The Experts below are selected from a list of 267 Experts worldwide ranked by ideXlab platform

Michael R Scott - One of the best experts on this subject based on the ideXlab platform.

  • primary Medulla Oblongata germinoma a case report and review of the literature
    Journal of Neuro-oncology, 2003
    Co-Authors: Andy Shaubin Chou, Chijen Chen, Shihming Jung, Huoli Chuang, Michael R Scott
    Abstract:

    We describe a case of primary intracranial Medulla Oblongata germinoma in a 16-year-old girl who presented with progressive headache and blurred vision. Magnetic resonance imaging demonstrated a heterogeneous exophytic mass arising from dorsal aspect of Medulla Oblongata with extension into fourth ventricle. The differential diagnosis for this patient had included ependymoma, exophytic glioma, medulloblastoma and choroid plexus papilloma. After surgical resection and radiation therapy, she remains alive and recurrence-free for 7 years.

Liwei Zhang - One of the best experts on this subject based on the ideXlab platform.

  • Primary Medulla Oblongata teratomas
    Journal of Neurosurgery, 2014
    Co-Authors: Da Li, Zhen Wu, Liwei Zhang, Junting Zhang
    Abstract:

    Medulla Oblongata teratomas are rare. The authors report 2 new cases of teratomas that occurred exclusively in the Medulla Oblongata. The first case was in a 9-year-old boy who presented with a 6-month history of neck pain and repeated paroxysmal vomiting. Based on preoperative radiographic findings, the initial diagnosis was of an intraaxial Medulla Oblongata hemangioblastoma. Intraoperatively, the cystic component of the tumor was gray, gelatinous, and soft in consistency. The solid component was light pink, rubbery, and nodular in appearance, with an identifiable boundary. The lesion was completely removed. Histopathological investigation revealed a mature teratoma. Postoperatively, the patient was supported with ventilator assistance and received a tracheotomy, but died of intracranial infection. The second case was in a 10-year-old boy with intermittent headache for 1 month. Radiographs revealed an exophytic cystic and solid lesion with dorsal involvement of the Medulla Oblongata. The lesion was pred...

  • primary Medulla Oblongata germinomas two case reports and review of the literature
    World Journal of Surgical Oncology, 2013
    Co-Authors: Da Li, Zhen Wu, Junting Zhang, Jie Feng, Liang Wang, Liwei Zhang
    Abstract:

    An intracranial germinoma is a tumor that is sensitive to radiotherapy. As Medulla Oblongata germinomas are extremely rare, determining an accurate preoperative diagnosis is challenging. Two cases of Medulla Oblongata lesions were surgically treated, and a postoperative diagnosis of germinoma was determined in both of the cases. The tumor in one patient completely resolved after a treatment course consisting of surgical intervention, radiotherapy and chemotherapy; the other patient, who did not receive any type of adjuvant treatment after surgery, suffered from tumor relapse and died from pneumonia 8 months following surgery. A preoperative diagnosis of Medulla Oblongata germinoma is difficult because of the lack of specific clinical signs and symptoms. If the correct diagnosis is reached, patients can have a favorable prognosis with proper evaluation and treatment. An invasive operation can potentially lesion and impair the function of the Medulla Oblongata, which is fatal to the patient.

  • Surgical management of cavernous malformation in Medulla Oblongata with dyspnea
    Chinese Journal of Neurosurgery, 2011
    Co-Authors: Da Li, Zhen Wu, Junting Zhang, Jie Tang, Xinru Xiao, Liwei Zhang
    Abstract:

    Objective To discuss the surgical management of cavernous malformation (CM) in Medulla Oblongata with dyspnea after hemorrhage.Methods The clinical data of four patients with CM in Medulla Oblongata with dyspnea after hemorrhage were analyzed retrospectively.The mean preoperative Karnofsky Performance Scale (KPS) was 17.5.All of the patients underwent operation through posterior midline suboccipital approach.Results Complete resection was achieved in four patients.The main clinical symptoms of dyspnea, facial paralysis and pain were totally improved.But there was no change of motor deficits or sensory disturbance.The mean postoperative KPS was 60.Two patients were improved and others were stabilized.The mean follow - up duration was 15.0 months without recurrent hemorrhage.The recent mean KPS was 70.Conclusions Patients with CM in Medulla Oblongata suffering from dyspnea could obtain favorable prognosis through surgical treatment. Key words: Cavernous;  Angioma;  Medulla Oblongata;  Microsurgery;  Prognosis

