The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Jengkae Jiang - One of the best experts on this subject based on the ideXlab platform.

  • author correction microRNA 146a directs the symmetric division of snail dominant colorectal cancer stem cells
    Nature Cell Biology, 2019
    Co-Authors: Wei Lun Hwang, Hao Wei Teng, Chih Yung Yang, Yaping Tsai, Tse Shun Huang, Hseiwei Wang, Shung-haur Yang, Jengkae Jiang, Muhhwa Yang
    Abstract:

    In the version of Supplementary Fig. 6c originally published with this Article, the immunoprecipitation (IP) and immunoblotting (IB) tags in the top panel were mislabelled. In addition, in Supplementary Fig. 6e, the blot of the IP: Numb; IB: β-Trcp panel for HCT15 was mistakenly duplicated for HCT116. The correct versions of these figures are shown below. An independent repeat of the experiments presented in Supplementary Fig. 6c and e, showing results that are consistent with those reported in the unprocessed blots, have been deposited in figshare ( 10.6084/m9.figshare.7570685 ).

  • microRNA 146a directs the symmetric division of snail dominant colorectal cancer stem cells
    Nature Cell Biology, 2014
    Co-Authors: Wei Lun Hwang, Hao Wei Teng, Chih Yung Yang, Yaping Tsai, Tse Shun Huang, Hseiwei Wang, Shung-haur Yang, Jengkae Jiang, Muhhwa Yang
    Abstract:

    Wang, Yang and colleagues delineate a Snail–β-catenin-miR-146a signalling axis that directs a switch from asymmetric to symmetric cell division, resulting in colorectal cancer stem cell expansion.

  • microRNA 146a directs the symmetric division of snail dominant colorectal cancer stem cells
    Nature, 2014
    Co-Authors: Wei Lun Hwang, Hao Wei Teng, Chih Yung Yang, Yaping Tsai, Tse Shun Huang, Shung-haur Yang, Jengkae Jiang, Hsin Yi Lan, Chi Hung Lin, Hseiwei Wang
    Abstract:

    Asymmetrical cell division (ACD) maintains the proper number of stem cells to ensure self-renewal. In cancer cells, the deregulation of ACD disrupts the homeostasis of the stem cell pool and promotes tumour growth. However, this mechanism is unclear. Here, we show a reduction of ACD in spheroid-derived colorectal cancer stem cells (CRCSCs) compared with differentiated cancer cells. The epithelial-mesenchymal transition (EMT) inducer Snail is responsible for the ACD-to-symmetrical cell division (SCD) switch in CRCSCs. Mechanistically, Snail induces the expression of microRNA-146a (miR-146a) through the β-catenin-TCF4 complex. miR-146a targets Numb to stabilize β-catenin, which forms a feedback circuit to maintain Wnt activity and directs SCD. Interference with the Snail-miR-146a–β-catenin loop by inhibiting the MEK or Wnt activity reduces the symmetrical division of CRCSCs and attenuates tumorigenicity. In colorectal cancer patients, the Snail(High)Numb(Low) profile is correlated with cetuximab resistance and a poorer prognosis. This study elucidates a unique mechanism of EMT-induced CRCSC expansion.

Hseiwei Wang - One of the best experts on this subject based on the ideXlab platform.

  • author correction microRNA 146a directs the symmetric division of snail dominant colorectal cancer stem cells
    Nature Cell Biology, 2019
    Co-Authors: Wei Lun Hwang, Hao Wei Teng, Chih Yung Yang, Yaping Tsai, Tse Shun Huang, Hseiwei Wang, Shung-haur Yang, Jengkae Jiang, Muhhwa Yang
    Abstract:

    In the version of Supplementary Fig. 6c originally published with this Article, the immunoprecipitation (IP) and immunoblotting (IB) tags in the top panel were mislabelled. In addition, in Supplementary Fig. 6e, the blot of the IP: Numb; IB: β-Trcp panel for HCT15 was mistakenly duplicated for HCT116. The correct versions of these figures are shown below. An independent repeat of the experiments presented in Supplementary Fig. 6c and e, showing results that are consistent with those reported in the unprocessed blots, have been deposited in figshare ( 10.6084/m9.figshare.7570685 ).

