The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform
Marijn Schuurman - One of the best experts on this subject based on the ideXlab platform.
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Severe hemolysis and Methemoglobinemia following fava beans ingestion in glucose-6-phosphatase dehydrogenase deficiency—case report and literature review
European Journal of Pediatrics, 2009Co-Authors: Marijn Schuurman, Dick Waardenburg, Joost Da Costa, Hendrik Niemarkt, Piet LeroyAbstract:Introduction Reduced concentrations of glucose-6-phospate dehydrogenase (G6PD) render erythrocytes susceptible to hemolysis under conditions of oxidative stress. In favism, the ingestion of fava beans induces an oxidative stress to erythrocytes, leading to acute hemolysis. Discussion The simultaneous occurrence of Methemoglobinemia has been reported only scarcely, despite the fact that both phenomena are the consequence of a common pathophysiologic mechanism. The presence of Methemoglobinemia has important diagnostic and therapeutic consequences. We report a previously healthy boy who presented with combined severe hemolytic anemia and cyanosis due to Methemoglobinemia, following the ingestion of fava beans. His condition was complicated by the development of transient acute renal failure. A G6PD-deficiency was diagnosed. We review the literature on the combination of acute hemolysis and Methemoglobinemia in favism. Pathophysiologic, diagnostic, and therapeutic aspects of this disorder are discussed.
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severe hemolysis and Methemoglobinemia following fava beans ingestion in glucose 6 phosphatase dehydrogenase deficiency case report and literature review
European Journal of Pediatrics, 2009Co-Authors: Marijn Schuurman, Dick Waardenburg, Hendrik Niemarkt, Joost Da Costa, Piet L J M LeroyAbstract:INTRODUCTION: Reduced concentrations of glucose-6-phospate dehydrogenase (G6PD) render erythrocytes susceptible to hemolysis under conditions of oxidative stress. In favism, the ingestion of fava beans induces an oxidative stress to erythrocytes, leading to acute hemolysis. DISCUSSION: The simultaneous occurrence of Methemoglobinemia has been reported only scarcely, despite the fact that both phenomena are the consequence of a common pathophysiologic mechanism. The presence of Methemoglobinemia has important diagnostic and therapeutic consequences. We report a previously healthy boy who presented with combined severe hemolytic anemia and cyanosis due to Methemoglobinemia, following the ingestion of fava beans. His condition was complicated by the development of transient acute renal failure. A G6PD-deficiency was diagnosed. We review the literature on the combination of acute hemolysis and Methemoglobinemia in favism. Pathophysiologic, diagnostic, and therapeutic aspects of this disorder are discussed.
Piet Leroy - One of the best experts on this subject based on the ideXlab platform.
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Severe hemolysis and Methemoglobinemia following fava beans ingestion in glucose-6-phosphatase dehydrogenase deficiency—case report and literature review
European Journal of Pediatrics, 2009Co-Authors: Marijn Schuurman, Dick Waardenburg, Joost Da Costa, Hendrik Niemarkt, Piet LeroyAbstract:Introduction Reduced concentrations of glucose-6-phospate dehydrogenase (G6PD) render erythrocytes susceptible to hemolysis under conditions of oxidative stress. In favism, the ingestion of fava beans induces an oxidative stress to erythrocytes, leading to acute hemolysis. Discussion The simultaneous occurrence of Methemoglobinemia has been reported only scarcely, despite the fact that both phenomena are the consequence of a common pathophysiologic mechanism. The presence of Methemoglobinemia has important diagnostic and therapeutic consequences. We report a previously healthy boy who presented with combined severe hemolytic anemia and cyanosis due to Methemoglobinemia, following the ingestion of fava beans. His condition was complicated by the development of transient acute renal failure. A G6PD-deficiency was diagnosed. We review the literature on the combination of acute hemolysis and Methemoglobinemia in favism. Pathophysiologic, diagnostic, and therapeutic aspects of this disorder are discussed.
Piet L J M Leroy - One of the best experts on this subject based on the ideXlab platform.
