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Priyanka Sharma - One of the best experts on this subject based on the ideXlab platform.

  • Maximum Contaminant Level of arsenic in drinking water potentiates quinalphos-induced renal damage on co-administration of both arsenic and quinalphos in Wistar rats
    Environmental Science and Pollution Research, 2020
    Co-Authors: Parvinder Singh, Pawan Kumar Verma, Rajinder Raina, Shilpa Sood, Priyanka Sharma
    Abstract:

    This study was designed to determine alterations in renal biomarkers, antioxidant profile, and histomorphology of renal tissue following subacute exposure to quinalphos alone or in conjunction with arsenic in rats. A total of 54 adult Wistar rats were randomly divided into nine groups of six rats each and were administered sub-lethal concentrations of quinalphos (1/100^th and 1/10^th of LD_50) orally daily and arsenic (50 and 100 ppb) in drinking water for 28 days. Significantly ( p  

  • Maximum Contaminant Level of arsenic in drinking water potentiates quinalphos-induced renal damage on co-administration of both arsenic and quinalphos in Wistar rats.
    Environmental Science and Pollution Research, 2020
    Co-Authors: Parvinder Pal Singh, Pawan Kumar Verma, Rajinder Raina, Shilpa Sood, Priyanka Sharma
    Abstract:

    This study was designed to determine alterations in renal biomarkers, antioxidant profile, and histomorphology of renal tissue following subacute exposure to quinalphos alone or in conjunction with arsenic in rats. A total of 54 adult Wistar rats were randomly divided into nine groups of six rats each and were administered sub-lethal concentrations of quinalphos (1/100th and 1/10th of LD50) orally daily and arsenic (50 and 100 ppb) in drinking water for 28 days. Significantly (p < 0.05) decreased Levels of antioxidant biomarkers in renal tissue, viz., total thiols, catalase, superoxide dismutase, glutathione peroxidase, glutathione-s-transferase, and glutathione reductase along with increased (p < 0.05) thiobarbituric acid reacting substance (TBRAS) Levels indicated that significant oxidative damage to renal tissue occurred following repeated administrations of quinalphos at either dose Levels or arsenic at the concentration of 100 ppb when compared with the control rats. The alterations in the antioxidant parameters were observed to be more pronounced in co-administered groups as compared with either toxicant administered group. Similarly, activity of renal acetylcholinesterase was decreased after repeated exposure to quinalphos or arsenic, but inhibition was higher (up to 48%) in rat renal tissue co-exposed with quinalphos and arsenic at the higher concentration. These findings corroborated with the histopathological alterations in renal tissue of toxicant exposed rats. The altered plasma and tissue antioxidant biomarkers along with histopathological changes in the kidney at higher dose Level of either toxicant indicate that renal tissue is significantly impacted by these toxicants, and these effects become more pronounced after their co-administration.

Pawan Kumar Verma - One of the best experts on this subject based on the ideXlab platform.

  • Maximum Contaminant Level of arsenic in drinking water potentiates quinalphos-induced renal damage on co-administration of both arsenic and quinalphos in Wistar rats
    Environmental Science and Pollution Research, 2020
    Co-Authors: Parvinder Singh, Pawan Kumar Verma, Rajinder Raina, Shilpa Sood, Priyanka Sharma
    Abstract:

    This study was designed to determine alterations in renal biomarkers, antioxidant profile, and histomorphology of renal tissue following subacute exposure to quinalphos alone or in conjunction with arsenic in rats. A total of 54 adult Wistar rats were randomly divided into nine groups of six rats each and were administered sub-lethal concentrations of quinalphos (1/100^th and 1/10^th of LD_50) orally daily and arsenic (50 and 100 ppb) in drinking water for 28 days. Significantly ( p  

  • Maximum Contaminant Level of arsenic in drinking water potentiates quinalphos-induced renal damage on co-administration of both arsenic and quinalphos in Wistar rats.
    Environmental Science and Pollution Research, 2020
    Co-Authors: Parvinder Pal Singh, Pawan Kumar Verma, Rajinder Raina, Shilpa Sood, Priyanka Sharma
    Abstract:

