSTM1 and GSTT1.

Young Ju Kim - One of the best experts on this subject based on the ideXlab platform.

  • Maternal Exposure to environmental tobacco smoke, GSTM1/T1 polymorphisms and oxidative stress.
    Reproductive Toxicology, 2008
    Co-Authors: Eun Young Park, Yun-chul Hong, Kwan-hee Lee, Young Ju Kim
    Abstract:

    Abstract Environmental tobacco smoking (ETS) is known to be associated with adverse pregnancy outcomes. The purpose of this study was to investigate the relationship between Maternal Exposure to ETS and oxidative stress for neonates, as well as the effect of Maternal genetic polymorphisms, glutathione- S -transferase M1 (GSTM1) and GSTT1, on this relationship. We used the radioimmunoassay to measure the urinary concentration of cotinine in 266 pregnant women who denied smoking cigarettes during pregnancy and in their singleton babies. In addition, the urinary concentration of malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OH-dG) were assessed using high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. We also extracted DNA from whole blood obtained from the mothers and then conducted polymerase chain reaction on the samples to determine the GSTM1 and GSTT1 genotypes. The Maternal cotinine concentration was found to be significantly associated with the fetal cotinine concentration, particularly for mothers whose urine cotinine concentrations were above 120 μg/g cr ( p p p p These results suggest that the Maternal Exposure to ETS affects the fetal urine cotinine concentration and induces production of Maternal oxidative stress. In addition, Maternal genetic polymorphisms of GSTM1 and GSTT1 may modify the oxidative stress by Maternal Exposure to ETS.

  • Maternal Exposure to environmental tobacco smoke, GSTM1/T1 polymorphisms and oxidative stress.
    Reproductive toxicology (Elmsford N.Y.), 2008
    Co-Authors: Eun Young Park, Yun-chul Hong, Kwan-hee Lee, Young Ju Kim
    Abstract:

    Environmental tobacco smoking (ETS) is known to be associated with adverse pregnancy outcomes. The purpose of this study was to investigate the relationship between Maternal Exposure to ETS and oxidative stress for neonates, as well as the effect of Maternal genetic polymorphisms, glutathione-S-transferase M1 (GSTM1) and GSTT1, on this relationship. We used the radioimmunoassay to measure the urinary concentration of cotinine in 266 pregnant women who denied smoking cigarettes during pregnancy and in their singleton babies. In addition, the urinary concentration of malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OH-dG) were assessed using high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. We also extracted DNA from whole blood obtained from the mothers and then conducted polymerase chain reaction on the samples to determine the GSTM1 and GSTT1 genotypes. The Maternal cotinine concentration was found to be significantly associated with the fetal cotinine concentration, particularly for mothers whose urine cotinine concentrations were above 120 microg/gcr (p

Kwan-hee Lee - One of the best experts on this subject based on the ideXlab platform.

  • Maternal Exposure to environmental tobacco smoke, GSTM1/T1 polymorphisms and oxidative stress.
    Reproductive Toxicology, 2008
    Co-Authors: Eun Young Park, Yun-chul Hong, Kwan-hee Lee, Young Ju Kim
    Abstract:

    Abstract Environmental tobacco smoking (ETS) is known to be associated with adverse pregnancy outcomes. The purpose of this study was to investigate the relationship between Maternal Exposure to ETS and oxidative stress for neonates, as well as the effect of Maternal genetic polymorphisms, glutathione- S -transferase M1 (GSTM1) and GSTT1, on this relationship. We used the radioimmunoassay to measure the urinary concentration of cotinine in 266 pregnant women who denied smoking cigarettes during pregnancy and in their singleton babies. In addition, the urinary concentration of malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OH-dG) were assessed using high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. We also extracted DNA from whole blood obtained from the mothers and then conducted polymerase chain reaction on the samples to determine the GSTM1 and GSTT1 genotypes. The Maternal cotinine concentration was found to be significantly associated with the fetal cotinine concentration, particularly for mothers whose urine cotinine concentrations were above 120 μg/g cr ( p p p p These results suggest that the Maternal Exposure to ETS affects the fetal urine cotinine concentration and induces production of Maternal oxidative stress. In addition, Maternal genetic polymorphisms of GSTM1 and GSTT1 may modify the oxidative stress by Maternal Exposure to ETS.

