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Jeffrey B. Blumberg - One of the best experts on this subject based on the ideXlab platform.

  • a review of the bioactivity and potential health benefits of chamomile tea Matricaria recutita l
    Phytotherapy Research, 2006
    Co-Authors: Diane L. Mckay, Jeffrey B. Blumberg
    Abstract:

    Chamomile (Matricaria recutita L., Chamomilla recutita L., Matricaria chamomilla) is one of the most popular single ingredient herbal teas, or tisanes. Chamomile tea, brewed from dried flower heads, has been used traditionally for medicinal purposes. Evidence-based information regarding the bioactivity of this herb is presented. The main constituents of the flowers include several phenolic compounds, primarily the flavonoids apigenin, quercetin, patuletin, luteolin and their glucosides. The principal components of the essential oil extracted from the flowers are the terpenoids α-bisabolol and its oxides and azulenes, including chamazulene. Chamomile has moderate antioxidant and antimicrobial activities, and significant antiplatelet activity in vitro. Animal model studies indicate potent antiinflammatory action, some antimutagenic and cholesterol-lowering activities, as well as antispasmotic and anxiolytic effects. However, human studies are limited, and clinical trials examining the purported sedative properties of chamomile tea are absent. Adverse reactions to chamomile, consumed as a tisane or applied topically, have been reported among those with allergies to other plants in the daisy family, i.e. Asteraceae or Compositae. Copyright © 2006 John Wiley & Sons, Ltd.

  • A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.)
    Phytotherapy Research, 2006
    Co-Authors: Diane L. Mckay, Jeffrey B. Blumberg
    Abstract:

    Chamomile (Matricaria recutita L., Chamomilla recutita L., Matricaria chamomilla) is one of the most popular single ingredient herbal teas, or tisanes. Chamomile tea, brewed from dried flower heads, has been used traditionally for medicinal purposes. Evidence-based information regarding the bioactivity of this herb is presented. The main constituents of the flowers include several phenolic compounds, primarily the flavonoids apigenin, quercetin, patuletin, luteolin and their glucosides. The principal components of the essential oil extracted from the flowers are the terpenoids alpha-bisabolol and its oxides and azulenes, including chamazulene. Chamomile has moderate antioxidant and antimicrobial activities, and significant antiplatelet activity in vitro. Animal model studies indicate potent antiinflammatory action, some antimutagenic and cholesterol-lowering activities, as well as antispasmotic and anxiolytic effects. However, human studies are limited, and clinical trials examining the purported sedative properties of chamomile tea are absent. Adverse reactions to chamomile, consumed as a tisane or applied topically, have been reported among those with allergies to other plants in the daisy family, i.e. Asteraceae or Compositae.

Hichem Sebai - One of the best experts on this subject based on the ideXlab platform.

  • protective effect of chamomile Matricaria recutita l decoction extract against alcohol induced injury in rat gastric mucosa
    Pathophysiology, 2017
    Co-Authors: Mohamed-amine Jabri, Mohsen Sakly, Hichem Sebai, Nadhem Aissani, H Tounsi, Lamjed Marzouki
    Abstract:

    Abstract Background Matricaria recutita L. (Asteraceae), German chamomile, has been widely used in the traditional Tunisian medicine because of having the powerful health benefits. the current study was conducted to determine the protective effect of chamomile ( Matricaria recutita L.) decoction extract (CDE) in ethanol-induced ulcer and oxidative stress on gastric mucosa in rat. Methods Adult male wistar rats were used and divided into seven groups: Control, EtOH, EtOH+various doses of CDE (25, 50 and 100mg/kg, b.w. ), EtOH+famotidine (FAM) and EtOH+ascorbic acid (AA). Gastric ulceration was induced by EtOH (4g/kg, b.w. p.o. ). Results Firsly, we found that acute alcohol administration leads to mark macroscopic and histologic changes in gastric mucosa. EtOH also induced lipoperoxidation (486.99%), thiol (-SH) groups decrease (40.98%) as well as antioxidant enzyme activity depletion such as superoxide dismutase (SOD) (49.05%), catalase (CAT) (46.80%) and glutathione peroxidase (GPx) (38.20%). Our results also demonstrated that alcohol intoxication increased tissue and plasmatic hydrogen peroxide, calcium and free iron levels. More importantly, CDE reversed all macroscopic, histologic and biochemical changes induced by EtOH administration. Conclusion A potential gastropreotective effect of CDE against EtOH-induced ulcer and oxidative stress might be partially to its antioxidant properties as well as to various gastric mucosal defense mechanisms, including protection of gastric sulfhydryls and its opposite effect on some intracellular mediators such as free iron, hydrogen peroxide and calcium.

