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A J Afolayan - One of the best experts on this subject based on the ideXlab platform.
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The effects of hydrodistillation and solvent free microwave extraction methods on the chemical composition and toxicity of essential oils from the leaves of Mentha longifolia L. subsp. capensis.
African Journal of Pharmacy and Pharmacology, 2011Co-Authors: O. O. Okoh, A J AfolayanAbstract:The effects of hydrodistillation (HD) and solvent free microwave extraction (SFME) methods on the chemical composition and toxicity of Mentha longifolia subsp. capensis leaves were studied. Colourless oils of 1.52 and 1.63% (wet/dry weight) were obtained from HD and SFME methods, respectively. Analyses of the two oils revealed a total of 21 components. These accounted for about 80% of the total oil composition. The HD oil was found to be characterized by monoterpenoids with oxygenated monoterpenes, such as menthone (41.9%), a-pinene (5.4%), pulegone (34.2%), β-pinene (2.4%) and 1, 8-cineole (6.5%). Other identified constituents, include cis-sabinene hydrate (0.4%), linalool (1.0%), piperitenone (1.3%), β-caryophyllene (0.4%), germacrene D (0.5%) and isomenthone (0.4%). However, the hydrodistilled oil showed the presence of 3 octanol (0.2%), bicyclogermacrene (0.1%) and caryophyllene oxide (0.1%) which were not found in the oil extracted with solvent free microwave extractor. The SFME oil was characterized by menthone (28.0%), a-pinene (3.6%), pulegone (23.0%), β-pinene (1.0%) and 1, 8-cineole (5.4%). Other identified constituents, include cis-sabinene hydrate (0.1%), linalool (0.5%), piperitenone (0.1%), β-caryophyllene (0.3%), germacrene D (0.2%) and isomenthone (0.3%). In vitro cytotoxicity test was also studied by brine shrimp lethality bioassay. At 40 µg/ml which was the least concentration used, the oil was not toxic; all the brine shrimps survived. While maximum mortalities happened at 200 µg/ml, the least mortalities were observed at 40 µg/ml. Key words: Mentha longifolia, essential oils, hydrodistillation, solvent free microwave extraction, toxicity.
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toxicological evaluation of the essential oil from Mentha longifolia l subsp capensis leaves in rats
Journal of Medicinal Food, 2009Co-Authors: O O Odeyemi, M T Yakubu, P J Masika, A J AfolayanAbstract:Abstract The effects of the essential oil from the leaves of Mentha longifolia L. subsp. capensis on some biochemical parameters of Wistar rats were studied. The oil at 125, 250, 375, and 500 μL/kg...
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insecticidal activities of essential oil from the leaves of Mentha longifolia l subsp capensis against sitophilus zeamais motschulsky coleoptera curculionidae
African Entomology, 2008Co-Authors: O O Odeyemi, P J Masika, A J AfolayanAbstract:Toxicity of the essential oil from the leaves of Mentha longifolia (Lamiaceae) was evaluated against Sitophilus zeamais, an insect that is the major cause of deterioration in stored grains, including maize. The contact, fumigation and repellency bioassays revealed that the oil was toxic to the insect. Increases in oil concentration and time of exposure resulted in a progressive increase in insect mortality. The dose of essential oil at 0.50 μl/g of maize grains in the contact bioassay caused 100 % mortality of S. zeamais, compared to less than 10 % mortality recorded at 0.125 μl/g. The essential oil demonstrated moderate fumigation toxicity against the test insects at concentrations of 24 and 32 μl of oil per litre of air, respectively. A high repellency was recorded for the oil at all the concentrations tested. Repellency values of as high as 100 % were recorded for most concentrations. Mentha longifolia could be a potential agent for the protection of agricultural stored products against S. zeamais.
