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Thierry C Gillebert - One of the best experts on this subject based on the ideXlab platform.
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early and late systolic wall stress differentially relate to myocardial contraction and relaxation in middle aged Adults the asklepios study
Hypertension, 2013Co-Authors: Julio A. Chirinos, Patrick Segers, Ernst Rietzschel, Muhammad W Raja, Tom Claessens, Dirk De Bacquer, Martin St John Sutton, Marc De Buyzere, Thierry C GillebertAbstract:Experimental studies implicate late systolic load as a determinant of impaired left-ventricular relaxation. We aimed to assess the relationship between the myocardial loading sequence and left-ventricular contraction and relaxation. Time-resolved central pressure and time-resolved left-ventricular geometry were measured with carotid tonometry and speckle-tracking echocardiography, respectively, for computation of time-resolved ejection-phase myocardial wall stress (EP-MWS) among 1214 Middle-Aged Adults without manifest cardiovascular disease from the general population. Early diastolic annular velocity and systolic annular velocities were measured with tissue Doppler imaging, and segment-averaged longitudinal strain was measured with speckle-tracking echocardiography. After adjustment for age, sex, and potential confounders, late EP-MWS was negatively associated with early diastolic mitral annular velocity (standardized β=−0.25; P P =0.02). In contrast, early EP-MWS was positively associated with early diastolic mitral annular velocity (standardized β=0.18; P P P P P =0.002) and greater longitudinal strain (standardized β=−0.24; P =0.002). The loading sequence remained independently associated with early diastolic mitral annular velocity after adjustment for systolic mitral annular velocity or systolic longitudinal strain. In the context of available experimental data, our findings support the role of the myocardial loading sequence as a determinant of left-ventricular systolic and diastolic function. A loading sequence characterized by prominent late systolic wall stress was associated with lower longitudinal systolic function and diastolic relaxation.
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early and late systolic wall stress differentially relate to myocardial contraction and relaxation in middle aged Adults the asklepios study
Hypertension, 2013Co-Authors: Julio A. Chirinos, Patrick Segers, Ernst Rietzschel, Muhammad W Raja, Tom Claessens, Dirk De Bacquer, Martin St John Sutton, Marc De Buyzere, Thierry C GillebertAbstract:Experimental studies implicate late systolic load as a determinant of impaired left-ventricular relaxation. We aimed to assess the relationship between the myocardial loading sequence and left-ventricular contraction and relaxation. Time-resolved central pressure and time-resolved left-ventricular geometry were measured with carotid tonometry and speckle-tracking echocardiography, respectively, for computation of time-resolved ejection-phase myocardial wall stress (EP-MWS) among 1214 Middle-Aged Adults without manifest cardiovascular disease from the general population. Early diastolic annular velocity and systolic annular velocities were measured with tissue Doppler imaging, and segment-averaged longitudinal strain was measured with speckle-tracking echocardiography. After adjustment for age, sex, and potential confounders, late EP-MWS was negatively associated with early diastolic mitral annular velocity (standardized β=-0.25; P<0.0001) and mitral inflow propagation velocity (standardized β=-0.13; P=0.02). In contrast, early EP-MWS was positively associated with early diastolic mitral annular velocity (standardized β=0.18; P<0.0001) and mitral inflow propagation velocity (standardized β=0.22; P<0.0001). A higher late EP-MWS predicted a lower systolic mitral annular velocity (standardized β=-0.31; P<0.0001) and lesser myocardial longitudinal strain (standardized β=0.32; P<0.0001), whereas a higher early EP-MWS was associated with a higher systolic mitral annular velocity (standardized β=0.16; P=0.002) and greater longitudinal strain (standardized β=-0.24; P=0.002). The loading sequence remained independently associated with early diastolic mitral annular velocity after adjustment for systolic mitral annular velocity or systolic longitudinal strain. In the context of available experimental data, our findings support the role of the myocardial loading sequence as a determinant of left-ventricular systolic and diastolic function. A loading sequence characterized by prominent late systolic wall stress was associated with lower longitudinal systolic function and diastolic relaxation.
