The Experts below are selected from a list of 162 Experts worldwide ranked by ideXlab platform

Atsumi Mori - One of the best experts on this subject based on the ideXlab platform.

  • Optimal Perfusion Pressure For Experimental Retrograde Cerebral Perfusion
    Journal of Cardiac Surgery, 1994
    Co-Authors: Takehisa Nojima, Yasuhiko Nakajima, Shoji Waterida, Takaaki Sugita, Tatsuo Magara, Masahiko Onoe, Atsumi Mori
    Abstract:

    We evaluated cerebral metabolism during retrograde cerebral perfusion (RCP) and circulatory arrest during profound hypothermia, and also investigated the effects of perfusion pressure on RCP. Twenty-four adult mongrel dogs were placed on cardiopulmonary bypass and cooled to a nasopharyngeal temperature of 20°C. At this temperature, hypothermic circulatory arrest (HCA; n = 6), and RCP with a perfusion pressure of 10 mmHg (RCP10; n = 6), 20 mmHg (RCPPO; n = 6), and 30 mmHg (RCPBO; n = 6) were carried out for 60 minutes. RCP was performed with oxygenated blood via the bilateral Maxillary Veins, and the retrograde flow rate was regulated to maintain a mean perfusion pressure of 10, 20, or 30 mmHg in the external jugular vein. At 60 minutes of RCP, we measured nasopharyngeal temperature; regional cerebral blood flow (rCBF); cerebral oxygen consumption, carbon dioxide excretion, and excess lactate; cerebral tissue adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and energy charge; and cerebral tissue water content. In the RCP10 group, there was excess cerebral lactate, and ATP and energy charge were low. In the RCP30 group, the water content of cerebral tissue was significantly higher than in other groups. In the RCP20 group, temperature was maintained in a narrow range, oxygen consumption and carbon dioxide excretion could be observed, there was no excess lactate, and ATP and energy charge were significantly higher than In the HCA group. In conclusion, RCP can provide adequate metabolic support for the brain during circulatory arrest, and a perfusion pressure of 20 mmHg is most appropriate for RCP. (J Card Surg 1994;9:548–559)

  • Experimental study of optimal perfusion pressure during retrograde cerebral perfusion
    [Zasshi] [Journal]. Nihon Kyobu Geka Gakkai, 1994
    Co-Authors: Takehisa Nojima, Yasuhiko Nakajima, Atsumi Mori, Masahiko Onoe, Shoji Watarida, Sugita T, Matsuno S, Ryoko Tabata
    Abstract:

    The effects of retrograde perfusion pressure on the brain was experimentally investigated during profound hypothermic circulatory arrest. Fifteen adult mongrel dogs were placed cardiopulmonary bypass and induced profound hypothermia of 20 degrees C at nasopharyngeal temperature. Retrograde cerebral perfusion (RCP) with perfusion pressure of 10 mmHg (RCP10; n = 5), 20 mmHg (RCP20; n = 5), 30 mmHg (RCP30; n = 5) underwent for 60 minutes. The oxygenated blood was infused via the bilateral Maxillary Veins, and the flow rate was kept to maintain a desired pressure in the external jugular vein for each group. Regional cerebral blood flow (rCBF), excess lactate, cerebrospinal fluid pressure (CSFP), adenosine triphosphate (ATP) concentration of cerebral tissue, and water content of cerebral tissue were measured. In the RCP10 group, cerebral excess lactate was positive and ATP concentration was low. In the RCP30 group, the water content of cerebral tissue was significantly higher than those in the other groups. In the RCP20 group, the excess lactate was maintained in a negative range, and ATP concentration was significantly higher than in the RCP10 group. In conclusion, RCP may provide metabolically adequate support for the brain and a perfusion pressure of 20 mmHg was appropriate for RCP in dogs.

