The Experts below are selected from a list of 264 Experts worldwide ranked by ideXlab platform

Peter M Villiger - One of the best experts on this subject based on the ideXlab platform.

  • effect of rheumatoid arthritis and age on Metacarpal Bone shaft geometry and density a longitudinal pqct study in postmenopausal women
    Seminars in Arthritis and Rheumatism, 2020
    Co-Authors: Daniel Aeberli, H Bonel, Burkhard Moller, Niklaus Fankhauser, Roger Zebaze, Peter M Villiger
    Abstract:

    Abstract Objective This study aimed to elucidate the effects of changes in the geometry and density of the Metacarpal Bone of patients with rheumatoid arthritis (RA). Methods This prospective study included consecutive postmenopausal RA patients who met the American College of Rheumatology Criteria and healthy controls (HC). Peripheral quantitative computed tomography scans at 50% of the total Metacarpal shaft (third Metacarpal Bone) were obtained at baseline and follow-ups. Use of bisphosphonates (BP), glucocorticoids (GC), biologics, and disease-modifying anti-rheumatic drugs (DMARD) was monitored (baseline to follow-up). Total cross-sectional area (CSA), cortical-transitional zone and compact zone CSA, cortical volumetric Bone mineral density, and compact cortex porosity were measured. A linear mixed-effects model was used to determine significant differences in the rate of change in the RA and control groups and in RA patient subgroups. Results Thirty-nine RA patients and 42 consecutive postmenopausal HC were followed for 63 months. RA and HC depicted a time-dependent increase of medullary CSA (+0.41 mm2/year, P  Conclusion Increase in medullary Metacarpal CSA and thinning of the cortical CSA are physiological and time dependent. RA status is associated with loss in cortical density. Even upon biological therapy, low glucocorticoid dose affects Metacarpal Bone shaft geometry and density over time.

  • reduced trabecular Bone mineral density and cortical thickness accompanied by increased outer Bone circumference in Metacarpal Bone of rheumatoid arthritis patients a cross sectional study
    Arthritis Research & Therapy, 2010
    Co-Authors: Daniel Aeberli, Prisca Eser, H Bonel, Jolanda Widmer, Gion Caliezi, Pierrealain Varisco, Burkhard Moller, Peter M Villiger
    Abstract:

    Introduction: The objective of this study was to assess three-dimensional Bone geometry and density at the epiphysis and shaft of the third meta-carpal Bone of rheumatoid arthritis (RA) patients in comparison to healthy controls with the novel method of peripheral quantitative computed tomography (pQCT). Methods: PQCT scans were performed in 50 female RA patients and 100 healthy female controls at the distal epiphyses and shafts of the third Metacarpal Bone, the radius and the tibia. Reproducibility was determined by coefficient of varia-tion. Bone densitometric and geometric parameters were compared between the two groups and correlated to disease characteristics. Results: Reproducibility of different pQCT parameters was between 0.7% and 2.5%. RA patients had 12% to 19% lower trabecular Bone mineral density (BMD) (P ≤ 0.001) at the distal epiphyses of radius, tibia and Metacarpal Bone. At the shafts of these Bones RA patients had 7% to 16% thinner cortices (P ≤ 0.03). Total cross-sectional area (CSA) at the Metacarpal Bone shaft of pa-tients was larger (between 5% and 7%, P < 0.02), and relative cortical area was reduced by 13%. Erosiveness by Ratingen score correlated negatively with tra-becular and total BMD at the epiphyses and shaft cortical thickness of all measured Bones (P < 0.04). Conclusions: Reduced trabecular BMD and thinner cortices at peripheral Bones, and a greater Bone shaft diameter at the Metacarpal Bone suggest RA spe-cific Bone alterations. The proposed pQCT protocol is reliable and allows measuring juxta-articular trabecular BMD and shaft geometry at the Metacarpal Bone.

Mesut Ozcan - One of the best experts on this subject based on the ideXlab platform.

  • osteocutaneous posterior interosseous flap for reconstruction of the Metacarpal Bone and soft tissue defects in the hand
    Plastic and Reconstructive Surgery, 2002
    Co-Authors: Selcuk Akin, Yesim Ozgenel, Mesut Ozcan
    Abstract:

    A vascularized Bone segment of the ulna together with a posterior interosseous fasciocutaneous flap is harvested, including a cuff of the extensor pollicis longus muscle. The authors treated five male patients with Metacarpal Bone and soft-tissue defects of the hand using a distally based island osteocutaneous posterior interosseous flap. Their ages at the time of surgery ranged from 15 to 37 years (mean, 24 years). The Bone defects were in the first Metacarpal in three cases, the fourth Metacarpal in one, and the fifth Metacarpal in one. The length of the donated ulna ranged from 3 to 7 cm (mean, 5 cm). The follow-up period ranged from 5 to 92 months (mean, 39 months). All flaps survived completely. The posterior interosseous flap provides thin skin of good texture, together with vascularized Bone, for a one-stage reconstruction of the Metacarpal Bone and soft-tissue defects in the hand.

