The Experts below are selected from a list of 1278 Experts worldwide ranked by ideXlab platform
Susumu Shiomi - One of the best experts on this subject based on the ideXlab platform.
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illustration of protein loss from the stomach by using spect ct a case of Menetrier Disease
Clinical Nuclear Medicine, 2014Co-Authors: Shigeaki Higashiyama, Joji Kawabe, Atsushi Yoshida, Kohei Kotani, Susumu ShiomiAbstract:We report a 47-year-old man in whom Tc human serum albumin diethylene-triamine-pentaacetic acid protein-losing scintigraphy, performed with SPECT/CT, was useful for diagnosing Menetrier Disease. Planar images taken 1 and 3 hours after radioactive isotope injection yielded a suspicion that the stomach was the site of protein loss in this case. However, the protein loss from the stomach was precisely diagnosed after SPECT/CT was performed; this helped to diagnose Menetrier Disease.
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Illustration of protein loss from the stomach by using SPECT/CT: a case of Ménétrier Disease.
Clinical Nuclear Medicine, 2014Co-Authors: Shigeaki Higashiyama, Joji Kawabe, Atsushi Yoshida, Kohei Kotani, Susumu ShiomiAbstract:We report a 47-year-old man in whom Tc human serum albumin diethylene-triamine-pentaacetic acid protein-losing scintigraphy, performed with SPECT/CT, was useful for diagnosing Menetrier Disease. Planar images taken 1 and 3 hours after radioactive isotope injection yielded a suspicion that the stomach was the site of protein loss in this case. However, the protein loss from the stomach was precisely diagnosed after SPECT/CT was performed; this helped to diagnose Menetrier Disease.
Nick Barker - One of the best experts on this subject based on the ideXlab platform.
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abstract lb 139 tissue stem cell specific enhancer element identifies two types of stem cells in the corpus epithelium of the stomach
Cancer Research, 2015Co-Authors: Junichi Matsuo, Shunichi Kimura, Zakir Hossain, Akihiro Yamamura, Kazuyoshi Kohu, Michiaki Unno, Jimmy So, Shiv Srivastava, Teh Meng, Nick BarkerAbstract:The activity of a previously identified hematopoietic stem cell marker, Runx1 enhancer element (eR1) (Ng et al, Stem Cells 28, 1869-1881, 2010), was found to mark tissue stem cells of multiple organs. In corpus of stomach, stem cells are known to reside at isthmus, upper part of gastric unit. They are undifferentiated cells. However, molecular approach to these stem cells has not been described. Recently, fully differentiated Pepsinogen expressing chief cells at the bottom of gastric unit were shown to have tissue regeneration activity, and these cell were named reserve stem cells (Stange et al, Cell 155, 357-368, 2013). In our study, eR1 was shown to mark stem cells of both types. Lineage tracing experiments demonstrated that both types of stem cells continuously gave rise to mature cells to maintain the gastric unit. Manipulation of gene expression in a stem cell-specific manner in the stomach, especially in undifferentiated stem cells, is a long sought-after approach to study gastric carcinogenesis. We crossed transgenic mouse carrying eR1-CreERT2 with LSL-K-rasG12D mice. After tamoxifen treatment, rapid differentiation from the stem cells in the isthmus was observed, mainly into Muc5ac+ cells (surface epithelial cells). As a result, pseudo-pyloric metaplasia was induced which is similar to that observed in human gastritis. Acid-producing parietal cells were eliminated during this process. Rapid generation of Muc5ac+ cells and other phenotype are similar, but not identical, to the phenotype described in Menetrier Disease which is known to be caused by excessive production of TGF-α and hyper-stimulation of EGF receptor (Reviewed in Coffey et al, J Clin Invest. 117:70-80, 2007). Menetrier Disease is considered to be pre-malignant state. Activation of K-rasG12D in eR1+ chief cells also induced metaplastic lesions. In this case, pepsinogen producing chief cells robustly expressed the marker of mucous neck cells that are considered to be a precursor to chief cells. Therefore, chief cells appeared to be de-differentiated to precursor cells and acquired the stem cell property. We are using eR1 to study step-wise carcinogenesis in stomach and other organs. Citation Format: Junichi Matsuo, Shunichi Kimura, Cai Ping Koh, Md Zakir Hossain, Akihiro Yamamura, Kazuyoshi Kohu, Michiaki Unno, Jimmy Bok Yan So, Feng Zhu, Supriya Srivastava, Teh Meng, Nicholas Barker, Khay Guan Yeoh, Motomi Osato, Yoshiaki Ito. Tissue stem cell specific enhancer element identifies two types of stem cells in the corpus epithelium of the stomach. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr LB-139. doi:10.1158/1538-7445.AM2015-LB-139
Shigeaki Higashiyama - One of the best experts on this subject based on the ideXlab platform.