  • chamomile decoction extract inhibits human neutrophils ros production and attenuates alcohol induced haematological parameters changes and erythrocytes oxidative stress in rat
    Lipids in Health and Disease, 2016
    Co-Authors: Kais Rtibi, Mohamed-amine Jabri, Mohsen Sakly, Jamel Elbenna, Lamjed Marzouki, Mamane Sani, Hichem Sebai
    Abstract:

    Background The aim of this study was to evaluate the protective effects of subacute pre-treatment with chamomile (Matricaria recutita L.) decoction extract (CDE) against stimulated neutrophils ROS production as well as ethanol (EtOH)-induced haematological changes and erythrocytes oxidative stress in rat.

  • chemical composition antioxidant properties and hepatoprotective effects of chamomile Matricaria recutita l decoction extract against alcohol induced oxidative stress in rat
    General Physiology and Biophysics, 2015
    Co-Authors: Hichem Sebai, Abdelaziz Souli, Olfa Tebourbi, Kais Rtibi, Mohamed-amine Jabri, Jamel Elbenna, Karim Hosni, Mohsen Sakly
    Abstract:

    : The present study assessed the chemical composition, antioxidant properties, and hepatoprotective effects of subacute pre-treatment with chamomile (Matricaria recutita L.) decoction extract (CDE) against ethanol (EtOH)-induced oxidative stress in rats. The colorimetric analysis demonstrated that the CDE is rich in total polyphenols, total flavonoids and condensed tannins, and exhibited an important in vitro antioxidant activity. The use of LC/MS technique allowed us to identify 10 phenolic compounds in CDE. We found that CDE pretreatment, in vivo, protected against EtOH-induced liver injury evident by plasma transaminases activity and preservation of the hepatic tissue structure. The CDE counteracted EtOH-induced liver lipoperoxidation, preserved thiol -SH groups and prevented the depletion of antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). We also showed that acute alcohol administration increased tissue and plasma hydrogen peroxide (H(2)O(2)), calcium and free iron levels. More importantly, CDE pre-treatment reversed all EtOH-induced disturbances in intracellular mediators. In conclusion, our data suggest that CDE exerted a potential hepatoprotective effect against EtOH-induced oxidative stress in rat, at least in part, by negatively regulating Fenton reaction components such as H(2)O(2) and free iron, which are known to lead to cytotoxicity mediated by intracellular calcium deregulation.

  • antidiarrheal and antioxidant activities of chamomile Matricaria recutita l decoction extract in rats
    Journal of Ethnopharmacology, 2014
    Co-Authors: Hichem Sebai, Abdelaziz Souli, Slimen Selmi, Olfa Tebourbi, Kais Rtibi, Mohamed-amine Jabri, Jamel Elbenna, Mohsen Sakly
    Abstract:

    Abstract Ethnopharmacological relevance Matricaria recutita L. (Chamomile) has been widely used in the Tunisian traditional medicine for the treatment of digestive system disorders. The present work aims to investigate the protective effects of chamomile decoction extract (CDE) against castor oil-induced diarrhea and oxidative stress in rats. Methods The antidiarrheal activity was evaluated using castor oil-induced diarrhea method. In this respect, rats were divided into six groups: Control, Castor oil, Castor oil+Loperamide (LOP) and Castor oil+various doses of CDE. Animals were per orally (p.o.) pre-treated with CDE during 1 h and intoxicated for 2 or 4 h by acute oral administration of castor oil. Results Our results showed that CDE produced a significant dose-dependent protection against castor oil-induced diarrhea and intestinal fluid accumulation. On the other hand, we showed that diarrhea was accompagned by an oxidative stress status assessed by an increase of malondialdehyde (MDA) level and depletion of antioxidant enzyme activities as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Castor oil also increased gastric and intestinal mucosa hydrogen peroxide (H2O2) and free iron levels. Importantly, we showed that chamomile pre-treatment abrogated all these biochemical alterations. Conclusion These findings suggested that chamomile extract had a potent antidiarrheal and antioxidant properties in rats confirming their use in traditional medicine.

Mohamed-amine Jabri - One of the best experts on this subject based on the ideXlab platform.