Christopher F Baum - One of the best experts on this subject based on the ideXlab platform.
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county level housing affordability in relation to risk factors for cardiovascular disease among middle aged Adults the national longitudinal survey of youths 1979
Health & Place, 2019Co-Authors: Justin Rodgers, Becky A Briesacher, Robert B. Wallace, Christopher F BaumAbstract:Abstract Background Housing is a fundamental social determinant of health yet housing affordability has diminished over much of the twenty-first century. Research on housing affordability as a determinant of health is limited, but early studies have shown possible correlations with mental health. However, few studies have examined the relationship between housing affordability and risk factors for cardiovascular disease, the leading cause of morbidity and mortality among Americans. Methods Using a nationally-representative sample of Middle-Aged Adults from the National Longitudinal Survey of Youths 1979 (NLSY79) and exploiting quasi-experimental variation before and after the Great Recession, we estimated the associations between the change in median county-level percentage of household income spent on housing (rent/mortgage) between 2000 and 2008 and individual-level risks of incident hypertension, obesity, diabetes, and depression from 2008 to 2014. We employed conditional fixed effects logistic regression models to reduce bias due to time-invariant confounding. Results Each percentage point increase in county-level median percentage of household income spent on housing was associated with a 22% increase in the odds of incident hypertension (OR = 1.22, 95% CI = 1.06 to 1.42; p = 0.01), a 37% increased odds of obesity (OR = 1.37, 95% CI = 1.00–1.87; p = 0.049), and a 15% increased odds of depression (OR = 1.15, 95% CI = 1.01–1.31; p = 0.03), controlling for individual- and area-level factors. These associations were stronger among renters than homeowners, and men compared to women. Conclusions Our findings suggest that lower levels of housing affordability contribute to worse risk profiles for cardiovascular disease. Policies that make housing more affordable may help reduce the population burden of cardiovascular disease.
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county level housing affordability in relation to risk factors for cardiovascular disease among middle aged Adults the national longitudinal survey of youths 1979
Health & Place, 2019Co-Authors: Justin Rodgers, Becky A Briesacher, Robert B. Wallace, Ichiro Kawachi, Christopher F BaumAbstract:Abstract Background Housing is a fundamental social determinant of health yet housing affordability has diminished over much of the twenty-first century. Research on housing affordability as a determinant of health is limited, but early studies have shown possible correlations with mental health. However, few studies have examined the relationship between housing affordability and risk factors for cardiovascular disease, the leading cause of morbidity and mortality among Americans. Methods Using a nationally-representative sample of Middle-Aged Adults from the National Longitudinal Survey of Youths 1979 (NLSY79) and exploiting quasi-experimental variation before and after the Great Recession, we estimated the associations between the change in median county-level percentage of household income spent on housing (rent/mortgage) between 2000 and 2008 and individual-level risks of incident hypertension, obesity, diabetes, and depression from 2008 to 2014. We employed conditional fixed effects logistic regression models to reduce bias due to time-invariant confounding. Results Each percentage point increase in county-level median percentage of household income spent on housing was associated with a 22% increase in the odds of incident hypertension (OR = 1.22, 95% CI = 1.06 to 1.42; p = 0.01), a 37% increased odds of obesity (OR = 1.37, 95% CI = 1.00–1.87; p = 0.049), and a 15% increased odds of depression (OR = 1.15, 95% CI = 1.01–1.31; p = 0.03), controlling for individual- and area-level factors. These associations were stronger among renters than homeowners, and men compared to women. Conclusions Our findings suggest that lower levels of housing affordability contribute to worse risk profiles for cardiovascular disease. Policies that make housing more affordable may help reduce the population burden of cardiovascular disease.
Donald M Lloydjones - One of the best experts on this subject based on the ideXlab platform.
