The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform
Michelle Allender - One of the best experts on this subject based on the ideXlab platform.
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Racial/Ethnic, Nativity, and Sociodemographic Disparities in Maternal Hypertension in the United States, 2014-2015
International journal of hypertension, 2018Co-Authors: Gopal K. Singh, Mohammad Siahpush, Lihua Liu, Michelle AllenderAbstract:This study examines racial/ethnic, nativity, and sociodemographic variations in the prevalence of Maternal Hypertension in the United States. The 2014-2015 national birth cohort data ( = 7,966,573) were modeled by logistic regression to derive unadjusted and adjusted differentials in Maternal Hypertension consisting of both pregnancy-related Hypertension and chronic Hypertension. Substantial racial/ethnic differences existed, with prevalence of Maternal Hypertension ranging from 2.2% for Chinese and 2.9% for Vietnamese women to 8.9% for American Indians/Alaska Natives (AIANs) and 9.8% for non-Hispanic blacks. Compared with Chinese women, women in all other ethnic groups had significantly higher risks of Maternal Hypertension, with Filipinos, non-Hispanic blacks, and AIANs showing 2.0 to 2.9 times higher adjusted odds. Immigrant women in most racial/ethnic groups had lower rates of Maternal Hypertension than the US-born, with prevalence ranging from 1.9% for Chinese immigrants to 10.3% for US-born blacks. Increasing Maternal age, lower education, US-born status, nonmetropolitan residence, prepregnancy obesity, excess weight gain during pregnancy, and gestational diabetes were other important risk factors. AIANs, non-Hispanic whites, blacks, Puerto Ricans, and some Asian/Pacific Islander subgroups were at substantially higher risk of Maternal Hypertension. Ethnicity, nativity status, older Maternal age, and prepregnancy obesity and excess weight gain should be included among the criteria used for screening for gestational Hypertension.
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racial ethnic nativity and sociodemographic disparities in Maternal Hypertension in the united states 2014 2015
International Journal of Hypertension, 2018Co-Authors: Gopal K. Singh, Mohammad Siahpush, Lihua Liu, Michelle AllenderAbstract:This study examines racial/ethnic, nativity, and sociodemographic variations in the prevalence of Maternal Hypertension in the United States. The 2014-2015 national birth cohort data ( = 7,966,573) were modeled by logistic regression to derive unadjusted and adjusted differentials in Maternal Hypertension consisting of both pregnancy-related Hypertension and chronic Hypertension. Substantial racial/ethnic differences existed, with prevalence of Maternal Hypertension ranging from 2.2% for Chinese and 2.9% for Vietnamese women to 8.9% for American Indians/Alaska Natives (AIANs) and 9.8% for non-Hispanic blacks. Compared with Chinese women, women in all other ethnic groups had significantly higher risks of Maternal Hypertension, with Filipinos, non-Hispanic blacks, and AIANs showing 2.0 to 2.9 times higher adjusted odds. Immigrant women in most racial/ethnic groups had lower rates of Maternal Hypertension than the US-born, with prevalence ranging from 1.9% for Chinese immigrants to 10.3% for US-born blacks. Increasing Maternal age, lower education, US-born status, nonmetropolitan residence, prepregnancy obesity, excess weight gain during pregnancy, and gestational diabetes were other important risk factors. AIANs, non-Hispanic whites, blacks, Puerto Ricans, and some Asian/Pacific Islander subgroups were at substantially higher risk of Maternal Hypertension. Ethnicity, nativity status, older Maternal age, and prepregnancy obesity and excess weight gain should be included among the criteria used for screening for gestational Hypertension.
Patrick W. F. Hadoke - One of the best experts on this subject based on the ideXlab platform.
