The Experts below are selected from a list of 50370 Experts worldwide ranked by ideXlab platform
Thibaud Spinetti - One of the best experts on this subject based on the ideXlab platform.
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omega 3 fatty acids prevent inflammation and Metabolic Disorder through inhibition of nlrp3 inflammasome activation
Immunity, 2013Co-Authors: Yiqing Yan, Wei Jiang, Thibaud Spinetti, Aubry Tardivel, Rosa Castillo, Carole Bourquin, Greta Guarda, Zhigang Tian, Jurg TschoppAbstract:Omega-3 fatty acids (ω-3 FAs) have potential anti-inflammatory activity in a variety of inflammatory human diseases, but the mechanisms remain poorly understood. Here we show that stimulation of macrophages with ω-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1β secretion. In addition, G protein-coupled receptor 120 (GPR120) and GPR40 and their downstream scaffold protein β-arrestin-2 were shown to be involved in inflammasome inhibition induced by ω-3 FAs. Importantly, ω-3 FAs also prevented NLRP3 inflammasome-dependent inflammation and Metabolic Disorder in a high-fat-diet-induced type 2 diabetes model. Our results reveal a mechanism through which ω-3 FAs repress inflammation and prevent inflammation-driven diseases and suggest the potential clinical use of ω-3 FAs in gout, autoinflammatory syndromes, or other NLRP3 inflammasome-driven inflammatory diseases.
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omega 3 fatty acids prevent inflammation and Metabolic Disorder through inhibition of nlrp3 inflammasome activation
Immunity, 2013Co-Authors: Wei Jiang, Thibaud Spinetti, Aubry Tardivel, Rosa Castillo, Carole Bourquin, Greta Guarda, Zhigang Tian, Jurg Tschopp, Rongbin ZhouAbstract:Omega-3 fatty acids (ω-3 FAs) have potential anti-inflammatory activity in a variety of inflammatory human diseases, but the mechanisms remain poorly understood. Here we show that stimulation of macrophages with ω-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1β secretion. In addition, G protein-coupled receptor 120 (GPR120) and GPR40 and their downstream scaffold protein β-arrestin-2 were shown to be involved in inflammasome inhibition induced by ω-3 FAs. Importantly, ω-3 FAs also prevented NLRP3 inflammasome-dependent inflammation and Metabolic Disorder in a high-fat-diet-induced type 2 diabetes model. Our results reveal a mechanism through which ω-3 FAs repress inflammation and prevent inflammation-driven diseases and suggest the potential clinical use of ω-3 FAs in gout, autoinflammatory syndromes, or other NLRP3 inflammasome-driven inflammatory diseases.
Jurg Tschopp - One of the best experts on this subject based on the ideXlab platform.
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omega 3 fatty acids prevent inflammation and Metabolic Disorder through inhibition of nlrp3 inflammasome activation
Immunity, 2013Co-Authors: Yiqing Yan, Wei Jiang, Thibaud Spinetti, Aubry Tardivel, Rosa Castillo, Carole Bourquin, Greta Guarda, Zhigang Tian, Jurg TschoppAbstract:Omega-3 fatty acids (ω-3 FAs) have potential anti-inflammatory activity in a variety of inflammatory human diseases, but the mechanisms remain poorly understood. Here we show that stimulation of macrophages with ω-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1β secretion. In addition, G protein-coupled receptor 120 (GPR120) and GPR40 and their downstream scaffold protein β-arrestin-2 were shown to be involved in inflammasome inhibition induced by ω-3 FAs. Importantly, ω-3 FAs also prevented NLRP3 inflammasome-dependent inflammation and Metabolic Disorder in a high-fat-diet-induced type 2 diabetes model. Our results reveal a mechanism through which ω-3 FAs repress inflammation and prevent inflammation-driven diseases and suggest the potential clinical use of ω-3 FAs in gout, autoinflammatory syndromes, or other NLRP3 inflammasome-driven inflammatory diseases.
