The Experts below are selected from a list of 252 Experts worldwide ranked by ideXlab platform

M.m. Avram - One of the best experts on this subject based on the ideXlab platform.

Thomas Schermerhorn - One of the best experts on this subject based on the ideXlab platform.

  • Evaluation of Mean Corpuscular Volume difference as a marker for serum hypertonicity during water deprivation in dogs.
    American journal of veterinary research, 2015
    Co-Authors: Jennifer M. Reinhart, Misty R. Yancey, Lisa M. Pohlman, Thomas Schermerhorn
    Abstract:

    OBJECTIVE To evaluate Mean Corpuscular Volume difference (dMCV) as a marker for hypertonicity induced by water deprivation in dogs. ANIMALS 5 healthy Greyhounds maintained in a research colony. PROCEDURES Water was withheld for 24 hours. Blood and urine samples were collected before (time 0) and every 6 hours during water deprivation. Serum and urine osmolality were measured on the basis of freezing point depression, and dMCV was calculated from routine hematologic variables. RESULTS Serum and urine osmolality significantly increased and body weight decreased over time in healthy Greyhounds during water deprivation, although most dogs developed only a slight increase in serum osmolality. The dMCV also increased over time, but the value at 24 hours did not differ significantly from the value at time 0. However, a significant correlation was found between serum osmolality and dMCV. A dMCV ≥ 5 fL yielded 100% specificity for predicting hypertonicity when hypertonicity was defined as serum osmolality ≥ 310 mO...

  • In vitro increase of Mean Corpuscular Volume difference (dMCV) as a marker for serum hypertonicity in dogs
    Research in veterinary science, 2014
    Co-Authors: Jennifer M. Reinhart, Misty R. Yancey, Lisa M. Pohlman, Thomas Schermerhorn
    Abstract:

    Spurious increase in erythrocyte Mean Corpuscular Volume (MCV) on automated cell analyzers is a well-characterized lab error in hypertonic patients. A difference between automated and manual MCV (dMCV) greater than 2 fl has been shown to predict hypertonicity in humans. The purpose of this study was to investigate dMCV as a marker for serum hypertonicity in dogs and to examine the relationship between dMCV and three methods of estimating serum tonicity: measured (OsMM), calculated (OsMC), and calculated effective (OsMCE) osmolalities. OsMC, OsMCE, and dMCV were calculated from routine blood values and OsMM was directly measured in 121 dogs. The dMCV of hypertonic dogs was significantly larger than that of normotonic dogs for all three osmolality methods. dMCV predicted hypertonicity as estimated by OsMM better than it predicted hypertonicity as estimated by OsMC and OsMCE. A cutoff of 2.96 fl yielded the best sensitivity (76%) and specificity (71%) for hypertonicity estimated by OsMM.

P. Goldwasser - One of the best experts on this subject based on the ideXlab platform.

Meinhard Haltmayer - One of the best experts on this subject based on the ideXlab platform.

  • Erythrocyte Mean Corpuscular Volume Associated with Severity of Peripheral Arterial Disease: An Angiographic Evaluation
    Annals of vascular surgery, 2002
    Co-Authors: Meinhard Haltmayer, Thomas Mueller, Christian Luft, Werner Poelz, Dieter Haidinger
    Abstract:

    Elevated erythrocyte Mean Corpuscular Volume (MCV) may be a risk factor for peripheral arterial disease (PAD). The aim of the present study was to evaluate whether MCV was associated with the severity of atherosclerotic findings in the lower limbs of PAD patients, as measured by an angiographic scoring system based on vessel lumen reduction. One hundred male patients with symptomatic PAD were studied. MCV was significantly correlated with the angiographic score (rs = 0.247, p = 0.013). PAD patients with an angiographic score in the lower third were compared to those with values in the upper third using a logistic regression model with age, smoking, hypertension, MCV, homocysteine, and total cholesterol and triglycerides as independent variables. This model revealed significant odds ratios (OR) for MCV (OR = 2.02 for an increment of 5 fl, 95% CI = 1.08-3.8) and for age (OR = 2.41 for an increment of 10 years, 95% CI = 1.21-4.81) and facilitated classification of 71% of all subjects correctly. In conclusion, MCV may be associated with angiographically determined disease severity in patients with PAD. This finding supports the hypothesis that MCV is a risk factor for PAD, although the mechanism by which MCV may contribute to the presence and severity of the disease is not yet determined.

  • association between erythrocyte Mean Corpuscular Volume and peripheral arterial disease in male subjects a case control study
    Angiology, 2001
    Co-Authors: Thomas Mueller, Dieter Haidinger, Christian Luft, Werner Horvath, Werner Poelz, Meinhard Haltmayer
    Abstract:

