The Experts below are selected from a list of 18 Experts worldwide ranked by ideXlab platform
Frank Musshoff - One of the best experts on this subject based on the ideXlab platform.
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unintentional lethal overdose with Metildigoxin in a 36 week old infant post mortem tissue distribution of Metildigoxin and its metabolites by liquid chromatography tandem mass spectrometry
Forensic Science International, 2014Co-Authors: Cornelius Hess, Christopher Brockmann, Elke Doberentz, Burkhard Madea, Frank MusshoffAbstract:A massive lethal overdose with beta-Metildigoxin in a 36-week-old infant is presented. Determination of beta-Metildigoxin and its metabolites digoxin, digoxigenin and digoxigenin-monodigitoxosid is achieved by a liquid chromatographic mass spectrometric (LC-MS/MS) method. Measured concentrations for beta-Metildigoxin and digoxin in peripheral blood were 40.2 ng/ml and 25.6 ng/ml, respectively. Tissue distribution showed highest concentrations in kidney tissue and gastric content. The metabolite digoxigenin-monodigitoxosid could be detected in heart blood, duodenal content, gastric content and fat tissue while the metabolite digoxigenin could only be detected in gastric content since the drug was given by a stomach tube.
Cornelius Hess - One of the best experts on this subject based on the ideXlab platform.
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unintentional lethal overdose with Metildigoxin in a 36 week old infant post mortem tissue distribution of Metildigoxin and its metabolites by liquid chromatography tandem mass spectrometry
Forensic Science International, 2014Co-Authors: Cornelius Hess, Christopher Brockmann, Elke Doberentz, Burkhard Madea, Frank MusshoffAbstract:A massive lethal overdose with beta-Metildigoxin in a 36-week-old infant is presented. Determination of beta-Metildigoxin and its metabolites digoxin, digoxigenin and digoxigenin-monodigitoxosid is achieved by a liquid chromatographic mass spectrometric (LC-MS/MS) method. Measured concentrations for beta-Metildigoxin and digoxin in peripheral blood were 40.2 ng/ml and 25.6 ng/ml, respectively. Tissue distribution showed highest concentrations in kidney tissue and gastric content. The metabolite digoxigenin-monodigitoxosid could be detected in heart blood, duodenal content, gastric content and fat tissue while the metabolite digoxigenin could only be detected in gastric content since the drug was given by a stomach tube.
Christopher Brockmann - One of the best experts on this subject based on the ideXlab platform.
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unintentional lethal overdose with Metildigoxin in a 36 week old infant post mortem tissue distribution of Metildigoxin and its metabolites by liquid chromatography tandem mass spectrometry
Forensic Science International, 2014Co-Authors: Cornelius Hess, Christopher Brockmann, Elke Doberentz, Burkhard Madea, Frank MusshoffAbstract:A massive lethal overdose with beta-Metildigoxin in a 36-week-old infant is presented. Determination of beta-Metildigoxin and its metabolites digoxin, digoxigenin and digoxigenin-monodigitoxosid is achieved by a liquid chromatographic mass spectrometric (LC-MS/MS) method. Measured concentrations for beta-Metildigoxin and digoxin in peripheral blood were 40.2 ng/ml and 25.6 ng/ml, respectively. Tissue distribution showed highest concentrations in kidney tissue and gastric content. The metabolite digoxigenin-monodigitoxosid could be detected in heart blood, duodenal content, gastric content and fat tissue while the metabolite digoxigenin could only be detected in gastric content since the drug was given by a stomach tube.
Elke Doberentz - One of the best experts on this subject based on the ideXlab platform.
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unintentional lethal overdose with Metildigoxin in a 36 week old infant post mortem tissue distribution of Metildigoxin and its metabolites by liquid chromatography tandem mass spectrometry
Forensic Science International, 2014Co-Authors: Cornelius Hess, Christopher Brockmann, Elke Doberentz, Burkhard Madea, Frank MusshoffAbstract:A massive lethal overdose with beta-Metildigoxin in a 36-week-old infant is presented. Determination of beta-Metildigoxin and its metabolites digoxin, digoxigenin and digoxigenin-monodigitoxosid is achieved by a liquid chromatographic mass spectrometric (LC-MS/MS) method. Measured concentrations for beta-Metildigoxin and digoxin in peripheral blood were 40.2 ng/ml and 25.6 ng/ml, respectively. Tissue distribution showed highest concentrations in kidney tissue and gastric content. The metabolite digoxigenin-monodigitoxosid could be detected in heart blood, duodenal content, gastric content and fat tissue while the metabolite digoxigenin could only be detected in gastric content since the drug was given by a stomach tube.
Burkhard Madea - One of the best experts on this subject based on the ideXlab platform.
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unintentional lethal overdose with Metildigoxin in a 36 week old infant post mortem tissue distribution of Metildigoxin and its metabolites by liquid chromatography tandem mass spectrometry
Forensic Science International, 2014Co-Authors: Cornelius Hess, Christopher Brockmann, Elke Doberentz, Burkhard Madea, Frank MusshoffAbstract:A massive lethal overdose with beta-Metildigoxin in a 36-week-old infant is presented. Determination of beta-Metildigoxin and its metabolites digoxin, digoxigenin and digoxigenin-monodigitoxosid is achieved by a liquid chromatographic mass spectrometric (LC-MS/MS) method. Measured concentrations for beta-Metildigoxin and digoxin in peripheral blood were 40.2 ng/ml and 25.6 ng/ml, respectively. Tissue distribution showed highest concentrations in kidney tissue and gastric content. The metabolite digoxigenin-monodigitoxosid could be detected in heart blood, duodenal content, gastric content and fat tissue while the metabolite digoxigenin could only be detected in gastric content since the drug was given by a stomach tube.