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Denyse Gautrin - One of the best experts on this subject based on the ideXlab platform.

  • Is Metal Fume Fever a determinant of welding related respiratory symptoms and/or increased bronchial responsiveness? A longitudinal study.
    Occupational and Environmental Medicine, 2005
    Co-Authors: Claire Infante-rivard, Jean-luc Malo, Denyse Gautrin
    Abstract:

    Background: The current prospective study investigated the hypothesis of Metal Fume Fever (MFF) being a predictor for the development of respiratory symptoms and functional abnormalities. Methods: The study consisted of a pre-exposure and two follow up assessments of 286 welding apprentices during an average period of 15 months. A respiratory and a systemic symptom questionnaire, skin prick tests to common allergens and Metal salts, spirometry, and methacholine challenge tests were administered. Results: Developing at least one positive skin prick test to a Metallic salt solution was found in 11.8% of apprentices. Possible MFF (at least one of Fever, feelings of flu, general malaise, chills, dry cough, Metallic taste, or shortness of breath) was reported by 39.2% of apprentices. The presence of at least one welding related respiratory symptom (cough, wheezing, or chest tightness) suggestive of welding related asthma was reported by 13.8%. MFF was significantly associated with these respiratory symptoms (OR = 4.92, 95% CI 2.10 to 11.52), after adjusting for age, atopy, smoking, physician diagnosed asthma, and symptoms of non-welding related asthma. Apprentices with possible MFF, and no welding related respiratory symptoms suggestive of welding related asthma at the first follow up, had an increased risk of developing the latter symptoms by the second follow up visit (OR = 7.4, 95% CI 1.97 to 27.45) compared with those not having MFF. MFF was not significantly associated with an increase in bronchial responsiveness. Conclusion: MFF could be a predictor for the development of respiratory symptoms but not for functional abnormalities in welders.

  • is Metal Fume Fever a determinant of welding related respiratory symptoms and or increased bronchial responsiveness a longitudinal study
    Occupational and Environmental Medicine, 2005
    Co-Authors: Mariam Elzein, Jean-luc Malo, Claire Infanterivard, Denyse Gautrin
    Abstract:

    Background: The current prospective study investigated the hypothesis of Metal Fume Fever (MFF) being a predictor for the development of respiratory symptoms and functional abnormalities. Methods: The study consisted of a pre-exposure and two follow up assessments of 286 welding apprentices during an average period of 15 months. A respiratory and a systemic symptom questionnaire, skin prick tests to common allergens and Metal salts, spirometry, and methacholine challenge tests were administered. Results: Developing at least one positive skin prick test to a Metallic salt solution was found in 11.8% of apprentices. Possible MFF (at least one of Fever, feelings of flu, general malaise, chills, dry cough, Metallic taste, or shortness of breath) was reported by 39.2% of apprentices. The presence of at least one welding related respiratory symptom (cough, wheezing, or chest tightness) suggestive of welding related asthma was reported by 13.8%. MFF was significantly associated with these respiratory symptoms (OR = 4.92, 95% CI 2.10 to 11.52), after adjusting for age, atopy, smoking, physician diagnosed asthma, and symptoms of non-welding related asthma. Apprentices with possible MFF, and no welding related respiratory symptoms suggestive of welding related asthma at the first follow up, had an increased risk of developing the latter symptoms by the second follow up visit (OR = 7.4, 95% CI 1.97 to 27.45) compared with those not having MFF. MFF was not significantly associated with an increase in bronchial responsiveness. Conclusion: MFF could be a predictor for the development of respiratory symptoms but not for functional abnormalities in welders.