    This study was designed to determine alterations in renal biomarkers, antioxidant profile, and histomorphology of renal tissue following subacute exposure to quinalphos alone or in conjunction with arsenic in rats. A total of 54 adult Wistar rats were randomly divided into nine groups of six rats each and were administered sub-lethal concentrations of quinalphos (1/100th and 1/10th of LD50) orally daily and arsenic (50 and 100 ppb) in drinking water for 28 days. Significantly (p < 0.05) decreased Levels of antioxidant biomarkers in renal tissue, viz., total thiols, catalase, superoxide dismutase, glutathione peroxidase, glutathione-s-transferase, and glutathione reductase along with increased (p < 0.05) thiobarbituric acid reacting substance (TBRAS) Levels indicated that significant oxidative damage to renal tissue occurred following repeated administrations of quinalphos at either dose Levels or arsenic at the concentration of 100 ppb when compared with the control rats. The alterations in the antioxidant parameters were observed to be more pronounced in co-administered groups as compared with either toxicant administered group. Similarly, activity of renal acetylcholinesterase was decreased after repeated exposure to quinalphos or arsenic, but inhibition was higher (up to 48%) in rat renal tissue co-exposed with quinalphos and arsenic at the higher concentration. These findings corroborated with the histopathological alterations in renal tissue of toxicant exposed rats. The altered plasma and tissue antioxidant biomarkers along with histopathological changes in the kidney at higher dose Level of either toxicant indicate that renal tissue is significantly impacted by these toxicants, and these effects become more pronounced after their co-administration.

Shilpa Sood - One of the best experts on this subject based on the ideXlab platform.

  • Maximum Contaminant Level of arsenic in drinking water potentiates quinalphos-induced renal damage on co-administration of both arsenic and quinalphos in Wistar rats
    Environmental Science and Pollution Research, 2020
    Co-Authors: Parvinder Singh, Pawan Kumar Verma, Rajinder Raina, Shilpa Sood, Priyanka Sharma
    Abstract:

    This study was designed to determine alterations in renal biomarkers, antioxidant profile, and histomorphology of renal tissue following subacute exposure to quinalphos alone or in conjunction with arsenic in rats. A total of 54 adult Wistar rats were randomly divided into nine groups of six rats each and were administered sub-lethal concentrations of quinalphos (1/100^th and 1/10^th of LD_50) orally daily and arsenic (50 and 100 ppb) in drinking water for 28 days. Significantly ( p  

  • Maximum Contaminant Level of arsenic in drinking water potentiates quinalphos-induced renal damage on co-administration of both arsenic and quinalphos in Wistar rats.
    Environmental Science and Pollution Research, 2020
    Co-Authors: Parvinder Pal Singh, Pawan Kumar Verma, Rajinder Raina, Shilpa Sood, Priyanka Sharma
    Abstract:

    This study was designed to determine alterations in renal biomarkers, antioxidant profile, and histomorphology of renal tissue following subacute exposure to quinalphos alone or in conjunction with arsenic in rats. A total of 54 adult Wistar rats were randomly divided into nine groups of six rats each and were administered sub-lethal concentrations of quinalphos (1/100th and 1/10th of LD50) orally daily and arsenic (50 and 100 ppb) in drinking water for 28 days. Significantly (p < 0.05) decreased Levels of antioxidant biomarkers in renal tissue, viz., total thiols, catalase, superoxide dismutase, glutathione peroxidase, glutathione-s-transferase, and glutathione reductase along with increased (p < 0.05) thiobarbituric acid reacting substance (TBRAS) Levels indicated that significant oxidative damage to renal tissue occurred following repeated administrations of quinalphos at either dose Levels or arsenic at the concentration of 100 ppb when compared with the control rats. The alterations in the antioxidant parameters were observed to be more pronounced in co-administered groups as compared with either toxicant administered group. Similarly, activity of renal acetylcholinesterase was decreased after repeated exposure to quinalphos or arsenic, but inhibition was higher (up to 48%) in rat renal tissue co-exposed with quinalphos and arsenic at the higher concentration. These findings corroborated with the histopathological alterations in renal tissue of toxicant exposed rats. The altered plasma and tissue antioxidant biomarkers along with histopathological changes in the kidney at higher dose Level of either toxicant indicate that renal tissue is significantly impacted by these toxicants, and these effects become more pronounced after their co-administration.

Rajinder Raina - One of the best experts on this subject based on the ideXlab platform.

  • Maximum Contaminant Level of arsenic in drinking water potentiates quinalphos-induced renal damage on co-administration of both arsenic and quinalphos in Wistar rats
    Environmental Science and Pollution Research, 2020
    Co-Authors: Parvinder Singh, Pawan Kumar Verma, Rajinder Raina, Shilpa Sood, Priyanka Sharma
    Abstract:

    This study was designed to determine alterations in renal biomarkers, antioxidant profile, and histomorphology of renal tissue following subacute exposure to quinalphos alone or in conjunction with arsenic in rats. A total of 54 adult Wistar rats were randomly divided into nine groups of six rats each and were administered sub-lethal concentrations of quinalphos (1/100^th and 1/10^th of LD_50) orally daily and arsenic (50 and 100 ppb) in drinking water for 28 days. Significantly ( p  

  • Maximum Contaminant Level of arsenic in drinking water potentiates quinalphos-induced renal damage on co-administration of both arsenic and quinalphos in Wistar rats.
    Environmental Science and Pollution Research, 2020
    Co-Authors: Parvinder Pal Singh, Pawan Kumar Verma, Rajinder Raina, Shilpa Sood, Priyanka Sharma
    Abstract:

    This study was designed to determine alterations in renal biomarkers, antioxidant profile, and histomorphology of renal tissue following subacute exposure to quinalphos alone or in conjunction with arsenic in rats. A total of 54 adult Wistar rats were randomly divided into nine groups of six rats each and were administered sub-lethal concentrations of quinalphos (1/100th and 1/10th of LD50) orally daily and arsenic (50 and 100 ppb) in drinking water for 28 days. Significantly (p < 0.05) decreased Levels of antioxidant biomarkers in renal tissue, viz., total thiols, catalase, superoxide dismutase, glutathione peroxidase, glutathione-s-transferase, and glutathione reductase along with increased (p < 0.05) thiobarbituric acid reacting substance (TBRAS) Levels indicated that significant oxidative damage to renal tissue occurred following repeated administrations of quinalphos at either dose Levels or arsenic at the concentration of 100 ppb when compared with the control rats. The alterations in the antioxidant parameters were observed to be more pronounced in co-administered groups as compared with either toxicant administered group. Similarly, activity of renal acetylcholinesterase was decreased after repeated exposure to quinalphos or arsenic, but inhibition was higher (up to 48%) in rat renal tissue co-exposed with quinalphos and arsenic at the higher concentration. These findings corroborated with the histopathological alterations in renal tissue of toxicant exposed rats. The altered plasma and tissue antioxidant biomarkers along with histopathological changes in the kidney at higher dose Level of either toxicant indicate that renal tissue is significantly impacted by these toxicants, and these effects become more pronounced after their co-administration.

Chang Oh Choo - One of the best experts on this subject based on the ideXlab platform.

  • Geochemical Behavior of Uranium and Radon in Groundwater of Jurassic Granite Area, Icheon, Middle Korea
    Water, 2019
    Co-Authors: Byong Wook Cho, Chang Oh Choo
    Abstract:

    Uranium concentrations (a total of 82 samples) in groundwater in Icheon, middle Korea, showed a wide range from 0.02 to 1640 μg/L with a mean of 56.77 μg/L, a median of 3.03 μg/L, and a standard deviation of 228.63 μg/L. Most groundwater samples had quite low concentrations: 32.9% were below 1 μg/L, while 15.9% exceeded 30 μg/L, the Maximum Contaminant Level (MCL) of the US EPA (Environmental Protection Agency). Radon concentrations also ranged widely from 1.48 to 865.8 Bq/L. Although the standard deviation of radon was large (151.8 Bq/L), the mean was 211.29 Bq/L and the median was 176.86 Bq/L. Overall, 64.6% of the samples exceeded the alternative Maximum Contaminant Level (AMCL) of the US EPA (148 Bq/L). According to statistical analyses, there was no close correlations between uranium and radon, but there were correlations between uranium and redox potential (Eh) (−0.54), dissolved oxygen (DO) (−0.50), HCO3− (0.45), Sr (0.65), and SiO2 (−0.44). Radon showed independent behavior with respect to most components in groundwater. Uranium concentrations in groundwater increased with increasing water–rock interactions. Anomalously high uranium and radon concentrations in groundwater are preferentially localized in granite areas and spatial distributions are remarkably heterogeneous.

  • Characteristics of Occurrence and Distribution of Natural Radioactive Materials, Uranium and Radon in Groundwater of the Danyang Area
    The Journal of Engineering Geology, 2013
    Co-Authors: Byong Wook Cho, Moon Su Kim, Tae Seung Kim, Yun, Byeong Dae Lee, Jae Hong Hwang, Chang Oh Choo
    Abstract:

    Natural radionuclides in groundwater in the Danyang area were investigated to characterize the behaviors of uranium and radon with respect to lithology and physico-chemical components, which can aid our understanding of their occurrence, properties, and origins. To this end, a total of 100 groundwater samples were collected and analyzed, and radionuclide Levels were used to construct detailed concentration maps. The water type of the groundwater, assessed using a Piper diagram, is mainly Ca-Na-. The concentrations of uranium range from 0.02 to (average, ) and only 1% exceed USEPA`s MCL (Maximum Contaminant Level). Uranium is enriched in groundwaters of Cretaceous granites and Precambrian metamorphic rocks, whereas it is depleted in groundwaters of sedimentary rocks. The concentrations of radon range from 13 to 28,470 pCi/L (average, 2397 pCi/L). Only 15% of the samples exceed AMCL (Alternative Maximum Contaminant Level) of 4000 pCi/L. The radon concentration is highest in groundwater of Cretaceous granites and lowest in groundwater of sedimentary rocks. In conclusion, the distribution and occurrence of radionuclides are intimately related to the basic geological characteristics of the rocks in which the radiogenic minerals are primarily contained. The behavior of uranium is only weakly related to that of radon (correlation coefficient