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effects of drying methods on the quality and quantity of the essential oil of Mentha longifolia l subsp capensis
Food Chemistry, 2007Co-Authors: O T Asekun, Donald Grierson, A J AfolayanAbstract:The effects of various methods of drying on the content and chemical quality of the essential oil of Mentha longifolia was studied. The most prominent component in both the air-dried and sun-dried leaf oils was menthone (47.9% and 38.3%, respectively), while oven-dried leaf oil had limonene as the major compound (40.8%), whereas pulegone was the major compound from the original fresh leaf oil. Menthone and pulegone were not detected in the oven-dried leaf oil. The essential oil underwent significant chemical transformation in its monoterpenoids when the leaves were dried by the three different methods. Due to the significant reduction of the potentially harmful pulegone and menthone by oven-drying, it is suggested that this herb should be oven-dried or cooked before consumption in order to reduce toxicity.
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chemical composition and antibacterial activity of the essential oil isolated from south african Mentha longifolia l l subsp capensis thunb briq
Journal of Essential Oil Research, 2006Co-Authors: Adebola O Oyedeji, A J AfolayanAbstract:The essential oil obtained by hydrodistillation from Mentha longifolia of South Africa origin was analyzed by GC and GC/M S. A total of 31 components were identified, accounting for 99.7% of the oil composition. Menthone (50.9%), pulegone (19.3%) and 1,8-cineole (11,9%) were the major constituents of the oil. The oil was screened against Gram + and Gram - bacteria and found to be very active against Bacillus subtilis, Micrococcus kristinae, Staphylococcus aureus and Staphylococcus epidermidis with minimum inhibitory concentrations ranging from 0.039 to 0.078 pg/mL.
Medine Gulluce - One of the best experts on this subject based on the ideXlab platform.
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Article Isolation of a flavonoid, apigenin 7-O-glucoside, from Mentha longifolia (L.)
2016Co-Authors: Medine Gulluce, Derya Yanmis, Zuhal Guvenalp, Furkan Orhan, Tulin Arasoglu, Lutfiye Omur DemirezerAbstract:Mentha is a medicinal and aromatic plant belonging to the Lamiaceae family, which is widely used in food, flavor, cosmetic and pharmaceutical industries. Recently, it has been found that the use ofMentha as a pharmaceutical source is based on its phytochemical constituents that have far been identified as tannins, saponins, phenolic acids and flavonoids. This study was designed to evaluate the mutagenic and antimutagenic activities of apigenin 7-O-glucoside (A7G), a flavonoid isolated from Mentha longifolia (L.) Hudson subspecies longifolia (ML). The possible antimutagenic potential of A7G was examined against mutagens ethyl methanesulfonate and acridine in an eukaryotic cell system Saccharomyces cerevisiae and sodium azide in Salmonella typhimurium TA1535 and 9-aminoacridine in S. typhimurium TA1537. According to our findings, any concentrations of the A7G used did not showmutagenic activity but exerted strong antimutagenic activities at tested concentrations. The inhibition rates for the Ames test ranged from 27.2 % (S. typhimurium TA1535: 0.4 mM/plate) to 91.1% (S. typhimurium TA1537: 0.2 mM/plate) and for the yeast deletion assay from 4 % to 57.7%. This genotoxicolo-gical study suggests that a flavonoid from ML owing to antimutagenic properties is of great pharmacological importance and might be beneficial to industries producing food additives, cosmetics and pharmaceuticals products
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determination of antimutagenic properties of apigenin 7 o rutinoside a flavonoid isolated from Mentha longifolia l huds ssp longifolia with yeast del assay
Toxicology and Industrial Health, 2013Co-Authors: Medine Gulluce, Zuhal Guvenalp, Tugba Bal, Furkan Orhan, Ahmet Adiguzel, Lutfiye Omur DermirezerAbstract:Lamiaceae is an important plant family that has been investigated for its medicinal properties due to its large amounts of phenolic acids and flavonoids. Flavonoids have been shown to have antioxidant and antimutagenic activities in different test systems, but their certain mechanisms are still unclear. This study was designed to evaluate the mutagenic and antimutagenic activities of apigenin 7-O-rutinoside, a flavonoid isolated from Mentha longifolia (L.) Huds. ssp. longifolia. The possible antimutagenic potential of apigenin 7-O-rutinoside (A7R) was examined against mutagens ethyl methanesulfonate (EMS) and acridine (AC) in a eukaryotic cell system Saccharomyces cerevisiae RS112. The results showed that A7R has different inhibition rates against EMS and AC-induced mutagenicity. Thus, the properties of A7R are of great pharmacological importance and might be beneficial for reducing the risk of reactive oxygen species-related diseases.