  • Prevalence and association of welding related systemic and respiratory symptoms in welders
    Occupational and Environmental Medicine, 2003
    Co-Authors: Jean-luc Malo, Claire Infante-rivard, Denyse Gautrin
    Abstract:

    Background: The prevalence of welding related respiratory symptoms coexisting with welding related systemic symptoms in welders is unknown. Aims: To determine in a sample of welders the prevalence of coexisting welding related systemic symptoms indicative of Metal Fume Fever (MFF) and welding related respiratory symptoms suggestive of occupational asthma (OA), and the strength and significance of any association between these two groups of symptoms. Methods: A respiratory symptoms questionnaire, a systemic symptoms questionnaire, and a questionnaire on occupational history were administered by telephone to 351 of a sample of 441 welders (79.6%) from two cities in Quebec, Canada. Results: The co-occurrence of possible MFF (defined as having at least two symptoms of Fever, feelings of flu, general malaise, chills, dry cough, Metallic taste, and shortness of breath, occurring at the beginning of the working week, 3–10 hours after exposure to welding Fumes) together with welding related respiratory symptoms suggestive of OA (defined as having at least two welding related symptoms of cough, wheezing, and chest tightness) was 5.8%. These two groups of symptoms were significantly associated (χ2 = 18.9, p < 0.001). Conclusion: There is a strong association between welding related MFF and welding related respiratory symptoms suggestive of OA. As such, MFF could be viewed as a pre-marker of welding related OA, a hypothesis that requires further investigation.

Jean-luc Malo - One of the best experts on this subject based on the ideXlab platform.

  • Is Metal Fume Fever a determinant of welding related respiratory symptoms and/or increased bronchial responsiveness? A longitudinal study.
    Occupational and Environmental Medicine, 2005
    Co-Authors: Claire Infante-rivard, Jean-luc Malo, Denyse Gautrin
    Abstract:

    Background: The current prospective study investigated the hypothesis of Metal Fume Fever (MFF) being a predictor for the development of respiratory symptoms and functional abnormalities. Methods: The study consisted of a pre-exposure and two follow up assessments of 286 welding apprentices during an average period of 15 months. A respiratory and a systemic symptom questionnaire, skin prick tests to common allergens and Metal salts, spirometry, and methacholine challenge tests were administered. Results: Developing at least one positive skin prick test to a Metallic salt solution was found in 11.8% of apprentices. Possible MFF (at least one of Fever, feelings of flu, general malaise, chills, dry cough, Metallic taste, or shortness of breath) was reported by 39.2% of apprentices. The presence of at least one welding related respiratory symptom (cough, wheezing, or chest tightness) suggestive of welding related asthma was reported by 13.8%. MFF was significantly associated with these respiratory symptoms (OR = 4.92, 95% CI 2.10 to 11.52), after adjusting for age, atopy, smoking, physician diagnosed asthma, and symptoms of non-welding related asthma. Apprentices with possible MFF, and no welding related respiratory symptoms suggestive of welding related asthma at the first follow up, had an increased risk of developing the latter symptoms by the second follow up visit (OR = 7.4, 95% CI 1.97 to 27.45) compared with those not having MFF. MFF was not significantly associated with an increase in bronchial responsiveness. Conclusion: MFF could be a predictor for the development of respiratory symptoms but not for functional abnormalities in welders.

  • is Metal Fume Fever a determinant of welding related respiratory symptoms and or increased bronchial responsiveness a longitudinal study
    Occupational and Environmental Medicine, 2005
    Co-Authors: Mariam Elzein, Jean-luc Malo, Claire Infanterivard, Denyse Gautrin
    Abstract:

    Background: The current prospective study investigated the hypothesis of Metal Fume Fever (MFF) being a predictor for the development of respiratory symptoms and functional abnormalities. Methods: The study consisted of a pre-exposure and two follow up assessments of 286 welding apprentices during an average period of 15 months. A respiratory and a systemic symptom questionnaire, skin prick tests to common allergens and Metal salts, spirometry, and methacholine challenge tests were administered. Results: Developing at least one positive skin prick test to a Metallic salt solution was found in 11.8% of apprentices. Possible MFF (at least one of Fever, feelings of flu, general malaise, chills, dry cough, Metallic taste, or shortness of breath) was reported by 39.2% of apprentices. The presence of at least one welding related respiratory symptom (cough, wheezing, or chest tightness) suggestive of welding related asthma was reported by 13.8%. MFF was significantly associated with these respiratory symptoms (OR = 4.92, 95% CI 2.10 to 11.52), after adjusting for age, atopy, smoking, physician diagnosed asthma, and symptoms of non-welding related asthma. Apprentices with possible MFF, and no welding related respiratory symptoms suggestive of welding related asthma at the first follow up, had an increased risk of developing the latter symptoms by the second follow up visit (OR = 7.4, 95% CI 1.97 to 27.45) compared with those not having MFF. MFF was not significantly associated with an increase in bronchial responsiveness. Conclusion: MFF could be a predictor for the development of respiratory symptoms but not for functional abnormalities in welders.