  • Optimal perfusion pressure for experimental retrograde cerebral perfusion.
    Journal of cardiac surgery, 1994
    Co-Authors: Takehisa Nojima, Yasuhiko Nakajima, Shoji Waterida, Takaaki Sugita, Tatsuo Magara, Masahiko Onoe, Atsumi Mori
    Abstract:

    We evaluated cerebral metabolism during retrograde cerebral perfusion (RCP) and circulatory arrest during profound hypothermia, and also investigated the effects of perfusion pressure on RCP. Twenty-four adult mongrel dogs were placed on cardiopulmonary bypass and cooled to a nasopharyngeal temperature of 20 degrees C. At this temperature, hypothermic circulatory arrest (HCA; n = 6), and RCP with a perfusion pressure of 10 mmHg (RCP10; n = 6), 20 mmHg (RCP20; n = 6), and 30 mmHg (RCP30; n = 6) were carried out for 60 minutes. RCP was performed with oxygenated blood via the bilateral Maxillary Veins, and the retrograde flow rate was regulated to maintain a mean perfusion pressure of 10, 20, or 30 mmHg in the external jugular vein. At 60 minutes of RCP, we measured nasopharyngeal temperature; regional cerebral blood flow (rCBF); cerebral oxygen consumption, carbon dioxide excretion, and excess lactate; cerebral tissue adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and energy charge; and cerebral tissue water content. In the RCP10 group, there was excess cerebral lactate, and ATP and energy charge were low. In the RCP30 group, the water content of cerebral tissue was significantly higher than in other groups. In the RCP20 group, temperature was maintained in a narrow range, oxygen consumption and carbon dioxide excretion could be observed, there was no excess lactate, and ATP and energy charge were significantly higher than in the HCA group. In conclusion, RCP can provide adequate metabolic support for the brain during circulatory arrest, and a perfusion pressure of 20 mmHg is most appropriate for RCP.

  • Cerebral metabolism and effects of pulsatile flow during retrograde cerebral perfusion.
    The Journal of cardiovascular surgery, 1993
    Co-Authors: Takehisa Nojima, Atsumi Mori, Shoji Watarida, Masahiko Onoe
    Abstract:

    We evaluated cerebral metabolism during retrograde cerebral perfusion (RCP) and circulatory arrest under profound hypothermia, and also investigated the effect of pulsatile flow on RCP. Eighteen adult mongrel dogs were placed on cardiopulmonary bypass and were cooled to a nasopharyngeal temperature of 20 degrees C. At this temperature, hypothermic circulatory arrest (HCA; n = 6), non-pulsatile RCP (NP-RCP; n = 6), and pulsatile RCP (P-RCP; n = 6) were performed for 60 minutes. Retrograde cerebral perfusion was performed via the bilateral internal Maxillary Veins, and retrograde flow rate was regulated to maintain a mean perfusion pressure of 20 mmHg in the external jugular vein. During RCP, the temperature was maintained in a narrow range, oxygen consumption and carbon dioxide excretion could be observed, the excess lactate was maintained at a negative value, and cerebral tissue ATP concentration was significantly higher than in the HCA group. The cerebral tissue water content was significantly lower in the P-RCP group than in the NP-RCP group. These findings suggest that hypothermia of the central nervous system, the supply of oxygen, the excretion of metabolites, aerobic metabolism, and the cerebral ATP level were maintained by RCP. In conclusion, RCP may possibly provide adequate metabolic support for the brain during total circulatory arrest, and pulsatile flow appears to reduce cerebral edema when compared with non-pulsatile flow in dogs.

Takehisa Nojima - One of the best experts on this subject based on the ideXlab platform.

  • Optimal Perfusion Pressure For Experimental Retrograde Cerebral Perfusion
    Journal of Cardiac Surgery, 1994
    Co-Authors: Takehisa Nojima, Yasuhiko Nakajima, Shoji Waterida, Takaaki Sugita, Tatsuo Magara, Masahiko Onoe, Atsumi Mori
    Abstract:

    We evaluated cerebral metabolism during retrograde cerebral perfusion (RCP) and circulatory arrest during profound hypothermia, and also investigated the effects of perfusion pressure on RCP. Twenty-four adult mongrel dogs were placed on cardiopulmonary bypass and cooled to a nasopharyngeal temperature of 20°C. At this temperature, hypothermic circulatory arrest (HCA; n = 6), and RCP with a perfusion pressure of 10 mmHg (RCP10; n = 6), 20 mmHg (RCPPO; n = 6), and 30 mmHg (RCPBO; n = 6) were carried out for 60 minutes. RCP was performed with oxygenated blood via the bilateral Maxillary Veins, and the retrograde flow rate was regulated to maintain a mean perfusion pressure of 10, 20, or 30 mmHg in the external jugular vein. At 60 minutes of RCP, we measured nasopharyngeal temperature; regional cerebral blood flow (rCBF); cerebral oxygen consumption, carbon dioxide excretion, and excess lactate; cerebral tissue adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and energy charge; and cerebral tissue water content. In the RCP10 group, there was excess cerebral lactate, and ATP and energy charge were low. In the RCP30 group, the water content of cerebral tissue was significantly higher than in other groups. In the RCP20 group, temperature was maintained in a narrow range, oxygen consumption and carbon dioxide excretion could be observed, there was no excess lactate, and ATP and energy charge were significantly higher than In the HCA group. In conclusion, RCP can provide adequate metabolic support for the brain during circulatory arrest, and a perfusion pressure of 20 mmHg is most appropriate for RCP. (J Card Surg 1994;9:548–559)

  • Experimental study of optimal perfusion pressure during retrograde cerebral perfusion
    [Zasshi] [Journal]. Nihon Kyobu Geka Gakkai, 1994
    Co-Authors: Takehisa Nojima, Yasuhiko Nakajima, Atsumi Mori, Masahiko Onoe, Shoji Watarida, Sugita T, Matsuno S, Ryoko Tabata
    Abstract:

    The effects of retrograde perfusion pressure on the brain was experimentally investigated during profound hypothermic circulatory arrest. Fifteen adult mongrel dogs were placed cardiopulmonary bypass and induced profound hypothermia of 20 degrees C at nasopharyngeal temperature. Retrograde cerebral perfusion (RCP) with perfusion pressure of 10 mmHg (RCP10; n = 5), 20 mmHg (RCP20; n = 5), 30 mmHg (RCP30; n = 5) underwent for 60 minutes. The oxygenated blood was infused via the bilateral Maxillary Veins, and the flow rate was kept to maintain a desired pressure in the external jugular vein for each group. Regional cerebral blood flow (rCBF), excess lactate, cerebrospinal fluid pressure (CSFP), adenosine triphosphate (ATP) concentration of cerebral tissue, and water content of cerebral tissue were measured. In the RCP10 group, cerebral excess lactate was positive and ATP concentration was low. In the RCP30 group, the water content of cerebral tissue was significantly higher than those in the other groups. In the RCP20 group, the excess lactate was maintained in a negative range, and ATP concentration was significantly higher than in the RCP10 group. In conclusion, RCP may provide metabolically adequate support for the brain and a perfusion pressure of 20 mmHg was appropriate for RCP in dogs.

  • Optimal perfusion pressure for experimental retrograde cerebral perfusion.
    Journal of cardiac surgery, 1994
    Co-Authors: Takehisa Nojima, Yasuhiko Nakajima, Shoji Waterida, Takaaki Sugita, Tatsuo Magara, Masahiko Onoe, Atsumi Mori
    Abstract:

    We evaluated cerebral metabolism during retrograde cerebral perfusion (RCP) and circulatory arrest during profound hypothermia, and also investigated the effects of perfusion pressure on RCP. Twenty-four adult mongrel dogs were placed on cardiopulmonary bypass and cooled to a nasopharyngeal temperature of 20 degrees C. At this temperature, hypothermic circulatory arrest (HCA; n = 6), and RCP with a perfusion pressure of 10 mmHg (RCP10; n = 6), 20 mmHg (RCP20; n = 6), and 30 mmHg (RCP30; n = 6) were carried out for 60 minutes. RCP was performed with oxygenated blood via the bilateral Maxillary Veins, and the retrograde flow rate was regulated to maintain a mean perfusion pressure of 10, 20, or 30 mmHg in the external jugular vein. At 60 minutes of RCP, we measured nasopharyngeal temperature; regional cerebral blood flow (rCBF); cerebral oxygen consumption, carbon dioxide excretion, and excess lactate; cerebral tissue adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and energy charge; and cerebral tissue water content. In the RCP10 group, there was excess cerebral lactate, and ATP and energy charge were low. In the RCP30 group, the water content of cerebral tissue was significantly higher than in other groups. In the RCP20 group, temperature was maintained in a narrow range, oxygen consumption and carbon dioxide excretion could be observed, there was no excess lactate, and ATP and energy charge were significantly higher than in the HCA group. In conclusion, RCP can provide adequate metabolic support for the brain during circulatory arrest, and a perfusion pressure of 20 mmHg is most appropriate for RCP.

