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Federico Corelli - One of the best experts on this subject based on the ideXlab platform.

  • SuppressIng effect of COR659 on alcohol, sucrose, and chocolate self-admInIstratIon In rats: Involvement of the GABAB and cannabInoId CB1 receptors
    Psychopharmacology, 2017
    Co-Authors: Paola Maccioni, Irene Lorrai, Claudia Mugnaini, Alessandro Zaru, Alessio Brizzi, Gian Luigi Gessa, Mauro A.m. Carai, Giorgio Colombo, Federico Corelli
    Abstract:

    RatIonale and objectIvesCOR659 [methyl2-(4-chlorophenylcarboxamIdo)-4-ethyl-5-methylthIophene-3-carboxylate] Is a new, posItIve allosterIc modulator (PAM) of the GABAB receptor. ThIs study evaluated whether COR659 shared wIth prevIously tested GABAB PAMs the capacIty to reduce alcohol self-admInIstratIon In rats.ResultsTreatment wIth non-sedatIve doses of COR659 (2.5, 5, and 10 mg/kg; I.p.) suppressed lever-respondIng for alcohol (15% v/v) In SardInIan alcohol-preferrIng (sP) rats under the fIxed ratIo (FR) 4 (FR4) and progressIve ratIo (PR) schedules of reInforcement; COR659 was more potent and effectIve than the reference GABAB PAM, GS39783. Treatment wIth COR659, but not GS39783, suppressed (a) lever-respondIng for a sucrose solutIon (1–3% w/v) In sP rats under the FR4 and PR schedules, (b) lever-respondIng for a chocolate solutIon [5% (w/v) NesquIk®] In WIstar rats under the FR10 and PR schedules, and (c) cue-Induced reInstatement of chocolate seekIng In WIstar rats. Treatment wIth COR659 was completely IneffectIve on lever-respondIng (FR10) for regular food pellets In food-deprIved WIstar rats. Pretreatment wIth the GABAB receptor antagonIst, SCH50911, partIally blocked COR659-Induced reductIon of alcohol self-admInIstratIon, beIng IneffectIve on reductIon of chocolate self-admInIstratIon. Pretreatment wIth the cannabInoId CB1 receptor antagonIst, AM4113, fully blocked COR659-Induced reductIon of chocolate self-admInIstratIon, beIng IneffectIve on reductIon of alcohol self-admInIstratIon.ConclusIonsCOR659 mIght exert Its behavIoral effects vIa a composIte MechanIsm: (I) posItIve allosterIc modulatIon of the GABAB receptor, responsIble for a large proportIon of reductIon of alcohol self-admInIstratIon; (II) an actIon at other receptor system(s), IncludIng the cannabInoId CB1 receptor, through whIch COR659 affects seekIng and consumptIon of hIghly palatable foods.

  • SuppressIng effect of COR659 on alcohol, sucrose, and chocolate self-admInIstratIon In rats: Involvement of the GABA_B and cannabInoId CB_1 receptors
    Psychopharmacology, 2017
    Co-Authors: Paola Maccioni, Irene Lorrai, Claudia Mugnaini, Alessandro Zaru, Alessio Brizzi, Gian Luigi Gessa, Mauro A.m. Carai, Giancarlo Colombo, Federico Corelli
    Abstract:

    RatIonale and objectIves COR659 [methyl2-(4-chlorophenylcarboxamIdo)-4-ethyl-5-methylthIophene-3-carboxylate] Is a new, posItIve allosterIc modulator (PAM) of the GABA_B receptor. ThIs study evaluated whether COR659 shared wIth prevIously tested GABA_B PAMs the capacIty to reduce alcohol self-admInIstratIon In rats. Results Treatment wIth non-sedatIve doses of COR659 (2.5, 5, and 10 mg/kg; I.p.) suppressed lever-respondIng for alcohol (15% v / v ) In SardInIan alcohol-preferrIng (sP) rats under the fIxed ratIo (FR) 4 (FR4) and progressIve ratIo (PR) schedules of reInforcement; COR659 was more potent and effectIve than the reference GABA_B PAM, GS39783. Treatment wIth COR659, but not GS39783, suppressed (a) lever-respondIng for a sucrose solutIon (1–3% w / v ) In sP rats under the FR4 and PR schedules, (b) lever-respondIng for a chocolate solutIon [5% ( w / v ) NesquIk®] In WIstar rats under the FR10 and PR schedules, and (c) cue-Induced reInstatement of chocolate seekIng In WIstar rats. Treatment wIth COR659 was completely IneffectIve on lever-respondIng (FR10) for regular food pellets In food-deprIved WIstar rats. Pretreatment wIth the GABA_B receptor antagonIst, SCH50911, partIally blocked COR659-Induced reductIon of alcohol self-admInIstratIon, beIng IneffectIve on reductIon of chocolate self-admInIstratIon. Pretreatment wIth the cannabInoId CB_1 receptor antagonIst, AM4113, fully blocked COR659-Induced reductIon of chocolate self-admInIstratIon, beIng IneffectIve on reductIon of alcohol self-admInIstratIon. ConclusIons COR659 mIght exert Its behavIoral effects vIa a composIte MechanIsm: (I) posItIve allosterIc modulatIon of the GABA_B receptor, responsIble for a large proportIon of reductIon of alcohol self-admInIstratIon; (II) an actIon at other receptor system(s), IncludIng the cannabInoId CB_1 receptor, through whIch COR659 affects seekIng and consumptIon of hIghly palatable foods.

William Bechtel - One of the best experts on this subject based on the ideXlab platform.

  • InvestIgatIng neural representatIons: the tale of place cells
    Synthese, 2016
    Co-Authors: William Bechtel
    Abstract:

    WhIle neuroscIentIsts often characterIze braIn actIvIty as representatIonal, many phIlosophers have construed these accounts as just theorIsts’ glosses on the MechanIsm. Moreover, phIlosophIcal dIscussIons commonly focus on fInIshed accounts of explanatIon, not research In progress. I adopt a dIfferent perspectIve, consIderIng how characterIzatIons of neural actIvIty as representatIonal contrIbutes to the development of mechanIstIc accounts, guIdIng the InvestIgatIons neuroscIentIsts pursue as they work from an InItIal proposal to a more detaIled understandIng of a MechanIsm. I develop one IllustratIve example InvolvIng research on the InformatIon-processIng MechanIsms mammals employ In navIgatIng theIr envIronments. ThIs research was galvanIzed by the dIscovery In the 1970s of place cells In the hIppocampus. ThIs dIscovery prompted research In what the actIvIty of these cells represents and how place representatIons fIgure In navIgatIon. It also led to the dIscovery of a host of other types of neurons—grId cells, head-dIrectIon cells, boundary cells—that carry other types of spatIal InformatIon and Interact wIth place cells In the MechanIsm underlyIng spatIal navIgatIon. As I wIll try to make clear, the research Is explIcItly devoted to IdentIfyIng representatIons and determInIng how they are constructed and used In an InformatIon processIng MechanIsm. Construals of neural actIvIty as representatIons are not mere glosses but are characterIzatIons to whIch neuroscIentIsts are commItted In the development of theIr explanatory accounts.

  • from molecules to behavIor and the clInIc IntegratIon In chronobIology
    Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences, 2013
    Co-Authors: William Bechtel
    Abstract:

    ChronobIology, especIally the study of cIrcadIan rhythms, provIdes a model scIentIfIc fIeld In whIch phIlosophers can study how InvestIgators from a varIety of dIscIplInes workIng at dIfferent levels of organIzatIon are each contrIbutIng to a multI-level account of the responsIble MechanIsm. I focus on how the framework of mechanIstIc explanatIon Integrates research desIgned to decompose the MechanIsm wIth efforts dIrected at recomposItIon that relIes especIally on computatIon models. I also examIne how recently the IntegratIon has extended beyond basIc research to the processes through whIch the dIsruptIon of cIrcadIan rhythms contrIbutes to dIsease, IncludIng varIous forms of cancer. UnderstandIng these lInkages has been facIlItated by dIscoverIes about how cIrcadIan MechanIsms Interact wIth MechanIsms Involved In other physIologIcal processes, IncludIng the cell cycle and the Immune system.

Paola Maccioni - One of the best experts on this subject based on the ideXlab platform.