  • Primary Medulla Oblongata germinoma,two cases report and literature review
    Chinese Journal of Neurosurgery, 2009
    Co-Authors: De-zhi Li, Zhen Wu, Junting Zhang, Siyuan Chen, Liwei Zhang
    Abstract:

    Objective To report two cases of primary Medulla Oblongata genninoma,and review the relative literatures.Methods Operation was performed for the diagnosis,and the patients were followed up.Results The patients were dignosised as germinoma after operation.The tumor in one patient complelely dispeared after radiotherapy and chemotherapy followed operation;the other patient's tumor recurrented without adjacent treatments after surgery,and died in 8th months.Conclusions Primary intracranial germinoma is a rare tumor and the patient could get good results with partial surgical resection,chemotherapy and radiotherapy. Key words: Medulla Oblongata;  Germinoma;  Treatment

Andy Shaubin Chou - One of the best experts on this subject based on the ideXlab platform.

  • primary Medulla Oblongata germinoma a case report and review of the literature
    Journal of Neuro-oncology, 2003
    Co-Authors: Andy Shaubin Chou, Chijen Chen, Shihming Jung, Huoli Chuang, Michael R Scott
    Abstract:

    We describe a case of primary intracranial Medulla Oblongata germinoma in a 16-year-old girl who presented with progressive headache and blurred vision. Magnetic resonance imaging demonstrated a heterogeneous exophytic mass arising from dorsal aspect of Medulla Oblongata with extension into fourth ventricle. The differential diagnosis for this patient had included ependymoma, exophytic glioma, medulloblastoma and choroid plexus papilloma. After surgical resection and radiation therapy, she remains alive and recurrence-free for 7 years.

Menek Goldstein - One of the best experts on this subject based on the ideXlab platform.

  • Glutamatergic regulation of [3H]-noradrenaline release in the Medulla Oblongata of normotensive and spontaneously hypertensive rats.
    Journal of Hypertension, 1994
    Co-Authors: Kazushi Tsuda, Seiko Tsuda, Ichiro Nishio, Yoshiaki Masuyama, Menek Goldstein
    Abstract:

    OBJECTIVE: To assess in vitro the role of glutamate receptors in the regulation of noradrenaline release from the Medulla Oblongata of normotensive and hypertensive rats. DESIGN AND METHODS: The effects of L-glutamate (an endogenous ligand for glutamate receptors), glycine (an allosteric agonist for the N-methyl-D-aspartate type of glutamate receptors) and MK-801 (an antagonist for N-methyl-D-aspartate receptors) on [3H]-noradrenaline release were examined in slices of rat Medulla Oblongata. RESULTS: L-Glutamate elicited [3H]-noradrenaline release from slices of rat Medulla Oblongata in magnesium-free medium. Glycine also increased the release of noradrenaline. Moreover, the effect of L-glutamate on noradrenaline release was significantly potentiated by glycine. MK-801 inhibited the increase in noradrenaline release evoked by L-glutamate. In spontaneously hypertensive rats (SHR) the facilitatory effect of L-glutamate on noradrenaline release was significantly more pronounced than in Wistar-Kyoto (WKY) rats. Furthermore, glycine alone and in combination with L-glutamate increased the noradrenaline release to a greater extent in SHR than in WKY rats. CONCLUSION: The present results show that the excitatory amino acids might increase noradrenaline release from rat Medulla Oblongata, which was partially dependent on the N-methyl-D-aspartate type of glutamate receptors. The greater effect of L-glutamate and glycine in SHR suggests that these amino acids might be involved in the regulation of noradrenaline release in the Medulla Oblongata of hypertension.