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illustration of protein loss from the stomach by using spect ct a case of Menetrier Disease
Clinical Nuclear Medicine, 2014Co-Authors: Shigeaki Higashiyama, Joji Kawabe, Atsushi Yoshida, Kohei Kotani, Susumu ShiomiAbstract:We report a 47-year-old man in whom Tc human serum albumin diethylene-triamine-pentaacetic acid protein-losing scintigraphy, performed with SPECT/CT, was useful for diagnosing Menetrier Disease. Planar images taken 1 and 3 hours after radioactive isotope injection yielded a suspicion that the stomach was the site of protein loss in this case. However, the protein loss from the stomach was precisely diagnosed after SPECT/CT was performed; this helped to diagnose Menetrier Disease.
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Illustration of protein loss from the stomach by using SPECT/CT: a case of Ménétrier Disease.
Clinical Nuclear Medicine, 2014Co-Authors: Shigeaki Higashiyama, Joji Kawabe, Atsushi Yoshida, Kohei Kotani, Susumu ShiomiAbstract:We report a 47-year-old man in whom Tc human serum albumin diethylene-triamine-pentaacetic acid protein-losing scintigraphy, performed with SPECT/CT, was useful for diagnosing Menetrier Disease. Planar images taken 1 and 3 hours after radioactive isotope injection yielded a suspicion that the stomach was the site of protein loss in this case. However, the protein loss from the stomach was precisely diagnosed after SPECT/CT was performed; this helped to diagnose Menetrier Disease.
Akira Kurisaki - One of the best experts on this subject based on the ideXlab platform.
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generation of stomach tissue from mouse embryonic stem cells
Nature Cell Biology, 2015Co-Authors: Takaaki K Noguchi, Naoto Ninomiya, Mari Sekine, Shinji Komazaki, Pichao Wang, Makoto Asashima, Akira KurisakiAbstract:Successful pluripotent stem cell differentiation methods have been developed for several endoderm-derived cells, including hepatocytes, β-cells and intestinal cells. However, stomach lineage commitment from pluripotent stem cells has remained a challenge, and only antrum specification has been demonstrated. We established a method for stomach differentiation from embryonic stem cells by inducing mesenchymal Barx1, an essential gene for in vivo stomach specification from gut endoderm. Barx1-inducing culture conditions generated stomach primordium-like spheroids, which differentiated into mature stomach tissue cells in both the corpus and antrum by three-dimensional culture. This embryonic stem cell-derived stomach tissue (e-ST) shared a similar gene expression profile with adult stomach, and secreted pepsinogen as well as gastric acid. Furthermore, TGFA overexpression in e-ST caused hypertrophic mucus and gastric anacidity, which mimicked Menetrier Disease in vitro. Thus, in vitro stomach tissue derived from pluripotent stem cells mimics in vivo development and can be used for stomach Disease models.
Sandra Trapani - One of the best experts on this subject based on the ideXlab platform.
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Menetrier Disease and Cytomegalovirus infection in paediatric age: report of three cases and a review of the literature
European Journal of Pediatrics, 2020Co-Authors: Federica Barbati, Edoardo Marrani, Giuseppe Indolfi, Paolo Lionetti, Sandra TrapaniAbstract:Paediatric Menetrier Disease (PMD) is a protein-losing gastropathy, presenting with generalized oedema and abdominal symptoms. PMD commonly has an acute course and may be associated with Cytomegalovirus (CMV) infection. The aim of this retrospective study is to assess the epidemiological and clinical data, diagnostic procedures, treatment and outcome of CMV-associated PMD. The medical charts of the patients with PMD and CMV infection diagnosed at our hospital have been reviewed. Then, a systematic literature’s review of all the cases of PMD and a selection of those associated with CMV infection have been performed. Three previously healthy boys were admitted for vomiting and oedema. Endoscopy showed hypertrophic gastric folds and CMV infection was diagnosed. Albumin was administered in all cases, with clinical resolution within few weeks. In literature, PMD has been described in 150 children and the association between CMV and PMD was found in 89 cases. Clinical and laboratory data, radiological and histological exams, therapy and outcome were reviewed. Conclusions : Basing on the present experience and on the current knowledge, PMD has a benign course without long-term sequelae. Although PMD is rare in children, we recommend paediatricians to consider CMV-related PMD when facing children with vomiting and diffuse oedema. What is Known: • Paediatricians should consider Menetrier Disease (MD) when facing oedematous child complaining of abdominal symptoms with hypoalbuminemia, without proteinuria and liver dysfunction. • Typical ultrasound features (hypertrophic gastric folds) suggest such condition which requires endoscopy and biopsy for definitive diagnosis. What is New: • A familial susceptibility to CMV gastric infection has been recently suggested; thus when suspecting MD, the family history of gastric Diseases should be investigated. • Menetrier Disease has been found associated with other unusual conditions either benign (such as gastric bezoar) or malign as neoplasms (acute lymphatic leukaemia and adenocarcinoma) even in children.