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isolation of a flavonoid apigenin 7 o glucoside from Mentha longifolia l hudson subspecies longifolia and its genotoxic potency
Toxicology and Industrial Health, 2013Co-Authors: Medine Gulluce, Derya Yanmis, Zuhal Guvenalp, Furkan Orhan, Tulin Arasoglu, Lutfiye Omur DemirezerAbstract:Mentha is a medicinal and aromatic plant belonging to the Lamiaceae family, which is widely used in food, flavor, cosmetic and pharmaceutical industries. Recently, it has been found that the use of Mentha as a pharmaceutical source is based on its phytochemical constituents that have far been identified as tannins, saponins, phenolic acids and flavonoids. This study was designed to evaluate the mutagenic and antimutagenic activities of apigenin 7-O-glucoside (A7G), a flavonoid isolated from Mentha longifolia (L.) Hudson subspecies longifolia (ML). The possible antimutagenic potential of A7G was examined against mutagens ethyl methanesulfonate and acridine in an eukaryotic cell system Saccharomyces cerevisiae and sodium azide in Salmonella typhimurium TA1535 and 9-aminoacridine in S. typhimurium TA1537. According to our findings, any concentrations of the A7G used did not show mutagenic activity but exerted strong antimutagenic activities at tested concentrations. The inhibition rates for the Ames test ran...
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isolation of some luteolin derivatives from Mentha longifolia l hudson subsp longifolia and determination of their genotoxic potencies
Food Chemistry, 2012Co-Authors: Furkan Orhan, Ozlem Baris, Derya Yanmis, Zuhal Guvenalp, Tugba Bal, Medine GulluceAbstract:This study was designed to evaluate the mutagenic and antimutagenic activities of luteolin derivatives (luteolin 7-O-glucoside, luteolin 7-O-rutinoside and luteolin 7-O-glucuronide) isolated from Mentha longifolia (L.) Huds. subsp. longifolia by using Ames Salmonella test (TA 1535 and TA1537 strains). In the antimutagenicity assays, luteolin 7-O-glucoside, luteolin 7-O-rutinoside and luteolin 7-O-glucuronide showed antimutagenic effects on TA1537 and TA1535 strains. The highest inhibition rates for luteolin 7-O-glucoside, luteolin 7-O-rutinoside and luteolin 7-O-glucuronide on TA1537 strain were 84.03%, 87.63% and 67.77%, respectively. Similarly, in the antimutagenicity assays performed with the TA1535 strain, the inhibition rates for luteolin 7-O-glucoside and luteolin 7-O-rutinoside were 23.86% and 23.76% respectively. Our findings showed that the antimutagenic properties of luteolin derivatives on TA1537 and TA1535 strains have been found to be structure dependent. The clarification of differences in antimutagenic potency of these luteolin derivatives based on their structures has been demonstrated in this study.
