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Robert E Guldberg - One of the best experts on this subject based on the ideXlab platform.

  • microarchitectural and mechanical characterization of oriented porous polymer scaffolds
    Biomaterials, 2003
    Co-Authors: Angela S P Lin, Thomas Harry Barrows, S H Cartmell, Robert E Guldberg
    Abstract:

    Biodegradable porous polymer scaffolds are widely used in tissue engineering to provide a structural template for cell seeding and extracellular matrix formation. Scaffolds must often possess sufficient structural integrity to temporarily withstand functional loadingin vivo or cell traction forces in vitro. Both the mechanical and biolog ical properties of porous scaffolds are determined in part by the local microarchitecture. Quantification of scaffold structure-function relationships is therefore critical for optimizing mechanical and biological performance. In this study, porous poly(l-lactide-co-dl-lactide) scaffolds with axially oriented macroporosity and random Microporosity were produced usinga solution coatingand porog en decomposition method. Microarchitectural parameters were quantified as a function of porogen concentration using microcomputed tomography (microCT) analysis and related to compressive mechanical properties. With increasingporog en concentration, volume fraction decreased consistently due to microarchitectural changes in average strut thickness, spacing, and density. The three-dimensional interconnectivity of the scaffold porosity was greater than 99% for all porogen concentration levels tested. Over a porosity range of 58–80%, the average compressive modulus and ultimate strength of the scaffolds ranged from 43.5–168.3 MPa and 2.7–11.0 MPa, respectively. Thus, biodegradable porous polymer scaffolds have been produced with oriented microarchitectural features designed to facilitate vascular invasion and cellular attachment and with initial mechanical properties comparable to those of trabecular bone. r 2002 Elsevier Science Ltd. All rights reserved.

  • microarchitectural and mechanical characterization of oriented porous polymer scaffolds
    Biomaterials, 2003
    Co-Authors: Angela S P Lin, Thomas Harry Barrows, S H Cartmell, Robert E Guldberg
    Abstract:

    Biodegradable porous polymer scaffolds are widely used in tissue engineering to provide a structural template for cell seeding and extracellular matrix formation. Scaffolds must often possess sufficient structural integrity to temporarily withstand functional loading in vivo or cell traction forces in vitro. Both the mechanical and biological properties of porous scaffolds are determined in part by the local microarchitecture. Quantification of scaffold structure-function relationships is therefore critical for optimizing mechanical and biological performance. In this study, porous poly(L-lactide-co-DL-lactide) scaffolds with axially oriented macroporosity and random Microporosity were produced using a solution coating and porogen decomposition method. Microarchitectural parameters were quantified as a function of porogen concentration using microcomputed tomography (micro-CT) analysis and related to compressive mechanical properties. With increasing porogen concentration, volume fraction decreased consistently due to microarchitectural changes in average strut thickness, spacing, and density. The three-dimensional interconnectivity of the scaffold porosity was greater than 99% for all porogen concentration levels tested. Over a porosity range of 58-80%, the average compressive modulus and ultimate strength of the scaffolds ranged from 43.5-168.3 MPa and 2.7-11.0 MPa, respectively. Thus, biodegradable porous polymer scaffolds have been produced with oriented microarchitectural features designed to facilitate vascular invasion and cellular attachment and with initial mechanical properties comparable to those of trabecular bone.

Angela S P Lin - One of the best experts on this subject based on the ideXlab platform.

  • microarchitectural and mechanical characterization of oriented porous polymer scaffolds
    Biomaterials, 2003
    Co-Authors: Angela S P Lin, Thomas Harry Barrows, S H Cartmell, Robert E Guldberg
    Abstract:

    Biodegradable porous polymer scaffolds are widely used in tissue engineering to provide a structural template for cell seeding and extracellular matrix formation. Scaffolds must often possess sufficient structural integrity to temporarily withstand functional loadingin vivo or cell traction forces in vitro. Both the mechanical and biolog ical properties of porous scaffolds are determined in part by the local microarchitecture. Quantification of scaffold structure-function relationships is therefore critical for optimizing mechanical and biological performance. In this study, porous poly(l-lactide-co-dl-lactide) scaffolds with axially oriented macroporosity and random Microporosity were produced usinga solution coatingand porog en decomposition method. Microarchitectural parameters were quantified as a function of porogen concentration using microcomputed tomography (microCT) analysis and related to compressive mechanical properties. With increasingporog en concentration, volume fraction decreased consistently due to microarchitectural changes in average strut thickness, spacing, and density. The three-dimensional interconnectivity of the scaffold porosity was greater than 99% for all porogen concentration levels tested. Over a porosity range of 58–80%, the average compressive modulus and ultimate strength of the scaffolds ranged from 43.5–168.3 MPa and 2.7–11.0 MPa, respectively. Thus, biodegradable porous polymer scaffolds have been produced with oriented microarchitectural features designed to facilitate vascular invasion and cellular attachment and with initial mechanical properties comparable to those of trabecular bone. r 2002 Elsevier Science Ltd. All rights reserved.

