The Experts below are selected from a list of 195 Experts worldwide ranked by ideXlab platform
R Arriagada - One of the best experts on this subject based on the ideXlab platform.
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Post-mastectomy Megavoltage Radiotherapy: the Oslo and Stockholm trials.
European journal of cancer (Oxford England : 1990), 1992Co-Authors: A Auquier, Lars Erik Rutqvist, Sam Rotstein, H Host, R ArriagadaAbstract:The ability of adjuvant Radiotherapy to prevent distant metastasis and to prolong survival in patients with early breast cancer is much debated. The paper presents a joint analysis of long-term results (13-16 years' follow-up) from the Oslo and Stockholm randomised trials of post-operative Megavoltage Radiotherapy versus surgery alone. Among node-positive patients there was a significant 37% relative reduction of distant metastases with radiation (P less than 0.01) and an overall survival difference in favor of the irradiated patients which corresponded with a 22% relative reduction of deaths of borderline significance (P less than 0.06). No significant benefit with radiation in terms of distant metastasis-free survival or overall survival was observed among node-negative patients. The results show that effective local treatment can prevent distant dissemination in some patients and contradict the contention that node-positive breast cancer invariably is a systemic disease already at primary diagnosis.
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post mastectomy Megavoltage Radiotherapy the oslo and stockholm trials
European Journal of Cancer, 1992Co-Authors: A Auquier, Lars Erik Rutqvist, Sam Rotstein, H Host, R ArriagadaAbstract:The ability of adjuvant Radiotherapy to prevent distant metastasis and to prolong survival in patients with early breast cancer is much debated. The paper presents a joint analysis of long-term results (13–16 years' follow-up) from the Oslo and Stockholm randomised trials of post-operative Megavoltage Radiotherapy versus surgery alone. Among node-positive patients there was a significant 37% relative reduction of distant metastases with radiation ( P P
D V Webb - One of the best experts on this subject based on the ideXlab platform.
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water equivalence of plastic organic scintillators in Megavoltage Radiotherapy bremsstrahlung beams
Physics in Medicine and Biology, 2000Co-Authors: M A Clift, R A Sutton, D V WebbAbstract:Plastic organic scintillators are often considered `water equivalent' in Megavoltage photon beams as they have similar atomic composition and density to water. Two plastic scintillators are evaluated for their `water equivalence', using the Burlin cavity theory, in the photon energy range of 200 keV to 20 MeV. The Burlin theory predicts that the two investigated scintillator materials are likely to be `water equivalent' in the energy range investigated. The prediction of the Burlin theory for one of these scintillators has been confirmed by absorbed dose measurements in bremsstrahlung beams between 13 and 19 MeV.
A Auquier - One of the best experts on this subject based on the ideXlab platform.
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Post-mastectomy Megavoltage Radiotherapy: the Oslo and Stockholm trials.
European journal of cancer (Oxford England : 1990), 1992Co-Authors: A Auquier, Lars Erik Rutqvist, Sam Rotstein, H Host, R ArriagadaAbstract:The ability of adjuvant Radiotherapy to prevent distant metastasis and to prolong survival in patients with early breast cancer is much debated. The paper presents a joint analysis of long-term results (13-16 years' follow-up) from the Oslo and Stockholm randomised trials of post-operative Megavoltage Radiotherapy versus surgery alone. Among node-positive patients there was a significant 37% relative reduction of distant metastases with radiation (P less than 0.01) and an overall survival difference in favor of the irradiated patients which corresponded with a 22% relative reduction of deaths of borderline significance (P less than 0.06). No significant benefit with radiation in terms of distant metastasis-free survival or overall survival was observed among node-negative patients. The results show that effective local treatment can prevent distant dissemination in some patients and contradict the contention that node-positive breast cancer invariably is a systemic disease already at primary diagnosis.
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post mastectomy Megavoltage Radiotherapy the oslo and stockholm trials
European Journal of Cancer, 1992Co-Authors: A Auquier, Lars Erik Rutqvist, Sam Rotstein, H Host, R ArriagadaAbstract:The ability of adjuvant Radiotherapy to prevent distant metastasis and to prolong survival in patients with early breast cancer is much debated. The paper presents a joint analysis of long-term results (13–16 years' follow-up) from the Oslo and Stockholm randomised trials of post-operative Megavoltage Radiotherapy versus surgery alone. Among node-positive patients there was a significant 37% relative reduction of distant metastases with radiation ( P P
R A Street - One of the best experts on this subject based on the ideXlab platform.
