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Kin Hung Liu - One of the best experts on this subject based on the ideXlab platform.
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Mesenteric Fat thickness is associated with metabolic syndrome independently of apnoea hypopnoea index in subjects with obstructive sleep apnoea
Respirology, 2016Co-Authors: Kin Hung Liu, J Ngai, Anil T Ahuja, Winnie C.w. Chu, Ka Pang Chan, Wing Ho Yip, David HuiAbstract:Background and objective Mesenteric Fat thickness (MFT) was associated with metabolic syndrome (MetS) and obstructive sleep apnoea (OSA) in separate studies. This study aimed to assess whether the association of MFT with MetS was independent of OSA in subjects with suspected OSA. Methods Two hundred forty-two subjects (men: 181; women: 61) with suspected OSA underwent ultrasound examinations for measurements of Mesenteric, subcutaneous and preperitoneal Fat thicknesses after overnight polysomnography. Anthropometric measurements and metabolic risk profile were assessed. Results Two hundred twenty-one (91%) subjects were confirmed to have OSA with Apnoea–Hypopnoea Index (AHI) >5/h. MFT had significant correlation (P < 0.01) with AHI and most MetS components. In partial correlation with adjustment for AHI, MFT had significant correlation (P < 0.01) with most MetS components including fasting plasma glucose (r = 0.25), triglycerides (r = 0.24), HDL cholesterol (r = −0.29) and waist circumference (r = 0.56). In multivariate logistic regression with adjustments for the confounding variables including AHI, MFT was the only variable independently associated with MetS, with the odds ratio of 5.48 (95% CI: 1.5–20.0) for every 1 cm increase of MFT. When the subjects were subdivided into obese (BMI ≥ 27.5 kg/m2) and non-obese (BMI < 27.5 kg/m2) groups, the positive association of MFT with MetS persisted in the non-obese group only, with the odds ratio of 22 (95% CI 2.8–174.1) for every 1 cm increase of MFT. The AHI had significant association with MetS in male subjects only. Conclusion MFT, rather than AHI, is the major independent determinant of MetS in subjects with suspected OSA, particularly in non-obese subjects.
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Mesenteric Fat thickness is associated with metabolic syndrome independently of Apnoea-Hypopnoea Index in subjects with obstructive sleep apnoea.
Respirology (Carlton Vic.), 2015Co-Authors: Kin Hung Liu, J Ngai, Anil T Ahuja, Winnie C.w. Chu, Ka Pang Chan, Ho Yip, David HuiAbstract:Background and objective Mesenteric Fat thickness (MFT) was associated with metabolic syndrome (MetS) and obstructive sleep apnoea (OSA) in separate studies. This study aimed to assess whether the association of MFT with MetS was independent of OSA in subjects with suspected OSA. Methods Two hundred forty-two subjects (men: 181; women: 61) with suspected OSA underwent ultrasound examinations for measurements of Mesenteric, subcutaneous and preperitoneal Fat thicknesses after overnight polysomnography. Anthropometric measurements and metabolic risk profile were assessed. Results Two hundred twenty-one (91%) subjects were confirmed to have OSA with Apnoea–Hypopnoea Index (AHI) >5/h. MFT had significant correlation (P
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Mesenteric Fat thickness is associated with increased risk of obstructive sleep apnoea
Respirology, 2014Co-Authors: Kin Hung Liu, Winnie Cw W Chu, J Ngai, Jeff Wai Sang Chan, Anil T Ahuja, David Sc HuiAbstract:Background and objective Mesenteric Fat is a type of intraperitoneal adipose tissue draining into portal circulation. The objective of this study was to investigate the relationships between Mesenteric Fat thickness and obstructive sleep apnoea (OSA) in patients with suspected OSA. Methods One hundred forty-nine subjects (men: 114; women: 35) with suspected OSA underwent ultrasound examinations of Mesenteric, preperitoneal and subcutaneous Fat thickness after overnight polysomnography. Body mass index (BMI) and neck circumference were recorded. Results The subjects with OSA (n = 130, apnoea/hypopnoea index (AHI) >5/h) had greater neck circumference, higher BMI, and greater Mesenteric and preperitoneal Fat thickness than those without OSA (n = 19, AHI ≤ 5/h). There was positive correlation of AHI with Mesenteric (r = 0.43, P < 0.001) and preperitoneal Fat thickness (r = 0.3, P < 0.001), whereas no significant association was observed between AHI and subcutaneous Fat thickness (r = 0.09, P = 0.27). On multivariate logistic regression, after adjustments for gender, age, BMI, neck circumference, and preperitoneal and subcutaneous Fat thickness, the Mesenteric Fat thickness had a positive association with the presence of moderate OSA and severe OSA, with odds ratios of 7.18 and 7.45 for every 1 cm increase in Mesenteric Fat thickness when AHI was defined as ≥15/h and AHI ≥ 30/h, respectively. Conclusions Mesenteric Fat thickness is associated with increased risk of OSA, independent of other abdominal Fat thickness, BMI and neck circumference. Sonographic measurement is potentially a useful tool for further evaluating the complex association of visceral Fat, metabolic syndrome and OSA.