  • Prevalence and association of welding related systemic and respiratory symptoms in welders
    Occupational and Environmental Medicine, 2003
    Co-Authors: Jean-luc Malo, Claire Infante-rivard, Denyse Gautrin
    Abstract:

    Background: The prevalence of welding related respiratory symptoms coexisting with welding related systemic symptoms in welders is unknown. Aims: To determine in a sample of welders the prevalence of coexisting welding related systemic symptoms indicative of Metal Fume Fever (MFF) and welding related respiratory symptoms suggestive of occupational asthma (OA), and the strength and significance of any association between these two groups of symptoms. Methods: A respiratory symptoms questionnaire, a systemic symptoms questionnaire, and a questionnaire on occupational history were administered by telephone to 351 of a sample of 441 welders (79.6%) from two cities in Quebec, Canada. Results: The co-occurrence of possible MFF (defined as having at least two symptoms of Fever, feelings of flu, general malaise, chills, dry cough, Metallic taste, and shortness of breath, occurring at the beginning of the working week, 3–10 hours after exposure to welding Fumes) together with welding related respiratory symptoms suggestive of OA (defined as having at least two welding related symptoms of cough, wheezing, and chest tightness) was 5.8%. These two groups of symptoms were significantly associated (χ2 = 18.9, p < 0.001). Conclusion: There is a strong association between welding related MFF and welding related respiratory symptoms suggestive of OA. As such, MFF could be viewed as a pre-marker of welding related OA, a hypothesis that requires further investigation.

Claire Infante-rivard - One of the best experts on this subject based on the ideXlab platform.

  • Is Metal Fume Fever a determinant of welding related respiratory symptoms and/or increased bronchial responsiveness? A longitudinal study.
    Occupational and Environmental Medicine, 2005
    Co-Authors: Claire Infante-rivard, Jean-luc Malo, Denyse Gautrin
    Abstract:

    Background: The current prospective study investigated the hypothesis of Metal Fume Fever (MFF) being a predictor for the development of respiratory symptoms and functional abnormalities. Methods: The study consisted of a pre-exposure and two follow up assessments of 286 welding apprentices during an average period of 15 months. A respiratory and a systemic symptom questionnaire, skin prick tests to common allergens and Metal salts, spirometry, and methacholine challenge tests were administered. Results: Developing at least one positive skin prick test to a Metallic salt solution was found in 11.8% of apprentices. Possible MFF (at least one of Fever, feelings of flu, general malaise, chills, dry cough, Metallic taste, or shortness of breath) was reported by 39.2% of apprentices. The presence of at least one welding related respiratory symptom (cough, wheezing, or chest tightness) suggestive of welding related asthma was reported by 13.8%. MFF was significantly associated with these respiratory symptoms (OR = 4.92, 95% CI 2.10 to 11.52), after adjusting for age, atopy, smoking, physician diagnosed asthma, and symptoms of non-welding related asthma. Apprentices with possible MFF, and no welding related respiratory symptoms suggestive of welding related asthma at the first follow up, had an increased risk of developing the latter symptoms by the second follow up visit (OR = 7.4, 95% CI 1.97 to 27.45) compared with those not having MFF. MFF was not significantly associated with an increase in bronchial responsiveness. Conclusion: MFF could be a predictor for the development of respiratory symptoms but not for functional abnormalities in welders.