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hemodynamic and mechanical properties of the proximal aorta in young and middle aged Adults with isolated systolic hypertension the dallas heart study
Hypertension, 2017Co-Authors: Donald M Lloydjones, Yuichiro Yano, Ian J Neeland, Colby Ayers, Ronald M Peshock, Jarett D Berry, Philip Greenland, Gary F Mitchell, Wanpen VongpatanasinAbstract:The aim of this study was to assess characteristic impedance (Zc) of the proximal aorta in young and Middle-Aged individuals with isolated systolic hypertension (ISH). Zc is an index of aortic stiffness relative to aortic size. In the Dallas Heart Study, 2001 untreated participants 18 to 64 years of age (mean age: 42.3 years; 44% black race) were divided into the following groups based on office blood pressure (BP) measurements: (1) optimal BP (systolic BP [SBP] 0.2). Results were similar in a subgroup of 1551 participants 18 to 49 years of age. In a multiracial population-based sample, we found evidence of a mismatch between proximal aortic stiffness and diameter in young and Middle-Aged Adults with ISH.
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isolated systolic hypertension in young and middle aged Adults and 31 year risk for cardiovascular mortality the chicago heart association detection project in industry study
Journal of the American College of Cardiology, 2015Co-Authors: Yuichiro Yano, Kiang Liu, Mercedes R Carnethon, Philip Greenland, Jeremiah Stamler, Daniel B Garside, Martha L Daviglus, Stanley S Franklin, Donald M LloydjonesAbstract:Abstract Background Isolated systolic hypertension (ISH), defined as systolic blood pressure (SBP) ≥140 mm Hg and diastolic blood pressure (DBP) Objective The aim of this study was to assess the risk for cardiovascular disease (CVD) with ISH in younger and Middle-Aged Adults. Methods CVD risks were explored in 15,868 men and 11,213 women 18 to 49 years of age (mean age 34 years) at baseline, 85% non-Hispanic white, free of coronary heart disease (CHD) and antihypertensive therapy, from the Chicago Heart Association Detection Project in Industry study. Participant classifications were as follows: 1) optimal-normal blood pressure (BP) (SBP Results During a 31-year average follow-up period (842,600 person-years), there were 1,728 deaths from CVD, 1,168 from CHD, and 223 from stroke. Cox proportional hazards models were adjusted for age, race, education, body mass index, current smoking, total cholesterol, and diabetes. In men, with optimal-normal BP as the reference stratum, hazard ratios for CVD and CHD mortality risk for those with ISH were 1.23 (95% confidence interval [CI]: 1.03 to 1.46) and 1.28 (95% CI: 1.04 to 1.58), respectively. ISH risks were similar to those with high-normal BP and less than those associated with isolated diastolic hypertension and systolic diastolic hypertension. In women with ISH, hazard ratios for CVD and CHD mortality risk were 1.55 (95% CI: 1.18 to 2.05) and 2.12 (95% CI: 1.49 to 3.01), respectively. ISH risks were higher than in those with high-normal BP or isolated diastolic hypertension and less than those associated with systolic diastolic hypertension. Conclusions Over long-term follow-up, younger and Middle-Aged Adults with ISH had higher relative risk for CVD and CHD mortality than those with optimal-normal BP.
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associations between nonalcoholic fatty liver disease and subclinical atherosclerosis in middle aged Adults the coronary artery risk development in young Adults study
Atherosclerosis, 2014Co-Authors: Lisa B Vanwagner, Donald M Lloydjones, Hongyan Ning, Cora E Lewis, Christina M Shay, John T Wilkins, Jeffrey J Carr, James G Terry, David R Jacobs, Mercedes R CarnethonAbstract:Objective Non-alcoholic fatty liver disease (NAFLD) is an obesity-related condition associated with cardiovascular mortality. Yet, whether or not NAFLD is independently related to atherosclerosis is unclear. In a population-based cross-sectional sample of Middle-Aged Adults free from liver or heart disease, we tested the hypothesis that NAFLD is associated with subclinical atherosclerosis (coronary artery (CAC) and abdominal aortic calcification (AAC)) independent of obesity.
