The Experts below are selected from a list of 4962 Experts worldwide ranked by ideXlab platform

Shusheng Gong - One of the best experts on this subject based on the ideXlab platform.

  • abnormal regional activity and functional connectivity in resting state brain networks associated with etiology confirmed unilateral pulsatile tinnitus in the early stage of disease
    Hearing Research, 2017
    Co-Authors: Pengfei Zhao, Zhaohui Liu, Ling Zhang, Peng Wang, Fei Yan, Liheng Liu, Guopeng Wang, Rong Zeng, Cheng Dong, Shusheng Gong
    Abstract:

    Abnormal neural activities can be revealed by resting-state functional magnetic resonance imaging (rs-fMRI) using analyses of the regional activity and functional connectivity (FC) of the networks in the brain. This study was designed to demonstrate the functional network alterations in the patients with pulsatile tinnitus (PT). In this study, we recruited 45 patients with unilateral PT in the early stage of disease (less than 48 months of disease duration) and 45 normal controls. We used regional homogeneity (ReHo) and seed-based FC computational methods to reveal resting-state brain activity features associated with pulsatile tinnitus. Compared with healthy controls, PT patients showed regional abnormalities mainly in the left Middle Occipital Gyrus (MOG), posterior cingulate Gyrus (PCC), precuneus and right anterior insula (AI). When these regions were defined as seeds, we demonstrated widespread modification of interaction between the auditory and non-auditory networks. The auditory network was positively connected with the cognitive control network (CCN), which may associate with tinnitus related distress. Both altered regional activity and changed FC were found in the visual network. The modification of interactions of higher order networks were mainly found in the DMN, CCN and limbic networks. Functional connectivity between the left MOG and left parahippocampal Gyrus could also be an index to reflect the disease duration. This study helped us gain a better understanding of the characteristics of neural network modifications in patients with pulsatile tinnitus.

Ning Zhang - One of the best experts on this subject based on the ideXlab platform.

  • abnormal resting state activity of left Middle Occipital Gyrus and its functional connectivity in female patients with major depressive disorder
    BMC Psychiatry, 2018
    Co-Authors: Changjun Teng, Jing Zhou, Yarong Tan, Chengbin Guan, Huifen Qiao, Yuan Zhong, Chun Wang, Ning Zhang
    Abstract:

    Women are more susceptible to major depressive disorder (MDD). A possible explanation is that women have a trait tendency to engage in a ruminative response style. Depending on cognitive model of depression, attention bias, memory bias and self-referential bias were closely related among depressed patients. Previous studies have explored the neural mechanism of the cognitive biases by using amplitude of low frequency fluctuations (ALFF) or functional connectivity (FC), and few combined these two metrics, especially focusing on female patients. We assessed 25 female patients diagnosed with MDD and 13 well matched healthy controls (HCs) using Rs-fMRI. Two metrics ALFF and FC based on abnormal ALFF were explored and made comparisons. Compared with HCs, female patients with MDD showed that one cluster with significantly decreased ALFF in the left Middle Occipital Gyrus(L-MOG). Furtherly we founded depressed female subjects showed significantly lower FC between the L-MOG seed and left orbitofrontal cortex, and significantly higher FC between the L-MOG seed and left medial prefrontal Gyrus and left hippocampus. Our results showed L-MOG may act as a connection, which involved in the processing of cognitive biases of MDD by connected with limbic-cortical regions in resting state. These findings may enhance the understanding of the neurobiological mechanism in female patients with MDD.

Pengfei Zhao - One of the best experts on this subject based on the ideXlab platform.

