The Experts below are selected from a list of 5310 Experts worldwide ranked by ideXlab platform
Catherine Nyssenbehets - One of the best experts on this subject based on the ideXlab platform.
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sclerostin antibody treatment decreases fracture rates in axial skeleton and improves the skeletal phenotype in growing oim oim mice
Calcified Tissue International, 2020Co-Authors: Mickael Cardinal, Alicia Dessain, Thomas Roels, Sebastien Lafont, Michael S Ominsky, Jeanpierre Devogelaer, Daniel Chappard, Guillaume Mabilleau, Patrick Ammann, Catherine NyssenbehetsAbstract:: In osteogenesis imperfecta (OI), vertebrae brittleness causes thorax deformations and leads to cardiopulmonary failure. As sclerostin-neutralizing antibodies increase bone mass and strength in animal models of osteoporosis, their administration in two murine models of severe OI enhanced the strength of vertebrae in growing female Crtap-/- mice but not in growing male Col1a1Jrt/+ mice. However, these two studies ignored the impact of antibodies on spine growth, fracture rates, and compressive mechanical properties. Here, we conducted a randomized controlled trial in oim/oim mice, an established model of human severe OI type III due to a mutation in Col1a2. Five-week-old female WT and oim/oim mice received either PBS or sclerostin antibody (Scl-Ab) for 9 weeks. Analyses included radiography, histomorphometry, pQCT, microcomputed tomography, and biomechanical testing. Though it did not modify vertebral axial growth, Scl-Ab treatment markedly reduced the fracture prevalence in the pelvis and caudal vertebrae, enhanced osteoblast activity (L4), increased cervico-sacral spine BMD, and improved the lumbosacral spine bone cross-sectional area. Scl-Ab did not impact vertebral height and body size but enhanced the cortical thickness and trabecular bone volume significantly in the two Scl-Ab groups. At lumbar vertebrae and tibial Metaphysis, the absolute increase in cortical and trabecular bone mass was higher in Scl-Ab WT than in Scl-Ab oim/oim. The effects on trabecular bone mass were mainly due to changes in trabecular number at vertebrae and in trabecular thickness at metaphyses. Additionally, Scl-Ab did not restore a standard trabecular network, but improved bone compressive ultimate load with more robust effects at vertebrae than at Metaphysis. Overall, Scl-Ab treatment may be beneficial for reducing vertebral fractures and spine deformities in patients with severe OI.
Tallal C Mamisch - One of the best experts on this subject based on the ideXlab platform.
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femoral morphology due to impingement influences the range of motion in slipped capital femoral epiphysis
Clinical Orthopaedics and Related Research, 2009Co-Authors: Tallal C Mamisch, Youngjo Kim, Jens A Richol, Michael Millis, Jens KordelleAbstract:Femoroacetabular impingement due to metaphyseal prominence is associated with the slippage in patients with slipped capital femoral epiphysis (SCFE), but it is unclear whether the changes in femoral Metaphysis morphology are associated with range of motion (ROM) changes or type of impingement. We asked whether the femoral head-neck junction morphology influences ROM analysis and type of impingement in addition to the slip angle and the acetabular version. We analyzed in 31 patients with SCFE the relationship between the proximal femoral morphology and limitation in ROM due to impingement based on simulated ROM of preoperative CT data. The ROM was analyzed in relation to degree of slippage, femoral Metaphysis morphology, acetabular version, and pathomechanical terms of “impaction” and “inclusion.” The ROM in the affected hips was comparable to that in the unaffected hips for mild slippage and decreased for slippage of more than 30°. The limitation correlated with changes in the metaphysic morphology and changed acetabular version. Decreased head-neck offset in hips with slip angles between 30° and 50° had restricted ROM to nearly the same degree as in severe SCFE. Therefore, in addition to the slip angle, the femoral Metaphysis morphology should be used as criteria for reconstructive surgery.
Mickael Cardinal - One of the best experts on this subject based on the ideXlab platform.