  • Modulation of norepinephrine release by galanin in rat Medulla Oblongata.
    Hypertension, 1992
    Co-Authors: Kazushi Tsuda, Seiko Tsuda, Ichiro Nishio, Yoshiaki Masuyama, Menek Goldstein
    Abstract:

    Galanin, a 29-amino acid peptide, is widely distributed in both the central and peripheral nervous systems and is colocalized with catecholamines, although its physiological significance remains to be elucidated. In the present study we investigated the regulatory mechanisms of galanin on norepinephrine release in rat Medulla Oblongata. In slices of Medulla Oblongata of Sprague-Dawley rats, galanin inhibited the stimulation-evoked [3H]norepinephrine release in a concentration-dependent manner (fractional release ratio during electrical stimulation: control 0.937 +/- 0.043, mean +/- SEM, n = 6; galanin 1 x 10(-7) M 0.501 +/- 0.037, n = 6, p less than 0.05; and galanin 1 x 10(-6) M 0.299 +/- 0.018 n = 6, p less than 0.05). Galanin potentiated inhibition of [3H]norepinephrine release by the alpha 2-agonists (UK 14,304 and clonidine). The blockade of alpha 2-adrenergic receptors by RX 781094 diminished the inhibition of norepinephrine release by galanin. Pretreatment of pertussis toxin, which interferes with the coupling of inhibitory guanosine triphosphate-binding proteins to adenylate cyclase, significantly attenuated the suppressive effects of galanin on norepinephrine release. In slices of Medulla Oblongata obtained from spontaneously hypertensive rats (SHR), the inhibitory effect of galanin on norepinephrine release was significantly less than in those from age-matched Wistar-Kyoto rats. These results show that galanin might inhibit the stimulation-evoked norepinephrine release in rat Medulla Oblongata, at least partially mediated by alpha 2-adrenergic receptors and the pertussis toxin-sensitive guanosine triphosphate-binding proteins. Moreover, less suppression of norepinephrine release by galanin in SHR suggests that galanin might be involved in the regulation of central sympathetic nervous activity in hypertension.

  • Norepinephrine release and neuropeptide Y in Medulla Oblongata of spontaneously hypertensive rats.
    Hypertension (Dallas Tex. : 1979), 1990
    Co-Authors: Kazushi Tsuda, Seiko Tsuda, Yoshiaki Masuyama, Menek Goldstein
    Abstract:

    Neuropeptide Y is colocalized with norepinephrine in both central and peripheral noradrenergic neurons. In this study, we examined the regulatory mechanisms of neuropeptide Y on norepinephrine release in the Medulla Oblongata of rats. Neuropeptide Y inhibited the stimulation-evoked [3H]norepinephrine release in a dose-dependent manner in slices of Medulla Oblongata of Sprague-Dawley rats (1 Hz, S2/S1 ratio, control, 0.946 +/- 0.040 [+/- SEM], n = 6; neuropeptide Y 1 x 10(-8) M, 0.676 +/- 0.022, n = 6, p less than 0.05; neuropeptide Y 1 x 10(-7) M, 0.589 +/- 0.014, n = 6, p less than 0.05). Neuropeptide Y potentiated inhibition of [3H]norepinephrine release by the alpha 2-agonists UK 14,304 and clonidine. The blockade of alpha 2-adrenergic receptors by RX 781,094 diminished inhibitory effects of neuropeptide Y on norepinephrine release. Pretreatment of pertussis toxin (a toxin that interferes with the coupling of inhibitory receptors to adenylate cyclase) attenuated the suppression of norepinephrine release by neuropeptide Y. In spontaneously hypertensive rats, the inhibitory effect of UK 14,304 and neuropeptide Y on norepinephrine release from the Medulla Oblongata was significantly less than in age-matched Wistar-Kyoto rats. These results show that neuropeptide Y inhibits norepinephrine release partially mediated by alpha 2-adrenergic receptors and the pertussis toxin-sensitive guanosine triphosphate-binding proteins in rat Medulla Oblongata. Furthermore, less suppression of norepinephrine release by UK 14,304 and neuropeptide Y in spontaneously hypertensive rats suggests that alpha 2-adrenergic receptors and neuropeptide Y might be involved in the regulation of central sympathetic tone in hypertension.

Junting Zhang - One of the best experts on this subject based on the ideXlab platform.