  • microRNA 146a directs the symmetric division of snail dominant colorectal cancer stem cells
    Nature Cell Biology, 2014
    Co-Authors: Wei Lun Hwang, Hao Wei Teng, Chih Yung Yang, Yaping Tsai, Tse Shun Huang, Hseiwei Wang, Shung-haur Yang, Jengkae Jiang, Muhhwa Yang
    Abstract:

    Wang, Yang and colleagues delineate a Snail–β-catenin-miR-146a signalling axis that directs a switch from asymmetric to symmetric cell division, resulting in colorectal cancer stem cell expansion.

  • microRNA 146a directs the symmetric division of snail dominant colorectal cancer stem cells
    Nature, 2014
    Co-Authors: Wei Lun Hwang, Hao Wei Teng, Chih Yung Yang, Yaping Tsai, Tse Shun Huang, Shung-haur Yang, Jengkae Jiang, Hsin Yi Lan, Chi Hung Lin, Hseiwei Wang
    Abstract:

    Asymmetrical cell division (ACD) maintains the proper number of stem cells to ensure self-renewal. In cancer cells, the deregulation of ACD disrupts the homeostasis of the stem cell pool and promotes tumour growth. However, this mechanism is unclear. Here, we show a reduction of ACD in spheroid-derived colorectal cancer stem cells (CRCSCs) compared with differentiated cancer cells. The epithelial-mesenchymal transition (EMT) inducer Snail is responsible for the ACD-to-symmetrical cell division (SCD) switch in CRCSCs. Mechanistically, Snail induces the expression of microRNA-146a (miR-146a) through the β-catenin-TCF4 complex. miR-146a targets Numb to stabilize β-catenin, which forms a feedback circuit to maintain Wnt activity and directs SCD. Interference with the Snail-miR-146a–β-catenin loop by inhibiting the MEK or Wnt activity reduces the symmetrical division of CRCSCs and attenuates tumorigenicity. In colorectal cancer patients, the Snail(High)Numb(Low) profile is correlated with cetuximab resistance and a poorer prognosis. This study elucidates a unique mechanism of EMT-induced CRCSC expansion.

Wei Lun Hwang - One of the best experts on this subject based on the ideXlab platform.

  • author correction microRNA 146a directs the symmetric division of snail dominant colorectal cancer stem cells
    Nature Cell Biology, 2019
    Co-Authors: Wei Lun Hwang, Hao Wei Teng, Chih Yung Yang, Yaping Tsai, Tse Shun Huang, Hseiwei Wang, Shung-haur Yang, Jengkae Jiang, Muhhwa Yang
    Abstract:

    In the version of Supplementary Fig. 6c originally published with this Article, the immunoprecipitation (IP) and immunoblotting (IB) tags in the top panel were mislabelled. In addition, in Supplementary Fig. 6e, the blot of the IP: Numb; IB: β-Trcp panel for HCT15 was mistakenly duplicated for HCT116. The correct versions of these figures are shown below. An independent repeat of the experiments presented in Supplementary Fig. 6c and e, showing results that are consistent with those reported in the unprocessed blots, have been deposited in figshare ( 10.6084/m9.figshare.7570685 ).

  • microRNA 146a directs the symmetric division of snail dominant colorectal cancer stem cells
    Nature Cell Biology, 2014
    Co-Authors: Wei Lun Hwang, Hao Wei Teng, Chih Yung Yang, Yaping Tsai, Tse Shun Huang, Hseiwei Wang, Shung-haur Yang, Jengkae Jiang, Muhhwa Yang
    Abstract:

    Wang, Yang and colleagues delineate a Snail–β-catenin-miR-146a signalling axis that directs a switch from asymmetric to symmetric cell division, resulting in colorectal cancer stem cell expansion.