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Mesenteric Fat thickness is associated with increased risk of obstructive sleep apnoea.
Respirology (Carlton Vic.), 2013Co-Authors: Kin Hung Liu, Winnie Cw W Chu, J Ngai, Jeff Wai Sang Chan, Anil T Ahuja, David Sc HuiAbstract:Background and objective Mesenteric Fat is a type of intraperitoneal adipose tissue draining into portal circulation. The objective of this study was to investigate the relationships between Mesenteric Fat thickness and obstructive sleep apnoea (OSA) in patients with suspected OSA. Methods One hundred forty-nine subjects (men: 114; women: 35) with suspected OSA underwent ultrasound examinations of Mesenteric, preperitoneal and subcutaneous Fat thickness after overnight polysomnography. Body mass index (BMI) and neck circumference were recorded. Results The subjects with OSA (n = 130, apnoea/hypopnoea index (AHI) >5/h) had greater neck circumference, higher BMI, and greater Mesenteric and preperitoneal Fat thickness than those without OSA (n = 19, AHI ≤ 5/h). There was positive correlation of AHI with Mesenteric (r = 0.43, P
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Sonographic measurement of Mesenteric Fat predicts presence of Fatty liver among subjects with polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism, 2010Co-Authors: Ronald C.w., Kin Hung Liu, Po Mui Lam, Lai Ping Cheung, Hung Tam, Michael Ho-ming Chan, Christopher W.k. Lam, Winnie C.w. ChuAbstract:Sonographic measurement of Mesenteric Fat predicts presence of Fatty liver and can impact on manifestation of hyperandrogenism through its effects on SHBG.
Laurent Dubuquoy - One of the best experts on this subject based on the ideXlab platform.
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Mesenteric Fat as a source of c reactive protein and as a target for bacterial translocation in crohn s disease
Gut, 2012Co-Authors: Laurent Peyrinbiroulet, Florent Gonzalez, Laurent Dubuquoy, Christel Rousseaux, Caroline Dubuquoy, Cecilia Decourcelle, Alain Saudemont, Mickael Tachon, Elodie Beclin, Mariefrancoise OdouAbstract:Objective Mesenteric Fat hyperplasia is a hallmark of Crohn’s disease (CD), and C reactive protein (CRP) is correlated with disease activity. The authors investigated whether Mesenteric adipocytes may be a source of CRP in CD and whether inflammatory and bacterial triggers may stimulate its production by adipocytes. Design CRP expression in the Mesenteric and subcutaneous Fats of patients with CD and the correlation between CRP plasma concentrations and Mesenteric messenger RNA (mRNA) levels were assessed. The impact of inflammatory and bacterial challenges on CRP synthesis was tested using an adipocyte cell line. Bacterial translocation to Mesenteric Fat was studied in experimental models of colitis and ileitis and in patients with CD. Results CRP expression was increased in the Mesenteric Fat of patients with CD, with mRNA levels being 80640 (p<0.05) and 140665 (p¼0.04) times higher than in the Mesenteric Fat of patients with ulcerative colitis and in the subcutaneous Fat of the same CD subjects, respectively, and correlated with plasma levels. Escherichia coli (12306175-fold, p<0.01), lipopolysaccharide (2660.5-fold, p<0.01), tumour necrosis factor a (1560.3-fold, p<0.01) and interleukin-6 (1060.7-fold, p<0.05) increased CRP mRNA levels in adipocyte 3T3-L1 cells. Bacterial translocation to Mesenteric Fat occurred in 13% and 27% of healthy and CD subjects, respectively, and was increased in experimental colitis and ileitis. Human Mesenteric adipocytes constitutively expressed mRNA for TLR2, TLR4, NOD1 and NOD2. Conclusion Mesenteric Fat is an important source of CRP in CD. CRP production by Mesenteric adipocytes may be triggered by local inflammation and bacterial translocation to Mesenteric Fat, providing a mechanism whereby Mesenteric Fat hyperplasia may contribute to inflammatory response in CD.
