The Experts below are selected from a list of 81 Experts worldwide ranked by ideXlab platform
Herngsheng Lee - One of the best experts on this subject based on the ideXlab platform.
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malignant mesenchymal tumor with leiomyosarcoma rhabdomyosarcoma chondrosarcoma and osteosarcoma differentiation case report and literature review
Diagnostic Pathology, 2011Co-Authors: Mingshen Dai, Herngsheng LeeAbstract:A case of malignant Mesenchymoma of the bladder containing leiomyosarcoma, rhabdomyosarcoma, chondrosarcoma, osteosarcoma, and myxomatous components is described. The primary pedunculated tumor measuring 14 × 13 × 7 cm and weighing 343 g arose from the left trigone of the bladder and was treated by total cystectomy. The histogenesis of malignant Mesenchymomas and their optimal management strategy and prognosis remain uncertain. Herein, we present the fifth case of malignant Mesenchymoma of the urinary bladder to be reported in the literature, which presented five unrelated differentiated tissues more than did previously reported cases.
M J Mcmaster - One of the best experts on this subject based on the ideXlab platform.
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fibrocartilaginous Mesenchymoma of the fifth lumbar vertebra treated by vertebrectomy
Spine, 1994Co-Authors: J N A Gibson, R Reid, M J McmasterAbstract:Study Design. This is the first report of a fibrocatilaginous Mesenchymoma in the spine. Summary of Background Data. This is a rare bone tumor composed of islands of hyaline cartilage in a collagen-producing spindle cell stroma. Seven cases of fibrocartilaginous Mesenchymoma have been reproted previously. Of these, four occurred in the long bones. Methods. The tumor is hypercellular with mild nuclear hyperchromasia. Few mitotic figures are present. However, it is highly infiltrative, and in the present patient, it completely encircled the spinal cord
J N A Gibson - One of the best experts on this subject based on the ideXlab platform.
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fibrocartilaginous Mesenchymoma of the fifth lumbar vertebra treated by vertebrectomy
Spine, 1994Co-Authors: J N A Gibson, R Reid, M J McmasterAbstract:Study Design. This is the first report of a fibrocatilaginous Mesenchymoma in the spine. Summary of Background Data. This is a rare bone tumor composed of islands of hyaline cartilage in a collagen-producing spindle cell stroma. Seven cases of fibrocartilaginous Mesenchymoma have been reproted previously. Of these, four occurred in the long bones. Methods. The tumor is hypercellular with mild nuclear hyperchromasia. Few mitotic figures are present. However, it is highly infiltrative, and in the present patient, it completely encircled the spinal cord
Jeanmichel Coindre - One of the best experts on this subject based on the ideXlab platform.
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dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk a study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomas
The American Journal of Surgical Pathology, 2007Co-Authors: Matthieu Bui Nguyen Binh, Louis Guillou, Isabelle Hostein, Marie Christine Château, Francoise Collin, Alain Aurias, Bui Nguyen Binh, Eberhard Stoeckle, Jeanmichel CoindreAbstract:Dedifferentiated liposarcoma (DLPS) is one of the most frequent sarcomas of the retroperitoneum and represents most undifferentiated sarcomas of the internal trunk. In about 5% cases, the dedifferentiated component is an heterologous sarcoma such as leiomyosarcoma or rhabdomyosarcoma. We reviewed a series of 65 sarcomas with a myogenic differentiation developed in the internal trunk for which initial diagnoses were leiomyosarcoma (37), rhabdomyosarcoma (6), malignant Mesenchymoma (6), and DLPS (16). Immunostainings for MDM2, CDK4, alpha smooth actin, desmin, caldesmon, myogenin, c-kit, and progesterone receptor were performed. In 48 cases, the amplification status of MDM2 and CDK4 could be evaluated with quantitative polymerase chain reaction on paraffin-embedded tissues extracted DNAs. After review of the cases, final diagnoses were leiomyosarcoma (35), rhabdomyosarcomatous (20) or leiomyosarcomatous (7) DLPS, probable DLPS (2), and malignant Mesenchymoma (1). DLPS were bigger tumors (median: 18.2 cm) than leiomyosarcomas (median: 12 cm). They had a lower 5-year recurrence-free survival than leiomyosarcomas (45% vs. 71%) but a higher 5-year metastasis-free survival (73% vs. 39%). There was no significant difference in overall survival (57% vs. 34%). Outcome of patients with a DLPS with a myosarcomatous component did not differ from conventional DLPS. In conclusion, most sarcomas with a rhabdomyosarcomatous differentiation occurring in the internal trunk of adults are DLPS. Moreover, DLPS with a myogenic component have a low metastatic potential, similar to conventional DLPS and significantly lower to the metastatic potential of leiomyosarcomas.