  • microRNA 146a directs the symmetric division of snail dominant colorectal cancer stem cells
    Nature, 2014
    Co-Authors: Wei Lun Hwang, Hao Wei Teng, Chih Yung Yang, Yaping Tsai, Tse Shun Huang, Shung-haur Yang, Jengkae Jiang, Hsin Yi Lan, Chi Hung Lin, Hseiwei Wang
    Abstract:

    Asymmetrical cell division (ACD) maintains the proper number of stem cells to ensure self-renewal. In cancer cells, the deregulation of ACD disrupts the homeostasis of the stem cell pool and promotes tumour growth. However, this mechanism is unclear. Here, we show a reduction of ACD in spheroid-derived colorectal cancer stem cells (CRCSCs) compared with differentiated cancer cells. The epithelial-mesenchymal transition (EMT) inducer Snail is responsible for the ACD-to-symmetrical cell division (SCD) switch in CRCSCs. Mechanistically, Snail induces the expression of microRNA-146a (miR-146a) through the β-catenin-TCF4 complex. miR-146a targets Numb to stabilize β-catenin, which forms a feedback circuit to maintain Wnt activity and directs SCD. Interference with the Snail-miR-146a–β-catenin loop by inhibiting the MEK or Wnt activity reduces the symmetrical division of CRCSCs and attenuates tumorigenicity. In colorectal cancer patients, the Snail(High)Numb(Low) profile is correlated with cetuximab resistance and a poorer prognosis. This study elucidates a unique mechanism of EMT-induced CRCSC expansion.

Tse Shun Huang - One of the best experts on this subject based on the ideXlab platform.

  • author correction microRNA 146a directs the symmetric division of snail dominant colorectal cancer stem cells
    Nature Cell Biology, 2019
    Co-Authors: Wei Lun Hwang, Hao Wei Teng, Chih Yung Yang, Yaping Tsai, Tse Shun Huang, Hseiwei Wang, Shung-haur Yang, Jengkae Jiang, Muhhwa Yang
    Abstract:

    In the version of Supplementary Fig. 6c originally published with this Article, the immunoprecipitation (IP) and immunoblotting (IB) tags in the top panel were mislabelled. In addition, in Supplementary Fig. 6e, the blot of the IP: Numb; IB: β-Trcp panel for HCT15 was mistakenly duplicated for HCT116. The correct versions of these figures are shown below. An independent repeat of the experiments presented in Supplementary Fig. 6c and e, showing results that are consistent with those reported in the unprocessed blots, have been deposited in figshare ( 10.6084/m9.figshare.7570685 ).

  • microRNA 146a directs the symmetric division of snail dominant colorectal cancer stem cells
    Nature Cell Biology, 2014
    Co-Authors: Wei Lun Hwang, Hao Wei Teng, Chih Yung Yang, Yaping Tsai, Tse Shun Huang, Hseiwei Wang, Shung-haur Yang, Jengkae Jiang, Muhhwa Yang
    Abstract:

    Wang, Yang and colleagues delineate a Snail–β-catenin-miR-146a signalling axis that directs a switch from asymmetric to symmetric cell division, resulting in colorectal cancer stem cell expansion.

  • microRNA 146a directs the symmetric division of snail dominant colorectal cancer stem cells
    Nature, 2014
    Co-Authors: Wei Lun Hwang, Hao Wei Teng, Chih Yung Yang, Yaping Tsai, Tse Shun Huang, Shung-haur Yang, Jengkae Jiang, Hsin Yi Lan, Chi Hung Lin, Hseiwei Wang
    Abstract:

    Asymmetrical cell division (ACD) maintains the proper number of stem cells to ensure self-renewal. In cancer cells, the deregulation of ACD disrupts the homeostasis of the stem cell pool and promotes tumour growth. However, this mechanism is unclear. Here, we show a reduction of ACD in spheroid-derived colorectal cancer stem cells (CRCSCs) compared with differentiated cancer cells. The epithelial-mesenchymal transition (EMT) inducer Snail is responsible for the ACD-to-symmetrical cell division (SCD) switch in CRCSCs. Mechanistically, Snail induces the expression of microRNA-146a (miR-146a) through the β-catenin-TCF4 complex. miR-146a targets Numb to stabilize β-catenin, which forms a feedback circuit to maintain Wnt activity and directs SCD. Interference with the Snail-miR-146a–β-catenin loop by inhibiting the MEK or Wnt activity reduces the symmetrical division of CRCSCs and attenuates tumorigenicity. In colorectal cancer patients, the Snail(High)Numb(Low) profile is correlated with cetuximab resistance and a poorer prognosis. This study elucidates a unique mechanism of EMT-induced CRCSC expansion.

Hao Wei Teng - One of the best experts on this subject based on the ideXlab platform.

  • author correction microRNA 146a directs the symmetric division of snail dominant colorectal cancer stem cells
    Nature Cell Biology, 2019
    Co-Authors: Wei Lun Hwang, Hao Wei Teng, Chih Yung Yang, Yaping Tsai, Tse Shun Huang, Hseiwei Wang, Shung-haur Yang, Jengkae Jiang, Muhhwa Yang
    Abstract:

    In the version of Supplementary Fig. 6c originally published with this Article, the immunoprecipitation (IP) and immunoblotting (IB) tags in the top panel were mislabelled. In addition, in Supplementary Fig. 6e, the blot of the IP: Numb; IB: β-Trcp panel for HCT15 was mistakenly duplicated for HCT116. The correct versions of these figures are shown below. An independent repeat of the experiments presented in Supplementary Fig. 6c and e, showing results that are consistent with those reported in the unprocessed blots, have been deposited in figshare ( 10.6084/m9.figshare.7570685 ).

  • microRNA 146a directs the symmetric division of snail dominant colorectal cancer stem cells
    Nature Cell Biology, 2014
    Co-Authors: Wei Lun Hwang, Hao Wei Teng, Chih Yung Yang, Yaping Tsai, Tse Shun Huang, Hseiwei Wang, Shung-haur Yang, Jengkae Jiang, Muhhwa Yang
    Abstract:

    Wang, Yang and colleagues delineate a Snail–β-catenin-miR-146a signalling axis that directs a switch from asymmetric to symmetric cell division, resulting in colorectal cancer stem cell expansion.

  • microRNA 146a directs the symmetric division of snail dominant colorectal cancer stem cells
    Nature, 2014
    Co-Authors: Wei Lun Hwang, Hao Wei Teng, Chih Yung Yang, Yaping Tsai, Tse Shun Huang, Shung-haur Yang, Jengkae Jiang, Hsin Yi Lan, Chi Hung Lin, Hseiwei Wang
    Abstract:

    Asymmetrical cell division (ACD) maintains the proper number of stem cells to ensure self-renewal. In cancer cells, the deregulation of ACD disrupts the homeostasis of the stem cell pool and promotes tumour growth. However, this mechanism is unclear. Here, we show a reduction of ACD in spheroid-derived colorectal cancer stem cells (CRCSCs) compared with differentiated cancer cells. The epithelial-mesenchymal transition (EMT) inducer Snail is responsible for the ACD-to-symmetrical cell division (SCD) switch in CRCSCs. Mechanistically, Snail induces the expression of microRNA-146a (miR-146a) through the β-catenin-TCF4 complex. miR-146a targets Numb to stabilize β-catenin, which forms a feedback circuit to maintain Wnt activity and directs SCD. Interference with the Snail-miR-146a–β-catenin loop by inhibiting the MEK or Wnt activity reduces the symmetrical division of CRCSCs and attenuates tumorigenicity. In colorectal cancer patients, the Snail(High)Numb(Low) profile is correlated with cetuximab resistance and a poorer prognosis. This study elucidates a unique mechanism of EMT-induced CRCSC expansion.