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sclerostin antibody treatment decreases fracture rates in axial skeleton and improves the skeletal phenotype in growing oim oim mice
Calcified Tissue International, 2020Co-Authors: Mickael Cardinal, Alicia Dessain, Thomas Roels, Sebastien Lafont, Michael S Ominsky, Jeanpierre Devogelaer, Daniel Chappard, Guillaume Mabilleau, Patrick Ammann, Catherine NyssenbehetsAbstract:: In osteogenesis imperfecta (OI), vertebrae brittleness causes thorax deformations and leads to cardiopulmonary failure. As sclerostin-neutralizing antibodies increase bone mass and strength in animal models of osteoporosis, their administration in two murine models of severe OI enhanced the strength of vertebrae in growing female Crtap-/- mice but not in growing male Col1a1Jrt/+ mice. However, these two studies ignored the impact of antibodies on spine growth, fracture rates, and compressive mechanical properties. Here, we conducted a randomized controlled trial in oim/oim mice, an established model of human severe OI type III due to a mutation in Col1a2. Five-week-old female WT and oim/oim mice received either PBS or sclerostin antibody (Scl-Ab) for 9 weeks. Analyses included radiography, histomorphometry, pQCT, microcomputed tomography, and biomechanical testing. Though it did not modify vertebral axial growth, Scl-Ab treatment markedly reduced the fracture prevalence in the pelvis and caudal vertebrae, enhanced osteoblast activity (L4), increased cervico-sacral spine BMD, and improved the lumbosacral spine bone cross-sectional area. Scl-Ab did not impact vertebral height and body size but enhanced the cortical thickness and trabecular bone volume significantly in the two Scl-Ab groups. At lumbar vertebrae and tibial Metaphysis, the absolute increase in cortical and trabecular bone mass was higher in Scl-Ab WT than in Scl-Ab oim/oim. The effects on trabecular bone mass were mainly due to changes in trabecular number at vertebrae and in trabecular thickness at metaphyses. Additionally, Scl-Ab did not restore a standard trabecular network, but improved bone compressive ultimate load with more robust effects at vertebrae than at Metaphysis. Overall, Scl-Ab treatment may be beneficial for reducing vertebral fractures and spine deformities in patients with severe OI.
Apichet Techataweewan - One of the best experts on this subject based on the ideXlab platform.
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determination of the role of the cancellous bone in generation of screw holding power at Metaphysis
Clinical Biomechanics, 1999Co-Authors: Thossart Harnroongroj, Apichet TechataweewanAbstract:Objective. To determine whether cancellous bone at Metaphysis plays a significant role in generation of holding power of the cancellous screw. Design. Maximal holding power of the cancellous screw at distal Metaphysis of the femur with and without cancellous bone inside was determined by applying a load to push out the screw. Background. Generation of screw holding power from the cancellous bone can arise by a mechanism of compression of cancellous bone between screw threads when a screw is inserted by non-tapping technique. Metaphysis has intermediate amount of cancellous and cortical bone when compared with diaphysis and intercondyle of a long bone. Methods. Eight pairs of fresh cadaveric femurs were used. One femur of a pair was removed of cancellous bone at the distal Metaphysis; cancellous bone of the other was preserved. A full thread cancellous screw was inserted into the distal femoral Metaphysis. An axial load was applied at the screw tip to push out the screw by using a universal testing machine. Result. Mean push-out force of the screw at distal femoral Metaphysis without cancellous bone inside was 1824.76 N and stiffness was 746.76 N/mm. Mean push-out force of the screw at distal femoral Metaphysis with preservation of cancellous bone was 2015.86 N and stiffiness was 853.09 N/mm. The statistical analysis of both groups showed no significant differences. Conclusions. This study confirmed that cancellous bone at Metaphysis plays no significant role in generation of holding power of the cancellous screw. Relevance Because metaphyseal cancellous bone plays no role in generation of screw holding power, only a well-inserted cancellous screw into bone cortices can achieve good screw holding power at Metaphysis of a long bone.
Jens Kordelle - One of the best experts on this subject based on the ideXlab platform.
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femoral morphology due to impingement influences the range of motion in slipped capital femoral epiphysis
Clinical Orthopaedics and Related Research, 2009Co-Authors: Tallal C Mamisch, Youngjo Kim, Jens A Richol, Michael Millis, Jens KordelleAbstract:Femoroacetabular impingement due to metaphyseal prominence is associated with the slippage in patients with slipped capital femoral epiphysis (SCFE), but it is unclear whether the changes in femoral Metaphysis morphology are associated with range of motion (ROM) changes or type of impingement. We asked whether the femoral head-neck junction morphology influences ROM analysis and type of impingement in addition to the slip angle and the acetabular version. We analyzed in 31 patients with SCFE the relationship between the proximal femoral morphology and limitation in ROM due to impingement based on simulated ROM of preoperative CT data. The ROM was analyzed in relation to degree of slippage, femoral Metaphysis morphology, acetabular version, and pathomechanical terms of “impaction” and “inclusion.” The ROM in the affected hips was comparable to that in the unaffected hips for mild slippage and decreased for slippage of more than 30°. The limitation correlated with changes in the metaphysic morphology and changed acetabular version. Decreased head-neck offset in hips with slip angles between 30° and 50° had restricted ROM to nearly the same degree as in severe SCFE. Therefore, in addition to the slip angle, the femoral Metaphysis morphology should be used as criteria for reconstructive surgery.