The Experts below are selected from a list of 147 Experts worldwide ranked by ideXlab platform
Victoria Castel - One of the best experts on this subject based on the ideXlab platform.
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Herpesvirus-6 Encephalitis Complicated by Wernicke–korsakoff Syndrome in a Pediatric Recipient of Unrelated Cord Blood Transplantation
Journal of Pediatric Hematology Oncology, 2001Co-Authors: Eva Carvajal, Amparo Verdeguer, Jose-maria Fernandez, Adela Cañete, Victoria CastelAbstract:Abstract: A 10-year-old girl with M2 acute myeloid leukemia underwent an unrelated cord blood transplantation in refractory first relapse. On day +13, after 48 hours with fever, she showed a Measles-Like Rash, and on day +15, she began experiencing neurologic symptoms (headache, tremors, weakness, nystagmus, mild confusion, speaking, taste, and behavior disturbances, and focal seizures). She also had amnesia for recent events with disability to learn, mimicking Wernicke–Korsakoff syndrome. Computed tomography of the brain and cerebrospinal fluid (CSF) and electroencephalogram were nonspecific. We found human herpesvirus 6 (HHV-6) DNA in CSF and cytomegalovirus in bronchoalveolar lavage using polymerase chain reaction techniques. Treatment with ganciclovir and foscarnet was effective, with total resolution of symptoms.
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herpesvirus 6 encephalitis complicated by wernicke korsakoff syndrome in a pediatric recipient of unrelated cord blood transplantation
Journal of Pediatric Hematology Oncology, 2001Co-Authors: Eva Carvajal, Amparo Verdeguer, Jose-maria Fernandez, Adela Cañete, Victoria CastelAbstract:Abstract: A 10-year-old girl with M2 acute myeloid leukemia underwent an unrelated cord blood transplantation in refractory first relapse. On day +13, after 48 hours with fever, she showed a Measles-Like Rash, and on day +15, she began experiencing neurologic symptoms (headache, tremors, weakness, nystagmus, mild confusion, speaking, taste, and behavior disturbances, and focal seizures). She also had amnesia for recent events with disability to learn, mimicking Wernicke–Korsakoff syndrome. Computed tomography of the brain and cerebrospinal fluid (CSF) and electroencephalogram were nonspecific. We found human herpesvirus 6 (HHV-6) DNA in CSF and cytomegalovirus in bronchoalveolar lavage using polymerase chain reaction techniques. Treatment with ganciclovir and foscarnet was effective, with total resolution of symptoms.
Peter Aaby - One of the best experts on this subject based on the ideXlab platform.
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Seroconversions in unvaccinated infants: further evidence for subclinical Measles from vaccine trials in Niakhar, Senegal.
International journal of epidemiology, 1999Co-Authors: John V. Bennett, Hilton Whittle, Badara Samb, Badara Cisse, François Simondon, Peter AabyAbstract:Background Increases in Measles antibodies without Rash-illnesses have been documented in previously vaccinated children exposed to Measles cases. The phenomenon has been incompletely evaluated in young unvaccinated infants with immunity of maternal origin. Methods Monthly cohorts of newborns were prospectively randomized to vaccine and placebo control groups during a trial of high-titre vaccines in Niakhar, Senegal. Measles antibodies were assayed in blood samples of enrolled children collected at 5 months old, when controls received a placebo injection, and at 10 months, when the placebo group was given Measles vaccine. Intensive prospective surveillance for Measles was conducted throughout the trial. Results One-fifth (n = 53) of the placebo controls seroconverted, with known exposure to a Measles case in only three of them. None of the seroconverters developed a Measles-Like Rash. Sixteen-fold or greater increases in titres were noted in about one-quarter of them. Compared with placebo controls who did not seroconvert, seroconverters were more Likely to have had exposure to a Measles case and to travel, more Likely to be boys than girls, and had significantly lower baseline antibody titres. Measles was endemic in the study area throughout the trial. Seroconversions did not adversely effect subsequent nutritional indices or mortality. Conclusions Although laboratory errors and inadvertent injection of vaccine rather than placebo may have played some role, they do not fully explain the above observations, which are consistent with subclinical Measles in the seroconverters. The possible role of subclinical Measles in occult transmission, its potential effect on the type and duration of subsequent immunity, and its impact on response to primary vaccination need to be determined.
Eva Carvajal - One of the best experts on this subject based on the ideXlab platform.
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Herpesvirus-6 Encephalitis Complicated by Wernicke–korsakoff Syndrome in a Pediatric Recipient of Unrelated Cord Blood Transplantation
Journal of Pediatric Hematology Oncology, 2001Co-Authors: Eva Carvajal, Amparo Verdeguer, Jose-maria Fernandez, Adela Cañete, Victoria CastelAbstract:Abstract: A 10-year-old girl with M2 acute myeloid leukemia underwent an unrelated cord blood transplantation in refractory first relapse. On day +13, after 48 hours with fever, she showed a Measles-Like Rash, and on day +15, she began experiencing neurologic symptoms (headache, tremors, weakness, nystagmus, mild confusion, speaking, taste, and behavior disturbances, and focal seizures). She also had amnesia for recent events with disability to learn, mimicking Wernicke–Korsakoff syndrome. Computed tomography of the brain and cerebrospinal fluid (CSF) and electroencephalogram were nonspecific. We found human herpesvirus 6 (HHV-6) DNA in CSF and cytomegalovirus in bronchoalveolar lavage using polymerase chain reaction techniques. Treatment with ganciclovir and foscarnet was effective, with total resolution of symptoms.