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omega 3 fatty acids prevent inflammation and Metabolic Disorder through inhibition of nlrp3 inflammasome activation
Immunity, 2013Co-Authors: Wei Jiang, Thibaud Spinetti, Aubry Tardivel, Rosa Castillo, Carole Bourquin, Greta Guarda, Zhigang Tian, Jurg Tschopp, Rongbin ZhouAbstract:Omega-3 fatty acids (ω-3 FAs) have potential anti-inflammatory activity in a variety of inflammatory human diseases, but the mechanisms remain poorly understood. Here we show that stimulation of macrophages with ω-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1β secretion. In addition, G protein-coupled receptor 120 (GPR120) and GPR40 and their downstream scaffold protein β-arrestin-2 were shown to be involved in inflammasome inhibition induced by ω-3 FAs. Importantly, ω-3 FAs also prevented NLRP3 inflammasome-dependent inflammation and Metabolic Disorder in a high-fat-diet-induced type 2 diabetes model. Our results reveal a mechanism through which ω-3 FAs repress inflammation and prevent inflammation-driven diseases and suggest the potential clinical use of ω-3 FAs in gout, autoinflammatory syndromes, or other NLRP3 inflammasome-driven inflammatory diseases.
Wei Jiang - One of the best experts on this subject based on the ideXlab platform.
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omega 3 fatty acids prevent inflammation and Metabolic Disorder through inhibition of nlrp3 inflammasome activation
Immunity, 2013Co-Authors: Yiqing Yan, Wei Jiang, Thibaud Spinetti, Aubry Tardivel, Rosa Castillo, Carole Bourquin, Greta Guarda, Zhigang Tian, Jurg TschoppAbstract:Omega-3 fatty acids (ω-3 FAs) have potential anti-inflammatory activity in a variety of inflammatory human diseases, but the mechanisms remain poorly understood. Here we show that stimulation of macrophages with ω-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1β secretion. In addition, G protein-coupled receptor 120 (GPR120) and GPR40 and their downstream scaffold protein β-arrestin-2 were shown to be involved in inflammasome inhibition induced by ω-3 FAs. Importantly, ω-3 FAs also prevented NLRP3 inflammasome-dependent inflammation and Metabolic Disorder in a high-fat-diet-induced type 2 diabetes model. Our results reveal a mechanism through which ω-3 FAs repress inflammation and prevent inflammation-driven diseases and suggest the potential clinical use of ω-3 FAs in gout, autoinflammatory syndromes, or other NLRP3 inflammasome-driven inflammatory diseases.
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omega 3 fatty acids prevent inflammation and Metabolic Disorder through inhibition of nlrp3 inflammasome activation
Immunity, 2013Co-Authors: Wei Jiang, Thibaud Spinetti, Aubry Tardivel, Rosa Castillo, Carole Bourquin, Greta Guarda, Zhigang Tian, Jurg Tschopp, Rongbin ZhouAbstract:Omega-3 fatty acids (ω-3 FAs) have potential anti-inflammatory activity in a variety of inflammatory human diseases, but the mechanisms remain poorly understood. Here we show that stimulation of macrophages with ω-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1β secretion. In addition, G protein-coupled receptor 120 (GPR120) and GPR40 and their downstream scaffold protein β-arrestin-2 were shown to be involved in inflammasome inhibition induced by ω-3 FAs. Importantly, ω-3 FAs also prevented NLRP3 inflammasome-dependent inflammation and Metabolic Disorder in a high-fat-diet-induced type 2 diabetes model. Our results reveal a mechanism through which ω-3 FAs repress inflammation and prevent inflammation-driven diseases and suggest the potential clinical use of ω-3 FAs in gout, autoinflammatory syndromes, or other NLRP3 inflammasome-driven inflammatory diseases.
Ikhlas A. Khan - One of the best experts on this subject based on the ideXlab platform.
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prenylated flavonol glycosides from epimedium grandiflorum cytotoxicity and evaluation against inflammation and Metabolic Disorder
Phytochemistry Letters, 2017Co-Authors: Fazila Zulfiqar, Shabana I. Khan, Samir A Ross, Zulfiqar Ali, Ikhlas A. KhanAbstract:Abstract Two new prenylated flavonol glycosides, epimedigrandiosides A and B ( 1 and 2 ), and 28 previously known compounds including prenylated flavonol derivatives, flavonol glycoside, megastigmanes, phenyl alkanoids, sesquiterpenoid glycoside, lignan, and hexene glucoside were isolated from the methanol extract of Epimedium grandiflorum . Structure elucidation was achieved by means of spectroscopic and spectrometric techniques including 1D and 2D NMR and HRESIMS. The absolute configuration of sugars was determined by chemical methods Structure elucidation of 3‴-carbonyl-2″-β- l -quinovosyl icariin ( 19 ) was not previously described, so its 1 H and 13 C NMR data were reported for the first time. The methanol extract and the isolated compounds were evaluated for their activity towards several targets related to inflammation and Metabolic Disorder including NF-κB, iNOS, PPARα and PPARγ. Moreover, their cytotoxic activity against four cancer cell lines (SK-MEL, KB, BT-549, SK-OV-3) and two noncancerous kidney cell lines (LLC-PK1 and Vero) were also evaluated.