  • Cerebral metabolism and effects of pulsatile flow during retrograde cerebral perfusion.
    The Journal of cardiovascular surgery, 1993
    Co-Authors: Takehisa Nojima, Atsumi Mori, Shoji Watarida, Masahiko Onoe
    Abstract:

    We evaluated cerebral metabolism during retrograde cerebral perfusion (RCP) and circulatory arrest under profound hypothermia, and also investigated the effect of pulsatile flow on RCP. Eighteen adult mongrel dogs were placed on cardiopulmonary bypass and were cooled to a nasopharyngeal temperature of 20 degrees C. At this temperature, hypothermic circulatory arrest (HCA; n = 6), non-pulsatile RCP (NP-RCP; n = 6), and pulsatile RCP (P-RCP; n = 6) were performed for 60 minutes. Retrograde cerebral perfusion was performed via the bilateral internal Maxillary Veins, and retrograde flow rate was regulated to maintain a mean perfusion pressure of 20 mmHg in the external jugular vein. During RCP, the temperature was maintained in a narrow range, oxygen consumption and carbon dioxide excretion could be observed, the excess lactate was maintained at a negative value, and cerebral tissue ATP concentration was significantly higher than in the HCA group. The cerebral tissue water content was significantly lower in the P-RCP group than in the NP-RCP group. These findings suggest that hypothermia of the central nervous system, the supply of oxygen, the excretion of metabolites, aerobic metabolism, and the cerebral ATP level were maintained by RCP. In conclusion, RCP may possibly provide adequate metabolic support for the brain during total circulatory arrest, and pulsatile flow appears to reduce cerebral edema when compared with non-pulsatile flow in dogs.

Masahiko Onoe - One of the best experts on this subject based on the ideXlab platform.

  • Optimal Perfusion Pressure For Experimental Retrograde Cerebral Perfusion
    Journal of Cardiac Surgery, 1994
    Co-Authors: Takehisa Nojima, Yasuhiko Nakajima, Shoji Waterida, Takaaki Sugita, Tatsuo Magara, Masahiko Onoe, Atsumi Mori
    Abstract:

    We evaluated cerebral metabolism during retrograde cerebral perfusion (RCP) and circulatory arrest during profound hypothermia, and also investigated the effects of perfusion pressure on RCP. Twenty-four adult mongrel dogs were placed on cardiopulmonary bypass and cooled to a nasopharyngeal temperature of 20°C. At this temperature, hypothermic circulatory arrest (HCA; n = 6), and RCP with a perfusion pressure of 10 mmHg (RCP10; n = 6), 20 mmHg (RCPPO; n = 6), and 30 mmHg (RCPBO; n = 6) were carried out for 60 minutes. RCP was performed with oxygenated blood via the bilateral Maxillary Veins, and the retrograde flow rate was regulated to maintain a mean perfusion pressure of 10, 20, or 30 mmHg in the external jugular vein. At 60 minutes of RCP, we measured nasopharyngeal temperature; regional cerebral blood flow (rCBF); cerebral oxygen consumption, carbon dioxide excretion, and excess lactate; cerebral tissue adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and energy charge; and cerebral tissue water content. In the RCP10 group, there was excess cerebral lactate, and ATP and energy charge were low. In the RCP30 group, the water content of cerebral tissue was significantly higher than in other groups. In the RCP20 group, temperature was maintained in a narrow range, oxygen consumption and carbon dioxide excretion could be observed, there was no excess lactate, and ATP and energy charge were significantly higher than In the HCA group. In conclusion, RCP can provide adequate metabolic support for the brain during circulatory arrest, and a perfusion pressure of 20 mmHg is most appropriate for RCP. (J Card Surg 1994;9:548–559)