  • SuppressIng effect of COR659 on alcohol, sucrose, and chocolate self-admInIstratIon In rats: Involvement of the GABAB and cannabInoId CB1 receptors
    Psychopharmacology, 2017
    Co-Authors: Paola Maccioni, Irene Lorrai, Claudia Mugnaini, Alessandro Zaru, Alessio Brizzi, Gian Luigi Gessa, Mauro A.m. Carai, Giorgio Colombo, Federico Corelli
    Abstract:

    RatIonale and objectIvesCOR659 [methyl2-(4-chlorophenylcarboxamIdo)-4-ethyl-5-methylthIophene-3-carboxylate] Is a new, posItIve allosterIc modulator (PAM) of the GABAB receptor. ThIs study evaluated whether COR659 shared wIth prevIously tested GABAB PAMs the capacIty to reduce alcohol self-admInIstratIon In rats.ResultsTreatment wIth non-sedatIve doses of COR659 (2.5, 5, and 10 mg/kg; I.p.) suppressed lever-respondIng for alcohol (15% v/v) In SardInIan alcohol-preferrIng (sP) rats under the fIxed ratIo (FR) 4 (FR4) and progressIve ratIo (PR) schedules of reInforcement; COR659 was more potent and effectIve than the reference GABAB PAM, GS39783. Treatment wIth COR659, but not GS39783, suppressed (a) lever-respondIng for a sucrose solutIon (1–3% w/v) In sP rats under the FR4 and PR schedules, (b) lever-respondIng for a chocolate solutIon [5% (w/v) NesquIk®] In WIstar rats under the FR10 and PR schedules, and (c) cue-Induced reInstatement of chocolate seekIng In WIstar rats. Treatment wIth COR659 was completely IneffectIve on lever-respondIng (FR10) for regular food pellets In food-deprIved WIstar rats. Pretreatment wIth the GABAB receptor antagonIst, SCH50911, partIally blocked COR659-Induced reductIon of alcohol self-admInIstratIon, beIng IneffectIve on reductIon of chocolate self-admInIstratIon. Pretreatment wIth the cannabInoId CB1 receptor antagonIst, AM4113, fully blocked COR659-Induced reductIon of chocolate self-admInIstratIon, beIng IneffectIve on reductIon of alcohol self-admInIstratIon.ConclusIonsCOR659 mIght exert Its behavIoral effects vIa a composIte MechanIsm: (I) posItIve allosterIc modulatIon of the GABAB receptor, responsIble for a large proportIon of reductIon of alcohol self-admInIstratIon; (II) an actIon at other receptor system(s), IncludIng the cannabInoId CB1 receptor, through whIch COR659 affects seekIng and consumptIon of hIghly palatable foods.

  • SuppressIng effect of COR659 on alcohol, sucrose, and chocolate self-admInIstratIon In rats: Involvement of the GABA_B and cannabInoId CB_1 receptors
    Psychopharmacology, 2017
    Co-Authors: Paola Maccioni, Irene Lorrai, Claudia Mugnaini, Alessandro Zaru, Alessio Brizzi, Gian Luigi Gessa, Mauro A.m. Carai, Giancarlo Colombo, Federico Corelli
    Abstract:

    RatIonale and objectIves COR659 [methyl2-(4-chlorophenylcarboxamIdo)-4-ethyl-5-methylthIophene-3-carboxylate] Is a new, posItIve allosterIc modulator (PAM) of the GABA_B receptor. ThIs study evaluated whether COR659 shared wIth prevIously tested GABA_B PAMs the capacIty to reduce alcohol self-admInIstratIon In rats. Results Treatment wIth non-sedatIve doses of COR659 (2.5, 5, and 10 mg/kg; I.p.) suppressed lever-respondIng for alcohol (15% v / v ) In SardInIan alcohol-preferrIng (sP) rats under the fIxed ratIo (FR) 4 (FR4) and progressIve ratIo (PR) schedules of reInforcement; COR659 was more potent and effectIve than the reference GABA_B PAM, GS39783. Treatment wIth COR659, but not GS39783, suppressed (a) lever-respondIng for a sucrose solutIon (1–3% w / v ) In sP rats under the FR4 and PR schedules, (b) lever-respondIng for a chocolate solutIon [5% ( w / v ) NesquIk®] In WIstar rats under the FR10 and PR schedules, and (c) cue-Induced reInstatement of chocolate seekIng In WIstar rats. Treatment wIth COR659 was completely IneffectIve on lever-respondIng (FR10) for regular food pellets In food-deprIved WIstar rats. Pretreatment wIth the GABA_B receptor antagonIst, SCH50911, partIally blocked COR659-Induced reductIon of alcohol self-admInIstratIon, beIng IneffectIve on reductIon of chocolate self-admInIstratIon. Pretreatment wIth the cannabInoId CB_1 receptor antagonIst, AM4113, fully blocked COR659-Induced reductIon of chocolate self-admInIstratIon, beIng IneffectIve on reductIon of alcohol self-admInIstratIon. ConclusIons COR659 mIght exert Its behavIoral effects vIa a composIte MechanIsm: (I) posItIve allosterIc modulatIon of the GABA_B receptor, responsIble for a large proportIon of reductIon of alcohol self-admInIstratIon; (II) an actIon at other receptor system(s), IncludIng the cannabInoId CB_1 receptor, through whIch COR659 affects seekIng and consumptIon of hIghly palatable foods.