Daniel Aeberli - One of the best experts on this subject based on the ideXlab platform.

  • effect of rheumatoid arthritis and age on Metacarpal Bone shaft geometry and density a longitudinal pqct study in postmenopausal women
    Seminars in Arthritis and Rheumatism, 2020
    Co-Authors: Daniel Aeberli, H Bonel, Burkhard Moller, Niklaus Fankhauser, Roger Zebaze, Peter M Villiger
    Abstract:

    Abstract Objective This study aimed to elucidate the effects of changes in the geometry and density of the Metacarpal Bone of patients with rheumatoid arthritis (RA). Methods This prospective study included consecutive postmenopausal RA patients who met the American College of Rheumatology Criteria and healthy controls (HC). Peripheral quantitative computed tomography scans at 50% of the total Metacarpal shaft (third Metacarpal Bone) were obtained at baseline and follow-ups. Use of bisphosphonates (BP), glucocorticoids (GC), biologics, and disease-modifying anti-rheumatic drugs (DMARD) was monitored (baseline to follow-up). Total cross-sectional area (CSA), cortical-transitional zone and compact zone CSA, cortical volumetric Bone mineral density, and compact cortex porosity were measured. A linear mixed-effects model was used to determine significant differences in the rate of change in the RA and control groups and in RA patient subgroups. Results Thirty-nine RA patients and 42 consecutive postmenopausal HC were followed for 63 months. RA and HC depicted a time-dependent increase of medullary CSA (+0.41 mm2/year, P  Conclusion Increase in medullary Metacarpal CSA and thinning of the cortical CSA are physiological and time dependent. RA status is associated with loss in cortical density. Even upon biological therapy, low glucocorticoid dose affects Metacarpal Bone shaft geometry and density over time.

  • reduced trabecular Bone mineral density and cortical thickness accompanied by increased outer Bone circumference in Metacarpal Bone of rheumatoid arthritis patients a cross sectional study
    Arthritis Research & Therapy, 2010
    Co-Authors: Daniel Aeberli, Prisca Eser, H Bonel, Jolanda Widmer, Gion Caliezi, Pierrealain Varisco, Burkhard Moller, Peter M Villiger
    Abstract:

    Introduction: The objective of this study was to assess three-dimensional Bone geometry and density at the epiphysis and shaft of the third meta-carpal Bone of rheumatoid arthritis (RA) patients in comparison to healthy controls with the novel method of peripheral quantitative computed tomography (pQCT). Methods: PQCT scans were performed in 50 female RA patients and 100 healthy female controls at the distal epiphyses and shafts of the third Metacarpal Bone, the radius and the tibia. Reproducibility was determined by coefficient of varia-tion. Bone densitometric and geometric parameters were compared between the two groups and correlated to disease characteristics. Results: Reproducibility of different pQCT parameters was between 0.7% and 2.5%. RA patients had 12% to 19% lower trabecular Bone mineral density (BMD) (P ≤ 0.001) at the distal epiphyses of radius, tibia and Metacarpal Bone. At the shafts of these Bones RA patients had 7% to 16% thinner cortices (P ≤ 0.03). Total cross-sectional area (CSA) at the Metacarpal Bone shaft of pa-tients was larger (between 5% and 7%, P < 0.02), and relative cortical area was reduced by 13%. Erosiveness by Ratingen score correlated negatively with tra-becular and total BMD at the epiphyses and shaft cortical thickness of all measured Bones (P < 0.04). Conclusions: Reduced trabecular BMD and thinner cortices at peripheral Bones, and a greater Bone shaft diameter at the Metacarpal Bone suggest RA spe-cific Bone alterations. The proposed pQCT protocol is reliable and allows measuring juxta-articular trabecular BMD and shaft geometry at the Metacarpal Bone.

Selcuk Akin - One of the best experts on this subject based on the ideXlab platform.