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dysregulation of hydrogen sulfide producing enzyme cystathionine γ lyase contributes to Maternal Hypertension and placental abnormalities in preeclampsia
Circulation, 2013Co-Authors: Keqing Wang, Shakil Ahmad, Meng Cai, Jillian Rennie, Takeshi Fujisawa, Fatima Crispi, James Baily, Mark R. Miller, Melissa J. Cudmore, Patrick W. F. HadokeAbstract:Background-The exact etiology of preeclampsia is unknown, but there is growing evidence of an imbalance in angiogenic growth factors and abnormal placentation. Hydrogen sulfide (H2S), a gaseous messenger produced mainly by cystathionine γ-lyase (CSE), is a proangiogenic vasodilator. We hypothesized that a reduction in CSE activity may alter the angiogenic balance in pregnancy and induce abnormal placentation and Maternal Hypertension. Methods and Results-Plasma levels of H2S were significantly decreased in women with preeclampsia (P<0.01), which was associated with reduced placental CSE expression as determined by real-time polymerase chain reaction and immunohistochemistry. Inhibition of CSE activity by DL-propargylglycine reduced placental growth factorproduction from first-trimester (8-12 weeks gestation) human placental explants and inhibited trophoblast invasion in vitro. Knockdown of CSE in human umbilical vein endothelial cells by small-interfering RNA increased the release of soluble fms-like tyrosine kinase-1 and soluble endoglin, as assessed by enzyme-linked immunosorbent assay, whereas adenoviral-mediated CSE overexpression in human umbilical vein endothelial cells inhibited their release. Administration of DL-propargylglycine to pregnant mice induced Hypertension and liver damage, promoted abnormal labyrinth vascularization in the placenta, and decreased fetal growth. Finally, a slow-releasing H2S-generating compound, GYY4137, inhibited circulating soluble fms-like tyrosine kinase-1 and soluble endoglin levels and restored fetal growth in mice that was compromised by DL-propargylglycine treatment, demonstrating that the effect of CSE inhibitor was attributable to inhibition of H2S production. Conclusions-These results imply that endogenous H2S is required for healthy placental vasculature and that a decrease in CSE/H2S activity may contribute to the pathogenesis of preeclampsia. © 2013 American Heart Association, Inc.
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Dysregulation of Hydrogen Sulfide Producing Enzyme Cystathionine γ-lyase Contributes to Maternal Hypertension and Placental Abnormalities in Preeclampsia
Circulation, 2013Co-Authors: Keqing Wang, Shakil Ahmad, Meng Cai, Jillian Rennie, Takeshi Fujisawa, Fatima Crispi, James Baily, Mark R. Miller, Melissa J. Cudmore, Patrick W. F. HadokeAbstract:Background-The exact etiology of preeclampsia is unknown, but there is growing evidence of an imbalance in angiogenic growth factors and abnormal placentation. Hydrogen sulfide (H2S), a gaseous messenger produced mainly by cystathionine γ-lyase (CSE), is a proangiogenic vasodilator. We hypothesized that a reduction in CSE activity may alter the angiogenic balance in pregnancy and induce abnormal placentation and Maternal Hypertension. Methods and Results-Plasma levels of H2S were significantly decreased in women with preeclampsia (P
Joey P Granger - One of the best experts on this subject based on the ideXlab platform.
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Abstract 013: Soluble Guanylate Cyclase Activators Improve Vascular Function and Attenuate Placental Ischemia-Induced Hypertension
Hypertension, 2018Co-Authors: Bhavisha A Bakrania, Frank T Spradley, Adam B Travis, Peter Sandner, Joey P GrangerAbstract:Preeclampsia (PE) is a pregnancy specific disorder associated with Maternal Hypertension and endothelial dysfunction caused by the release of anti-angiogenic and pro-inflammatory factors from the i...