  • Primary Medulla Oblongata teratomas
    Journal of Neurosurgery, 2014
    Co-Authors: Da Li, Zhen Wu, Liwei Zhang, Junting Zhang
    Abstract:

    Medulla Oblongata teratomas are rare. The authors report 2 new cases of teratomas that occurred exclusively in the Medulla Oblongata. The first case was in a 9-year-old boy who presented with a 6-month history of neck pain and repeated paroxysmal vomiting. Based on preoperative radiographic findings, the initial diagnosis was of an intraaxial Medulla Oblongata hemangioblastoma. Intraoperatively, the cystic component of the tumor was gray, gelatinous, and soft in consistency. The solid component was light pink, rubbery, and nodular in appearance, with an identifiable boundary. The lesion was completely removed. Histopathological investigation revealed a mature teratoma. Postoperatively, the patient was supported with ventilator assistance and received a tracheotomy, but died of intracranial infection. The second case was in a 10-year-old boy with intermittent headache for 1 month. Radiographs revealed an exophytic cystic and solid lesion with dorsal involvement of the Medulla Oblongata. The lesion was pred...

  • primary Medulla Oblongata germinomas two case reports and review of the literature
    World Journal of Surgical Oncology, 2013
    Co-Authors: Da Li, Zhen Wu, Junting Zhang, Jie Feng, Liang Wang, Liwei Zhang
    Abstract:

    An intracranial germinoma is a tumor that is sensitive to radiotherapy. As Medulla Oblongata germinomas are extremely rare, determining an accurate preoperative diagnosis is challenging. Two cases of Medulla Oblongata lesions were surgically treated, and a postoperative diagnosis of germinoma was determined in both of the cases. The tumor in one patient completely resolved after a treatment course consisting of surgical intervention, radiotherapy and chemotherapy; the other patient, who did not receive any type of adjuvant treatment after surgery, suffered from tumor relapse and died from pneumonia 8 months following surgery. A preoperative diagnosis of Medulla Oblongata germinoma is difficult because of the lack of specific clinical signs and symptoms. If the correct diagnosis is reached, patients can have a favorable prognosis with proper evaluation and treatment. An invasive operation can potentially lesion and impair the function of the Medulla Oblongata, which is fatal to the patient.

  • Surgical management of cavernous malformation in Medulla Oblongata with dyspnea
    Chinese Journal of Neurosurgery, 2011
    Co-Authors: Da Li, Zhen Wu, Junting Zhang, Jie Tang, Xinru Xiao, Liwei Zhang
    Abstract:

    Objective To discuss the surgical management of cavernous malformation (CM) in Medulla Oblongata with dyspnea after hemorrhage.Methods The clinical data of four patients with CM in Medulla Oblongata with dyspnea after hemorrhage were analyzed retrospectively.The mean preoperative Karnofsky Performance Scale (KPS) was 17.5.All of the patients underwent operation through posterior midline suboccipital approach.Results Complete resection was achieved in four patients.The main clinical symptoms of dyspnea, facial paralysis and pain were totally improved.But there was no change of motor deficits or sensory disturbance.The mean postoperative KPS was 60.Two patients were improved and others were stabilized.The mean follow - up duration was 15.0 months without recurrent hemorrhage.The recent mean KPS was 70.Conclusions Patients with CM in Medulla Oblongata suffering from dyspnea could obtain favorable prognosis through surgical treatment. Key words: Cavernous;  Angioma;  Medulla Oblongata;  Microsurgery;  Prognosis

  • Primary Medulla Oblongata germinoma,two cases report and literature review
    Chinese Journal of Neurosurgery, 2009
    Co-Authors: De-zhi Li, Zhen Wu, Junting Zhang, Siyuan Chen, Liwei Zhang
    Abstract:

    Objective To report two cases of primary Medulla Oblongata genninoma,and review the relative literatures.Methods Operation was performed for the diagnosis,and the patients were followed up.Results The patients were dignosised as germinoma after operation.The tumor in one patient complelely dispeared after radiotherapy and chemotherapy followed operation;the other patient's tumor recurrented without adjacent treatments after surgery,and died in 8th months.Conclusions Primary intracranial germinoma is a rare tumor and the patient could get good results with partial surgical resection,chemotherapy and radiotherapy. Key words: Medulla Oblongata;  Germinoma;  Treatment