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Visceral Fat and gut inflammation.
Nutrition (Burbank Los Angeles County Calif.), 2012Co-Authors: Maryline Drouet, Laurent Dubuquoy, Pierre Desreumaux, Benjamin BertinAbstract:The etiology of inflammatory bowel disease and, in particular, Crohn's disease involves a deregulated mucosal immune system under the influence of intestinal flora and environmental factors in genetically susceptible individuals. A new hypothesis has focused on Mesenteric Fat hypertrophy and the presence of ectopic Fat surrounding inflamed bowel, the so-called creeping Fat, which are hallmarks of Crohn's disease. Mesenteric adipose tissue is currently recognized as an active actor in immunity with a capacity for mediator secretion. These mediators include classic pro- and anti-inflammatory cytokines or chemokines and hormone-like adipokines with multiple effects. Mesenteric Fat participates in the course of Crohn's disease and may play an active role in the regulation of intestinal inflammation. However, little is known about the origin and role of Mesenteric Fat in Crohn's disease, essentially because of a lack of experimental models that develop creeping Fat. The purpose of this review is to present the recent data describing the immune properties of Mesenteric Fat and the recent advances in animal models, which have suggested a new hypothesis about the role of creeping Fat in Crohn's disease.
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Mesenteric Fat as a source of C reactive protein and as a target for bacterial translocation in Crohn's disease
Gut, 2011Co-Authors: Laurent Peyrin-biroulet, Florent Gonzalez, Laurent Dubuquoy, Christel Rousseaux, Caroline Dubuquoy, Cecilia Decourcelle, Alain Saudemont, Mickael Tachon, Elodie Beclin, Mariefrancoise OdouAbstract:Objective Mesenteric Fat hyperplasia is a hallmark of Crohn’s disease (CD), and C reactive protein (CRP) is correlated with disease activity. The authors investigated whether Mesenteric adipocytes may be a source of CRP in CD and whether inflammatory and bacterial triggers may stimulate its production by adipocytes. Design CRP expression in the Mesenteric and subcutaneous Fats of patients with CD and the correlation between CRP plasma concentrations and Mesenteric messenger RNA (mRNA) levels were assessed. The impact of inflammatory and bacterial challenges on CRP synthesis was tested using an adipocyte cell line. Bacterial translocation to Mesenteric Fat was studied in experimental models of colitis and ileitis and in patients with CD. Results CRP expression was increased in the Mesenteric Fat of patients with CD, with mRNA levels being 80640 (p
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Obesity, visceral Fat and Crohn's disease.