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sibling cardiovascular disease as a risk factor for cardiovascular disease in middle aged Adults
JAMA, 2005Co-Authors: Joanne M Murabito, Thomas J Wang, Ralph B Dagostino, Donald M Lloydjones, Michael J Pencina, Peter W F Wilson, Christopher J OdonnellAbstract:ContextWhile parental cardiovascular disease (CVD) doubles the risk for CVD in offspring, the extent of increased risk associated with sibling CVD is unclear.ObjectiveTo determine, using validated events, whether sibling CVD predicts outcome in Middle-Aged Adults independent of other risk factors.Design, Setting, and ParticipantsThe Framingham Offspring Study, an inception cohort of the Framingham Heart Study, a prospective population-based cohort study initiated in 1948 with the offspring cohort initiated in 1971. Participants (n = 2475) were members of the offspring cohort aged 30 years or older, free of CVD, and with at least 1 sibling in the study; all were followed up for 8 years.Main Outcome MeasuresAssociation of sibling CVD with 8-year personal risk for CVD using pooled logistic regression. A secondary analysis restricted to offspring with both parents in the study assessed the joint impact of parental and sibling CVD occurrence.ResultsAmong 973 person-examinations in the sibling CVD group (mean age, 57 years) and 4506 person-examinations in the no sibling CVD group (mean age, 47 years), 329 CVD events occurred during follow-up. Baseline risk factors were more prevalent in the sibling CVD group compared with the no sibling CVD group. Sibling CVD was associated with a significantly increased risk for incident CVD (age- and sex-adjusted odds ratio [OR], 1.55; 95% confidence interval [CI], 1.19-2.03). Adjustment for risk factors did not substantially attenuate the risk (adjusted OR, 1.45; 95% CI, 1.10-1.91). In the analysis restricted to persons with both parents in the study, in models adjusting for both sibling and parental CVD, the multivariable-adjusted OR for sibling CVD (1.99; 95% CI, 1.32-3.00) exceeded that for parental CVD (1.45; 95% CI, 1.02-2.05).ConclusionUsing validated events, sibling CVD conferred increased risk of future CVD events above and beyond established risk factors and parental CVD in Middle-Aged Adults.
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parental cardiovascular disease as a risk factor for cardiovascular disease in middle aged Adults a prospective study of parents and offspring
JAMA, 2004Co-Authors: Donald M Lloydjones, Thomas J Wang, Ralph B Dagostino, Daniel Levy, Joanne M MurabitoAbstract:ContextWhether parental cardiovascular disease confers increased risk independent of other risk factors remains controversial. Prior studies relied on offspring report, without complete validation of parental events.ObjectiveTo determine whether parental cardiovascular disease predicts offspring events independent of traditional risk factors, using a prospective design for both parents and offspring, and uniform criteria to validate events.DesignInception cohort study.SettingFramingham Heart Study, a US population-based epidemiologic cohort begun in 1948 with the offspring cohort established in 1971.ParticipantsAll Framingham Offspring Study participants (aged ≥30 years) who were free of cardiovascular disease and both parents in the original Framingham cohort.Main Outcome MeasuresWe examined the association of parental cardiovascular disease with 8-year risk of offspring cardiovascular disease, using pooled logistic regression.ResultsAmong 2302 men and women (mean age, 44 years), 164 men and 79 women had cardiovascular events during follow-up. Compared with participants with no parental cardiovascular disease, those with at least 1 parent with premature cardiovascular disease (onset age <55 years in father, <65 years in mother) had greater risk for events, with age-adjusted odds ratios of 2.6 (95% confidence interval [CI], 1.7-4.1) for men and 2.3 (95% CI, 1.3-4.3) for women. Multivariable adjustment resulted in odds ratios of 2.0 (95% CI, 1.2-3.1) for men and 1.7 (95% CI, 0.9-3.1) for women. Nonpremature parental cardiovascular disease and parental coronary disease were weaker predictors. Addition of parental information aided in discriminating event rates, notably among offspring with intermediate levels of cholesterol and blood pressure, as well as intermediate predicted multivariable risk.ConclusionsUsing validated events, we found that parental cardiovascular disease independently predicted future offspring events in Middle-Aged Adults. Addition of parental information may help clinicians and patients with primary prevention of cardiovascular disease, when treatment decisions may be difficult in patients at intermediate risk based on levels of single or multiple risk factors. These data also support further research into genetic determinants of cardiovascular risk.