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Heme oxygenase-1 is a potent inhibitor of placental ischemia-mediated endothelin-1 production in cultured human glomerular endothelial cells
American journal of physiology. Regulatory integrative and comparative physiology, 2017Co-Authors: Bhavisha A Bakrania, Frank T Spradley, Simon C Satchell, David E. Stec, John M. Rimoldi, Rama S.v. Gadepalli, Joey P GrangerAbstract:Preeclampsia is a pregnancy-specific disorder of Maternal Hypertension and reduced renal hemodynamics linked to reduced endothelial function. Placental ischemia is thought to be the culprit of this...
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abstract p175 soluble guanylate cyclase activator attenuates tumor necrosis factor α induced production of endothelin 1 from human glomerular endothelial cells
Hypertension, 2016Co-Authors: Bhavisha A Bakrania, Frank T Spradley, Simon C Satchell, Joey P GrangerAbstract:Preeclampsia (PE) is a disorder associated with Maternal Hypertension, endothelial dysfunction and reductions in renal hemodynamics. Placental ischemia leads to increases in circulating Maternal an...
Gopal K. Singh - One of the best experts on this subject based on the ideXlab platform.
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Racial/Ethnic, Nativity, and Sociodemographic Disparities in Maternal Hypertension in the United States, 2014-2015
International journal of hypertension, 2018Co-Authors: Gopal K. Singh, Mohammad Siahpush, Lihua Liu, Michelle AllenderAbstract:This study examines racial/ethnic, nativity, and sociodemographic variations in the prevalence of Maternal Hypertension in the United States. The 2014-2015 national birth cohort data ( = 7,966,573) were modeled by logistic regression to derive unadjusted and adjusted differentials in Maternal Hypertension consisting of both pregnancy-related Hypertension and chronic Hypertension. Substantial racial/ethnic differences existed, with prevalence of Maternal Hypertension ranging from 2.2% for Chinese and 2.9% for Vietnamese women to 8.9% for American Indians/Alaska Natives (AIANs) and 9.8% for non-Hispanic blacks. Compared with Chinese women, women in all other ethnic groups had significantly higher risks of Maternal Hypertension, with Filipinos, non-Hispanic blacks, and AIANs showing 2.0 to 2.9 times higher adjusted odds. Immigrant women in most racial/ethnic groups had lower rates of Maternal Hypertension than the US-born, with prevalence ranging from 1.9% for Chinese immigrants to 10.3% for US-born blacks. Increasing Maternal age, lower education, US-born status, nonmetropolitan residence, prepregnancy obesity, excess weight gain during pregnancy, and gestational diabetes were other important risk factors. AIANs, non-Hispanic whites, blacks, Puerto Ricans, and some Asian/Pacific Islander subgroups were at substantially higher risk of Maternal Hypertension. Ethnicity, nativity status, older Maternal age, and prepregnancy obesity and excess weight gain should be included among the criteria used for screening for gestational Hypertension.
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racial ethnic nativity and sociodemographic disparities in Maternal Hypertension in the united states 2014 2015
International Journal of Hypertension, 2018Co-Authors: Gopal K. Singh, Mohammad Siahpush, Lihua Liu, Michelle AllenderAbstract:This study examines racial/ethnic, nativity, and sociodemographic variations in the prevalence of Maternal Hypertension in the United States. The 2014-2015 national birth cohort data ( = 7,966,573) were modeled by logistic regression to derive unadjusted and adjusted differentials in Maternal Hypertension consisting of both pregnancy-related Hypertension and chronic Hypertension. Substantial racial/ethnic differences existed, with prevalence of Maternal Hypertension ranging from 2.2% for Chinese and 2.9% for Vietnamese women to 8.9% for American Indians/Alaska Natives (AIANs) and 9.8% for non-Hispanic blacks. Compared with Chinese women, women in all other ethnic groups had significantly higher risks of Maternal Hypertension, with Filipinos, non-Hispanic blacks, and AIANs showing 2.0 to 2.9 times higher adjusted odds. Immigrant women in most racial/ethnic groups had lower rates of Maternal Hypertension than the US-born, with prevalence ranging from 1.9% for Chinese immigrants to 10.3% for US-born blacks. Increasing Maternal age, lower education, US-born status, nonmetropolitan residence, prepregnancy obesity, excess weight gain during pregnancy, and gestational diabetes were other important risk factors. AIANs, non-Hispanic whites, blacks, Puerto Ricans, and some Asian/Pacific Islander subgroups were at substantially higher risk of Maternal Hypertension. Ethnicity, nativity status, older Maternal age, and prepregnancy obesity and excess weight gain should be included among the criteria used for screening for gestational Hypertension.