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isolation of 3 flavonoids from Mentha longifolia l hudson subsp longifolia and determination of their genotoxic potentials by using the e coli wp2 test system
Journal of Food Science, 2011Co-Authors: Ozlem Baris, Mehmet Karadayi, Derya Yanmis, Zuhal Guvenalp, Tugba Bal, Medine GulluceAbstract:: Flavonoids, abundant in most of plant species, are widely used in medicine and development studies on phytotherapeutic drugs due to their various biological activities. In the present study, 3 flavonoids, apigenin-7-O-glucoside, apigenin-7-O-rutinoside, and apigenin-7-O-glucuronide, were isolated from Mentha longifolia (L.) Hudson subsp. longifolia by using E. coli WP2 genotoxicity assay guided fractionation procedures. Later, the mutagenic and antimutagenic properties of each flavonoid were evaluated by using the same genotoxicity assay. The results showed that all the test compounds have significant antimutagenic activity at tested concentrations with or without S9 activation. The inhibition rates were between 25.3% (apigenin-7-O-glucoside with S9—2.0 μM/plate) and 59.0% (apigenin-7-O-rutinoside without S9—2.0 μM/plate). In conclusion, the results revealed that the 3 flavonoids from Mentha longifolia (L.) Hudson subsp. longifolia have significant antimutagenic activity, and the findings of the present study are valuable for further investigations, focus on the phytotherapeutic drug discovery. Practical Application: Apigenin derivatives can be thought as genetically safe at tested concentrations because they did not show mutagenic activity. Furthermore, they have also significant antimutagenic activity. These are valuable for further research focus on phytotherapeutic drug discovery and development.
Abdulaziz Alaskar - One of the best experts on this subject based on the ideXlab platform.
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anticandidal and anti carcinogenic activities of Mentha longifolia wild mint extracts in vitro
Journal of King Saud University - Science, 2020Co-Authors: Mohamed Taha Yassin, Ashraf A Mostafa, Abdulaziz AlaskarAbstract:Abstract Vulvovaginal candidiasis is a common health problem affecting about 75% of women at reproductive age. Teratogenicity and fetal toxicity resulting from antifungal therapy during pregnancy necessitates formulation of novel therapeutic agents. Disk diffusion method was performed to evaluate the antifungal activity of Mentha longifolia extracts against different candidal strains. Moreover, the anticancer activity of different M. longifolia extracts against MCF7 breast cancer cell line was evaluated by MTT assay. The M. longifolia n-hexane extract exhibited the highest antifungal activity, while the methanolic extract showed no antimicrobial activity against the tested Candida strains. Minimum inhibitory concentration (MIC) of n-hexane extract was 250 µg/disk against C. tropicalis while it was 500 µg/disk against C. albicans and C. glabrata. Minimum fungicidal concentration (MFC) was 0.5 mg/disk against C. albicans and C. tropicalis, and 1 mg/disk against C. glabrata. GC–MS analysis of the n-hexane extract was performed to detect the active phytochemical components. Menthone (18.37%) was the main phytochemical active component of n-hexane extract followed by butyloctanol (16.13%), 1,5-(1-Bromo-1-methylethyl)-2-methyl-2-cyclohexen-1-one (14.89%), α-tocopherol (13.13%), eugenol (12.21%), α-resorcylamide (11.56%), citronellal (3.71%), butylated hydroxytoluene (3.21%), isocaryophyllene (2.81%), 2-hexyldecanol (2.12%) and tau-cadinol (1.87%). The methanolic extract exhibited the highest anticancer activity against MCF7 breast cancer cell line while diethyl ether extract exhibited the lowest activity with IC50 of 91.67 and 244.70 µg/ml respectively. M. longifolia extracts could be used as a potential source of novel anticandidal and anti-carcinogenic therapeutic agents.
Polatoğlu Kaan - One of the best experts on this subject based on the ideXlab platform.