  • abnormal regional activity and functional connectivity in resting state brain networks associated with etiology confirmed unilateral pulsatile tinnitus in the early stage of disease
    Hearing Research, 2017
    Co-Authors: Pengfei Zhao, Zhaohui Liu, Ling Zhang, Peng Wang, Fei Yan, Liheng Liu, Guopeng Wang, Rong Zeng, Cheng Dong, Shusheng Gong
    Abstract:

    Abnormal neural activities can be revealed by resting-state functional magnetic resonance imaging (rs-fMRI) using analyses of the regional activity and functional connectivity (FC) of the networks in the brain. This study was designed to demonstrate the functional network alterations in the patients with pulsatile tinnitus (PT). In this study, we recruited 45 patients with unilateral PT in the early stage of disease (less than 48 months of disease duration) and 45 normal controls. We used regional homogeneity (ReHo) and seed-based FC computational methods to reveal resting-state brain activity features associated with pulsatile tinnitus. Compared with healthy controls, PT patients showed regional abnormalities mainly in the left Middle Occipital Gyrus (MOG), posterior cingulate Gyrus (PCC), precuneus and right anterior insula (AI). When these regions were defined as seeds, we demonstrated widespread modification of interaction between the auditory and non-auditory networks. The auditory network was positively connected with the cognitive control network (CCN), which may associate with tinnitus related distress. Both altered regional activity and changed FC were found in the visual network. The modification of interactions of higher order networks were mainly found in the DMN, CCN and limbic networks. Functional connectivity between the left MOG and left parahippocampal Gyrus could also be an index to reflect the disease duration. This study helped us gain a better understanding of the characteristics of neural network modifications in patients with pulsatile tinnitus.

Joshua J. Field - One of the best experts on this subject based on the ideXlab platform.

  • Periaqueductal gray (PAG) seed-based functional connectivity (FC) analyses between patients with SCD with chronic pain (CP) and without chronic pain (NCP).
    2019
    Co-Authors: Matthew S. Karafin, Guangyu Chen, Nancy J. Wandersee, Amanda M. Brandow, Robert W. Hurley, Pippa Simpson, Doug Ward, Joshua J. Field
    Abstract:

    Left: Images show the results of the two sample t-test pattern of NCP (SCD patients without chronic pain, blue) and patients with chronic pain (SCD patients with sickle cell disease and chronic pain, orange) PAG FC, respectively. Color is coded based on z-score of the significance. Brain regions with warm color represent the positive connection and cold color represents the autocorrelation with PAG regions. Brain regions are numbered: (1) right superior temporal Gyrus/ right insula/ right postcentral Gyrus/ right inferior parietal lobule, (2) left lingual Gyrus/ left inferior Occipital Gyrus/ left Middle Occipital Gyrus, (3) left Middle temporal Gyrus/ left precuneus/ left inferior parietal lobule/ left superior parietal lobule, (4) left and right superior frontal Gyrus (right most)/ medial frontal Gyrus, (5) left supramarginal Gyrus, (6) left superior frontal, (7) left posterior cingulate cortex, (8) right culmen of the cerebellum, and the (9) right Middle and superior frontal lobe. Right: In comparison to NCP, patients with chronic pain demonstrated increased connectivity in the (1) right superior temporal Gyrus/ right insula/ right postcentral Gyrus/ right inferior parietal lobule, (4) left and right superior frontal Gyrus (right most)/ medial frontal Gyrus, (5) left supramarginal Gyrus, (6) left superior frontal, (8) right culmen (cerebellum), and the (9) right Middle and superior frontal lobe. Decreased connectivity was noted in the (2) left lingual Gyrus/ left inferior Occipital Gyrus/ left Middle Occipital Gyrus, (3) left Middle temporal Gyrus/ left precuneus/ left inferior parietal lobule/ left superior parietal lobule, and (7) left posterior cingulate cortex (y-axis = z-score of the significance, x-axis = brain region of interest by number).