Julio A. Chirinos - One of the best experts on this subject based on the ideXlab platform.
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early and late systolic wall stress differentially relate to myocardial contraction and relaxation in middle aged Adults the asklepios study
Hypertension, 2013Co-Authors: Julio A. Chirinos, Patrick Segers, Ernst Rietzschel, Muhammad W Raja, Tom Claessens, Dirk De Bacquer, Martin St John Sutton, Marc De Buyzere, Thierry C GillebertAbstract:Experimental studies implicate late systolic load as a determinant of impaired left-ventricular relaxation. We aimed to assess the relationship between the myocardial loading sequence and left-ventricular contraction and relaxation. Time-resolved central pressure and time-resolved left-ventricular geometry were measured with carotid tonometry and speckle-tracking echocardiography, respectively, for computation of time-resolved ejection-phase myocardial wall stress (EP-MWS) among 1214 Middle-Aged Adults without manifest cardiovascular disease from the general population. Early diastolic annular velocity and systolic annular velocities were measured with tissue Doppler imaging, and segment-averaged longitudinal strain was measured with speckle-tracking echocardiography. After adjustment for age, sex, and potential confounders, late EP-MWS was negatively associated with early diastolic mitral annular velocity (standardized β=−0.25; P P =0.02). In contrast, early EP-MWS was positively associated with early diastolic mitral annular velocity (standardized β=0.18; P P P P P =0.002) and greater longitudinal strain (standardized β=−0.24; P =0.002). The loading sequence remained independently associated with early diastolic mitral annular velocity after adjustment for systolic mitral annular velocity or systolic longitudinal strain. In the context of available experimental data, our findings support the role of the myocardial loading sequence as a determinant of left-ventricular systolic and diastolic function. A loading sequence characterized by prominent late systolic wall stress was associated with lower longitudinal systolic function and diastolic relaxation.
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early and late systolic wall stress differentially relate to myocardial contraction and relaxation in middle aged Adults the asklepios study
Hypertension, 2013Co-Authors: Julio A. Chirinos, Patrick Segers, Ernst Rietzschel, Muhammad W Raja, Tom Claessens, Dirk De Bacquer, Martin St John Sutton, Marc De Buyzere, Thierry C GillebertAbstract:Experimental studies implicate late systolic load as a determinant of impaired left-ventricular relaxation. We aimed to assess the relationship between the myocardial loading sequence and left-ventricular contraction and relaxation. Time-resolved central pressure and time-resolved left-ventricular geometry were measured with carotid tonometry and speckle-tracking echocardiography, respectively, for computation of time-resolved ejection-phase myocardial wall stress (EP-MWS) among 1214 Middle-Aged Adults without manifest cardiovascular disease from the general population. Early diastolic annular velocity and systolic annular velocities were measured with tissue Doppler imaging, and segment-averaged longitudinal strain was measured with speckle-tracking echocardiography. After adjustment for age, sex, and potential confounders, late EP-MWS was negatively associated with early diastolic mitral annular velocity (standardized β=-0.25; P<0.0001) and mitral inflow propagation velocity (standardized β=-0.13; P=0.02). In contrast, early EP-MWS was positively associated with early diastolic mitral annular velocity (standardized β=0.18; P<0.0001) and mitral inflow propagation velocity (standardized β=0.22; P<0.0001). A higher late EP-MWS predicted a lower systolic mitral annular velocity (standardized β=-0.31; P<0.0001) and lesser myocardial longitudinal strain (standardized β=0.32; P<0.0001), whereas a higher early EP-MWS was associated with a higher systolic mitral annular velocity (standardized β=0.16; P=0.002) and greater longitudinal strain (standardized β=-0.24; P=0.002). The loading sequence remained independently associated with early diastolic mitral annular velocity after adjustment for systolic mitral annular velocity or systolic longitudinal strain. In the context of available experimental data, our findings support the role of the myocardial loading sequence as a determinant of left-ventricular systolic and diastolic function. A loading sequence characterized by prominent late systolic wall stress was associated with lower longitudinal systolic function and diastolic relaxation.