    Elevated serum total homocysteine, an established risk factor for peripheral arterial disease, is influenced by the vitamin B12 and folate status. Since these vitamins are inversely correlated with erythrocyte Mean Corpuscular Volume, an investigation of whether Mean Corpuscular Volume is higher in patients with symptomatic peripheral arterial disease than in healthy subjects was performed. Furthermore, a determination of predictors of increased Mean Corpuscular Volume levels in this population free of symptomatic coronary artery disease, cerebrovascular disease, and diabetes mellitus was carried out. From 469 consecutive patients with symptomatic peripheral arterial disease, 100 fulfilled study inclusion criteria. Peripheral arterial disease was confirmed by angiography. One hundred age-matched subjects without peripheral arterial disease as verified by ankle-brachial index measurements >0.9 served as control subjects. Patients with PAD displayed a significantly higher Mean Corpuscular Volume level (94.5 fl) than control subjects (90.9 fl, p<0.001). Logistic regression analysis showed that current smoking status (p<0.001) and Mean Corpuscular Volume (p=0.009), but not total homocysteine or lipid parameters discriminated case control status. In addition, logistic regression analysis revealed a relationship of Mean Corpuscular Volume with smoking (p=0.001), gamma-glutamyltransferase (p<0.001), and total homocysteine (p=0.012). This model predicted Mean Corpuscular Volume values with an accuracy of 83%. Elevated Mean Corpuscular Volume is a predictor of symptomatic peripheral arterial disease in the sample studied. A deficiency of folate and/or vitamin B12 may be responsible for this observation, as indicated by the correlation of Mean Corpuscular Volume with total homocysteine. Due to the additional association of Mean Corpuscular Volume with smoking and gamma-glutamyltransferase, an unhealthy lifestyle with low vitamin intake may cause elevated Mean Corpuscular Volume values in patients with PAD.

  • Association between erythrocyte Mean Corpuscular Volume and peripheral arterial disease in male subjects: a case control study
    Angiology, 2001
    Co-Authors: Thomas Mueller, Dieter Haidinger, Christian Luft, Werner Horvath, Werner Poelz, Meinhard Haltmayer
    Abstract:

    Elevated serum total homocysteine, an established risk factor for peripheral arterial disease, is influenced by the vitamin B12 and folate status. Since these vitamins are inversely correlated with erythrocyte Mean Corpuscular Volume, an investigation of whether Mean Corpuscular Volume is higher in patients with symptomatic peripheral arterial disease than in healthy subjects was performed. Furthermore, a determination of predictors of increased Mean Corpuscular Volume levels in this population free of symptomatic coronary artery disease, cerebrovascular disease, and diabetes mellitus was carried out. From 469 consecutive patients with symptomatic peripheral arterial disease, 100 fulfilled study inclusion criteria. Peripheral arterial disease was confirmed by angiography. One hundred age-matched subjects without peripheral arterial disease as verified by ankle-brachial index measurements >0.9 served as control subjects. Patients with PAD displayed a significantly higher Mean Corpuscular Volume level (94.5 fl) than control subjects (90.9 fl, p

Jennifer M. Reinhart - One of the best experts on this subject based on the ideXlab platform.

  • Evaluation of Mean Corpuscular Volume difference as a marker for serum hypertonicity during water deprivation in dogs.
    American journal of veterinary research, 2015
    Co-Authors: Jennifer M. Reinhart, Misty R. Yancey, Lisa M. Pohlman, Thomas Schermerhorn
    Abstract:

    OBJECTIVE To evaluate Mean Corpuscular Volume difference (dMCV) as a marker for hypertonicity induced by water deprivation in dogs. ANIMALS 5 healthy Greyhounds maintained in a research colony. PROCEDURES Water was withheld for 24 hours. Blood and urine samples were collected before (time 0) and every 6 hours during water deprivation. Serum and urine osmolality were measured on the basis of freezing point depression, and dMCV was calculated from routine hematologic variables. RESULTS Serum and urine osmolality significantly increased and body weight decreased over time in healthy Greyhounds during water deprivation, although most dogs developed only a slight increase in serum osmolality. The dMCV also increased over time, but the value at 24 hours did not differ significantly from the value at time 0. However, a significant correlation was found between serum osmolality and dMCV. A dMCV ≥ 5 fL yielded 100% specificity for predicting hypertonicity when hypertonicity was defined as serum osmolality ≥ 310 mO...

  • In vitro increase of Mean Corpuscular Volume difference (dMCV) as a marker for serum hypertonicity in dogs
    Research in veterinary science, 2014
    Co-Authors: Jennifer M. Reinhart, Misty R. Yancey, Lisa M. Pohlman, Thomas Schermerhorn
    Abstract:

    Spurious increase in erythrocyte Mean Corpuscular Volume (MCV) on automated cell analyzers is a well-characterized lab error in hypertonic patients. A difference between automated and manual MCV (dMCV) greater than 2 fl has been shown to predict hypertonicity in humans. The purpose of this study was to investigate dMCV as a marker for serum hypertonicity in dogs and to examine the relationship between dMCV and three methods of estimating serum tonicity: measured (OsMM), calculated (OsMC), and calculated effective (OsMCE) osmolalities. OsMC, OsMCE, and dMCV were calculated from routine blood values and OsMM was directly measured in 121 dogs. The dMCV of hypertonic dogs was significantly larger than that of normotonic dogs for all three osmolality methods. dMCV predicted hypertonicity as estimated by OsMM better than it predicted hypertonicity as estimated by OsMC and OsMCE. A cutoff of 2.96 fl yielded the best sensitivity (76%) and specificity (71%) for hypertonicity estimated by OsMM.