  • osteocutaneous posterior interosseous flap for reconstruction of the Metacarpal Bone and soft tissue defects in the hand
    Plastic and Reconstructive Surgery, 2002
    Co-Authors: Selcuk Akin, Yesim Ozgenel, Mesut Ozcan
    Abstract:

    A vascularized Bone segment of the ulna together with a posterior interosseous fasciocutaneous flap is harvested, including a cuff of the extensor pollicis longus muscle. The authors treated five male patients with Metacarpal Bone and soft-tissue defects of the hand using a distally based island osteocutaneous posterior interosseous flap. Their ages at the time of surgery ranged from 15 to 37 years (mean, 24 years). The Bone defects were in the first Metacarpal in three cases, the fourth Metacarpal in one, and the fifth Metacarpal in one. The length of the donated ulna ranged from 3 to 7 cm (mean, 5 cm). The follow-up period ranged from 5 to 92 months (mean, 39 months). All flaps survived completely. The posterior interosseous flap provides thin skin of good texture, together with vascularized Bone, for a one-stage reconstruction of the Metacarpal Bone and soft-tissue defects in the hand.

Burkhard Moller - One of the best experts on this subject based on the ideXlab platform.

  • effect of rheumatoid arthritis and age on Metacarpal Bone shaft geometry and density a longitudinal pqct study in postmenopausal women
    Seminars in Arthritis and Rheumatism, 2020
    Co-Authors: Daniel Aeberli, H Bonel, Burkhard Moller, Niklaus Fankhauser, Roger Zebaze, Peter M Villiger
    Abstract:

    Abstract Objective This study aimed to elucidate the effects of changes in the geometry and density of the Metacarpal Bone of patients with rheumatoid arthritis (RA). Methods This prospective study included consecutive postmenopausal RA patients who met the American College of Rheumatology Criteria and healthy controls (HC). Peripheral quantitative computed tomography scans at 50% of the total Metacarpal shaft (third Metacarpal Bone) were obtained at baseline and follow-ups. Use of bisphosphonates (BP), glucocorticoids (GC), biologics, and disease-modifying anti-rheumatic drugs (DMARD) was monitored (baseline to follow-up). Total cross-sectional area (CSA), cortical-transitional zone and compact zone CSA, cortical volumetric Bone mineral density, and compact cortex porosity were measured. A linear mixed-effects model was used to determine significant differences in the rate of change in the RA and control groups and in RA patient subgroups. Results Thirty-nine RA patients and 42 consecutive postmenopausal HC were followed for 63 months. RA and HC depicted a time-dependent increase of medullary CSA (+0.41 mm2/year, P  Conclusion Increase in medullary Metacarpal CSA and thinning of the cortical CSA are physiological and time dependent. RA status is associated with loss in cortical density. Even upon biological therapy, low glucocorticoid dose affects Metacarpal Bone shaft geometry and density over time.

  • reduced trabecular Bone mineral density and cortical thickness accompanied by increased outer Bone circumference in Metacarpal Bone of rheumatoid arthritis patients a cross sectional study
    Arthritis Research & Therapy, 2010
    Co-Authors: Daniel Aeberli, Prisca Eser, H Bonel, Jolanda Widmer, Gion Caliezi, Pierrealain Varisco, Burkhard Moller, Peter M Villiger
    Abstract:

    Introduction: The objective of this study was to assess three-dimensional Bone geometry and density at the epiphysis and shaft of the third meta-carpal Bone of rheumatoid arthritis (RA) patients in comparison to healthy controls with the novel method of peripheral quantitative computed tomography (pQCT). Methods: PQCT scans were performed in 50 female RA patients and 100 healthy female controls at the distal epiphyses and shafts of the third Metacarpal Bone, the radius and the tibia. Reproducibility was determined by coefficient of varia-tion. Bone densitometric and geometric parameters were compared between the two groups and correlated to disease characteristics. Results: Reproducibility of different pQCT parameters was between 0.7% and 2.5%. RA patients had 12% to 19% lower trabecular Bone mineral density (BMD) (P ≤ 0.001) at the distal epiphyses of radius, tibia and Metacarpal Bone. At the shafts of these Bones RA patients had 7% to 16% thinner cortices (P ≤ 0.03). Total cross-sectional area (CSA) at the Metacarpal Bone shaft of pa-tients was larger (between 5% and 7%, P < 0.02), and relative cortical area was reduced by 13%. Erosiveness by Ratingen score correlated negatively with tra-becular and total BMD at the epiphyses and shaft cortical thickness of all measured Bones (P < 0.04). Conclusions: Reduced trabecular BMD and thinner cortices at peripheral Bones, and a greater Bone shaft diameter at the Metacarpal Bone suggest RA spe-cific Bone alterations. The proposed pQCT protocol is reliable and allows measuring juxta-articular trabecular BMD and shaft geometry at the Metacarpal Bone.