  • Prevalence and association of welding related systemic and respiratory symptoms in welders
    Occupational and Environmental Medicine, 2003
    Co-Authors: Jean-luc Malo, Claire Infante-rivard, Denyse Gautrin
    Abstract:

    Background: The prevalence of welding related respiratory symptoms coexisting with welding related systemic symptoms in welders is unknown. Aims: To determine in a sample of welders the prevalence of coexisting welding related systemic symptoms indicative of Metal Fume Fever (MFF) and welding related respiratory symptoms suggestive of occupational asthma (OA), and the strength and significance of any association between these two groups of symptoms. Methods: A respiratory symptoms questionnaire, a systemic symptoms questionnaire, and a questionnaire on occupational history were administered by telephone to 351 of a sample of 441 welders (79.6%) from two cities in Quebec, Canada. Results: The co-occurrence of possible MFF (defined as having at least two symptoms of Fever, feelings of flu, general malaise, chills, dry cough, Metallic taste, and shortness of breath, occurring at the beginning of the working week, 3–10 hours after exposure to welding Fumes) together with welding related respiratory symptoms suggestive of OA (defined as having at least two welding related symptoms of cough, wheezing, and chest tightness) was 5.8%. These two groups of symptoms were significantly associated (χ2 = 18.9, p < 0.001). Conclusion: There is a strong association between welding related MFF and welding related respiratory symptoms suggestive of OA. As such, MFF could be viewed as a pre-marker of welding related OA, a hypothesis that requires further investigation.

Christian Monsé - One of the best experts on this subject based on the ideXlab platform.

  • Health effects after inhalation of micro- and nano-sized zinc oxide particles in human volunteers
    Archives of Toxicology, 2020
    Co-Authors: Christian Monsé, Benjamin Kendzia, Birger Jettkant, Monika Raulf, Vera Van Kampen, Leonie Schürmeyer, Christoph Edzard Seifert, Eike-maximilian Marek, Götz Westphal, Nina Rosenkranz
    Abstract:

    Inhalation of ZnO particles can cause inflammation of the airways and Metal Fume Fever. It is unclear if different sizes of the particles alter these effects. However, various studies report higher biological activity of other nano-sized particles compared to microparticles. No effects at all were observed after inhalation of micro- and nano-sized zinc oxide (ZnO) particle concentrations of 0.5 mg/m^3. Studies with different particle sizes of ZnO at higher exposures are not available. Accordingly, we hypothesized that inhalation of nano-sized ZnO particles induces stronger health effects than the inhalation of the same airborne mass concentration of micro-sized ZnO particles. 16 healthy volunteers (eight men, eight women) were exposed to filtered air and ZnO particles (2.0 mg/m^3) for 2 h (one session with nano- and one with micro-sized ZnO) including 1 h of cycling at moderate workload. Effect parameters were symptoms, body temperature, inflammatory markers in blood and in induced sputum. Induced sputum was obtained at baseline examination, 22 h after exposure and at the end of the final test. The effects were assessed before, immediately after, about 22 h after, as well as two and three days after each exposure. Neutrophils, monocytes and acute-phase proteins in blood increased 22 h after micro- and nano-sized ZnO exposure. Effects were generally stronger with micro-sized ZnO particles. Parameters in induced sputum showed partial increases on the next day, but the effect strengths were not clearly attributable to particle sizes. The hypothesis that nano-sized ZnO particles induce stronger health effects than micro-sized ZnO particles was not supported by our data. The stronger systemic inflammatory responses after inhalation of micro-sized ZnO particles can be explained by the higher deposition efficiency of micro-sized ZnO particles in the respiratory tract and a substance-specific mode of action, most likely caused by the formation of zinc ions.

  • Concentration-dependent systemic response after inhalation of nano-sized zinc oxide particles in human volunteers
    Particle and Fibre Toxicology, 2018
    Co-Authors: Christian Monsé, Vitali Gering, Günther Kappert, Benjamin Kendzia, Birger Jettkant, Tobias Weiss, Olaf Hagemeyer, Vera Van Kampen, Monika Raulf, Nadin Ulrich
    Abstract:

    BackgroundInhalation of high concentrations of zinc oxide particles (ZnO) may cause Metal Fume Fever. In an earlier human inhalation study, no effects were observed after exposure to ZnO concentrations of 0.5 mg/m3. Further data from experimental studies with pure ZnO in the concentration range between 0.5 and 2.5 mg/m3 are not available. It was the aim of this experimental study to establish the concentration-response relationship of pure nano-sized ZnO particles.MethodsSixteen healthy subjects were exposed to filtered air and ZnO particles (0.5, 1.0 and 2.0 mg/m3) for 4 h on 4 different days, including 2 h of cycling with a low workload. The effects were assessed before, immediately after, and about 24 h after each exposure. Effect parameters were symptoms, body temperature, inflammatory markers and clotting factors in blood, and lung function.ResultsConcentration-dependent increases in symptoms, body temperature, acute phase proteins and neutrophils in blood were detected after ZnO inhalation. Significant effects were detected with ZnO concentrations of 1.0 mg/m3 or higher, with the most sensitive parameters being inflammatory markers in blood.ConclusionA concentration-response relationship with nano-sized ZnO particles in a low concentration range was demonstrated. Systemic inflammatory effects of inhaled nano-sized ZnO particles were observed at concentrations well below the occpational exposure limit for ZnO in many countries. It is recommended to reassess the exposure limit for ZnO at workplaces.

Paul D Blanc - One of the best experts on this subject based on the ideXlab platform.

  • tumor necrosis factor alpha and interleukin 8 release from u937 human mononuclear cells exposed to zinc oxide in vitro mechanistic implications for Metal Fume Fever
    Journal of Occupational and Environmental Medicine, 1998
    Co-Authors: Ware G Kuschner, Alessandra Dalessandro, Julie Hambleton, Paul D Blanc
    Abstract:

    Respiratory exposure to zinc oxide results in Metal Fume Fever, a flu-like illness characterized by dose-dependent increases in pulmonary tumor necrosis factor-alpha (TNF) and interleukin-8 (IL-8). To examine whether mononuclear cells are a source of these proinflammatory cytokines, we exposed U937 cells to zinc oxide in vitro. Cell culture supernatant TNF and IL-8 was measured after 3, 8, and 24 hours of exposure to zinc oxide in varying concentrations. Zinc oxide exposure in vitro led to TNF release in a dose-dependent manner at 3, 8, and 24 hours (analysis of variance [ANOVA] P = 0. 0001). IL-8 demonstrated a statistically significant zinc exposure response at 8 hours (ANOVA P = 0.005) and 24 hours (ANOVA P = 0.02). IL-8 at 8 hours correlated with 3-hour TNF levels (r = 0.52, P = 0.04). These data demonstrate that in vitro zinc oxide exposure stimulates U937 mononuclear cells to release TNF and IL-8 consistent with in vivo observations in Metal Fume Fever.

  • cytokines in Metal Fume Fever
    The American review of respiratory disease, 1993
    Co-Authors: Paul D Blanc, Hofer Wong, Homer A Boushey, Stephen F Wintermeyer, Michael S Bernstein
    Abstract:

    Metal Fume Fever is a flulike illness caused by zinc oxide inhalation and accompanied by an impressive pulmonary cellular response. We hypothesized that the syndrome is mediated by cytokines released in the lung after exposure to zinc oxide Fume. We carried out 26 experimental welding exposures in 23 volunteer subjects, performing postexposure bronchoalveolar lavage (BAL) 3 h (n = 6), 8 h (n = 11), or 22 h (n = 9) after exposure. We detected tumor necrosis factor (TNF), interleukin-6 (IL-6), and interleukin-8 (IL-8) varying in a time- and exposure-related manner. The concentration of TNF in the BAL fluid supernatant was significantly greater at 3 h than at 8 h or 22 h after exposure (p < 0.05), exhibiting a statistically significant exposure-response relationship to airborne zinc at each follow-up time period (p < 0.05). TNF concentrations were statistically correlated with those of IL-6 in BAL supernatant obtained at 22 h (r = 0.78, p = 0.01) and with concentrations of IL-8 in BAL 8 h after exposure (r =...

  • an experimental human model of Metal Fume Fever
    Annals of Internal Medicine, 1991
    Co-Authors: Paul D Blanc, Hofer Wong, Michael S Bernstein, Homer A Boushey
    Abstract:

    Objective: To examine the pathogenesis of Metal Fume Fever in humans by studying functional, cellular, and biochemical responses after exposure to zinc welding Fume. Design: Clinical experimental s...