The Experts below are selected from a list of 15 Experts worldwide ranked by ideXlab platform
Takashi Yokoyama - One of the best experts on this subject based on the ideXlab platform.
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SusceptiBility of Methicillin-resistant Staphylococcus aureus Clinical Isolates to Various AntimicroBial Agents. III. Novel, InduciBle Resistance to Macrolide-lincosamides-treptogramin B (MLS) AntiBiotics.
Hiroshima journal of medical sciences, 1993Co-Authors: Yoshio Inouye, Kazuo Morifuji, Noriko Masumi, Masanori Sugiyama, Yoshio Takesue, Takashi Kodama, Takashi YokoyamaAbstract:Resistance patterns against 25 antimicroBial agents consisting of Beta-lactams, aminoglycosides, tetracyclines, fluoroquinolones, macrolides and etc. were examined for 69 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated at Hiroshima University Hospital from July 1991 to April 1992. Regarding overall resistance (the percentage of highly and moderately resistant strains), the following antimicroBial agents were no more effective chemotherapeutics for MRSA infections (%resistance): methicillin (100), flomoxef (100), kanamycin (100), toBramycin (100), amikacin (100), isepamicin (100), gentamicin (78), diBekacin (100), ofloxacin (99), levofloxacin (99), temafloxacin (99), erythromycin (100), clarithromycin (100), tetracycline (93), minocycline (93) and fosfomycin (100). Further spread of arBekacin-resistant strain, which was isolated in April 1991, into a clinical environment could not Be recognized during the period covered in the present study. All the MRSA strains were resistant either constitutively (26 strains) or induciBly (43 strains) to macrolide-lincosamide-streptogramin B (MLS) antiBiotics. When expression is constitutive, the strains are resistant to all MLS antiBiotics. In contrast, 16-memBered macrolide (i.e., jasamycin), lincomycin and <B>MikamycinB> B escape resistance in the strains with a typical induciBle resistance overcome in the presence of 14-memBered macrolides By a translational attenuation mechanism. Three of 4 Beta-lactamase-positive strains, however, can not Be classified in these two resistance groups, Being exclusively resistant to <B>MikamycinB> B. The strains grown in the presence of any inducing MLS antiBiotic Became susceptiBle to <B>MikamycinB> B even in the inducer-free culture.
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SusceptiBility of Methicillin-resistant Staphylococcus aureus Clinical Isolates to Various AntimicroBial Agents. IL Isolation of ArBekacin-resistant Strain.
Hiroshima journal of medical sciences, 1992Co-Authors: Yoshio Inouye, Kazuo Morifuji, Noriko Masumi, Yoshio Takesue, Shoshiro Nakamura, Takahiro Santou, Takashi YokoyamaAbstract:Resistance patterns against 24 antimicroBial agents were examined for 50 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated at Hiroshima University Hospital during the period OctoBer 1990 and July 1991. Overall resistance (the percentage of highly and moderately resistant strains) to the antimicroBial agents is summarized as follows: methicillin 100%, flomoxef 100% (Beta-lactams); kanamycin 94%, toBramycin 94%, amikacin 100%, isepamicin 94%, gentamicin 80%, diBekacin 94%, arBekacin 2% (Basic oligosaccharide group/aminocyclitols); ofloxacin 96%, temafloxacin 96%, levofloxacin 96% (fluoroquinolones); erythromycin 98%, clarithromycin 98%, josamycin 30% (macrolides); vancomycin 0% (glycopeptide); tetracycline 94%, minocycline 94% (tetracyclines); fosfomycin 100%; <B>MikamycinB> B 30%, nosiheptide 0% (peptide); rifampicin 2% (ansamycin); streptomycin 2% (Basic oligosaccharide group); chloramphenicol 2%. ArBekacin resistance was oBserved in one case: the cross resistance was complete among the aminocyclitol antiBiotics tested in this study and streptomycin, proBaBly due to the riBosomal alteration.