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herpesvirus 6 encephalitis complicated by wernicke korsakoff syndrome in a pediatric recipient of unrelated cord blood transplantation
Journal of Pediatric Hematology Oncology, 2001Co-Authors: Eva Carvajal, Amparo Verdeguer, Jose-maria Fernandez, Adela Cañete, Victoria CastelAbstract:Abstract: A 10-year-old girl with M2 acute myeloid leukemia underwent an unrelated cord blood transplantation in refractory first relapse. On day +13, after 48 hours with fever, she showed a Measles-Like Rash, and on day +15, she began experiencing neurologic symptoms (headache, tremors, weakness, nystagmus, mild confusion, speaking, taste, and behavior disturbances, and focal seizures). She also had amnesia for recent events with disability to learn, mimicking Wernicke–Korsakoff syndrome. Computed tomography of the brain and cerebrospinal fluid (CSF) and electroencephalogram were nonspecific. We found human herpesvirus 6 (HHV-6) DNA in CSF and cytomegalovirus in bronchoalveolar lavage using polymerase chain reaction techniques. Treatment with ganciclovir and foscarnet was effective, with total resolution of symptoms.
John V. Bennett - One of the best experts on this subject based on the ideXlab platform.
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Seroconversions in unvaccinated infants: further evidence for subclinical Measles from vaccine trials in Niakhar, Senegal.
International journal of epidemiology, 1999Co-Authors: John V. Bennett, Hilton Whittle, Badara Samb, Badara Cisse, François Simondon, Peter AabyAbstract:Background Increases in Measles antibodies without Rash-illnesses have been documented in previously vaccinated children exposed to Measles cases. The phenomenon has been incompletely evaluated in young unvaccinated infants with immunity of maternal origin. Methods Monthly cohorts of newborns were prospectively randomized to vaccine and placebo control groups during a trial of high-titre vaccines in Niakhar, Senegal. Measles antibodies were assayed in blood samples of enrolled children collected at 5 months old, when controls received a placebo injection, and at 10 months, when the placebo group was given Measles vaccine. Intensive prospective surveillance for Measles was conducted throughout the trial. Results One-fifth (n = 53) of the placebo controls seroconverted, with known exposure to a Measles case in only three of them. None of the seroconverters developed a Measles-Like Rash. Sixteen-fold or greater increases in titres were noted in about one-quarter of them. Compared with placebo controls who did not seroconvert, seroconverters were more Likely to have had exposure to a Measles case and to travel, more Likely to be boys than girls, and had significantly lower baseline antibody titres. Measles was endemic in the study area throughout the trial. Seroconversions did not adversely effect subsequent nutritional indices or mortality. Conclusions Although laboratory errors and inadvertent injection of vaccine rather than placebo may have played some role, they do not fully explain the above observations, which are consistent with subclinical Measles in the seroconverters. The possible role of subclinical Measles in occult transmission, its potential effect on the type and duration of subsequent immunity, and its impact on response to primary vaccination need to be determined.
Benoit Soubeyrand - One of the best experts on this subject based on the ideXlab platform.
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Disease-specific adverse events following nonlive vaccines: A paradoxical placebo effect or a nocebo phenomenon?
Vaccine, 2011Co-Authors: Claire Okaïs, Fabrice Seon, Lydie Buchaille, Emilie Chary, Benoit SoubeyrandAbstract:Vaccines can cause adverse reactions (AR), i.e. adverse events following immunization (AEFIs) due to the vaccine, such as local reactions or fever. In addition, live attenuated vaccines which replicate in vaccinees can cause disease-specific AR, e.g. Measles-Like Rash following Measles vaccination. However, nonlive vaccines because they are inactivated and they do not replicate in vaccinees, are not Likely to cause disease-specific AR. The aim of the study was to assess whether safety signals could be generated by an undescribed bias in spontaneous reporting of disease-specific AEFIs with nonlive vaccines. All AEFIs of Sanofi Pasteur MSD vaccines spontaneously reported in France from January 2000 to June 2010, coded according to MedDRA terms and collected in the company's pharmacovigilance database were analyzed. Vaccine-event pairs of interest were selected a priori. The disproportionality reporting rate methodology was used, comparing the proportion of a given event reported following a given vaccine to its proportion reported following all other studied vaccines. The Reporting Odds Ratio (ROR) was used for signals detection for each vaccine-event pair selected. A total of 33,275 AEFIs were analyzed. The calculated ROR showed a statistically disproportionate reporting rate and generated false safety signals for almost all the pairs tested. Three nonlive vaccine pairs were striking: gynaecological symptoms and the quadrivalent human papillomavirus (qHPV) vaccine; trismus and tetanus vaccines; hepatobiliary disorders and hepatitis B vaccines. In conclusion we have identified a new vaccine AE spontaneous reporting bias: "disease-specific adverse events following nonlive vaccines", showing that vaccinees and healthcare professionals tend to report preferentially the symptoms of the disease against which the nonlive vaccine was administered. We suggest that bias is subordinate to a paradoxical placebo effect and/or a nocebo phenomenon.