  • microarchitectural and mechanical characterization of oriented porous polymer scaffolds
    Biomaterials, 2003
    Co-Authors: Angela S P Lin, Thomas Harry Barrows, S H Cartmell, Robert E Guldberg
    Abstract:

    Biodegradable porous polymer scaffolds are widely used in tissue engineering to provide a structural template for cell seeding and extracellular matrix formation. Scaffolds must often possess sufficient structural integrity to temporarily withstand functional loading in vivo or cell traction forces in vitro. Both the mechanical and biological properties of porous scaffolds are determined in part by the local microarchitecture. Quantification of scaffold structure-function relationships is therefore critical for optimizing mechanical and biological performance. In this study, porous poly(L-lactide-co-DL-lactide) scaffolds with axially oriented macroporosity and random Microporosity were produced using a solution coating and porogen decomposition method. Microarchitectural parameters were quantified as a function of porogen concentration using microcomputed tomography (micro-CT) analysis and related to compressive mechanical properties. With increasing porogen concentration, volume fraction decreased consistently due to microarchitectural changes in average strut thickness, spacing, and density. The three-dimensional interconnectivity of the scaffold porosity was greater than 99% for all porogen concentration levels tested. Over a porosity range of 58-80%, the average compressive modulus and ultimate strength of the scaffolds ranged from 43.5-168.3 MPa and 2.7-11.0 MPa, respectively. Thus, biodegradable porous polymer scaffolds have been produced with oriented microarchitectural features designed to facilitate vascular invasion and cellular attachment and with initial mechanical properties comparable to those of trabecular bone.

Thomas Harry Barrows - One of the best experts on this subject based on the ideXlab platform.

  • microarchitectural and mechanical characterization of oriented porous polymer scaffolds
    Biomaterials, 2003
    Co-Authors: Angela S P Lin, Thomas Harry Barrows, S H Cartmell, Robert E Guldberg
    Abstract:

    Biodegradable porous polymer scaffolds are widely used in tissue engineering to provide a structural template for cell seeding and extracellular matrix formation. Scaffolds must often possess sufficient structural integrity to temporarily withstand functional loadingin vivo or cell traction forces in vitro. Both the mechanical and biolog ical properties of porous scaffolds are determined in part by the local microarchitecture. Quantification of scaffold structure-function relationships is therefore critical for optimizing mechanical and biological performance. In this study, porous poly(l-lactide-co-dl-lactide) scaffolds with axially oriented macroporosity and random Microporosity were produced usinga solution coatingand porog en decomposition method. Microarchitectural parameters were quantified as a function of porogen concentration using microcomputed tomography (microCT) analysis and related to compressive mechanical properties. With increasingporog en concentration, volume fraction decreased consistently due to microarchitectural changes in average strut thickness, spacing, and density. The three-dimensional interconnectivity of the scaffold porosity was greater than 99% for all porogen concentration levels tested. Over a porosity range of 58–80%, the average compressive modulus and ultimate strength of the scaffolds ranged from 43.5–168.3 MPa and 2.7–11.0 MPa, respectively. Thus, biodegradable porous polymer scaffolds have been produced with oriented microarchitectural features designed to facilitate vascular invasion and cellular attachment and with initial mechanical properties comparable to those of trabecular bone. r 2002 Elsevier Science Ltd. All rights reserved.

  • microarchitectural and mechanical characterization of oriented porous polymer scaffolds
    Biomaterials, 2003
    Co-Authors: Angela S P Lin, Thomas Harry Barrows, S H Cartmell, Robert E Guldberg
    Abstract:

    Biodegradable porous polymer scaffolds are widely used in tissue engineering to provide a structural template for cell seeding and extracellular matrix formation. Scaffolds must often possess sufficient structural integrity to temporarily withstand functional loading in vivo or cell traction forces in vitro. Both the mechanical and biological properties of porous scaffolds are determined in part by the local microarchitecture. Quantification of scaffold structure-function relationships is therefore critical for optimizing mechanical and biological performance. In this study, porous poly(L-lactide-co-DL-lactide) scaffolds with axially oriented macroporosity and random Microporosity were produced using a solution coating and porogen decomposition method. Microarchitectural parameters were quantified as a function of porogen concentration using microcomputed tomography (micro-CT) analysis and related to compressive mechanical properties. With increasing porogen concentration, volume fraction decreased consistently due to microarchitectural changes in average strut thickness, spacing, and density. The three-dimensional interconnectivity of the scaffold porosity was greater than 99% for all porogen concentration levels tested. Over a porosity range of 58-80%, the average compressive modulus and ultimate strength of the scaffolds ranged from 43.5-168.3 MPa and 2.7-11.0 MPa, respectively. Thus, biodegradable porous polymer scaffolds have been produced with oriented microarchitectural features designed to facilitate vascular invasion and cellular attachment and with initial mechanical properties comparable to those of trabecular bone.