  • Periaqueductal gray (PAG) seed-based functional connectivity (FC) analyses between patients with SCD without chronic pain (NCP) and controls (CN).
    2019
    Co-Authors: Matthew S. Karafin, Guangyu Chen, Nancy J. Wandersee, Amanda M. Brandow, Robert W. Hurley, Pippa Simpson, Doug Ward, Joshua J. Field
    Abstract:

    Left: Images show the results of the two sample t-test pattern of CN (controls, blue) and SCD without chronic pain (patients with sickle cell disease and no chronic pain, orange) PAG FC, respectively. Color is coded based on z-score of the significance. Brain regions with warm color represent the positive connection and cold color represents the autocorrelation with PAG regions. Brain regions are numbered: (1) Left and right Cuneus/ left inferior Occipital Gyrus (brodmann area 18)/ left Middle Occipital Gyrus/ left and right lingual Gyrus, and (2) Left and right superior frontal Gyrus. Right: In comparison to CN, NCP demonstrated increased connectivity only in the (1) Left and right Cuneus/ left inferior Occipital Gyrus (brodmann area 18)/ left Middle Occipital Gyrus/ left and right lingual Gyrus, and decreased connectivity of the (2) Left and right superior frontal Gyrus (y-axis = z-score of the significance, x-axis = brain region of interest by number).

Yan Zhang - One of the best experts on this subject based on the ideXlab platform.

  • abnormal baseline brain activity in posttraumatic stress disorder a resting state functional magnetic resonance imaging study
    Neuroscience Letters, 2011
    Co-Authors: Yan Yin, Tianzi Jiang, Changfeng Jin, Lian Duan, Lisa T Eyler, Qiyong Gong, Ming Song, Mei Liao, Yan Zhang
    Abstract:

    a b s t r a c t Little is known about how spontaneous brain activity during the resting state may be altered in post- traumatic stress disorder (PTSD) compared to traumatized individuals. In the current study, we used a measure of amplitude of low-frequency (0.01-0.08 Hz) fluctuation (ALFF) to investigate the regional baseline brain function of this disorder. Fifty-four medication-naive PTSD patients and seventy-two matched traumatized comparison subjects who experienced the Sichuan major earthquake participated in a functional magnetic resonance imaging (fMRI) scan. We analyzed the difference between the PTSD and comparison groups during a resting state using ALFF. PTSD patients showed decreased ALFF values in right lingual Gyrus, cuneus, Middle Occipital Gyrus, insula, and cerebellum, and increased ALFF values in right medial and Middle frontal gyri, relative to traumatized individuals without PTSD. The ALFF value in the right medial frontal Gyrus was positively correlated with severity of the disorder. Our findings show that abnormality of intrinsic brain activity exists under resting conditions in PTSD patients exposed to a major earthquake. Altered ALFF in predominantly right hemisphere cortical and subcortical regions and in cerebellum potentially contribute to the neural mechanisms underlying traumatic memory and symptoms in PTSD.

  • brain responses to symptom provocation and trauma related short term memory recall in coal mining accident survivors with acute severe ptsd
    Brain Research, 2007
    Co-Authors: Cailan Hou, Jun Liu, Kun Wang, Meng Liang, Yong Liu, Yan Zhang, Tianzi Jiang
    Abstract:

    Functional neuroimaging studies have largely been performed in patients with longstanding chronic posttraumatic stress disorder (PTSD). Additionally, memory function of PTSD patients has been proved to be impaired. We sought to characterize the brain responses of patients with acute PTSD and implemented a trauma-related short-term memory recall paradigm. Individuals with acute severe PTSD (n = 10) resulting from a mining accident and 7 men exposed to the mining accident without PTSD underwent functional magnetic resonance imaging (fMRI) while performing the symptom provocation and trauma-related short-term memory recall paradigms. During symptom provocation paradigm, PTSD subjects showed diminished responses in right anterior cingulate Gyrus, left inferior frontal Gyrus and bilateral Middle frontal Gyrus and enhanced left parahippocampal Gyrus response compared with controls. During the short-term memory recall paradigm, PTSD group showed diminished responses in right inferior frontal Gyrus, right Middle frontal and left Middle Occipital Gyrus in comparison with controls. PTSD group exhibited diminished right parahippocampal Gyrus response during the memory recall task as compared to the symptom provocation task. Our findings suggest that neurophysiological alterations and memory performance deficit have developed in acute severe PTSD.