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Octulosonic acid derivatives from Roman chamomile (Chamaemelum nobile) with activities against inflammation and Metabolic Disorder
Journal of Natural Products, 2014Co-Authors: Jianping Zhao, Yelkaira Vasquez, Min Hye Yang, Cristina Avonto, Troy J. Smillie, Bharathi Avula, Mei Wang, Yan-hong Wang, Shabana I. Khan, Ikhlas A. KhanAbstract:Six new octulosonic acid derivatives (1-6) were isolated from the flower heads of Roman chamomile (Chamaemelum nobile). Their structures were elucidated by means of spectroscopic interpretation. The biological activity of the isolated compounds was evaluated toward multiple targets related to inflammation and Metabolic Disorder such as NAG-1, NF-κB, iNOS, ROS, PPARα, PPARγ, and LXR. Similar to the action of NSAIDs, all the six compounds (1-6) increased NAG-1 activity 2-3-fold. They also decreased cellular oxidative stress by inhibiting ROS generation. Compounds 3, 5, and 6 activated PPARγ 1.6-2.1-fold, while PPARα was activated 1.4-fold by compounds 5 and 6 only. None of the compounds showed significant activity against iNOS or NF-κB. This is the first report of biological activity of octulosonic acid derivatives toward multiple pathways related to inflammation and Metabolic Disorder. The reported anti-inflammatory, hypoglycemic, antiedemic, and antioxidant activities of Roman chamomile could be partly explained as due to the presence of these constituents.
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Octulosonic Acid Derivatives from Roman Chamomile (Chamaemelum nobile) with Activities against Inflammation and Metabolic Disorder
2014Co-Authors: Jianping Zhao, Yelkaira Vasquez, Min Hye Yang, Cristina Avonto, Troy J. Smillie, Bharathi Avula, Mei Wang, Yan-hong Wang, Shabana I. Khan, Ikhlas A. KhanAbstract:Six new octulosonic acid derivatives (1–6) were isolated from the flower heads of Roman chamomile (Chamaemelum nobile). Their structures were elucidated by means of spectroscopic interpretation. The biological activity of the isolated compounds was evaluated toward multiple targets related to inflammation and Metabolic Disorder such as NAG-1, NF-κB, iNOS, ROS, PPARα, PPARγ, and LXR. Similar to the action of NSAIDs, all the six compounds (1–6) increased NAG-1 activity 2–3-fold. They also decreased cellular oxidative stress by inhibiting ROS generation. Compounds 3, 5, and 6 activated PPARγ 1.6–2.1-fold, while PPARα was activated 1.4-fold by compounds 5 and 6 only. None of the compounds showed significant activity against iNOS or NF-κB. This is the first report of biological activity of octulosonic acid derivatives toward multiple pathways related to inflammation and Metabolic Disorder. The reported anti-inflammatory, hypoglycemic, antiedemic, and antioxidant activities of Roman chamomile could be partly explained as due to the presence of these constituents
Rongbin Zhou - One of the best experts on this subject based on the ideXlab platform.
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omega 3 fatty acids prevent inflammation and Metabolic Disorder through inhibition of nlrp3 inflammasome activation
Immunity, 2013Co-Authors: Wei Jiang, Thibaud Spinetti, Aubry Tardivel, Rosa Castillo, Carole Bourquin, Greta Guarda, Zhigang Tian, Jurg Tschopp, Rongbin ZhouAbstract:Omega-3 fatty acids (ω-3 FAs) have potential anti-inflammatory activity in a variety of inflammatory human diseases, but the mechanisms remain poorly understood. Here we show that stimulation of macrophages with ω-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1β secretion. In addition, G protein-coupled receptor 120 (GPR120) and GPR40 and their downstream scaffold protein β-arrestin-2 were shown to be involved in inflammasome inhibition induced by ω-3 FAs. Importantly, ω-3 FAs also prevented NLRP3 inflammasome-dependent inflammation and Metabolic Disorder in a high-fat-diet-induced type 2 diabetes model. Our results reveal a mechanism through which ω-3 FAs repress inflammation and prevent inflammation-driven diseases and suggest the potential clinical use of ω-3 FAs in gout, autoinflammatory syndromes, or other NLRP3 inflammasome-driven inflammatory diseases.