Current opinion in clinical nutrition and metabolic care, 2010Co-Authors: Benjamin Bertin, Pierre Desreumaux, Laurent DubuquoyAbstract:Purpose of review Increasing evidence indicates that adipose tissue is an active endocrine organ involved in metabolic syndrome and regulation of inflammation. Visceral Fat accumulation is a hallmark of both obesity and Crohn's disease. Here, we present recent data describing the immune properties of intra-abdominal adipose tissue that could link the innate immune response to obesity-related disorders and gut inflammation. Recent findings Innate immune properties of adipocytes have become well characterized since recent studies described the Toll-like receptor (TLR) expression repertoire and specific TLR ligand responses of adipocytes. Adipokine secretion profiles have also been elucidated both in obese patients, when they may be involved in obesity-associated metabolic disease, and in Crohn's disease. Whereas Mesenteric Fat hypertrophy and Fat wrapping of the bowel are characteristic of Crohn's disease, there exists a paucity of information concerning this important pathophysiological aspect. Our current classical animal models are of limited interest when investigating the role of Mesenteric Fat in gut inflammation. Recent new alternative disease paradigms could help to design more specific models for elucidating chronic transmural inflammation of the gut. Summary Obesity and Crohn's disease share common features with the development of Mesenteric Fat that may be involved in gut inflammation. Further studies are required to clearly assess the origin and influence of intestinal Fat deposits upon gut inflammation, notably during Crohn's disease development.
Harvey C. Freetly - One of the best experts on this subject based on the ideXlab platform.
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Genes associated with body weight gain and feed intake identified by meta-analysis of the Mesenteric Fat from crossbred beef steers.
PloS one, 2020Co-Authors: Amanda K. Lindholm-perry, Harvey C. Freetly, W. T. Oliver, Lea A. Rempel, Brittney N. KeelAbstract:Mesenteric Fat is a visceral Fat depot that increases with cattle maturity and can be influenced by diet. There may be a relationship between the accumulation of Mesenteric Fat and feed efficiency in beef cattle. The purpose of this study was to identify genes that may be differentially expressed in steers with high and low BW gain and feed intake. RNA-Seq was used to evaluate the transcript abundance of genes in the Mesenteric Fat from a total of 78 steers collected over 5 different cohorts. A meta-analysis was used to identify genes involved with gain, feed intake or the interaction of both phenotypes. The interaction analysis identified 11 genes as differentially expressed. For the main effect of gain, a total of 87 differentially expressed genes (DEG) were identified (PADJ
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genes associated with body weight gain and feed intake identified by meta analysis of the Mesenteric Fat from crossbred beef steers
PLOS ONE, 2020Co-Authors: A K Lindholmperry, Harvey C. Freetly, W. T. Oliver, Lea A. Rempel, Brittney N. KeelAbstract:Mesenteric Fat is a visceral Fat depot that increases with cattle maturity and can be influenced by diet. There may be a relationship between the accumulation of Mesenteric Fat and feed efficiency in beef cattle. The purpose of this study was to identify genes that may be differentially expressed in steers with high and low BW gain and feed intake. RNA-Seq was used to evaluate the transcript abundance of genes in the Mesenteric Fat from a total of 78 steers collected over 5 different cohorts. A meta-analysis was used to identify genes involved with gain, feed intake or the interaction of both phenotypes. The interaction analysis identified 11 genes as differentially expressed. For the main effect of gain, a total of 87 differentially expressed genes (DEG) were identified (PADJ<0.05), and 24 were identified in the analysis for feed intake. Genes identified for gain were involved in functions and pathways including lipid metabolism, stress response/protein folding, cell proliferation/growth, axon guidance and inflammation. The genes for feed intake did not cluster into pathways, but some of the DEG for intake had functions related to inflammation, immunity, and/or signal transduction (JCHAIN, RIPK1, LY86, SPP1, LYZ, CD5, CD53, SRPX, and NF2). At PADJ<0.1, only 4 genes (OLFML3, LOC100300716, MRPL15, and PUS10) were identified as differentially expressed in two or more cohorts, highlighting the importance of evaluating the transcriptome of more than one group of animals and incorporating a meta-analysis. This meta-analysis has produced many Mesenteric Fat DEG that may be contributing to gain and feed intake in cattle.
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Relationships between the genes expressed in the Mesenteric adipose tissue of beef cattle and feed intake and gain.
