The Experts below are selected from a list of 282 Experts worldwide ranked by ideXlab platform
Toshio Fuchigami - One of the best experts on this subject based on the ideXlab platform.
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self supported Methoxylation and acetoxylation electrosynthesis using a simple thin layer flow cell
Journal of The Electrochemical Society, 2006Co-Authors: Daisuke Horii, Toshio Fuchigami, Mahito Atobe, Frank MarkenAbstract:Self-supported electrochemical Methoxylation and acetoxylation of various organic molecules were carried out using a thin-layer flow cell without intentionally added supporting electrolyte. The thin-layer flow cell employed in this work had a simple geometry with working and auxiliary electrodes directly facing each other with 80 mu m distance. Controlling factors for these kinds of self-supported electrochemical Methoxylation and acetoxylation, such as the electrode material, the current density, and the flow rate were optimized to allow moderate to high yields of the corresponding methoxylated and acetoxylated products to be achieved in single flow-through operations. (c) 2006 The Electrochemical Society.
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Anodic Methoxylation and acetoxylation of imines and imidates
Tetrahedron Letters, 2003Co-Authors: Daisuke Baba, Toshio FuchigamiAbstract:Abstract Anodic oxidation of cyclic imidates, 2-aryl-2-oxazolines, in methanol provided the corresponding 4-methoxylated products. Anodic α-Methoxylation and α-acetoxylation of open-chain imines derived from glycine esters and benzophenone were also achieved using a bromide ion mediator. On the other hand, anodic α-acetoxylation of CF3-containing imine and imidate was successful without use of the bromine mediator. This is the first example of successful anodic α-substitution of imines and imidates.
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Electrosynthesis using a fluoride ion mediator. Part V: Fluoride ion mediated anodic Methoxylation and acetoxylation of thiazolidines, 1,3-oxathiolanes, and 1,3-dithiolanes
Electrochimica Acta, 2003Co-Authors: Daisuke Baba, Toshio FuchigamiAbstract:Anodic Methoxylation and acetoxylation reactions of five membered cyclic sulfides such as thiazolidines, 1,3-oxathiolanes and 1,3-dithiolanes, which have been reported to not always undergo the Pummerer reaction, were successfully carried out by using a fluoride ion mediator.
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Electrolytic reactions of fluoroorganic compounds. 16. Regioselective anodic Methoxylation of 2-methoxy-2,3,3,3-tetrafluoropropylamines
Electrochimica Acta, 1998Co-Authors: Shoji Furuta, Toshio FuchigamiAbstract:Abstract Anodic oxidation of various types of 2-methoxy-2,3,3,3-tetrafluoropropylamines, ArRNCH2Y [Y=CF(OMe)CF3] was carried out in KOH/MeOH. Methoxylation α to the Y group and/or cleavage of a carbon–nitrogen bond took place depending on the kind of R groups. The regioselectivity of such Methoxylation and C–N cleavage can be explained mainly in terms of the α-CH kinetic acidities of the cation radicals formed by one-electron oxidation of the amines. Furthermore, reasonable diastereoselectivity was obtained in the anodic Methoxylation when the R group is alkyl. On the other hand, when the R group is aryl, the diastereoselectivity was extremely low.
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Electrolytic Reactions of Fluoroorganic Compounds. 14. Regioselective Anodic Methoxylation of N-(Fluoroethyl)amines. Preparation of Highly Useful Fluoroalkylated Building Blocks
The Journal of Organic Chemistry, 1994Co-Authors: Toshio Fuchigami, Shinji IchikawaAbstract:Anodic Methoxylation of various types of N-(fluoroethyl)amines, ArRNCH 2 R f (R f =CF 3 , CHF 2 , CH 2 F, etc.) has been systematically studied and it was found that a methoxy group was exclusively or preferentially introduced into the position a to the fluoromethyl (Rf) group, depending on the Rf and R groups. The effect of the R f group on the promotion of the anodic α-Methoxylation decreased in the order CF 3 , CHF 2 , and CH 2 F. This remarkable promotion effect and unique regioselectivity can be explained mainly in terms of the α-CH kinetic acidities of the cation radicals formed by one-electron oxidation of the amines. The α-methoxylated products are highly useful precursors for the construction of carbon-carbon bonds α to the trifluoromethyl and difluoromethyl groups, which is difficult by other methods
J. S. Yadav - One of the best experts on this subject based on the ideXlab platform.
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regioselective ortho acetoxylation Methoxylation of n 2 benzoylphenyl benzamides via substrate directed c h activation
Tetrahedron Letters, 2011Co-Authors: B Subba V Reddy, G. Revathi, Srinivas A Reddy, J. S. YadavAbstract:Abstract A highly regioselective ortho-acetoxylation of N-(2-benzoylphenyl)benzamides has been achieved using a catalytic amount of Pd(OAc)2 (10 mol %) and a stoichiometric amount of PhI(OAc)2 in a mixture of acetic anhydride and acetic acid via C–H activation to produce the corresponding 2-acetoxybenzamides in good yields. ortho-Methoxylation has been accomplished using methanol under similar conditions.