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SusceptiBility of Methicillin-resistant Staphylococcus aureus Clinical Isolates to Various AntimicroBial Agents
Hiroshima journal of medical sciences, 1991Co-Authors: Sho-ichiro Sowa, Yoshio Inouye, Noriko Masumi, Yoshio Takesue, Shoshiro Nakamura, Takashi YokoyamaAbstract:Resistance patterns against 23 antimicroBial agents were examined for 42 strains of methicillinresistant Staphylococcus aureus (MRSA). Thirty-four strains were isolated at Hiroshima University Hospital during 1984-1990 and 8 strains were collected in Tokushima city in 1986. Overall resistance to the antimicroBial agents in clinical use is summarized as follows: methicillin 100%, flomoxef 93% ({3-lactams); kanamycin 98%, toBramycin 88%, amikacin 83%, isepamicin 81 %, gentamicin 60%, diBekacin 64%, arBekacin 0% (aminocyclitol aminoglycosides); ofloxacin 31 %, TA-167 33% (fluoroquinolones); erythromycin 100%, clarithromycin 100%, josamycin 71 % (macrolides); vancomycin 0% (glycopeptide); tetracycline 43%, minocycline 31 % (tetracyclines); fosfomycin 93%. The MRSA strains remained susceptiBle to the non-clinical peptide group of antiBiotics except for <B>MikamycinB> B: <B>MikamycinB> A 2%, <B>MikamycinB> B 69%, nosiheptide 0%, Bottromycin A2 0%, Bottromycin D-1 0%, Bottromycin D-2 0%. Since April 1990, the MRSA stral.ns isolated at Hiroshima University Hospital showed a tendency to acquire resistance to tetracyclines and fluoroquinolones and to lose <B>MikamycinB> Bresistance. As of August 1990, none of the MRSA strains isolated at Hiroshima University Hospital was resistant to vancomycin and arBekacin.
Yoshio Inouye - One of the best experts on this subject based on the ideXlab platform.
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SusceptiBility of Methicillin-resistant Staphylococcus aureus Clinical Isolates to Various AntimicroBial Agents. III. Novel, InduciBle Resistance to Macrolide-lincosamides-treptogramin B (MLS) AntiBiotics.
Hiroshima journal of medical sciences, 1993Co-Authors: Yoshio Inouye, Kazuo Morifuji, Noriko Masumi, Masanori Sugiyama, Yoshio Takesue, Takashi Kodama, Takashi YokoyamaAbstract:Resistance patterns against 25 antimicroBial agents consisting of Beta-lactams, aminoglycosides, tetracyclines, fluoroquinolones, macrolides and etc. were examined for 69 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated at Hiroshima University Hospital from July 1991 to April 1992. Regarding overall resistance (the percentage of highly and moderately resistant strains), the following antimicroBial agents were no more effective chemotherapeutics for MRSA infections (%resistance): methicillin (100), flomoxef (100), kanamycin (100), toBramycin (100), amikacin (100), isepamicin (100), gentamicin (78), diBekacin (100), ofloxacin (99), levofloxacin (99), temafloxacin (99), erythromycin (100), clarithromycin (100), tetracycline (93), minocycline (93) and fosfomycin (100). Further spread of arBekacin-resistant strain, which was isolated in April 1991, into a clinical environment could not Be recognized during the period covered in the present study. All the MRSA strains were resistant either constitutively (26 strains) or induciBly (43 strains) to macrolide-lincosamide-streptogramin B (MLS) antiBiotics. When expression is constitutive, the strains are resistant to all MLS antiBiotics. In contrast, 16-memBered macrolide (i.e., jasamycin), lincomycin and <B>MikamycinB> B escape resistance in the strains with a typical induciBle resistance overcome in the presence of 14-memBered macrolides By a translational attenuation mechanism. Three of 4 Beta-lactamase-positive strains, however, can not Be classified in these two resistance groups, Being exclusively resistant to <B>MikamycinB> B. The strains grown in the presence of any inducing MLS antiBiotic Became susceptiBle to <B>MikamycinB> B even in the inducer-free culture.
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SusceptiBility of Methicillin-resistant Staphylococcus aureus Clinical Isolates to Various AntimicroBial Agents. IL Isolation of ArBekacin-resistant Strain.