  • Maternal Exposure to environmental tobacco smoke, GSTM1/T1 polymorphisms and oxidative stress.
    Reproductive toxicology (Elmsford N.Y.), 2008
    Co-Authors: Eun Young Park, Yun-chul Hong, Kwan-hee Lee, Young Ju Kim
    Abstract:

    Environmental tobacco smoking (ETS) is known to be associated with adverse pregnancy outcomes. The purpose of this study was to investigate the relationship between Maternal Exposure to ETS and oxidative stress for neonates, as well as the effect of Maternal genetic polymorphisms, glutathione-S-transferase M1 (GSTM1) and GSTT1, on this relationship. We used the radioimmunoassay to measure the urinary concentration of cotinine in 266 pregnant women who denied smoking cigarettes during pregnancy and in their singleton babies. In addition, the urinary concentration of malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OH-dG) were assessed using high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. We also extracted DNA from whole blood obtained from the mothers and then conducted polymerase chain reaction on the samples to determine the GSTM1 and GSTT1 genotypes. The Maternal cotinine concentration was found to be significantly associated with the fetal cotinine concentration, particularly for mothers whose urine cotinine concentrations were above 120 microg/gcr (p

  • Effects of the GSTM1 and GSTT1 polymorphisms on the relationship between Maternal Exposure to environmental tobacco smoke and neonatal birth weight.
    Journal of occupational and environmental medicine, 2003
    Co-Authors: Yun-chul Hong, Kwan-hee Lee, Byong Kwan Son, Hye Sung Moon
    Abstract:

    The purpose of the investigation was to determine whether genetic polymorphisms in enzymes that metabolize exogenous chemicals modulate the effects of environmental tobacco smoke (ETS) Exposure on birth weight. A survey was conducted from 2000 to 2001 among 266 pregnant women who were hospitalized for delivery and on their singleton live births. We determined Maternal GSTM1 and GSTT1 polymorphisms by polymerase chain reaction and measured the urinary cotinine of pregnant women at delivery by radioimmunoassay. Birth weight was found to decrease significantly with increasing concentrations of Maternal urinary cotinine (P < 0.05). The interactive effect of Exposure to ETS and the presence of the GSTT1 polymorphism was found to be significant by multivariate analysis (P < 0.01), whereas the interactive effect of Exposure to ETS and the presence of GSTM1 polymorphism did not reach statistical significance (P = 0.21). A combination of the GSTM1-null and the GSTT1 null-genotypes was found to exacerbate the effect of Maternal Exposure to ETS on birth weight more than the presence of either genotype alone. Our data indicate that Maternal Exposure to ETS negatively affects neonatal birth weight, and the adverse effect of Maternal Exposure to ETS on neonatal birth weight could be modified by the Maternal metabolic genotypes, GSTM1 and GSTT1.

Eun Young Park - One of the best experts on this subject based on the ideXlab platform.

  • Maternal Exposure to environmental tobacco smoke, GSTM1/T1 polymorphisms and oxidative stress.
    Reproductive Toxicology, 2008
    Co-Authors: Eun Young Park, Yun-chul Hong, Kwan-hee Lee, Young Ju Kim
    Abstract:

    Abstract Environmental tobacco smoking (ETS) is known to be associated with adverse pregnancy outcomes. The purpose of this study was to investigate the relationship between Maternal Exposure to ETS and oxidative stress for neonates, as well as the effect of Maternal genetic polymorphisms, glutathione- S -transferase M1 (GSTM1) and GSTT1, on this relationship. We used the radioimmunoassay to measure the urinary concentration of cotinine in 266 pregnant women who denied smoking cigarettes during pregnancy and in their singleton babies. In addition, the urinary concentration of malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OH-dG) were assessed using high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. We also extracted DNA from whole blood obtained from the mothers and then conducted polymerase chain reaction on the samples to determine the GSTM1 and GSTT1 genotypes. The Maternal cotinine concentration was found to be significantly associated with the fetal cotinine concentration, particularly for mothers whose urine cotinine concentrations were above 120 μg/g cr ( p p p p These results suggest that the Maternal Exposure to ETS affects the fetal urine cotinine concentration and induces production of Maternal oxidative stress. In addition, Maternal genetic polymorphisms of GSTM1 and GSTT1 may modify the oxidative stress by Maternal Exposure to ETS.

  • Maternal Exposure to environmental tobacco smoke, GSTM1/T1 polymorphisms and oxidative stress.
    Reproductive toxicology (Elmsford N.Y.), 2008
    Co-Authors: Eun Young Park, Yun-chul Hong, Kwan-hee Lee, Young Ju Kim
    Abstract:

    Environmental tobacco smoking (ETS) is known to be associated with adverse pregnancy outcomes. The purpose of this study was to investigate the relationship between Maternal Exposure to ETS and oxidative stress for neonates, as well as the effect of Maternal genetic polymorphisms, glutathione-S-transferase M1 (GSTM1) and GSTT1, on this relationship. We used the radioimmunoassay to measure the urinary concentration of cotinine in 266 pregnant women who denied smoking cigarettes during pregnancy and in their singleton babies. In addition, the urinary concentration of malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OH-dG) were assessed using high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. We also extracted DNA from whole blood obtained from the mothers and then conducted polymerase chain reaction on the samples to determine the GSTM1 and GSTT1 genotypes. The Maternal cotinine concentration was found to be significantly associated with the fetal cotinine concentration, particularly for mothers whose urine cotinine concentrations were above 120 microg/gcr (p

Laura E. Mitchell - One of the best experts on this subject based on the ideXlab platform.