  • protective effect of chamomile Matricaria recutita l decoction extract against alcohol induced injury in rat gastric mucosa
    Pathophysiology, 2017
    Co-Authors: Mohamed-amine Jabri, Mohsen Sakly, Hichem Sebai, Nadhem Aissani, H Tounsi, Lamjed Marzouki
    Abstract:

    Abstract Background Matricaria recutita L. (Asteraceae), German chamomile, has been widely used in the traditional Tunisian medicine because of having the powerful health benefits. the current study was conducted to determine the protective effect of chamomile ( Matricaria recutita L.) decoction extract (CDE) in ethanol-induced ulcer and oxidative stress on gastric mucosa in rat. Methods Adult male wistar rats were used and divided into seven groups: Control, EtOH, EtOH+various doses of CDE (25, 50 and 100mg/kg, b.w. ), EtOH+famotidine (FAM) and EtOH+ascorbic acid (AA). Gastric ulceration was induced by EtOH (4g/kg, b.w. p.o. ). Results Firsly, we found that acute alcohol administration leads to mark macroscopic and histologic changes in gastric mucosa. EtOH also induced lipoperoxidation (486.99%), thiol (-SH) groups decrease (40.98%) as well as antioxidant enzyme activity depletion such as superoxide dismutase (SOD) (49.05%), catalase (CAT) (46.80%) and glutathione peroxidase (GPx) (38.20%). Our results also demonstrated that alcohol intoxication increased tissue and plasmatic hydrogen peroxide, calcium and free iron levels. More importantly, CDE reversed all macroscopic, histologic and biochemical changes induced by EtOH administration. Conclusion A potential gastropreotective effect of CDE against EtOH-induced ulcer and oxidative stress might be partially to its antioxidant properties as well as to various gastric mucosal defense mechanisms, including protection of gastric sulfhydryls and its opposite effect on some intracellular mediators such as free iron, hydrogen peroxide and calcium.

  • chamomile decoction extract inhibits human neutrophils ros production and attenuates alcohol induced haematological parameters changes and erythrocytes oxidative stress in rat
    Lipids in Health and Disease, 2016
    Co-Authors: Kais Rtibi, Mohamed-amine Jabri, Mohsen Sakly, Jamel Elbenna, Lamjed Marzouki, Mamane Sani, Hichem Sebai
    Abstract:

    Background The aim of this study was to evaluate the protective effects of subacute pre-treatment with chamomile (Matricaria recutita L.) decoction extract (CDE) against stimulated neutrophils ROS production as well as ethanol (EtOH)-induced haematological changes and erythrocytes oxidative stress in rat.

  • chemical composition antioxidant properties and hepatoprotective effects of chamomile Matricaria recutita l decoction extract against alcohol induced oxidative stress in rat
    General Physiology and Biophysics, 2015
    Co-Authors: Hichem Sebai, Abdelaziz Souli, Olfa Tebourbi, Kais Rtibi, Mohamed-amine Jabri, Jamel Elbenna, Karim Hosni, Mohsen Sakly
    Abstract:

    : The present study assessed the chemical composition, antioxidant properties, and hepatoprotective effects of subacute pre-treatment with chamomile (Matricaria recutita L.) decoction extract (CDE) against ethanol (EtOH)-induced oxidative stress in rats. The colorimetric analysis demonstrated that the CDE is rich in total polyphenols, total flavonoids and condensed tannins, and exhibited an important in vitro antioxidant activity. The use of LC/MS technique allowed us to identify 10 phenolic compounds in CDE. We found that CDE pretreatment, in vivo, protected against EtOH-induced liver injury evident by plasma transaminases activity and preservation of the hepatic tissue structure. The CDE counteracted EtOH-induced liver lipoperoxidation, preserved thiol -SH groups and prevented the depletion of antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). We also showed that acute alcohol administration increased tissue and plasma hydrogen peroxide (H(2)O(2)), calcium and free iron levels. More importantly, CDE pre-treatment reversed all EtOH-induced disturbances in intracellular mediators. In conclusion, our data suggest that CDE exerted a potential hepatoprotective effect against EtOH-induced oxidative stress in rat, at least in part, by negatively regulating Fenton reaction components such as H(2)O(2) and free iron, which are known to lead to cytotoxicity mediated by intracellular calcium deregulation.

  • antidiarrheal and antioxidant activities of chamomile Matricaria recutita l decoction extract in rats
    Journal of Ethnopharmacology, 2014
    Co-Authors: Hichem Sebai, Abdelaziz Souli, Slimen Selmi, Olfa Tebourbi, Kais Rtibi, Mohamed-amine Jabri, Jamel Elbenna, Mohsen Sakly
    Abstract:

    Abstract Ethnopharmacological relevance Matricaria recutita L. (Chamomile) has been widely used in the Tunisian traditional medicine for the treatment of digestive system disorders. The present work aims to investigate the protective effects of chamomile decoction extract (CDE) against castor oil-induced diarrhea and oxidative stress in rats. Methods The antidiarrheal activity was evaluated using castor oil-induced diarrhea method. In this respect, rats were divided into six groups: Control, Castor oil, Castor oil+Loperamide (LOP) and Castor oil+various doses of CDE. Animals were per orally (p.o.) pre-treated with CDE during 1 h and intoxicated for 2 or 4 h by acute oral administration of castor oil. Results Our results showed that CDE produced a significant dose-dependent protection against castor oil-induced diarrhea and intestinal fluid accumulation. On the other hand, we showed that diarrhea was accompagned by an oxidative stress status assessed by an increase of malondialdehyde (MDA) level and depletion of antioxidant enzyme activities as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Castor oil also increased gastric and intestinal mucosa hydrogen peroxide (H2O2) and free iron levels. Importantly, we showed that chamomile pre-treatment abrogated all these biochemical alterations. Conclusion These findings suggested that chamomile extract had a potent antidiarrheal and antioxidant properties in rats confirming their use in traditional medicine.

