The Experts below are selected from a list of 264 Experts worldwide ranked by ideXlab platform

Sungjin Chung - One of the best experts on this subject based on the ideXlab platform.

  • Membranoproliferative Glomerulonephritis following allogeneic hematopoietic stem cell transplantation
    Clinical and experimental nephrology, 2010
    Co-Authors: Ju Youn Kim, Min Young Lee, Biro Kim, Cheol Whee Park, Yoon Sik Chang, Sungjin Chung
    Abstract:

    Nephrotic syndrome after allogeneic hematopoietic stem cell transplantation has been increasingly described as a manifestation of chronic graft-versus-host disease (GVHD); however, GVHD-associated Membranoproliferative Glomerulonephritis is extremely rare. A 44-year-old man developed nephrotic syndrome 24 months after HSCT for acute lymphoblastic leukemia. The renal biopsy showed type I Membranoproliferative Glomerulonephritis. Salivary gland biopsy demonstrated mild lymphocytic infiltration, indicating chronic GVHD. Improvement of the proteinuria and recovery of renal function were achieved within 11 months of treatment with oral prednisolone and azathioprine.

R A Rodby - One of the best experts on this subject based on the ideXlab platform.

  • Membranoproliferative Glomerulonephritis associated with hepatitis C virus infection.
    Journal of the American Society of Nephrology : JASN, 1993
    Co-Authors: D M Burstein, R A Rodby
    Abstract:

    The hepatitis C virus genome has been recently sequenced and cloned, allowing the identification of patients exposed to this virus, which is now felt to be the principal cause of "non-A, non-B" hepatitis. The hepatitis B virus has long been implicated in the pathogenesis of several glomerulopathies including Membranoproliferative Glomerulonephritis, mixed cryoglobulinemia, and membranous Glomerulonephritis. Several authors have recently reported an association between hepatitis C virus infection and glomerular disease. The case of a patient with chronic hepatitis C virus infection who developed the nephrotic syndrome 3 months after liver transplantation is described. Serologic testing was significant for an elevated rheumatoid factor, circulating cryoglobulins, and a mildly depressed C4 level. Hepatitis C virus antibody and viral RNA (by polymerase chain reaction) were present in both the serum and cryoglobulin fraction. A renal biopsy demonstrated Membranoproliferative Glomerulonephritis. It is believed that persistent infection with the hepatitis C virus is responsible for an immune complex-mediated Glomerulonephritis in this patient. Because hepatitis C has now been pathogenetically linked to several glomerulopathies, testing for this virus should be considered in the serologic work-up of the patient with Glomerulonephritis.

Ju Youn Kim - One of the best experts on this subject based on the ideXlab platform.

  • Membranoproliferative Glomerulonephritis following allogeneic hematopoietic stem cell transplantation
    Clinical and experimental nephrology, 2010
    Co-Authors: Ju Youn Kim, Min Young Lee, Biro Kim, Cheol Whee Park, Yoon Sik Chang, Sungjin Chung
    Abstract:

    Nephrotic syndrome after allogeneic hematopoietic stem cell transplantation has been increasingly described as a manifestation of chronic graft-versus-host disease (GVHD); however, GVHD-associated Membranoproliferative Glomerulonephritis is extremely rare. A 44-year-old man developed nephrotic syndrome 24 months after HSCT for acute lymphoblastic leukemia. The renal biopsy showed type I Membranoproliferative Glomerulonephritis. Salivary gland biopsy demonstrated mild lymphocytic infiltration, indicating chronic GVHD. Improvement of the proteinuria and recovery of renal function were achieved within 11 months of treatment with oral prednisolone and azathioprine.

Josep M. Grinyó - One of the best experts on this subject based on the ideXlab platform.

  • Hepatitis C virus-associated Membranoproliferative Glomerulonephritis in renal allografts.
    Journal of the American Society of Nephrology : JASN, 1996
    Co-Authors: Josep M. Cruzado, Salvador Gil-vernet, G Ercilla, Daniel Serón, M. Carrera, J. Bas, Joan Torras, Alsina J, Josep M. Grinyó
    Abstract:

    In renal transplantation, chronic allograft nephropathy is the leading cause of long-term graft losses, transplant glomerulopathy being its glomerular form. Differential diagnosis from recurrent or de novo Membranoproliferative Glomerulonephritis should be established. Whether hepatitis C virus is associated with cryoglobulinemia and glomerular damage in renal allograft recipients, as in native kidneys, is not known. We identified six hepatitis C virus-infected renal allograft recipients with proteinuria higher than 1.5 g/day, microhematuria, and Membranoproliferative Glomerulonephritis. Virologic and immunologic studies were conducted. Low serum levels of circulating immune complexes and cryoglobulins were observed, which were type II immunoglobulin G polyclonal-immunoglobulin Mk monoclonal in all six patients. Classical serum complement pathway activation and at least one type of autoantibodies were present in all of them. Hepatitis C virus RNA was found in higher concentrations in cryoprecipitate than in serum (percentage of enrichment ranged from 341 to 18,200%). Hepatitis C virus genotype was 1b in 4 of 6 patients, 1a in 1 of 6 patients, and 2a in 1 of 6 patients. In renal histology prominent parietal diffuse deposition of immunoglobulin M was the rule. Glomerular subendothelial electron-dense deposits with fibrillar appearance were observed in the two patients in which electron microscopy provided information about glomeruli. In renal allograft recipients hepatitis C virus infection may be associated with type II cryoglobulinemia which may lead to Membranoproliferative Glomerulonephritis. Immunologic and virologic studies may help to differentiate hepatitis C virus-associated Membranoproliferative Glomerulonephritis from transplant glomerulopathy.

Christoph Licht - One of the best experts on this subject based on the ideXlab platform.