  • Experimental study of optimal perfusion pressure during retrograde cerebral perfusion
    [Zasshi] [Journal]. Nihon Kyobu Geka Gakkai, 1994
    Co-Authors: Takehisa Nojima, Yasuhiko Nakajima, Atsumi Mori, Masahiko Onoe, Shoji Watarida, Sugita T, Matsuno S, Ryoko Tabata
    Abstract:

    The effects of retrograde perfusion pressure on the brain was experimentally investigated during profound hypothermic circulatory arrest. Fifteen adult mongrel dogs were placed cardiopulmonary bypass and induced profound hypothermia of 20 degrees C at nasopharyngeal temperature. Retrograde cerebral perfusion (RCP) with perfusion pressure of 10 mmHg (RCP10; n = 5), 20 mmHg (RCP20; n = 5), 30 mmHg (RCP30; n = 5) underwent for 60 minutes. The oxygenated blood was infused via the bilateral Maxillary Veins, and the flow rate was kept to maintain a desired pressure in the external jugular vein for each group. Regional cerebral blood flow (rCBF), excess lactate, cerebrospinal fluid pressure (CSFP), adenosine triphosphate (ATP) concentration of cerebral tissue, and water content of cerebral tissue were measured. In the RCP10 group, cerebral excess lactate was positive and ATP concentration was low. In the RCP30 group, the water content of cerebral tissue was significantly higher than those in the other groups. In the RCP20 group, the excess lactate was maintained in a negative range, and ATP concentration was significantly higher than in the RCP10 group. In conclusion, RCP may provide metabolically adequate support for the brain and a perfusion pressure of 20 mmHg was appropriate for RCP in dogs.

  • Optimal perfusion pressure for experimental retrograde cerebral perfusion.
    Journal of cardiac surgery, 1994
    Co-Authors: Takehisa Nojima, Yasuhiko Nakajima, Shoji Waterida, Takaaki Sugita, Tatsuo Magara, Masahiko Onoe, Atsumi Mori
    Abstract:

    We evaluated cerebral metabolism during retrograde cerebral perfusion (RCP) and circulatory arrest during profound hypothermia, and also investigated the effects of perfusion pressure on RCP. Twenty-four adult mongrel dogs were placed on cardiopulmonary bypass and cooled to a nasopharyngeal temperature of 20 degrees C. At this temperature, hypothermic circulatory arrest (HCA; n = 6), and RCP with a perfusion pressure of 10 mmHg (RCP10; n = 6), 20 mmHg (RCP20; n = 6), and 30 mmHg (RCP30; n = 6) were carried out for 60 minutes. RCP was performed with oxygenated blood via the bilateral Maxillary Veins, and the retrograde flow rate was regulated to maintain a mean perfusion pressure of 10, 20, or 30 mmHg in the external jugular vein. At 60 minutes of RCP, we measured nasopharyngeal temperature; regional cerebral blood flow (rCBF); cerebral oxygen consumption, carbon dioxide excretion, and excess lactate; cerebral tissue adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and energy charge; and cerebral tissue water content. In the RCP10 group, there was excess cerebral lactate, and ATP and energy charge were low. In the RCP30 group, the water content of cerebral tissue was significantly higher than in other groups. In the RCP20 group, temperature was maintained in a narrow range, oxygen consumption and carbon dioxide excretion could be observed, there was no excess lactate, and ATP and energy charge were significantly higher than in the HCA group. In conclusion, RCP can provide adequate metabolic support for the brain during circulatory arrest, and a perfusion pressure of 20 mmHg is most appropriate for RCP.

  • Cerebral metabolism and effects of pulsatile flow during retrograde cerebral perfusion.
    The Journal of cardiovascular surgery, 1993
    Co-Authors: Takehisa Nojima, Atsumi Mori, Shoji Watarida, Masahiko Onoe
    Abstract:

    We evaluated cerebral metabolism during retrograde cerebral perfusion (RCP) and circulatory arrest under profound hypothermia, and also investigated the effect of pulsatile flow on RCP. Eighteen adult mongrel dogs were placed on cardiopulmonary bypass and were cooled to a nasopharyngeal temperature of 20 degrees C. At this temperature, hypothermic circulatory arrest (HCA; n = 6), non-pulsatile RCP (NP-RCP; n = 6), and pulsatile RCP (P-RCP; n = 6) were performed for 60 minutes. Retrograde cerebral perfusion was performed via the bilateral internal Maxillary Veins, and retrograde flow rate was regulated to maintain a mean perfusion pressure of 20 mmHg in the external jugular vein. During RCP, the temperature was maintained in a narrow range, oxygen consumption and carbon dioxide excretion could be observed, the excess lactate was maintained at a negative value, and cerebral tissue ATP concentration was significantly higher than in the HCA group. The cerebral tissue water content was significantly lower in the P-RCP group than in the NP-RCP group. These findings suggest that hypothermia of the central nervous system, the supply of oxygen, the excretion of metabolites, aerobic metabolism, and the cerebral ATP level were maintained by RCP. In conclusion, RCP may possibly provide adequate metabolic support for the brain during total circulatory arrest, and pulsatile flow appears to reduce cerebral edema when compared with non-pulsatile flow in dogs.

Yasuhiko Nakajima - One of the best experts on this subject based on the ideXlab platform.

  • Optimal Perfusion Pressure For Experimental Retrograde Cerebral Perfusion
    Journal of Cardiac Surgery, 1994
    Co-Authors: Takehisa Nojima, Yasuhiko Nakajima, Shoji Waterida, Takaaki Sugita, Tatsuo Magara, Masahiko Onoe, Atsumi Mori
    Abstract:

    We evaluated cerebral metabolism during retrograde cerebral perfusion (RCP) and circulatory arrest during profound hypothermia, and also investigated the effects of perfusion pressure on RCP. Twenty-four adult mongrel dogs were placed on cardiopulmonary bypass and cooled to a nasopharyngeal temperature of 20°C. At this temperature, hypothermic circulatory arrest (HCA; n = 6), and RCP with a perfusion pressure of 10 mmHg (RCP10; n = 6), 20 mmHg (RCPPO; n = 6), and 30 mmHg (RCPBO; n = 6) were carried out for 60 minutes. RCP was performed with oxygenated blood via the bilateral Maxillary Veins, and the retrograde flow rate was regulated to maintain a mean perfusion pressure of 10, 20, or 30 mmHg in the external jugular vein. At 60 minutes of RCP, we measured nasopharyngeal temperature; regional cerebral blood flow (rCBF); cerebral oxygen consumption, carbon dioxide excretion, and excess lactate; cerebral tissue adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and energy charge; and cerebral tissue water content. In the RCP10 group, there was excess cerebral lactate, and ATP and energy charge were low. In the RCP30 group, the water content of cerebral tissue was significantly higher than in other groups. In the RCP20 group, temperature was maintained in a narrow range, oxygen consumption and carbon dioxide excretion could be observed, there was no excess lactate, and ATP and energy charge were significantly higher than In the HCA group. In conclusion, RCP can provide adequate metabolic support for the brain during circulatory arrest, and a perfusion pressure of 20 mmHg is most appropriate for RCP. (J Card Surg 1994;9:548–559)

  • Experimental study of optimal perfusion pressure during retrograde cerebral perfusion
    [Zasshi] [Journal]. Nihon Kyobu Geka Gakkai, 1994
    Co-Authors: Takehisa Nojima, Yasuhiko Nakajima, Atsumi Mori, Masahiko Onoe, Shoji Watarida, Sugita T, Matsuno S, Ryoko Tabata
    Abstract:

    The effects of retrograde perfusion pressure on the brain was experimentally investigated during profound hypothermic circulatory arrest. Fifteen adult mongrel dogs were placed cardiopulmonary bypass and induced profound hypothermia of 20 degrees C at nasopharyngeal temperature. Retrograde cerebral perfusion (RCP) with perfusion pressure of 10 mmHg (RCP10; n = 5), 20 mmHg (RCP20; n = 5), 30 mmHg (RCP30; n = 5) underwent for 60 minutes. The oxygenated blood was infused via the bilateral Maxillary Veins, and the flow rate was kept to maintain a desired pressure in the external jugular vein for each group. Regional cerebral blood flow (rCBF), excess lactate, cerebrospinal fluid pressure (CSFP), adenosine triphosphate (ATP) concentration of cerebral tissue, and water content of cerebral tissue were measured. In the RCP10 group, cerebral excess lactate was positive and ATP concentration was low. In the RCP30 group, the water content of cerebral tissue was significantly higher than those in the other groups. In the RCP20 group, the excess lactate was maintained in a negative range, and ATP concentration was significantly higher than in the RCP10 group. In conclusion, RCP may provide metabolically adequate support for the brain and a perfusion pressure of 20 mmHg was appropriate for RCP in dogs.