Keqing Wang - One of the best experts on this subject based on the ideXlab platform.
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dysregulation of hydrogen sulfide producing enzyme cystathionine γ lyase contributes to Maternal Hypertension and placental abnormalities in preeclampsia
Circulation, 2013Co-Authors: Keqing Wang, Shakil Ahmad, Meng Cai, Jillian Rennie, Takeshi Fujisawa, Fatima Crispi, James Baily, Mark R. Miller, Melissa J. Cudmore, Patrick W. F. HadokeAbstract:Background-The exact etiology of preeclampsia is unknown, but there is growing evidence of an imbalance in angiogenic growth factors and abnormal placentation. Hydrogen sulfide (H2S), a gaseous messenger produced mainly by cystathionine γ-lyase (CSE), is a proangiogenic vasodilator. We hypothesized that a reduction in CSE activity may alter the angiogenic balance in pregnancy and induce abnormal placentation and Maternal Hypertension. Methods and Results-Plasma levels of H2S were significantly decreased in women with preeclampsia (P<0.01), which was associated with reduced placental CSE expression as determined by real-time polymerase chain reaction and immunohistochemistry. Inhibition of CSE activity by DL-propargylglycine reduced placental growth factorproduction from first-trimester (8-12 weeks gestation) human placental explants and inhibited trophoblast invasion in vitro. Knockdown of CSE in human umbilical vein endothelial cells by small-interfering RNA increased the release of soluble fms-like tyrosine kinase-1 and soluble endoglin, as assessed by enzyme-linked immunosorbent assay, whereas adenoviral-mediated CSE overexpression in human umbilical vein endothelial cells inhibited their release. Administration of DL-propargylglycine to pregnant mice induced Hypertension and liver damage, promoted abnormal labyrinth vascularization in the placenta, and decreased fetal growth. Finally, a slow-releasing H2S-generating compound, GYY4137, inhibited circulating soluble fms-like tyrosine kinase-1 and soluble endoglin levels and restored fetal growth in mice that was compromised by DL-propargylglycine treatment, demonstrating that the effect of CSE inhibitor was attributable to inhibition of H2S production. Conclusions-These results imply that endogenous H2S is required for healthy placental vasculature and that a decrease in CSE/H2S activity may contribute to the pathogenesis of preeclampsia. © 2013 American Heart Association, Inc.
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Dysregulation of Hydrogen Sulfide Producing Enzyme Cystathionine γ-lyase Contributes to Maternal Hypertension and Placental Abnormalities in Preeclampsia
Circulation, 2013Co-Authors: Keqing Wang, Shakil Ahmad, Meng Cai, Jillian Rennie, Takeshi Fujisawa, Fatima Crispi, James Baily, Mark R. Miller, Melissa J. Cudmore, Patrick W. F. HadokeAbstract:Background-The exact etiology of preeclampsia is unknown, but there is growing evidence of an imbalance in angiogenic growth factors and abnormal placentation. Hydrogen sulfide (H2S), a gaseous messenger produced mainly by cystathionine γ-lyase (CSE), is a proangiogenic vasodilator. We hypothesized that a reduction in CSE activity may alter the angiogenic balance in pregnancy and induce abnormal placentation and Maternal Hypertension. Methods and Results-Plasma levels of H2S were significantly decreased in women with preeclampsia (P