Herman Van Den Berghe - One of the best experts on this subject based on the ideXlab platform.
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cytogenetic analysis of 46 pleomorphic soft tissue sarcomas and correlation with morphologic and clinical features a report of the champ study group
Genes Chromosomes and Cancer, 1998Co-Authors: Fredrik Mertens, Christopher D M Fletcher, Ivo De Wever, Nils Mandahl, Felix Mitelman, Juan Rosai, Anders Rydholm, Raf Sciot, Giovanni Tallini, Herman Van Den BergheAbstract:With the aim of identifying objective cytogenetic-morphologic correlations, we evaluated 46 pleomorphic soft tissue sarcomas (mainly diagnosed originally as malignant fibrous histiocytomas) with clonal chromosome aberrations both cytogenetically and morphologically as part of an international collaborative study. By detailed histopathologic examination, most cases could be categorized into specific tumor types. Eight sarcomas were diagnosed as lipogenic (4 pleomorphic, 1 combined pleomorphic and myxoid/round cell, and 3 dedifferentiated liposarcomas), 19 as myogenic [11 leiomyosarcomas, 1 rhabdomyosarcoma, 4 myosarcomas not otherwise specified (NOS), and 3 probable myosarcomas NOS], 8 as myxofibrosarcomas, 1 as a malignant peripheral nerve sheath tumor, 1 as malignant Mesenchymoma, 1 as extraskeletal osteosarcoma, 1 as sarcoma resembling proliferative fasciitis, and 7 as pleomorphic sarcomas NOS. In a three-grade system, 10 tumors were grade 2 and 36 were grade 3. The majority had highly complex karyotypes. A total of 24 recurrent abnormalities (defined by their presence in at least five cases) were detected: ring chromosomes, homogeneously staining regions (hsr) and/or double minute chromosomes (dmin), and structural rearrangement of 22 different chromosome bands or regions. The frequency and distribution of the recurrent karyotypic features were uneven. Grade 3 tumors displayed, on average, more aberrations per case than did grade 2 tumors. Nine of the selected abnormalities, including hsr/dmin and rearrangements of 19p13 and 19q13, were found only among the high-grade tumors. When the tumors were subdivided according to lineage of differentiation, the highest frequency of aberrations was seen in pleomorphic sarcomas NOS, followed by myxofibrosarcomas, myogenic sarcomas, and lipogenic sarcomas. None of the selected rearrangements was, however, specific for any of these subgroups. The sole consistent cytogenetic-morphologic association was that all three dedifferentiated liposarcomas had multiple abnormal clones, at least one of which contained supernumerary ring chromosomes. Due mainly to karyotype complexity, it therefore seems unlikely that cytogenetic analysis can assist in the differential diagnostic subclassification of pleomorphic sarcomas, nor was there any clear-cut indication that the karyotypic picture could be used to predict clinical outcome. Although the mean number of recurrent chromosome aberrations was almost twice as high in sarcomas that gave rise to metastases as among those that did not, no particular aberration was restricted to either of the two subgroups. Genes Chromosomes Cancer 22:16–25, 1998. © 1998 Wiley-Liss, Inc.