S H Cartmell - One of the best experts on this subject based on the ideXlab platform.

  • microarchitectural and mechanical characterization of oriented porous polymer scaffolds
    Biomaterials, 2003
    Co-Authors: Angela S P Lin, Thomas Harry Barrows, S H Cartmell, Robert E Guldberg
    Abstract:

    Biodegradable porous polymer scaffolds are widely used in tissue engineering to provide a structural template for cell seeding and extracellular matrix formation. Scaffolds must often possess sufficient structural integrity to temporarily withstand functional loadingin vivo or cell traction forces in vitro. Both the mechanical and biolog ical properties of porous scaffolds are determined in part by the local microarchitecture. Quantification of scaffold structure-function relationships is therefore critical for optimizing mechanical and biological performance. In this study, porous poly(l-lactide-co-dl-lactide) scaffolds with axially oriented macroporosity and random Microporosity were produced usinga solution coatingand porog en decomposition method. Microarchitectural parameters were quantified as a function of porogen concentration using microcomputed tomography (microCT) analysis and related to compressive mechanical properties. With increasingporog en concentration, volume fraction decreased consistently due to microarchitectural changes in average strut thickness, spacing, and density. The three-dimensional interconnectivity of the scaffold porosity was greater than 99% for all porogen concentration levels tested. Over a porosity range of 58–80%, the average compressive modulus and ultimate strength of the scaffolds ranged from 43.5–168.3 MPa and 2.7–11.0 MPa, respectively. Thus, biodegradable porous polymer scaffolds have been produced with oriented microarchitectural features designed to facilitate vascular invasion and cellular attachment and with initial mechanical properties comparable to those of trabecular bone. r 2002 Elsevier Science Ltd. All rights reserved.

  • microarchitectural and mechanical characterization of oriented porous polymer scaffolds
    Biomaterials, 2003
    Co-Authors: Angela S P Lin, Thomas Harry Barrows, S H Cartmell, Robert E Guldberg
    Abstract:

    Biodegradable porous polymer scaffolds are widely used in tissue engineering to provide a structural template for cell seeding and extracellular matrix formation. Scaffolds must often possess sufficient structural integrity to temporarily withstand functional loading in vivo or cell traction forces in vitro. Both the mechanical and biological properties of porous scaffolds are determined in part by the local microarchitecture. Quantification of scaffold structure-function relationships is therefore critical for optimizing mechanical and biological performance. In this study, porous poly(L-lactide-co-DL-lactide) scaffolds with axially oriented macroporosity and random Microporosity were produced using a solution coating and porogen decomposition method. Microarchitectural parameters were quantified as a function of porogen concentration using microcomputed tomography (micro-CT) analysis and related to compressive mechanical properties. With increasing porogen concentration, volume fraction decreased consistently due to microarchitectural changes in average strut thickness, spacing, and density. The three-dimensional interconnectivity of the scaffold porosity was greater than 99% for all porogen concentration levels tested. Over a porosity range of 58-80%, the average compressive modulus and ultimate strength of the scaffolds ranged from 43.5-168.3 MPa and 2.7-11.0 MPa, respectively. Thus, biodegradable porous polymer scaffolds have been produced with oriented microarchitectural features designed to facilitate vascular invasion and cellular attachment and with initial mechanical properties comparable to those of trabecular bone.

Franz E Weber - One of the best experts on this subject based on the ideXlab platform.

  • microporosities in 3d printed tricalcium phosphate based bone substitutes enhance osteoconduction and affect osteoclastic resorption
    International Journal of Molecular Sciences, 2020
    Co-Authors: Chafik Ghayor, Indranil Bhattacharya, Tsehsiang Chen, Mutlu Ozcan, Franz E Weber
    Abstract:

    Additive manufacturing is a key technology required to realize the production of a personalized bone substitute that exactly meets a patient's need and fills a patient-specific bone defect. Additive manufacturing can optimize the inner architecture of the scaffold for osteoconduction, allowing fast and reliable defect bridging by promoting rapid growth of new bone tissue into the scaffold. The role of scaffold Microporosity/nanoarchitecture in osteoconduction remains elusive. To elucidate this relationship, we produced lithography-based osteoconductive scaffolds from tricalcium phosphate (TCP) with identical macro- and microarchitecture, but varied their nanoarchitecture/Microporosity by ranging maximum sintering temperatures from 1000 °C to 1200 °C. After characterization of the different scaffolds' Microporosity, compression strength, and nanoarchitecture, we performed in vivo studies that showed that ingrowth of bone as an indicator of osteoconduction significantly decreased with decreasing Microporosity. Moreover, at the 1200 °C peak sinter temperature and lowest Microporosity, osteoclastic degradation of the material was inhibited. Thus, even for wide-open porous TCP-based scaffolds, a high degree of Microporosity appears to be essential for optimal osteoconduction and creeping substitution, which can prevent non-unions, the major complication during bone regeneration procedures.