Hiroshima journal of medical sciences, 1992Co-Authors: Yoshio Inouye, Kazuo Morifuji, Noriko Masumi, Yoshio Takesue, Shoshiro Nakamura, Takahiro Santou, Takashi YokoyamaAbstract:Resistance patterns against 24 antimicroBial agents were examined for 50 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated at Hiroshima University Hospital during the period OctoBer 1990 and July 1991. Overall resistance (the percentage of highly and moderately resistant strains) to the antimicroBial agents is summarized as follows: methicillin 100%, flomoxef 100% (Beta-lactams); kanamycin 94%, toBramycin 94%, amikacin 100%, isepamicin 94%, gentamicin 80%, diBekacin 94%, arBekacin 2% (Basic oligosaccharide group/aminocyclitols); ofloxacin 96%, temafloxacin 96%, levofloxacin 96% (fluoroquinolones); erythromycin 98%, clarithromycin 98%, josamycin 30% (macrolides); vancomycin 0% (glycopeptide); tetracycline 94%, minocycline 94% (tetracyclines); fosfomycin 100%; <B>MikamycinB> B 30%, nosiheptide 0% (peptide); rifampicin 2% (ansamycin); streptomycin 2% (Basic oligosaccharide group); chloramphenicol 2%. ArBekacin resistance was oBserved in one case: the cross resistance was complete among the aminocyclitol antiBiotics tested in this study and streptomycin, proBaBly due to the riBosomal alteration.
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SusceptiBility of Methicillin-resistant Staphylococcus aureus Clinical Isolates to Various AntimicroBial Agents
Hiroshima journal of medical sciences, 1991Co-Authors: Sho-ichiro Sowa, Yoshio Inouye, Noriko Masumi, Yoshio Takesue, Shoshiro Nakamura, Takashi YokoyamaAbstract:Resistance patterns against 23 antimicroBial agents were examined for 42 strains of methicillinresistant Staphylococcus aureus (MRSA). Thirty-four strains were isolated at Hiroshima University Hospital during 1984-1990 and 8 strains were collected in Tokushima city in 1986. Overall resistance to the antimicroBial agents in clinical use is summarized as follows: methicillin 100%, flomoxef 93% ({3-lactams); kanamycin 98%, toBramycin 88%, amikacin 83%, isepamicin 81 %, gentamicin 60%, diBekacin 64%, arBekacin 0% (aminocyclitol aminoglycosides); ofloxacin 31 %, TA-167 33% (fluoroquinolones); erythromycin 100%, clarithromycin 100%, josamycin 71 % (macrolides); vancomycin 0% (glycopeptide); tetracycline 43%, minocycline 31 % (tetracyclines); fosfomycin 93%. The MRSA strains remained susceptiBle to the non-clinical peptide group of antiBiotics except for <B>MikamycinB> B: <B>MikamycinB> A 2%, <B>MikamycinB> B 69%, nosiheptide 0%, Bottromycin A2 0%, Bottromycin D-1 0%, Bottromycin D-2 0%. Since April 1990, the MRSA stral.ns isolated at Hiroshima University Hospital showed a tendency to acquire resistance to tetracyclines and fluoroquinolones and to lose <B>MikamycinB> Bresistance. As of August 1990, none of the MRSA strains isolated at Hiroshima University Hospital was resistant to vancomycin and arBekacin.
U Keller - One of the best experts on this subject based on the ideXlab platform.