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severe hemolysis and Methemoglobinemia following fava beans ingestion in glucose 6 phosphatase dehydrogenase deficiency case report and literature review
European Journal of Pediatrics, 2009Co-Authors: Marijn Schuurman, Dick Waardenburg, Hendrik Niemarkt, Joost Da Costa, Piet L J M LeroyAbstract:INTRODUCTION: Reduced concentrations of glucose-6-phospate dehydrogenase (G6PD) render erythrocytes susceptible to hemolysis under conditions of oxidative stress. In favism, the ingestion of fava beans induces an oxidative stress to erythrocytes, leading to acute hemolysis. DISCUSSION: The simultaneous occurrence of Methemoglobinemia has been reported only scarcely, despite the fact that both phenomena are the consequence of a common pathophysiologic mechanism. The presence of Methemoglobinemia has important diagnostic and therapeutic consequences. We report a previously healthy boy who presented with combined severe hemolytic anemia and cyanosis due to Methemoglobinemia, following the ingestion of fava beans. His condition was complicated by the development of transient acute renal failure. A G6PD-deficiency was diagnosed. We review the literature on the combination of acute hemolysis and Methemoglobinemia in favism. Pathophysiologic, diagnostic, and therapeutic aspects of this disorder are discussed.
Ellen Mayer Sabik - One of the best experts on this subject based on the ideXlab platform.
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benzocaine induced Methemoglobinemia experience from a high volume transesophageal echocardiography laboratory
Journal of The American Society of Echocardiography, 2003Co-Authors: Gian M Novaro, Herbert D Aronow, Michael Militello, Mario J Garcia, Ellen Mayer SabikAbstract:Benzocaine (ethyl aminobenzoate), a topical anesthetic widely used before transesophageal echocardiography, has been reported to cause acquired Methemoglobinemia. The incidence of benzocaineinduced Methemoglobinemia in clinical practice, however, has been difficult to estimate. After systematic review of our institutional experience for clinically recognized cases of benzocaine-induced Methemoglobinemia in patients undergoing transesophageal echocardiography, we report an estimated incidence of 0.115% (95% confidence interval 0.037-0.269). This report also provides the largest analysis of the incidence of Methemoglobinemia in readministration cases. Although controversy remains as to whether this is an idiosyncratic versus dose-related response, a description of purported patient risk factors is included. (J Am Soc Echocardiogr 2003;16:170-5.)
Dick Waardenburg - One of the best experts on this subject based on the ideXlab platform.
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Severe hemolysis and Methemoglobinemia following fava beans ingestion in glucose-6-phosphatase dehydrogenase deficiency—case report and literature review
European Journal of Pediatrics, 2009Co-Authors: Marijn Schuurman, Dick Waardenburg, Joost Da Costa, Hendrik Niemarkt, Piet LeroyAbstract:Introduction Reduced concentrations of glucose-6-phospate dehydrogenase (G6PD) render erythrocytes susceptible to hemolysis under conditions of oxidative stress. In favism, the ingestion of fava beans induces an oxidative stress to erythrocytes, leading to acute hemolysis. Discussion The simultaneous occurrence of Methemoglobinemia has been reported only scarcely, despite the fact that both phenomena are the consequence of a common pathophysiologic mechanism. The presence of Methemoglobinemia has important diagnostic and therapeutic consequences. We report a previously healthy boy who presented with combined severe hemolytic anemia and cyanosis due to Methemoglobinemia, following the ingestion of fava beans. His condition was complicated by the development of transient acute renal failure. A G6PD-deficiency was diagnosed. We review the literature on the combination of acute hemolysis and Methemoglobinemia in favism. Pathophysiologic, diagnostic, and therapeutic aspects of this disorder are discussed.
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severe hemolysis and Methemoglobinemia following fava beans ingestion in glucose 6 phosphatase dehydrogenase deficiency case report and literature review
European Journal of Pediatrics, 2009Co-Authors: Marijn Schuurman, Dick Waardenburg, Hendrik Niemarkt, Joost Da Costa, Piet L J M LeroyAbstract:INTRODUCTION: Reduced concentrations of glucose-6-phospate dehydrogenase (G6PD) render erythrocytes susceptible to hemolysis under conditions of oxidative stress. In favism, the ingestion of fava beans induces an oxidative stress to erythrocytes, leading to acute hemolysis. DISCUSSION: The simultaneous occurrence of Methemoglobinemia has been reported only scarcely, despite the fact that both phenomena are the consequence of a common pathophysiologic mechanism. The presence of Methemoglobinemia has important diagnostic and therapeutic consequences. We report a previously healthy boy who presented with combined severe hemolytic anemia and cyanosis due to Methemoglobinemia, following the ingestion of fava beans. His condition was complicated by the development of transient acute renal failure. A G6PD-deficiency was diagnosed. We review the literature on the combination of acute hemolysis and Methemoglobinemia in favism. Pathophysiologic, diagnostic, and therapeutic aspects of this disorder are discussed.