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Composition and AChE-inhibitory properties of Mentha longifolia (L.) Hudson subsp. typhoides (Briq.) Harley var. typhoides (L.) Hudson essential oil
'National Library of Serbia', 2018Co-Authors: Tacer, Mehmet Emin, Servi Hüseyin, Yücel, Yasemin Yücel, Alkan Mustafa, Evlice Emre, Asav Ünal, Polatoğlu KaanAbstract:There are many reports on the essential-oil composition of the subspecies of Mentha longifolia (Lamiaceae). As an example, the essential oil of the capensis subspecies from South Africa was reported to contain menthone (50.9%), pulegone (19.3%), and 1,8-cineole (11.9%) [1]. Another report indicated carvone (67.3%), limonene (13.5%), and 1,8-cineole (5.4%) as the main components of M. longifolia subsp. schimperi oil [2]. Previously, ten different chemotypes of M. longifolia subsp. typhoides var. typhoides were reported in the Tokat flora [3]. Various chemotypes were also detected from Northern Turkey and from the Marmara region [4,5]. In the current study, the essential-oil composition of Mentha longifolia (L.) Hudson subsp. typhoides (Briq.) Harley var. typhoides (L.) Hudson from Maçka–Trabzon was investigated. The essential oil of the aerial parts of the plant was obtained by hydrodistillation (3 h) using a Clevenger apparatus. The essential-oil yield was found to be 0.65% (v/w). The essential oil was dried over anhydrous Na2SO4. The essential oil was diluted with n-hexane (1:10, v/v) and analyzed as such by GC-MS. The analysis was performed on an Agilent 5977 MSD GC-MS system. Ninety-one compounds were identified in the essential oil representing 97.2% of the detected oil constituents. The main components of the oil were isodihydrocarvone (31.4%), dihydrocarvone (14.5%), β-caryophyllene (9.2%), and limonene (7.5%). A similar carvone-rich chemotype was reported previously [5]. The essential oil was also demonstrated to cause 33.1±0.9%; 29±3%; 5.4±0.4% (n=3) of inhibition of AChE activity, at 10, 5 and 1 mg/mL, respectively
Mohamed Taha Yassin - One of the best experts on this subject based on the ideXlab platform.
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anticandidal and anti carcinogenic activities of Mentha longifolia wild mint extracts in vitro
Journal of King Saud University - Science, 2020Co-Authors: Mohamed Taha Yassin, Ashraf A Mostafa, Abdulaziz AlaskarAbstract:Abstract Vulvovaginal candidiasis is a common health problem affecting about 75% of women at reproductive age. Teratogenicity and fetal toxicity resulting from antifungal therapy during pregnancy necessitates formulation of novel therapeutic agents. Disk diffusion method was performed to evaluate the antifungal activity of Mentha longifolia extracts against different candidal strains. Moreover, the anticancer activity of different M. longifolia extracts against MCF7 breast cancer cell line was evaluated by MTT assay. The M. longifolia n-hexane extract exhibited the highest antifungal activity, while the methanolic extract showed no antimicrobial activity against the tested Candida strains. Minimum inhibitory concentration (MIC) of n-hexane extract was 250 µg/disk against C. tropicalis while it was 500 µg/disk against C. albicans and C. glabrata. Minimum fungicidal concentration (MFC) was 0.5 mg/disk against C. albicans and C. tropicalis, and 1 mg/disk against C. glabrata. GC–MS analysis of the n-hexane extract was performed to detect the active phytochemical components. Menthone (18.37%) was the main phytochemical active component of n-hexane extract followed by butyloctanol (16.13%), 1,5-(1-Bromo-1-methylethyl)-2-methyl-2-cyclohexen-1-one (14.89%), α-tocopherol (13.13%), eugenol (12.21%), α-resorcylamide (11.56%), citronellal (3.71%), butylated hydroxytoluene (3.21%), isocaryophyllene (2.81%), 2-hexyldecanol (2.12%) and tau-cadinol (1.87%). The methanolic extract exhibited the highest anticancer activity against MCF7 breast cancer cell line while diethyl ether extract exhibited the lowest activity with IC50 of 91.67 and 244.70 µg/ml respectively. M. longifolia extracts could be used as a potential source of novel anticandidal and anti-carcinogenic therapeutic agents.