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Radiation response characteristics of amorphous silicon arrays for Megavoltage Radiotherapy imaging
IEEE Transactions on Nuclear Science, 1992Co-Authors: Larry E Antonuk, John Yorkston, J. Boudry, E.j. Morton, M.j. Longo, W Huang, R A StreetAbstract:Signal measurements for a variety of pixelated a-Si:H imaging arrays irradiated by Megavoltage beams are reported. Data are presented for 6-, 10-, and 15-MV beam energies for screens containing gadolinium-oxysulfide and calcium tungstate. These results are quantitative radiation signal sizes reported for such arrays. The initialization times of these arrays are reported. The performance of arrays of various sizes and pitches with respect to these measured values is compared. These results are part of an ongoing effort to develop flat-panel, real-time gamma and X-ray imagers.
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Radiation response characteristics of amorphous silicon arrays for Megavoltage Radiotherapy imaging
Conference Record of the 1991 IEEE Nuclear Science Symposium and Medical Imaging Conference, 1991Co-Authors: Larry E Antonuk, John Yorkston, J. Boudry, E.j. Morton, M.j. Longo, W Huang, R A StreetAbstract:Signal measurements for a variety of pixelated a-Si:H imaging arrays irradiated by Megavoltage beams are reported. Data are presented for 6-, 10-, and 15-MV beam energies for screens containing gadolinium-oxysulfide and calcium tungstate. These results are the first quantitative radiation signal sizes reported for such arrays. In addition, the initialization times of these arrays are reported. The performances of arrays of various sizes and pitches with respect to these measured values are compared. These results are part of an ongoing effort to develop flat-panel, real-time gamma and X-ray imagers.
William F. Enneking - One of the best experts on this subject based on the ideXlab platform.
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Radiation therapy for giant cell tumors of bone.
Clinical Orthopaedics and Related Research, 2003Co-Authors: Steven J. Feigenberg, Mark T. Scarborough, Robert A. Zlotecki, Robert B. Marcus, B.h Berrey, William F. EnnekingAbstract:For giant cell tumors of bone, does Radiotherapy provide a safe and effective treatment? This retrospective review includes 24 patients with 26 histologically diagnosed tumors treated with Megavoltage Radiotherapy between March 1972 and July 1996. Of the 10 recurrent tumors, five had an intralesiona
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Megavoltage Radiotherapy for aneurysmal bone cysts
International Journal of Radiation Oncology Biology Physics, 2001Co-Authors: Steven J. Feigenberg, Mark T. Scarborough, Robert A. Zlotecki, Robert B. Marcus, Hudson B Berrey, William F. EnnekingAbstract:Abstract Purpose: An aneurysmal bone cyst (ABC) is a rapidly expansile and destructive benign tumor of bone that is usually treated by curettage and bone graft, with or without adjuvant treatment. For recurrent tumors, or tumors for which surgery would result in significant functional morbidity, does Radiotherapy (RT) provide a safe and effective alternative for local control? Patients and Methods: Nine patients with histologically diagnosed aneurysmal bone cysts without other associated benign or malignant tumors were treated at the University of Florida with Megavoltage RT between February 1964 and June 1992. The patients received local Radiotherapy doses between 20 and 60 Gy, with 6 patients receiving 26–30 Gy. In 6 patients the diagnosis was made by biopsy alone; 3 underwent intralesional curettage before RT. Minimum follow-up was 20 months; 7 of 9 patients (77%) had follow-up greater than 11 years. Results: No patient experienced a local recurrence (median follow-up, 17 years). One patient required stabilization of the cervical spine 10 months after RT because of dorsal kyphosis from vertebral body collapse. No other significant side effects were experienced, and no patients developed secondary malignancies. Four patients were lost to follow-up: at 20 months, 11.5 years, 17 years, and 20 years after the initiation of treatment, none with any evidence of local recurrence. All of the patients who had significant pain before RT had relief of their symptoms within 2 weeks of completion of therapy. Conclusions: Using modern-day RT, patients with recurrent or inoperable aneurysmal bone cysts can be treated effectively (with minimal toxicity) using a prescribed tumor dose of 26–30 Gy.