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chromophore activating enzyme involved in the Biosynthesis of the <B>MikamycinB> B antiBiotic etamycin from streptomyces griseoviridus
Journal of Biological Chemistry, 1990Co-Authors: Wilhelm Schlumbohm, U KellerAbstract:ABstract A 3-hydroxypicolinic acid activating enzyme from etamycin producing Streptomyces griseoviridus has Been purified to apparent homogeneity. Etamycin is a memBer of <B>MikamycinB> B antiBiotics, chromopeptide lactones, which contain 3-hydroxypicolinic acid (3-HPA) as the chromophoric group. The enzyme catalyzes Both the 3-HPA-dependent ATP-pyrophosphate exchange and the formation of 3-HPA adenylate from 3-HPA and ATP. SDS-polyacrylamide gel electrophoresis indicates that the enzyme is a single polypeptide chain with a Mr Between 56,000 and 58,000. The molecular mass of the native enzyme was in the same range. In addition to 3-HPA, the enzyme catalyzes the formation of adenylates from picolinic acid, nicotinic acid, and 2-pyrazinecarBoxylic acid. Nicotinic acid and picolinic acid when added externally to etamycin producing S. griseoviridus cultures gave rise to the formation of etamycin analogues each containing nicotinic acid or picolinic acid instead of the genuine 3-HPA. The data strongly suggest that the enzyme is involved in the Biosynthesis of the chromopeptide lactone etamycin and possiBly in that of other <B>MikamycinB> B antiBiotics.
Noriko Masumi - One of the best experts on this subject based on the ideXlab platform.
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SusceptiBility of Methicillin-resistant Staphylococcus aureus Clinical Isolates to Various AntimicroBial Agents. III. Novel, InduciBle Resistance to Macrolide-lincosamides-treptogramin B (MLS) AntiBiotics.
Hiroshima journal of medical sciences, 1993Co-Authors: Yoshio Inouye, Kazuo Morifuji, Noriko Masumi, Masanori Sugiyama, Yoshio Takesue, Takashi Kodama, Takashi YokoyamaAbstract:Resistance patterns against 25 antimicroBial agents consisting of Beta-lactams, aminoglycosides, tetracyclines, fluoroquinolones, macrolides and etc. were examined for 69 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated at Hiroshima University Hospital from July 1991 to April 1992. Regarding overall resistance (the percentage of highly and moderately resistant strains), the following antimicroBial agents were no more effective chemotherapeutics for MRSA infections (%resistance): methicillin (100), flomoxef (100), kanamycin (100), toBramycin (100), amikacin (100), isepamicin (100), gentamicin (78), diBekacin (100), ofloxacin (99), levofloxacin (99), temafloxacin (99), erythromycin (100), clarithromycin (100), tetracycline (93), minocycline (93) and fosfomycin (100). Further spread of arBekacin-resistant strain, which was isolated in April 1991, into a clinical environment could not Be recognized during the period covered in the present study. All the MRSA strains were resistant either constitutively (26 strains) or induciBly (43 strains) to macrolide-lincosamide-streptogramin B (MLS) antiBiotics. When expression is constitutive, the strains are resistant to all MLS antiBiotics. In contrast, 16-memBered macrolide (i.e., jasamycin), lincomycin and <B>MikamycinB> B escape resistance in the strains with a typical induciBle resistance overcome in the presence of 14-memBered macrolides By a translational attenuation mechanism. Three of 4 Beta-lactamase-positive strains, however, can not Be classified in these two resistance groups, Being exclusively resistant to <B>MikamycinB> B. The strains grown in the presence of any inducing MLS antiBiotic Became susceptiBle to <B>MikamycinB> B even in the inducer-free culture.
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SusceptiBility of Methicillin-resistant Staphylococcus aureus Clinical Isolates to Various AntimicroBial Agents. IL Isolation of ArBekacin-resistant Strain.
Hiroshima journal of medical sciences, 1992Co-Authors: Yoshio Inouye, Kazuo Morifuji, Noriko Masumi, Yoshio Takesue, Shoshiro Nakamura, Takahiro Santou, Takashi YokoyamaAbstract:Resistance patterns against 24 antimicroBial agents were examined for 50 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated at Hiroshima University Hospital during the period OctoBer 1990 and July 1991. Overall resistance (the percentage of highly and moderately resistant strains) to the antimicroBial agents is summarized as follows: methicillin 100%, flomoxef 100% (Beta-lactams); kanamycin 94%, toBramycin 94%, amikacin 100%, isepamicin 94%, gentamicin 80%, diBekacin 94%, arBekacin 2% (Basic oligosaccharide group/aminocyclitols); ofloxacin 96%, temafloxacin 96%, levofloxacin 96% (fluoroquinolones); erythromycin 98%, clarithromycin 98%, josamycin 30% (macrolides); vancomycin 0% (glycopeptide); tetracycline 94%, minocycline 94% (tetracyclines); fosfomycin 100%; <B>MikamycinB> B 30%, nosiheptide 0% (peptide); rifampicin 2% (ansamycin); streptomycin 2% (Basic oligosaccharide group); chloramphenicol 2%. ArBekacin resistance was oBserved in one case: the cross resistance was complete among the aminocyclitol antiBiotics tested in this study and streptomycin, proBaBly due to the riBosomal alteration.