Animal genetics, 2017Co-Authors: Amanda K. Lindholm-perry, H. C. Cunningham, Larry A. Kuehn, J. L. Vallet, John W. Keele, Andrew P. Foote, K. M. Cammack, Harvey C. FreetlyAbstract:Summary Mesenteric Fat, a depot within the visceral Fat, accumulates in cattle during maturation and finishing and may be a potential source of production inefficiency. The aim of this study was to determine whether the genes expressed in the Mesenteric Fat of steers were associated with body weight gain and feed intake. Sixteen steers chosen by their rank of distance from the bivariate mean for gain and feed intake were used for this study. Mesenteric Fat was obtained and evaluated for differences in gene expression. A total of 1831 genes were identified as differentially expressed among steers with variation in feed intake and gain. Many of these genes were involved with metabolic processes such as proteolysis, transcription and translation. In addition, the Gene Ontology annotations including transport and localization were both over-represented among the differentially expressed genes. Pathway analysis was also performed on the differentially expressed genes. The superoxide radical degradation pathway was identified as over-represented based on the differential expression of the genes GPX7, SOD2 and TYRP1, suggesting a potential role for oxidative stress or inflammatory pathways among low gain–high intake animals. GPX7 and SOD2 were in lower transcript abundance, and TYRP1 was higher in transcript abundance among the low gain–high feed intake animals. The retinoate biosynthesis pathway was also enriched due to the differential expression of the genes AKR1C3, ALDH8A1, RDH8, RDH13 and SDR9C7. These genes were all more highly expressed in the low gain–high intake animals. The glycerol degradation and granzyme A signaling pathways were both associated with gain. Three glycerol kinase genes and the GZMA gene were differentially expressed among high vs. low gain animals. Mesenteric Fat is a metabolically active tissue, and in this study, genes involved in proteolysis, transcription, translation, transport immune function, glycerol degradation and oxidative stress were differentially expressed among beef steers with variation in body weight gain and feed intake.
Mariefrancoise Odou - One of the best experts on this subject based on the ideXlab platform.
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Mesenteric Fat as a source of c reactive protein and as a target for bacterial translocation in crohn s disease
Gut, 2012Co-Authors: Laurent Peyrinbiroulet, Florent Gonzalez, Laurent Dubuquoy, Christel Rousseaux, Caroline Dubuquoy, Cecilia Decourcelle, Alain Saudemont, Mickael Tachon, Elodie Beclin, Mariefrancoise OdouAbstract:Objective Mesenteric Fat hyperplasia is a hallmark of Crohn’s disease (CD), and C reactive protein (CRP) is correlated with disease activity. The authors investigated whether Mesenteric adipocytes may be a source of CRP in CD and whether inflammatory and bacterial triggers may stimulate its production by adipocytes. Design CRP expression in the Mesenteric and subcutaneous Fats of patients with CD and the correlation between CRP plasma concentrations and Mesenteric messenger RNA (mRNA) levels were assessed. The impact of inflammatory and bacterial challenges on CRP synthesis was tested using an adipocyte cell line. Bacterial translocation to Mesenteric Fat was studied in experimental models of colitis and ileitis and in patients with CD. Results CRP expression was increased in the Mesenteric Fat of patients with CD, with mRNA levels being 80640 (p<0.05) and 140665 (p¼0.04) times higher than in the Mesenteric Fat of patients with ulcerative colitis and in the subcutaneous Fat of the same CD subjects, respectively, and correlated with plasma levels. Escherichia coli (12306175-fold, p<0.01), lipopolysaccharide (2660.5-fold, p<0.01), tumour necrosis factor a (1560.3-fold, p<0.01) and interleukin-6 (1060.7-fold, p<0.05) increased CRP mRNA levels in adipocyte 3T3-L1 cells. Bacterial translocation to Mesenteric Fat occurred in 13% and 27% of healthy and CD subjects, respectively, and was increased in experimental colitis and ileitis. Human Mesenteric adipocytes constitutively expressed mRNA for TLR2, TLR4, NOD1 and NOD2. Conclusion Mesenteric Fat is an important source of CRP in CD. CRP production by Mesenteric adipocytes may be triggered by local inflammation and bacterial translocation to Mesenteric Fat, providing a mechanism whereby Mesenteric Fat hyperplasia may contribute to inflammatory response in CD.