Diane L. Mckay - One of the best experts on this subject based on the ideXlab platform.

  • a review of the bioactivity and potential health benefits of chamomile tea Matricaria recutita l
    Phytotherapy Research, 2006
    Co-Authors: Diane L. Mckay, Jeffrey B. Blumberg
    Abstract:

    Chamomile (Matricaria recutita L., Chamomilla recutita L., Matricaria chamomilla) is one of the most popular single ingredient herbal teas, or tisanes. Chamomile tea, brewed from dried flower heads, has been used traditionally for medicinal purposes. Evidence-based information regarding the bioactivity of this herb is presented. The main constituents of the flowers include several phenolic compounds, primarily the flavonoids apigenin, quercetin, patuletin, luteolin and their glucosides. The principal components of the essential oil extracted from the flowers are the terpenoids α-bisabolol and its oxides and azulenes, including chamazulene. Chamomile has moderate antioxidant and antimicrobial activities, and significant antiplatelet activity in vitro. Animal model studies indicate potent antiinflammatory action, some antimutagenic and cholesterol-lowering activities, as well as antispasmotic and anxiolytic effects. However, human studies are limited, and clinical trials examining the purported sedative properties of chamomile tea are absent. Adverse reactions to chamomile, consumed as a tisane or applied topically, have been reported among those with allergies to other plants in the daisy family, i.e. Asteraceae or Compositae. Copyright © 2006 John Wiley & Sons, Ltd.

  • A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.)
    Phytotherapy Research, 2006
    Co-Authors: Diane L. Mckay, Jeffrey B. Blumberg
    Abstract:

    Chamomile (Matricaria recutita L., Chamomilla recutita L., Matricaria chamomilla) is one of the most popular single ingredient herbal teas, or tisanes. Chamomile tea, brewed from dried flower heads, has been used traditionally for medicinal purposes. Evidence-based information regarding the bioactivity of this herb is presented. The main constituents of the flowers include several phenolic compounds, primarily the flavonoids apigenin, quercetin, patuletin, luteolin and their glucosides. The principal components of the essential oil extracted from the flowers are the terpenoids alpha-bisabolol and its oxides and azulenes, including chamazulene. Chamomile has moderate antioxidant and antimicrobial activities, and significant antiplatelet activity in vitro. Animal model studies indicate potent antiinflammatory action, some antimutagenic and cholesterol-lowering activities, as well as antispasmotic and anxiolytic effects. However, human studies are limited, and clinical trials examining the purported sedative properties of chamomile tea are absent. Adverse reactions to chamomile, consumed as a tisane or applied topically, have been reported among those with allergies to other plants in the daisy family, i.e. Asteraceae or Compositae.

Isabel C.f.r. Ferreira - One of the best experts on this subject based on the ideXlab platform.

  • Development of a functional dairy food: Exploring bioactive and preservation effects of chamomile (Matricaria recutita L.)
    Journal of Functional Foods, 2015
    Co-Authors: Cristina Caleja, Joao C M Barreira, Amilcar L. Antonio, M. Beatriz P.p. Oliveira, Ana Ciric, Lillian Barros, Celestino Santos-buelga, Mirko Soković, Isabel C.f.r. Ferreira
    Abstract:

    The antioxidant (free radical scavenging activity, reducing power and lipid peroxidation inhibition) and antimicrobial (against bacteria and fungi) potential of Matricaria recutita L. (chamomile) extracts obtained by decoction was demonstrated. The characterization of the extracts highlighted dicaffeoyl-2,7-anhydro-3-deoxy-2-octulopyranosonic acid (diCDOA) and luteolin-. O-glucuronide as the main phenolic compounds. Extracts containing these natural ingredients were incorporated into cottage cheese, and the prepared products were compared with samples incorporated with chamomile powder and plain cottage cheese (control). Nutritional composition, colour and antioxidant activity of all samples were evaluated along storage time. Chamomile decoctions (natural bioactive ingredient) did not alter significantly the nutritional and fatty acid profiles of cottage cheese, but improved its antioxidant potential, independent of the storage time. Moreover, it increased the shelf life since only the control samples showed signs of degradation after 14 days of storage. The development of this novel functional dairy product emphasizes the bioactive and preservation potential of chamomile.