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SusceptiBility of Methicillin-resistant Staphylococcus aureus Clinical Isolates to Various AntimicroBial Agents
Hiroshima journal of medical sciences, 1991Co-Authors: Sho-ichiro Sowa, Yoshio Inouye, Noriko Masumi, Yoshio Takesue, Shoshiro Nakamura, Takashi YokoyamaAbstract:Resistance patterns against 23 antimicroBial agents were examined for 42 strains of methicillinresistant Staphylococcus aureus (MRSA). Thirty-four strains were isolated at Hiroshima University Hospital during 1984-1990 and 8 strains were collected in Tokushima city in 1986. Overall resistance to the antimicroBial agents in clinical use is summarized as follows: methicillin 100%, flomoxef 93% ({3-lactams); kanamycin 98%, toBramycin 88%, amikacin 83%, isepamicin 81 %, gentamicin 60%, diBekacin 64%, arBekacin 0% (aminocyclitol aminoglycosides); ofloxacin 31 %, TA-167 33% (fluoroquinolones); erythromycin 100%, clarithromycin 100%, josamycin 71 % (macrolides); vancomycin 0% (glycopeptide); tetracycline 43%, minocycline 31 % (tetracyclines); fosfomycin 93%. The MRSA strains remained susceptiBle to the non-clinical peptide group of antiBiotics except for <B>MikamycinB> B: <B>MikamycinB> A 2%, <B>MikamycinB> B 69%, nosiheptide 0%, Bottromycin A2 0%, Bottromycin D-1 0%, Bottromycin D-2 0%. Since April 1990, the MRSA stral.ns isolated at Hiroshima University Hospital showed a tendency to acquire resistance to tetracyclines and fluoroquinolones and to lose <B>MikamycinB> Bresistance. As of August 1990, none of the MRSA strains isolated at Hiroshima University Hospital was resistant to vancomycin and arBekacin.
Yoshio Takesue - One of the best experts on this subject based on the ideXlab platform.
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SusceptiBility of Methicillin-resistant Staphylococcus aureus Clinical Isolates to Various AntimicroBial Agents. III. Novel, InduciBle Resistance to Macrolide-lincosamides-treptogramin B (MLS) AntiBiotics.
Hiroshima journal of medical sciences, 1993Co-Authors: Yoshio Inouye, Kazuo Morifuji, Noriko Masumi, Masanori Sugiyama, Yoshio Takesue, Takashi Kodama, Takashi YokoyamaAbstract:Resistance patterns against 25 antimicroBial agents consisting of Beta-lactams, aminoglycosides, tetracyclines, fluoroquinolones, macrolides and etc. were examined for 69 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated at Hiroshima University Hospital from July 1991 to April 1992. Regarding overall resistance (the percentage of highly and moderately resistant strains), the following antimicroBial agents were no more effective chemotherapeutics for MRSA infections (%resistance): methicillin (100), flomoxef (100), kanamycin (100), toBramycin (100), amikacin (100), isepamicin (100), gentamicin (78), diBekacin (100), ofloxacin (99), levofloxacin (99), temafloxacin (99), erythromycin (100), clarithromycin (100), tetracycline (93), minocycline (93) and fosfomycin (100). Further spread of arBekacin-resistant strain, which was isolated in April 1991, into a clinical environment could not Be recognized during the period covered in the present study. All the MRSA strains were resistant either constitutively (26 strains) or induciBly (43 strains) to macrolide-lincosamide-streptogramin B (MLS) antiBiotics. When expression is constitutive, the strains are resistant to all MLS antiBiotics. In contrast, 16-memBered macrolide (i.e., jasamycin), lincomycin and <B>MikamycinB> B escape resistance in the strains with a typical induciBle resistance overcome in the presence of 14-memBered macrolides By a translational attenuation mechanism. Three of 4 Beta-lactamase-positive strains, however, can not Be classified in these two resistance groups, Being exclusively resistant to <B>MikamycinB> B. The strains grown in the presence of any inducing MLS antiBiotic Became susceptiBle to <B>MikamycinB> B even in the inducer-free culture.