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Mesenteric Fat as a source of C reactive protein and as a target for bacterial translocation in Crohn's disease
Gut, 2011Co-Authors: Laurent Peyrin-biroulet, Florent Gonzalez, Laurent Dubuquoy, Christel Rousseaux, Caroline Dubuquoy, Cecilia Decourcelle, Alain Saudemont, Mickael Tachon, Elodie Beclin, Mariefrancoise OdouAbstract:Objective Mesenteric Fat hyperplasia is a hallmark of Crohn’s disease (CD), and C reactive protein (CRP) is correlated with disease activity. The authors investigated whether Mesenteric adipocytes may be a source of CRP in CD and whether inflammatory and bacterial triggers may stimulate its production by adipocytes. Design CRP expression in the Mesenteric and subcutaneous Fats of patients with CD and the correlation between CRP plasma concentrations and Mesenteric messenger RNA (mRNA) levels were assessed. The impact of inflammatory and bacterial challenges on CRP synthesis was tested using an adipocyte cell line. Bacterial translocation to Mesenteric Fat was studied in experimental models of colitis and ileitis and in patients with CD. Results CRP expression was increased in the Mesenteric Fat of patients with CD, with mRNA levels being 80640 (p
Brittney N. Keel - One of the best experts on this subject based on the ideXlab platform.
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Genes associated with body weight gain and feed intake identified by meta-analysis of the Mesenteric Fat from crossbred beef steers.
PloS one, 2020Co-Authors: Amanda K. Lindholm-perry, Harvey C. Freetly, W. T. Oliver, Lea A. Rempel, Brittney N. KeelAbstract:Mesenteric Fat is a visceral Fat depot that increases with cattle maturity and can be influenced by diet. There may be a relationship between the accumulation of Mesenteric Fat and feed efficiency in beef cattle. The purpose of this study was to identify genes that may be differentially expressed in steers with high and low BW gain and feed intake. RNA-Seq was used to evaluate the transcript abundance of genes in the Mesenteric Fat from a total of 78 steers collected over 5 different cohorts. A meta-analysis was used to identify genes involved with gain, feed intake or the interaction of both phenotypes. The interaction analysis identified 11 genes as differentially expressed. For the main effect of gain, a total of 87 differentially expressed genes (DEG) were identified (PADJ
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genes associated with body weight gain and feed intake identified by meta analysis of the Mesenteric Fat from crossbred beef steers
PLOS ONE, 2020Co-Authors: A K Lindholmperry, Harvey C. Freetly, W. T. Oliver, Lea A. Rempel, Brittney N. KeelAbstract:Mesenteric Fat is a visceral Fat depot that increases with cattle maturity and can be influenced by diet. There may be a relationship between the accumulation of Mesenteric Fat and feed efficiency in beef cattle. The purpose of this study was to identify genes that may be differentially expressed in steers with high and low BW gain and feed intake. RNA-Seq was used to evaluate the transcript abundance of genes in the Mesenteric Fat from a total of 78 steers collected over 5 different cohorts. A meta-analysis was used to identify genes involved with gain, feed intake or the interaction of both phenotypes. The interaction analysis identified 11 genes as differentially expressed. For the main effect of gain, a total of 87 differentially expressed genes (DEG) were identified (PADJ<0.05), and 24 were identified in the analysis for feed intake. Genes identified for gain were involved in functions and pathways including lipid metabolism, stress response/protein folding, cell proliferation/growth, axon guidance and inflammation. The genes for feed intake did not cluster into pathways, but some of the DEG for intake had functions related to inflammation, immunity, and/or signal transduction (JCHAIN, RIPK1, LY86, SPP1, LYZ, CD5, CD53, SRPX, and NF2). At PADJ<0.1, only 4 genes (OLFML3, LOC100300716, MRPL15, and PUS10) were identified as differentially expressed in two or more cohorts, highlighting the importance of evaluating the transcriptome of more than one group of animals and incorporating a meta-analysis. This meta-analysis has produced many Mesenteric Fat DEG that may be contributing to gain and feed intake in cattle.