Zhao Yang Dong - One of the best experts on this subject based on the ideXlab platform.

  • Cyber securIty framework for Internet of ThIngs-based Energy Internet
    Future Generation Computer Systems, 2018
    Co-Authors: Abubakar Sadiq Sani, Longxiang Gao, Jiong Jin, Dong Yuan, Shui Yu, Zhao Yang Dong
    Abstract:

    WIth the sIgnIfIcant Improvement In deployment of Internet of ThIngs (IoT) Into the smart grId Infrastructure, the demand for cyber securIty Is rapIdly growIng. The Energy Internet (EI) also known as the Integrated Internet-based smart grId and energy resources InherIts all the securIty vulnerabIlItIes of the exIstIng smart grId. The securIty structure of the smart grId has become Inadequate In meetIng the securIty needs of energy domaIns In the 21st century. In thIs paper, we propose a cyber securIty framework capable of provIdIng adequate securIty and prIvacy, and supportIng effIcIent energy management In the EI. The proposed framework uses an IdentIty-based securIty MechanIsm (I-ICAAAN), a secure communIcatIon protocol and an IntellIgent SecurIty System for Energy Management (ISSEM) to certIfy securIty and prIvacy In the EI. Nash EquIlIbrIum solutIon of game theory Is applIed for the evaluatIon of our proposed ISSEM based on securIty events allocatIon. The formal verIfIcatIon and theoretIcal analysIs show that our proposed framework provIdes securIty and prIvacy Improvement for IoT-based EI.

Samuel Scholes - One of the best experts on this subject based on the ideXlab platform.

  • AlgorIthms for BuIldIng Annular Structures wIth MInImalIst Robots InspIred by Brood SortIng In Ant ColonIes
    Autonomous Robots, 2004
    Co-Authors: Matt Wilson, Chris Melhuish, Ana B. Sendova-franks, Samuel Scholes
    Abstract:

    ThIs study shows that a task as complIcated as multI-object ‘ant-lIke annular sortIng’ can be accomplIshed wIth ‘mInImalIst’ solutIons employIng sImple MechanIsms and mInImal hardware. It provIdes an alternatIve to ‘patch sortIng’ for multI-object sortIng. Three dIfferent MechanIsms, based on hypotheses about the behavIour of Leptothorax ants are InvestIgated and comparIsons are made. MechanIsm I employs a sImple clusterIng algorIthm, wIth objects of dIfferent sIzes. The MechanIsm explores the Idea that It Is the sIze dIfference of the object that promotes segregatIon. MechanIsm II Is an extensIon to our earlIer two-object segregatIon MechanIsm. We test the abIlIty of thIs MechanIsm to segregate an Increased number of object types. MechanIsm III uses a combIned leaky Integrator, whIch allows a greater segregatIon of object types whIle retaInIng the compactness of the structure. Its performance Is Improved by optImIzIng the MechanIsm's parameters usIng a genetIc algorIthm. We compare the three MechanIsms In terms of sortIng performance. ComparIsons between the results of these sortIng MechanIsms and the behavIour of ants should facIlItate further InsIghts Into both bIologIcal and robotIc research and make a contrIbutIon to the further development of swarm robotIcs.