  • Optimal perfusion pressure for experimental retrograde cerebral perfusion.
    Journal of cardiac surgery, 1994
    Co-Authors: Takehisa Nojima, Yasuhiko Nakajima, Shoji Waterida, Takaaki Sugita, Tatsuo Magara, Masahiko Onoe, Atsumi Mori
    Abstract:

    We evaluated cerebral metabolism during retrograde cerebral perfusion (RCP) and circulatory arrest during profound hypothermia, and also investigated the effects of perfusion pressure on RCP. Twenty-four adult mongrel dogs were placed on cardiopulmonary bypass and cooled to a nasopharyngeal temperature of 20 degrees C. At this temperature, hypothermic circulatory arrest (HCA; n = 6), and RCP with a perfusion pressure of 10 mmHg (RCP10; n = 6), 20 mmHg (RCP20; n = 6), and 30 mmHg (RCP30; n = 6) were carried out for 60 minutes. RCP was performed with oxygenated blood via the bilateral Maxillary Veins, and the retrograde flow rate was regulated to maintain a mean perfusion pressure of 10, 20, or 30 mmHg in the external jugular vein. At 60 minutes of RCP, we measured nasopharyngeal temperature; regional cerebral blood flow (rCBF); cerebral oxygen consumption, carbon dioxide excretion, and excess lactate; cerebral tissue adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and energy charge; and cerebral tissue water content. In the RCP10 group, there was excess cerebral lactate, and ATP and energy charge were low. In the RCP30 group, the water content of cerebral tissue was significantly higher than in other groups. In the RCP20 group, temperature was maintained in a narrow range, oxygen consumption and carbon dioxide excretion could be observed, there was no excess lactate, and ATP and energy charge were significantly higher than in the HCA group. In conclusion, RCP can provide adequate metabolic support for the brain during circulatory arrest, and a perfusion pressure of 20 mmHg is most appropriate for RCP.

Ryoko Tabata - One of the best experts on this subject based on the ideXlab platform.

  • Experimental study of optimal perfusion pressure during retrograde cerebral perfusion
    [Zasshi] [Journal]. Nihon Kyobu Geka Gakkai, 1994
    Co-Authors: Takehisa Nojima, Yasuhiko Nakajima, Atsumi Mori, Masahiko Onoe, Shoji Watarida, Sugita T, Matsuno S, Ryoko Tabata
    Abstract:

    The effects of retrograde perfusion pressure on the brain was experimentally investigated during profound hypothermic circulatory arrest. Fifteen adult mongrel dogs were placed cardiopulmonary bypass and induced profound hypothermia of 20 degrees C at nasopharyngeal temperature. Retrograde cerebral perfusion (RCP) with perfusion pressure of 10 mmHg (RCP10; n = 5), 20 mmHg (RCP20; n = 5), 30 mmHg (RCP30; n = 5) underwent for 60 minutes. The oxygenated blood was infused via the bilateral Maxillary Veins, and the flow rate was kept to maintain a desired pressure in the external jugular vein for each group. Regional cerebral blood flow (rCBF), excess lactate, cerebrospinal fluid pressure (CSFP), adenosine triphosphate (ATP) concentration of cerebral tissue, and water content of cerebral tissue were measured. In the RCP10 group, cerebral excess lactate was positive and ATP concentration was low. In the RCP30 group, the water content of cerebral tissue was significantly higher than those in the other groups. In the RCP20 group, the excess lactate was maintained in a negative range, and ATP concentration was significantly higher than in the RCP10 group. In conclusion, RCP may provide metabolically adequate support for the brain and a perfusion pressure of 20 mmHg was appropriate for RCP in dogs.