Justin Rodgers - One of the best experts on this subject based on the ideXlab platform.
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county level housing affordability in relation to risk factors for cardiovascular disease among middle aged Adults the national longitudinal survey of youths 1979
Health & Place, 2019Co-Authors: Justin Rodgers, Becky A Briesacher, Robert B. Wallace, Christopher F BaumAbstract:Abstract Background Housing is a fundamental social determinant of health yet housing affordability has diminished over much of the twenty-first century. Research on housing affordability as a determinant of health is limited, but early studies have shown possible correlations with mental health. However, few studies have examined the relationship between housing affordability and risk factors for cardiovascular disease, the leading cause of morbidity and mortality among Americans. Methods Using a nationally-representative sample of Middle-Aged Adults from the National Longitudinal Survey of Youths 1979 (NLSY79) and exploiting quasi-experimental variation before and after the Great Recession, we estimated the associations between the change in median county-level percentage of household income spent on housing (rent/mortgage) between 2000 and 2008 and individual-level risks of incident hypertension, obesity, diabetes, and depression from 2008 to 2014. We employed conditional fixed effects logistic regression models to reduce bias due to time-invariant confounding. Results Each percentage point increase in county-level median percentage of household income spent on housing was associated with a 22% increase in the odds of incident hypertension (OR = 1.22, 95% CI = 1.06 to 1.42; p = 0.01), a 37% increased odds of obesity (OR = 1.37, 95% CI = 1.00–1.87; p = 0.049), and a 15% increased odds of depression (OR = 1.15, 95% CI = 1.01–1.31; p = 0.03), controlling for individual- and area-level factors. These associations were stronger among renters than homeowners, and men compared to women. Conclusions Our findings suggest that lower levels of housing affordability contribute to worse risk profiles for cardiovascular disease. Policies that make housing more affordable may help reduce the population burden of cardiovascular disease.
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county level housing affordability in relation to risk factors for cardiovascular disease among middle aged Adults the national longitudinal survey of youths 1979
Health & Place, 2019Co-Authors: Justin Rodgers, Becky A Briesacher, Robert B. Wallace, Ichiro Kawachi, Christopher F BaumAbstract:Abstract Background Housing is a fundamental social determinant of health yet housing affordability has diminished over much of the twenty-first century. Research on housing affordability as a determinant of health is limited, but early studies have shown possible correlations with mental health. However, few studies have examined the relationship between housing affordability and risk factors for cardiovascular disease, the leading cause of morbidity and mortality among Americans. Methods Using a nationally-representative sample of Middle-Aged Adults from the National Longitudinal Survey of Youths 1979 (NLSY79) and exploiting quasi-experimental variation before and after the Great Recession, we estimated the associations between the change in median county-level percentage of household income spent on housing (rent/mortgage) between 2000 and 2008 and individual-level risks of incident hypertension, obesity, diabetes, and depression from 2008 to 2014. We employed conditional fixed effects logistic regression models to reduce bias due to time-invariant confounding. Results Each percentage point increase in county-level median percentage of household income spent on housing was associated with a 22% increase in the odds of incident hypertension (OR = 1.22, 95% CI = 1.06 to 1.42; p = 0.01), a 37% increased odds of obesity (OR = 1.37, 95% CI = 1.00–1.87; p = 0.049), and a 15% increased odds of depression (OR = 1.15, 95% CI = 1.01–1.31; p = 0.03), controlling for individual- and area-level factors. These associations were stronger among renters than homeowners, and men compared to women. Conclusions Our findings suggest that lower levels of housing affordability contribute to worse risk profiles for cardiovascular disease. Policies that make housing more affordable may help reduce the population burden of cardiovascular disease.