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SusceptiBility of Methicillin-resistant Staphylococcus aureus Clinical Isolates to Various AntimicroBial Agents. IL Isolation of ArBekacin-resistant Strain.
Hiroshima journal of medical sciences, 1992Co-Authors: Yoshio Inouye, Kazuo Morifuji, Noriko Masumi, Yoshio Takesue, Shoshiro Nakamura, Takahiro Santou, Takashi YokoyamaAbstract:Resistance patterns against 24 antimicroBial agents were examined for 50 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated at Hiroshima University Hospital during the period OctoBer 1990 and July 1991. Overall resistance (the percentage of highly and moderately resistant strains) to the antimicroBial agents is summarized as follows: methicillin 100%, flomoxef 100% (Beta-lactams); kanamycin 94%, toBramycin 94%, amikacin 100%, isepamicin 94%, gentamicin 80%, diBekacin 94%, arBekacin 2% (Basic oligosaccharide group/aminocyclitols); ofloxacin 96%, temafloxacin 96%, levofloxacin 96% (fluoroquinolones); erythromycin 98%, clarithromycin 98%, josamycin 30% (macrolides); vancomycin 0% (glycopeptide); tetracycline 94%, minocycline 94% (tetracyclines); fosfomycin 100%; <B>MikamycinB> B 30%, nosiheptide 0% (peptide); rifampicin 2% (ansamycin); streptomycin 2% (Basic oligosaccharide group); chloramphenicol 2%. ArBekacin resistance was oBserved in one case: the cross resistance was complete among the aminocyclitol antiBiotics tested in this study and streptomycin, proBaBly due to the riBosomal alteration.
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SusceptiBility of Methicillin-resistant Staphylococcus aureus Clinical Isolates to Various AntimicroBial Agents
Hiroshima journal of medical sciences, 1991Co-Authors: Sho-ichiro Sowa, Yoshio Inouye, Noriko Masumi, Yoshio Takesue, Shoshiro Nakamura, Takashi YokoyamaAbstract:Resistance patterns against 23 antimicroBial agents were examined for 42 strains of methicillinresistant Staphylococcus aureus (MRSA). Thirty-four strains were isolated at Hiroshima University Hospital during 1984-1990 and 8 strains were collected in Tokushima city in 1986. Overall resistance to the antimicroBial agents in clinical use is summarized as follows: methicillin 100%, flomoxef 93% ({3-lactams); kanamycin 98%, toBramycin 88%, amikacin 83%, isepamicin 81 %, gentamicin 60%, diBekacin 64%, arBekacin 0% (aminocyclitol aminoglycosides); ofloxacin 31 %, TA-167 33% (fluoroquinolones); erythromycin 100%, clarithromycin 100%, josamycin 71 % (macrolides); vancomycin 0% (glycopeptide); tetracycline 43%, minocycline 31 % (tetracyclines); fosfomycin 93%. The MRSA strains remained susceptiBle to the non-clinical peptide group of antiBiotics except for <B>MikamycinB> B: <B>MikamycinB> A 2%, <B>MikamycinB> B 69%, nosiheptide 0%, Bottromycin A2 0%, Bottromycin D-1 0%, Bottromycin D-2 0%. Since April 1990, the MRSA stral.ns isolated at Hiroshima University Hospital showed a tendency to acquire resistance to tetracyclines and fluoroquinolones and to lose <B>MikamycinB> Bresistance. As of August 1990, none of the MRSA strains isolated at Hiroshima University Hospital was resistant to vancomycin and arBekacin.