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Regioselective ortho-acetoxylation/Methoxylation of N-(2-benzoylphenyl)benzamides via substrate directed C–H activation
Tetrahedron Letters, 2011Co-Authors: B. V. Subba Reddy, G. Revathi, A. Srinivas Reddy, J. S. YadavAbstract:Abstract A highly regioselective ortho-acetoxylation of N-(2-benzoylphenyl)benzamides has been achieved using a catalytic amount of Pd(OAc)2 (10 mol %) and a stoichiometric amount of PhI(OAc)2 in a mixture of acetic anhydride and acetic acid via C–H activation to produce the corresponding 2-acetoxybenzamides in good yields. ortho-Methoxylation has been accomplished using methanol under similar conditions.
Bing-feng Shi - One of the best experts on this subject based on the ideXlab platform.
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copper ii catalyzed Methoxylation of unactivated hetero aryl c h bonds using a removable bidentate auxiliary
Organic chemistry frontiers, 2015Co-Authors: Xue-song Yin, Jun Yuan, Bing-feng ShiAbstract:A copper(II)-catalyzed Methoxylation of unactivated (hetero)aryl C–H bonds directed by our newly developed PIP directing group with methanol has been achieved. This protocol occurs efficiently with a catalytic amount of copper (5 mol%), is a simple and environmentally benign reaction system, has a broad substrate scope and high functional group tolerance.
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Copper(II)-catalyzed Methoxylation of unactivated (hetero)aryl C–H bonds using a removable bidentate auxiliary
Organic Chemistry Frontiers, 2015Co-Authors: Xue-song Yin, Jun Yuan, Bing-feng ShiAbstract:A copper(II)-catalyzed Methoxylation of unactivated (hetero)aryl C–H bonds directed by our newly developed PIP directing group with methanol has been achieved. This protocol occurs efficiently with a catalytic amount of copper (5 mol%), is a simple and environmentally benign reaction system, has a broad substrate scope and high functional group tolerance.
G. Revathi - One of the best experts on this subject based on the ideXlab platform.
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regioselective ortho acetoxylation Methoxylation of n 2 benzoylphenyl benzamides via substrate directed c h activation
Tetrahedron Letters, 2011Co-Authors: B Subba V Reddy, G. Revathi, Srinivas A Reddy, J. S. YadavAbstract:Abstract A highly regioselective ortho-acetoxylation of N-(2-benzoylphenyl)benzamides has been achieved using a catalytic amount of Pd(OAc)2 (10 mol %) and a stoichiometric amount of PhI(OAc)2 in a mixture of acetic anhydride and acetic acid via C–H activation to produce the corresponding 2-acetoxybenzamides in good yields. ortho-Methoxylation has been accomplished using methanol under similar conditions.
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Regioselective ortho-acetoxylation/Methoxylation of N-(2-benzoylphenyl)benzamides via substrate directed C–H activation
Tetrahedron Letters, 2011Co-Authors: B. V. Subba Reddy, G. Revathi, A. Srinivas Reddy, J. S. YadavAbstract:Abstract A highly regioselective ortho-acetoxylation of N-(2-benzoylphenyl)benzamides has been achieved using a catalytic amount of Pd(OAc)2 (10 mol %) and a stoichiometric amount of PhI(OAc)2 in a mixture of acetic anhydride and acetic acid via C–H activation to produce the corresponding 2-acetoxybenzamides in good yields. ortho-Methoxylation has been accomplished using methanol under similar conditions.
Chengrong Ding - One of the best experts on this subject based on the ideXlab platform.
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Silver-Mediated Methoxylation of Aryl C(sp2)–H Bonds Directing by DMEDA
Catalysts, 2019Co-Authors: Guofu Zhang, Jianfei Zhu, Lidi Xuan, Chengrong DingAbstract:The first example of silver-mediated phosphine-promoted Methoxylation of aryl C(sp2)–H bonds with the commercially available reagent for the preparation of alkyl aryl ethers has been developed. This protocol is characterized by mild reaction conditions, broad substrate scope, and high regioselectivity.
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Pharmaceutical-Oriented Methoxylation of Aryl C(sp2)–H Bonds using Copper Catalysts
Synlett, 2018Co-Authors: Guofu Zhang, Jianfei Zhu, Chaolai Tong, Chengrong DingAbstract:A pharmaceutical-oriented, copper(II)-catalyzed Methoxylation of aryl C(sp2)–H bonds has been developed. This simple and environmentally benign reaction system occurs efficiently using oxygen as oxidant with broad substrate scope and high functional group tolerance.